KR102926602B1 - 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물 - Google Patents

티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물

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Publication number
KR102926602B1
KR102926602B1 KR1020227000934A KR20227000934A KR102926602B1 KR 102926602 B1 KR102926602 B1 KR 102926602B1 KR 1020227000934 A KR1020227000934 A KR 1020227000934A KR 20227000934 A KR20227000934 A KR 20227000934A KR 102926602 B1 KR102926602 B1 KR 102926602B1
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mmol
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mixture
cycloalkyl
added
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KR20220042344A (ko
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샹양 천
위청 팡
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광저우 이노케어 파마 테크 씨오., 엘티디.
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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KR1020227000934A 2019-06-28 2020-06-24 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물 Active KR102926602B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
CN201910572091.9 2019-06-28
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (2)

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KR20220042344A KR20220042344A (ko) 2022-04-05
KR102926602B1 true KR102926602B1 (ko) 2026-02-11

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KR1020227000934A Active KR102926602B1 (ko) 2019-06-28 2020-06-24 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물

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US (2) US12448382B2 (enExample)
EP (1) EP3990449A4 (enExample)
JP (1) JP7560136B2 (enExample)
KR (1) KR102926602B1 (enExample)
CN (2) CN112142743A (enExample)
AU (1) AU2020301437B2 (enExample)
BR (1) BR112021026531A2 (enExample)
CA (1) CA3144799A1 (enExample)
MX (1) MX2021015969A (enExample)
PH (1) PH12021553257A1 (enExample)
TW (1) TWI851747B (enExample)
WO (1) WO2020259584A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도
CN122421968A (zh) * 2023-12-15 2026-07-17 北京诺诚健华医药科技有限公司 特应性皮炎的治疗方法
WO2026086809A1 (en) * 2024-10-25 2026-04-30 Beijing Innocare Pharma Tech Co., Ltd. Process for preparing 3- [ (3as, 6ar) -5- {5-chloro-2- [ (1-methyl-1h-pyrazol-4-yl) amino] pyrimidin-4-yl} -3a-methyl-octahydropyrrolo [3, 4-c] pyrrole-2-yl] -3-oxopropionitrile

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WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
CN108137559A (zh) 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

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JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
CN108137559A (zh) 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途
JP2018524356A (ja) * 2015-07-09 2018-08-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｂｔｋ阻害剤としてのピリミジン誘導体及びその使用
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

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JP2022540353A (ja) 2022-09-15
CN114096532A (zh) 2022-02-25
BR112021026531A2 (pt) 2022-02-15
US20220112200A1 (en) 2022-04-14
EP3990449A4 (en) 2023-07-26
US12448382B2 (en) 2025-10-21
AU2020301437A1 (en) 2022-02-17
CN112142743A (zh) 2020-12-29
AU2020301437B2 (en) 2026-02-26
WO2020259584A1 (en) 2020-12-30
PH12021553257A1 (en) 2022-08-08
TWI851747B (zh) 2024-08-11
CN114096532B (zh) 2023-12-01
MX2021015969A (es) 2022-04-18
TW202115034A (zh) 2021-04-16
US20260116887A1 (en) 2026-04-30
KR20220042344A (ko) 2022-04-05
EP3990449A1 (en) 2022-05-04
CA3144799A1 (en) 2020-12-30

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