JP7560136B2 - チロシンキナーゼ２活性を仲介する複素環式化合物 - Google Patents

チロシンキナーゼ２活性を仲介する複素環式化合物 Download PDF

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JP7560136B2
JP7560136B2 JP2021577587A JP2021577587A JP7560136B2 JP 7560136 B2 JP7560136 B2 JP 7560136B2 JP 2021577587 A JP2021577587 A JP 2021577587A JP 2021577587 A JP2021577587 A JP 2021577587A JP 7560136 B2 JP7560136 B2 JP 7560136B2
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alkyl
mmol
mixture
cycloalkyl
hydrogens
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JP2022540353A (ja
JP2022540353A5 (enExample
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チェン、シャンヤン
パン、イーチョン
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Guangzhou Innocare Pharma Tech Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
JP2021577587A 2019-06-28 2020-06-24 チロシンキナーゼ２活性を仲介する複素環式化合物 Active JP7560136B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
CN201910572091.9 2019-06-28
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

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JP2022540353A JP2022540353A (ja) 2022-09-15
JP2022540353A5 JP2022540353A5 (enExample) 2023-06-02
JP7560136B2 true JP7560136B2 (ja) 2024-10-02

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US (2) US12448382B2 (enExample)
EP (1) EP3990449A4 (enExample)
JP (1) JP7560136B2 (enExample)
KR (1) KR102926602B1 (enExample)
CN (2) CN112142743A (enExample)
AU (1) AU2020301437B2 (enExample)
BR (1) BR112021026531A2 (enExample)
CA (1) CA3144799A1 (enExample)
MX (1) MX2021015969A (enExample)
PH (1) PH12021553257A1 (enExample)
TW (1) TWI851747B (enExample)
WO (1) WO2020259584A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도
CN122421968A (zh) * 2023-12-15 2026-07-17 北京诺诚健华医药科技有限公司 特应性皮炎的治疗方法
WO2026086809A1 (en) * 2024-10-25 2026-04-30 Beijing Innocare Pharma Tech Co., Ltd. Process for preparing 3- [ (3as, 6ar) -5- {5-chloro-2- [ (1-methyl-1h-pyrazol-4-yl) amino] pyrimidin-4-yl} -3a-methyl-octahydropyrrolo [3, 4-c] pyrrole-2-yl] -3-oxopropionitrile

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
JP2018524356A (ja) 2015-07-09 2018-08-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｂｔｋ阻害剤としてのピリミジン誘導体及びその使用
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
JP2018524356A (ja) 2015-07-09 2018-08-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｂｔｋ阻害剤としてのピリミジン誘導体及びその使用
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

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KR102926602B1 (ko) 2026-02-11
CN114096532A (zh) 2022-02-25
BR112021026531A2 (pt) 2022-02-15
US20220112200A1 (en) 2022-04-14
EP3990449A4 (en) 2023-07-26
US12448382B2 (en) 2025-10-21
AU2020301437A1 (en) 2022-02-17
CN112142743A (zh) 2020-12-29
AU2020301437B2 (en) 2026-02-26
WO2020259584A1 (en) 2020-12-30
PH12021553257A1 (en) 2022-08-08
TWI851747B (zh) 2024-08-11
CN114096532B (zh) 2023-12-01
MX2021015969A (es) 2022-04-18
TW202115034A (zh) 2021-04-16
US20260116887A1 (en) 2026-04-30
KR20220042344A (ko) 2022-04-05
EP3990449A1 (en) 2022-05-04
CA3144799A1 (en) 2020-12-30

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