TWI837080B - 防護空氣汙染之不良影響的水溶性蕃茄萃取物 - Google Patents
防護空氣汙染之不良影響的水溶性蕃茄萃取物 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2116—Flavonoids, isoflavones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| ??16196794.8 | 2016-11-02 | ||
| EP16196794.8 | 2016-11-02 | ||
| EP16196794 | 2016-11-02 |
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| TW201821097A TW201821097A (zh) | 2018-06-16 |
| TWI837080B true TWI837080B (zh) | 2024-04-01 |
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| EP (2) | EP3534725A1 (enExample) |
| JP (1) | JP7104032B2 (enExample) |
| KR (3) | KR20240158385A (enExample) |
| CN (2) | CN109890223A (enExample) |
| AU (1) | AU2017353349B2 (enExample) |
| BR (1) | BR112019008687B1 (enExample) |
| CA (1) | CA3042720A1 (enExample) |
| IL (1) | IL266397B (enExample) |
| MX (1) | MX2019005054A (enExample) |
| MY (1) | MY199636A (enExample) |
| PH (1) | PH12019500953A1 (enExample) |
| TW (1) | TWI837080B (enExample) |
| WO (1) | WO2018083137A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2844083T3 (pl) | 2012-04-23 | 2018-12-31 | University Of Oslo | Zastosowanie ekstraktu pomidorowego jako środka przeciwdziałającego nadciśnieniu i proces do sporządzania rozpuszczalnego w wodzie ekstraktu pomidorowego bez cukru |
| GB201223365D0 (en) | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
| MX2019005054A (es) | 2016-11-02 | 2019-06-20 | Provexis Natural Products Ltd | Extracto de jitomate soluble en agua protege contra los efectos adversos de la contaminacion del aire. |
| GB202208323D0 (en) | 2022-06-07 | 2022-07-20 | Provexis Natural Products Ltd | Compostions |
| CN116688025A (zh) * | 2023-06-21 | 2023-09-05 | 汤臣倍健股份有限公司 | 水溶性番茄浓缩物在制备治疗脑缺血—再灌注损伤的组合物中的应用 |
| CN116803404B (zh) * | 2023-08-24 | 2023-12-15 | 汤臣倍健股份有限公司 | 水溶性番茄浓缩物在制备减少脱发、育发的产品中的应用 |
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| CN102271697A (zh) * | 2008-10-31 | 2011-12-07 | 普罗维斯天然产物有限公司 | 水果提取物 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6467173A (en) | 1987-09-04 | 1989-03-13 | Sanei Kagaku Kogyo Kk | Preparation of vegetable or fruit juices |
| JP2722670B2 (ja) | 1989-05-30 | 1998-03-04 | ライオン株式会社 | 高血圧症予防用飲食品及びその製造方法 |
| JP2997358B2 (ja) | 1992-01-30 | 2000-01-11 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| DK0656881T3 (da) | 1992-07-30 | 1999-06-23 | Cal Int Ltd | Ester og kombinationer af et organisk nitrat og et salicylat |
| US5502038A (en) | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| JP2905725B2 (ja) | 1995-07-01 | 1999-06-14 | カゴメ株式会社 | トマト由来の食品組成物 |
| FR2759904B1 (fr) | 1997-02-25 | 2000-01-28 | Alma Heny Reza | Compositions a usage cosmetique et/ou pharmaceutique et/ou dermatologique et leurs procedes de fabrication |
| DE19720767A1 (de) | 1997-05-07 | 1998-11-12 | Protekum Umweltinstitut Gmbh O | Pharmazeutisches Produkt, insbesondere zur Therapie und Prophylaxe von Herz-Kreislauf-Erkrankungen |
| GB9808796D0 (en) | 1998-04-24 | 1998-06-24 | Rowett Research Services Limit | Antithrombotic agents |
| DE69907342T2 (de) | 1998-09-02 | 2004-03-25 | Unilever N.V. | Mit beta-cyclocitral angereicherte Tomatenprodukte |
| AU5965399A (en) | 1998-10-12 | 2000-05-01 | Andreas Bockelmann | Pharmaceutically active composition |
| CN1352941A (zh) | 2000-11-11 | 2002-06-12 | 吉建军 | 亚油酸胶囊 |
| WO2002090386A2 (en) | 2001-05-04 | 2002-11-14 | Ato B.V. | Regulatory protein involved in pectin modification |
| DE10300049A1 (de) | 2003-01-03 | 2004-07-15 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Faktor VIIa inhibieren |
| ITMI20020632A1 (it) | 2002-03-27 | 2003-09-29 | Indena Spa | Processo per la preparazione di estratti di pomodoro ad elevato contenuto di licopene |
| EP1559421B1 (en) | 2002-11-06 | 2016-07-27 | Kao Corporation | Blood circulation promoting agent |
| JP4684893B2 (ja) | 2003-03-27 | 2011-05-18 | ユニジェン インク． | 炎症性及び血液循環疾患の治療及び予防活性を示す、竹抽出物並びにそれから分離された化合物を含有する組成物 |
| JP4571783B2 (ja) | 2003-04-14 | 2010-10-27 | 林原 健 | 抗微生物剤 |
| US20040223962A1 (en) | 2003-05-07 | 2004-11-11 | Riordan Neil H. | Method and composition for preventing or reducing edema, deep vein thrombosis and/or pulmonary embolism |
