TWI830456B - 一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法 - Google Patents
一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法 Download PDFInfo
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- TWI830456B TWI830456B TW111140298A TW111140298A TWI830456B TW I830456 B TWI830456 B TW I830456B TW 111140298 A TW111140298 A TW 111140298A TW 111140298 A TW111140298 A TW 111140298A TW I830456 B TWI830456 B TW I830456B
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- Prior art keywords
- cosmetic composition
- acid
- hydroxyacetophenone
- stabilizer
- weeks
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 128
- 239000002537 cosmetic Substances 0.000 title claims abstract description 117
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 title claims abstract description 98
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000003381 stabilizer Substances 0.000 claims abstract description 36
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- -1 alkali metal salts Chemical class 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 9
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 4
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- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 4
- OALYTRUKMRCXNH-UHFFFAOYSA-N 5-pentyloxolan-2-one Chemical group CCCCCC1CCC(=O)O1 OALYTRUKMRCXNH-UHFFFAOYSA-N 0.000 claims description 3
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- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
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- 239000001069 triethyl citrate Substances 0.000 claims description 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000013769 triethyl citrate Nutrition 0.000 claims description 3
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Abstract
本發明涉及一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法,其包括將pH穩定劑加入到含有對羥基苯乙酮的化妝品組合物中,以使該組合物的pH保持穩定,從而提高了對羥基苯乙酮在化妝品組合物中的穩定性,這顯著緩解了因對羥基苯乙酮的不穩定而導致的化妝品組合物變色(變黃)問題。其中該pH穩定劑為本領域已知的可使化妝品組合物的pH保持穩定的任何物質,例如,pH緩衝對,和可藉由水解緩慢釋放酸從而使化妝品組合物的pH保持穩定的試劑。
Description
本發明涉及一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法,其包括將pH穩定劑加入到含有對羥基苯乙酮的化妝品組合物中,以使該組合物的pH保持穩定,從而提高了對羥基苯乙酮在化妝品組合物中的穩定性,這顯著緩解了因對羥基苯乙酮的不穩定而導致的化妝品組合物變色(變黃)問題。其中,該pH穩定劑為本領域已知的可使化妝品組合物的pH保持穩定的物質,包括例如,pH緩衝對、可藉由水解緩慢釋放酸從而使化妝品組合物的pH保持穩定的試劑、或者它們的混合物。
對羥基苯乙酮是一種天然植物提取物,天然存在於菊科植物濱蒿的莖和葉,以及茵陳蒿、蘿藦科植物、人參娃兒藤等植物的根中,其為白色至灰白色的片狀固體,分子式為C
8H
8O
2,結構如下:
對羥基苯乙酮具有清利濕熱、利膽退黃的作用,對由於肝炎等疾病以及其他原因導致的眼球發黃具有很好的療效和輔助療效,故常用於製備利膽藥。對羥基苯乙酮還具有抗氧化性、抗刺激性、抑菌性等多重功效,在化妝品中常被用作防腐增效劑。其抗氧化性和抑菌性都來自於羥基,對真菌有效、對黑麯黴的殺滅能力很強、對銅綠假單胞菌也有一定的抑制效果。同時,對羥基苯乙酮溫和安全,與化妝品的相容性良好,因此在化妝品中的使用量逐年遞增。
當對羥基苯乙酮應用於化妝品中時,通常將其先加熱溶解在醇溶液中,然後再溶解於水中。然而,即使在常溫下,對羥基苯乙酮在醇溶液或水溶液中也不穩定,導致溶液的變色和同時pH向上漂移的問題。而且,在光照或高溫條件下,這種不穩定現象會更加顯著,成為其在化妝品中應用的主要問題。
為了解決該問題,先前技術通常有兩種方法。一種是將對羥基苯乙酮與其他防腐成分進行複配。另一種是嘗試保持對羥基苯乙酮穩定,從而避免變色和pH向上漂移的問題,例如CN111937874A藉由使用抗氧化劑作為穩定劑來緩解對羥基苯乙酮在醇溶液中引起的變色問題;然而,該方法的問題是,抗氧化劑本身通常極易被氧化,例如該申請中採用的表現出最好效果的維生素C,雖然其在醇溶液中較為穩定,但將其與對羥基苯乙酮的醇溶液應用於含水的化妝品組合物時,由於維生素C本身在水溶液中極易被氧化,因此難以再發揮其穩定對羥基苯乙酮的作用,從而使得該方法的實際應用受限。
因此,需要一種能夠真正解決對羥基苯乙酮在化妝品組合物中的穩定性問題的方法,從而發揮對羥基苯乙酮在化妝品組合物中的防腐增效作用。
本發明人藉由研究發現,採用pH穩定劑可以提高對羥基苯乙酮在化妝品組合物中的穩定性,從而顯著緩解因對羥基苯乙酮不穩定而導致的化妝品組合物的變黃問題。
因此,一方面,本發明提供了一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法,其包括將pH穩定劑加入到含有對羥基苯乙酮的化妝品組合物中,以使該組合物在整個保存期限內(通常為3年)的pH保持穩定,且即使在光照或高溫條件下一段相當長的時間內,本發明的方法也使得化妝品組合物的pH不會發生明顯的向上漂移。
另一方面,本發明涉及pH穩定劑在包含對羥基苯乙酮的化妝品組合物中用於提高對羥基苯乙酮的穩定性的用途。
再一方面,本發明提供了一種穩定的化妝品組合物,其包含對羥基苯乙酮和pH穩定劑,該組合物在整個保存期限內(通常為3年)不會隨著時間流逝而變黃。
該pH穩定劑為本領域已知的可使化妝品組合物的pH保持穩定從而避免組合物體系的pH隨保存時間延長而發生明顯漂移的物質,例如,pH緩衝對、可藉由水解緩慢釋放酸從而使化妝品組合物的pH保持穩定的試劑(簡稱“可藉由水解緩慢釋放酸的試劑”)。
