AU2020301437B2 - Heterocyclic compounds for mediating tyrosine kinase 2 activity - Google Patents

Heterocyclic compounds for mediating tyrosine kinase 2 activity

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Publication number
AU2020301437B2
AU2020301437B2 AU2020301437A AU2020301437A AU2020301437B2 AU 2020301437 B2 AU2020301437 B2 AU 2020301437B2 AU 2020301437 A AU2020301437 A AU 2020301437A AU 2020301437 A AU2020301437 A AU 2020301437A AU 2020301437 B2 AU2020301437 B2 AU 2020301437B2
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alkyl
mmol
methyl
pyrazol
mixture
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AU2020301437A
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AU2020301437A1 (en
Inventor
Xiangyang Chen
Yucheng PANG
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Guangzhou Innocare Pharma Tech Co Ltd
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Guangzhou Innocare Pharma Tech Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/07—Optical isomers

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AU2020301437A 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity Active AU2020301437B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
CN201910572091.9 2019-06-28
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (2)

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AU2020301437A1 AU2020301437A1 (en) 2022-02-17
AU2020301437B2 true AU2020301437B2 (en) 2026-02-26

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US (2) US12448382B2 (enExample)
EP (1) EP3990449A4 (enExample)
JP (1) JP7560136B2 (enExample)
KR (1) KR102926602B1 (enExample)
CN (2) CN112142743A (enExample)
AU (1) AU2020301437B2 (enExample)
BR (1) BR112021026531A2 (enExample)
CA (1) CA3144799A1 (enExample)
MX (1) MX2021015969A (enExample)
PH (1) PH12021553257A1 (enExample)
TW (1) TWI851747B (enExample)
WO (1) WO2020259584A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도
CN122421968A (zh) * 2023-12-15 2026-07-17 北京诺诚健华医药科技有限公司 特应性皮炎的治疗方法
WO2026086809A1 (en) * 2024-10-25 2026-04-30 Beijing Innocare Pharma Tech Co., Ltd. Process for preparing 3- [ (3as, 6ar) -5- {5-chloro-2- [ (1-methyl-1h-pyrazol-4-yl) amino] pyrimidin-4-yl} -3a-methyl-octahydropyrrolo [3, 4-c] pyrrole-2-yl] -3-oxopropionitrile

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2012062704A1 (en) * 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
EP2832734A1 (en) * 2012-03-28 2015-02-04 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN108137559A (zh) * 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012145581A1 (en) * 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
CN105622638B (zh) 2014-10-29 2018-10-02 广州必贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
TW201920170A (zh) * 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012062704A1 (en) * 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
EP2832734A1 (en) * 2012-03-28 2015-02-04 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN108137559A (zh) * 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途

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JP7560136B2 (ja) 2024-10-02
JP2022540353A (ja) 2022-09-15
KR102926602B1 (ko) 2026-02-11
CN114096532A (zh) 2022-02-25
BR112021026531A2 (pt) 2022-02-15
US20220112200A1 (en) 2022-04-14
EP3990449A4 (en) 2023-07-26
US12448382B2 (en) 2025-10-21
AU2020301437A1 (en) 2022-02-17
CN112142743A (zh) 2020-12-29
WO2020259584A1 (en) 2020-12-30
PH12021553257A1 (en) 2022-08-08
TWI851747B (zh) 2024-08-11
CN114096532B (zh) 2023-12-01
MX2021015969A (es) 2022-04-18
TW202115034A (zh) 2021-04-16
US20260116887A1 (en) 2026-04-30
KR20220042344A (ko) 2022-04-05
EP3990449A1 (en) 2022-05-04
CA3144799A1 (en) 2020-12-30

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