| EP1481669A1 (en) | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | Use of polyhydroxy phenols and polyphenols for modulating p-selectin activity |
| ES2322757T3 (es) | 2003-08-21 | 2009-06-26 | Nestec S.A. | Concentrado natural de licopeno y procedimiento de obtencion. |
| JP2004137287A (ja) | 2003-12-08 | 2004-05-13 | Kao Corp | 高血圧症予防・治療剤 |
| FR2871378B1 (fr) | 2004-06-15 | 2007-03-30 | Seppic Sa | Nouveau medicament a base de flavanois et de leurs derives et son utilisation pour obtenir un medicament destine a la prevention de la restenose et de la maladie atheromateuse chez les patients coronariens |
| EP1640001A1 (en) | 2004-09-24 | 2006-03-29 | New Pharma Investments Holding | Composition against cardiovascular diseases |
| CN100488535C (zh) | 2004-12-09 | 2009-05-20 | 郭富凤 | 一种番茄红素混合物 |
| US7419960B2 (en) | 2005-01-07 | 2008-09-02 | Hong Kong Baptist University | Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens |
| JP2006193435A (ja) | 2005-01-11 | 2006-07-27 | Kagome Co Ltd | 疲労改善剤 |
| GB0502985D0 (en) | 2005-02-14 | 2005-03-16 | Provexis Ltd | Therapeutic uses of tomato extracts |
| WO2006094120A2 (en) | 2005-03-02 | 2006-09-08 | The Regents Of The University Of California | Treatment for embolic stroke |
| JP4260158B2 (ja) | 2005-07-07 | 2009-04-30 | 長谷川香料株式会社 | トマトジュース濃縮物の製造方法およびトマト風味組成物 |
| US20070082071A1 (en) * | 2005-10-07 | 2007-04-12 | Willimann John A | Composition for controlling the respiratory effects of inhaled pollutants & allergens |
| AT503521A1 (de) | 2006-05-05 | 2007-11-15 | Omnica Gmbh | Verwendung eines extraktes von kiwi-frucht |
| GB0610790D0 (en) | 2006-06-02 | 2006-07-12 | Provexis Natural Products Ltd | Therapeutic uses of tomato extracts |
| US20080009449A1 (en) | 2006-07-07 | 2008-01-10 | Kailash Prasad | Lignan complex derived from flax seed used for treatment of hypercholesterolemic atherosclerosis |
| SG191445A1 (en) | 2006-12-22 | 2013-07-31 | Univ Johns Hopkins | Anti-cholesterolemic compounds and methods of use |
| US8759327B2 (en) | 2007-04-16 | 2014-06-24 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
| EP2036568A1 (en) | 2007-09-12 | 2009-03-18 | Nestec S.A. | Wolfberries and inflammation |
| JP2009240191A (ja) | 2008-03-31 | 2009-10-22 | Shimizu Shoko Kaigisho | 光照射によるリグナン類・リグニン類合成系遺伝子の発現増強 |
| GB0819958D0 (en) * | 2008-10-31 | 2008-12-10 | Provexis Natural Products Ltd | Therapeutic compositions |
| CA2785581A1 (en) * | 2009-12-24 | 2011-06-30 | Stanley Kubow | Compositions and methods for preventing and treating diseases and environmentally induced health disorders |
| PL2844083T3 (pl) | 2012-04-23 | 2018-12-31 | University Of Oslo | Zastosowanie ekstraktu pomidorowego jako środka przeciwdziałającego nadciśnieniu i proces do sporządzania rozpuszczalnego w wodzie ekstraktu pomidorowego bez cukru |
| GB201223365D0 (en) | 2012-12-24 | 2013-02-06 | Provexis Natural Products Ltd | Compositions |
| MX2019005054A (es) | 2016-11-02 | 2019-06-20 | Provexis Natural Products Ltd | Extracto de jitomate soluble en agua protege contra los efectos adversos de la contaminacion del aire. |
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Patent Citations (1)
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| CN102271697A (zh) * | 2008-10-31 | 2011-12-07 | 普罗维斯天然产物有限公司 | 水果提取物 |
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| US20210299205A1 (en) | 2021-09-30 |
| KR20230048169A (ko) | 2023-04-10 |
| IL266397A (en) | 2019-06-30 |
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| AU2017353349A1 (en) | 2019-06-06 |
| US20200054706A1 (en) | 2020-02-20 |
| WO2018083137A1 (en) | 2018-05-11 |
| JP2019532986A (ja) | 2019-11-14 |
| EP4445750A3 (en) | 2024-12-25 |
| CA3042720A1 (en) | 2018-05-11 |
| US10905733B2 (en) | 2021-02-02 |
| CN118217345A (zh) | 2024-06-21 |
| CN109890223A (zh) | 2019-06-14 |
| KR20240158385A (ko) | 2024-11-04 |
| IL266397B (en) | 2022-08-01 |
| TW201821097A (zh) | 2018-06-16 |
| BR112019008687B1 (pt) | 2023-02-07 |
| AU2017353349B2 (en) | 2022-04-21 |
| BR112019008687A2 (pt) | 2019-07-09 |
| MX2019005054A (es) | 2019-06-20 |
| KR20190101964A (ko) | 2019-09-02 |
| MY199636A (en) | 2023-11-11 |
| JP7104032B2 (ja) | 2022-07-20 |
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