該pH緩衝對是本領域已知的那些,包括弱酸及其鹽的混合物。該弱酸包括有機酸和無機酸,有機酸包括例如乙酸、乙醯丙酸、檸檬酸、乳酸、鄰苯二甲酸等,無機酸包括例如碳酸、磷酸、偏磷酸、亞硫酸、氫氟酸、氫硫酸、次氯酸等。該鹽可以是鹼金屬鹽,例如,鈉鹽、鉀鹽。pH緩衝對的較佳實例包括例如乙醯丙酸-乙醯丙酸鈉、檸檬酸-檸檬酸鈉/鉀和乳酸-乳酸鈉/鉀等。
此外,該pH緩衝對還可以是多元弱酸的酸式鹽及其對應的次級鹽,包括例如磷酸二氫鈉-磷酸氫二鈉、碳酸氫鈉-碳酸鈉和檸檬酸二氫鈉-檸檬酸氫二鈉等。
基於先前技術,本領域技術人員可以控制pH緩衝對中兩種物質的比。例如,通常弱酸與其鹽的莫耳比為約0.5:1.0-3.0:1.0,較佳約1:1,多元弱酸的酸式鹽與其對應的次級鹽的莫耳比為約0.5:1.0-3.0:1.0,較佳約1:1。
該可藉由水解緩慢釋放酸從而使化妝品組合物的pH保持穩定的試劑是本領域已知的那些,包括例如小分子內酯類及/或酯類物質。具體實例包括例如葡糖酸內酯、γ-壬內酯、泛內酯、葡庚糖酸內酯、檸檬酸三乙酯等等。
在本發明中,可單獨使用或者組合使用上述各pH緩衝對以及上述各可藉由水解緩慢釋放酸的試劑。
該pH穩定劑在化妝品組合物中以使在整個保存期限內(通常為3年)化妝品組合物的pH也不發生明顯的向上漂移的量存在。通常,該pH穩定劑在該化妝品組合物中的含量為約0.01-3%,較佳約0.05-2%,更佳約0.1-1%,基於該化妝品組合物的總重量。
本領域已知,化妝品組合物的pH通常為約4-7,較佳約5-7。在本發明中,藉由使用pH穩定劑可在整個保存期限內將化妝品組合物的pH穩定在上述範圍。通常,化妝品組合物在常溫(即,室溫,通常約20-25℃)下的保存期限為約3年。此外,即使在光照(例如,置於窗臺上暴露於自然光,或者置於標準光照箱中)或者高溫(例如,高於室溫,例如約30-60℃)下,藉由使用pH穩定劑也可將化妝品組合物的pH保持穩定相當長的時間段,例如在約48℃和約60℃的加速條件下,化妝品組合物的pH保持穩定4週,沒有出現明顯的變色,如後面實施例中所顯示的。
在含有對羥基苯乙酮的化妝品組合物中,對羥基苯乙酮的含量通常為約0.01-1%,較佳約0.05-0.8%,更佳約0.1-0.6%,基於該化妝品組合物的總重量。
含有對羥基苯乙酮的化妝品組合物除了包含對羥基苯乙酮和pH穩定劑之外,還任選地包含化妝品中常用的各種成分,其中包括活性成分、媒介物、表面活性劑和輔料等本領域已知的任何成分,這些是本領域技術人員已知的,且可根據需要具體選擇其類型和用量。
該媒介物可以是稀釋劑、分散劑或載體等,所有媒介物都是本領域已知的,本領域技術人員可根據需要選擇其類型和用量,包括但不限於乙醇、雙丙甘醇、丙二醇、丁二醇、戊二醇等;在本發明組合物中,該媒介物占該常用的成分的總重量的約1-20%。
該活性成分包括例如潤膚劑、保濕劑、皮膚調理劑等。其中,潤膚劑包括但不限於甘油三(乙基己酸)酯、辛酸/癸酸甘油三酯、牛油果樹果脂、鯨蠟醇、聚二甲基矽氧烷、季戊四醇四(乙基己酸)酯、橄欖油、葡萄籽油、白池花籽油、鱷梨油、玉米油、角鯊烷、碳酸二辛酯、肉豆蔻酸異丙酯、氫化聚癸烯、向日葵籽油、異十六烷、霍霍巴籽油、羊毛脂、石蠟、微晶蠟、蜂蠟等中的一種或多種;在本發明化妝品組合物中,該潤膚劑占該常用的成分的總重量的0-50%。
該保濕劑包括但不限於樺樹汁、甘油、甜菜鹼、甘油聚醚-26、海藻糖、蔗糖、丙二醇、1,2-戊二醇、甘露醇、鼠李糖、棉子糖、赤蘚醇、木糖醇、尿素、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、聚谷氨酸鈉、水解小核菌膠、出芽短梗酶多糖、銀耳多糖、聚谷氨酸鈉、甘油葡糖苷、PPG-10甲基葡糖醚、PPG-20甲基葡糖醚等中的一種或多種;在本發明化妝品組合物中,該保濕劑占該常用的成分的總重量的約0.1-30%。
該皮膚調理劑包括但不限於植物甾醇/辛基十二醇月桂醯谷氨酸酯、水解透明質酸鈉、乙醯植物鞘氨醇、薑黃根提取物、神經醯胺2、神經醯胺3、膽甾醇、曲酸、抗壞血酸、抗壞血酸葡糖苷、熊果苷、傳明酸、煙醯胺、白樺樹皮提取物、乙醯植物鞘氨醇、白藜蘆醇、花櫚木樹皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物、泛醌、紅沒藥醇、抗壞血酸四異棕櫚酸酯、吡哆素二辛酸酯、吡哆素二棕櫚酸酯、視黃醇棕櫚酸酯等中的一種或多種。該皮膚調理劑可用於保濕、抗皺、祛斑、祛痘、控油等功效,通常,在本發明的化妝品組合物中,該皮膚調理劑占該常用的成分的總重量的約0-50%。
該表面活性劑可以是常用於化妝品的任何類型的表面活性劑。用於降低界面的表面張力,達到清潔、乳化、穩定體系之目的,其可以是常用於化妝品的任何類型的表面活性劑,本領域技術人員可以根據所需選擇其類型及用量。例如,該表面活性劑可包括但不限於脂肪酸皂(例如月桂酸鈉、棕櫚酸鈉等)、高級烷基硫酸鹽(例如月桂基硫酸鈉等)、N-醯基肌氨酸(例如月桂醯基肌氨酸鈉等)、高級脂肪酸醯胺磺酸鹽(例如月桂基甲基牛磺酸鈉等)、烷基苯磺酸鹽、高級脂肪酸酯硫酸鹽(例如硬化椰子油脂肪酸甘油硫酸鈉等)、N-醯基谷氨酸鹽、月桂基二甲氨基乙酸甜菜鹼、烷基甜菜鹼、醯氨基甜菜鹼、脫水山梨糖醇脂肪酸酯類(例如,脫水山梨糖醇單油酸酯、脫水山梨糖醇單異硬脂酸酯、脫水山梨糖醇單月桂酸酯、脫水山梨糖醇單棕櫚酸酯、脫水山梨糖醇單硬脂酸酯、脫水山梨糖醇倍半油酸酯)、甘油聚甘油脂肪酸酯類(例如,單芥酸甘油酯、倍半油酸甘油酯、單硬脂酸甘油酯、單硬脂酸甘油蘋果酸酯等) 、PEG-脂肪酸酯類(例如,PEG-二硬脂酸酯、二硬脂酸乙二醇酯等)、PEG-烷基醚類(例如PEG-2-辛基十二烷基醚等)、蔗糖脂肪酸酯等中的一種或多種。該表面活性劑的含量在組合物中的含量是本領域已知的。通常,在本發明化妝品組合物中,該表面活性劑占該常用的成分的總重量的約0-50%。
該輔料包括但不限於表面活性劑、乳化劑、增稠劑、防腐劑、香料、pH調節劑等。其中,乳化劑包括但不限於:PEG-60氫化蓖麻油、甘油硬脂酸酯/PEG-100硬脂酸酯、山梨坦橄欖油酸酯、硬脂醇聚醚-21、PPG-13-癸基十四醇聚醚-24、鯨蠟硬脂基葡糖苷、鯨蠟硬脂基葡糖苷、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯等中的一種或多種;通常,在本發明化妝品組合物中,該乳化劑占該常用的成分總重量的約0-10%。
該增稠劑包括但不限於:卡波姆、黃原膠、SIMUGEL EG、阿拉伯膠、聚乙二醇-14M、聚乙二醇-90M、琥珀醯聚糖、羥乙基纖維素、羥丙基纖維素等中的一種或多種;通常,在本發明組合物中,該增稠劑占該常用的成分總重量的約0-10%。
對可用於本發明中的防腐劑沒有限制,其是本領域已知的,包括但不限於羥苯甲酯、羥苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、山梨酸鉀、苯甲酸鈉、氯苯甘醚等中的一種或多種及其它防腐增效劑,如戊二醇、己二醇、辛甘醇等常用防腐劑;通常,在本發明組合物中,該防腐劑占該常用的成分的總重量的約0.01-2%。
對可用於本發明中的pH調節劑沒有限制,其是本領域已知的,包括但不限於:檸檬酸、檸檬酸鈉、精氨酸等中的一種或多種。本領域技術人員可根據需要具體選擇其類型和用量。
本發明的化妝品組合物製備可以藉由本領域已知的任何合適的方法製備。例如,可使用化妝品領域中常用的溶解槽、乳化鍋、分散器、輸送泵等容器來製備。製備時,先將水溶性物質投入水相溶解釜,將油溶性物質投入油相溶解釜,分別將兩個釜的溫度加熱至80°C左右,其中對於易結塊的原料,可先用分散器將其預分散。待溶解完成後將油相和水相輸送至乳化鍋中,均質乳化約5-15分鐘。乳化完成後將料體溫度降至常溫,任選加入香精、防腐劑等,並視需要調節產物的pH。相關檢測指標都合格後方可灌裝出貨。以上製備方法可根據劑型要求進行刪減或調整,可根據需要製備水、乳液、膏、霜或凝膠等各種劑型。
實施例
以下結合實施例,對本發明進行進一步詳細說明。應當理解,此處所描述的具體實施例僅僅用以解釋本發明,並不用於限定本發明。所有類似的替換和改動對本領域技術人員來說是顯而易見的,他們都被視為包括在本發明的範圍內。
實施例1:製備和考察了含對羥基苯乙酮的化妝品組合物A(不添加pH穩定劑)和B-H(添加了不同的及/或不同濃度的pH穩定劑)的pH穩定性和顏色穩定性
化妝品組合物A-I的配方如下表1所示。
表1
成分% | 化妝品組合物A | 化妝品組合物B | 化妝品組合物C | 化妝品組合物D | 化妝品組合物E | 化妝品組合物F | 化妝品組合物G | 化妝品組合物H | 化妝品組合物I |
水 | 86.30 | 86 | 85.7 | 86.45 | 86.15 | 85.65 | 85.55 | 85.95 | 85.65 |
甘油 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
甜菜鹼 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
1,2-戊二醇 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
對羥基苯乙酮 | 0.5 | 0.5 | 0.8 | 0.05 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
羥苯甲酯 (防腐劑) | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 |
精氨酸 (pH調節劑) | 0.05 | 0 | 0 | 0 | 0 | 0 | 0.3 | 0 | 0 |
乙醯丙酸 | 0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0 | 0.1 | 0 |
乙醯丙酸鈉 | 0 | 0.25 | 0.25 | 0.25 | 0.1 | 0.5 | 0 | 0.25 | 0 |
葡糖酸內酯 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0.05 | 0 |
磷酸氫二鈉 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.2 |
磷酸二氫鈉 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 |
其中,乙醯丙酸(50%水溶液)來源於供應商舒美;乙醯丙酸鈉(粉末)採購自武漢拉那白醫藥化工。葡糖酸內酯來源於供應商科耐歐。磷酸氫二鈉和磷酸二氫鈉來源於阿拉丁生化科技。
上述化妝品組合物的製備工序如下:
(1)取對羥基苯乙酮,加入1,2-戊二醇,加熱至80℃,充分溶解、混勻;
(2)將水加熱至80℃,然後依次加入甘油、甜菜鹼、羥苯甲酯,攪拌至溶解均勻;
(3) 將上述(1)和(2)中獲得的混合物充分混合在一起,在80℃下保持30min,然後降溫至50℃以下,後加入乙醯丙酸/乙醯丙酸鈉、葡糖酸內酯及/或磷酸氫二鈉/磷酸二氫鈉、或者精氨酸,攪拌均勻,出料。
為考察pH穩定劑對含有對羥基苯乙酮的化妝品組合物的pH穩定性和顏色穩定性,首先分別測試了各化妝品組合物的初始pH,並對其外觀進行拍照,參見附圖1;隨後,將各化妝品組合物分裝,分別置於室溫、窗臺、光照(25℃,可見光強度16000LX)、高溫(48℃和60℃)2和4週,以考察不同條件下組合物的pH變化和顏色變化情況,並對4週後的外觀進行拍照。結果如下表2所示。
表2
放置條件 | 測試 指標 | 化妝品組合物A | 化妝品組合物B | 化妝品組合物C | 化妝品組合物D | 化妝品組合物E | 化妝品組合物F | 化妝品組合物G | 化妝品組合物H | 化妝品組合物I |
初始 | 初始pH | 5.57 | 4.88 | 4.84 | 4.89 | 4.48 | 5.00 | 4.08 | 4.69 | 5.09 |
初始顏色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
48℃ | 2週pH | 6.61 | 5.06 | 5.02 | 5.13 | 4.73 | 5.09 | 3.91 | 4.73 | 5.09 |
4週pH | 6.39 | 5.15 | 5.11 | 5.19 | 4.94 | 5.15 | 3.94 | 4.81 | 5.13 | |
4週外觀 | 深棕色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
60℃ | 2週pH | 6.45 | 5.09 | 5.09 | 5.11 | 4.73 | 5.13 | 3.88 | 4.79 | 5.12 |
4週pH | 6.41 | 5.00 | 4.98 | 5.08 | 4.76 | 5.07 | 4.02 | 4.77 | 5.12 | |
4週外觀 | 深棕色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
光照 | 2週pH | 6.80 | 4.94 | 4.93 | 4.96 | 4.63 | 5.06 | 3.82 | 4.67 | 5.10 |
4週pH | 6.79 | 5.18 | 5.13 | 5.19 | 4.91 | 5.20 | 3.96 | 4.84 | 5.11 | |
4週 外觀 | 深棕色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
窗臺 | 2週pH | 6.67 | 5.05 | 5.01 | 5.05 | 4.73 | 5.14 | 3.87 | 4.74 | 5.07 |
4週pH | 6.75 | 5.28 | 5.25 | 5.28 | 5.01 | 5.29 | 3.97 | 4.90 | 5.08 | |
4週外觀 | 深棕色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
室溫 | 2週pH | 6.96 | 4.87 | 4.86 | 4.88 | 4.52 | 5.00 | 3.79 | 4.62 | 5.11 |
4週pH | 7.15 | 4.95 | 4.94 | 4.98 | 4.63 | 5.10 | 3.82 | 4.71 | 5.10 | |
4週外觀 | 深棕色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 |
從上述結果可以看出,隨著時間的延長,未添加pH穩定劑的化妝品組合物A在常溫(室溫)、窗臺、高溫和光照條件下pH均發生不同程度的向上漂移,同時其顏色從無色透明逐漸變為黃色甚至深棕色,參見附圖1;相比之下,添加pH穩定劑的化妝品組合物B-I在各種條件下pH均無明顯變化,同時其顏色外觀亦無明顯改變,參見附圖1。該結果表明,pH穩定劑顯著提高了對羥基苯乙酮在化妝品組合物中的穩定性,從而顯著減緩了其導致的顏色變化和pH向上漂移的問題。
實施例2:考察化妝品組合物N(添加pH穩定劑)和化妝品組合物I(添加抗氧化劑)的pH穩定性和顏色穩定性
為考察pH穩定劑對含有對羥基苯乙酮的化妝品組合物顏色和pH穩定性的影響與先前技術CN111937874A中所採用的抗氧化劑的不同,製備了本發明的化妝品組合物N和對照化妝品組合物O,其配方如下表3所示。
表3
成分% | 化妝品組合物N | 化妝品組合物O |
水 | 89.2 | 89.45 |
甘油 | 3 | 3 |
甜菜鹼 | 2 | 2 |
1,3-丙二醇 | 5 | 5 |
對羥基苯乙酮 | 0.3 | 0.3 |
羥苯甲酯 | 0.15 | 0.15 |
乙醯丙酸 | 0.1 | 0 |
乙醯丙酸鈉 | 0.25 | 0 |
維生素C | 0 | 0.1 |
測試了化妝品組合物N和O的初始pH,並對其外觀進行拍照,參見附圖2;隨後將化妝品組合物N和O分裝,並分別置於光照、高溫(60℃)下2週和4週,觀察並測試在不同條件下的pH變化和顏色變化。結果如下表4所示。
表4
放置條件 | 測試指標 | 化妝品組合物N | 化妝品組合物O |
初始 | 初始pH | 5.17 | 4.95 |
初始顏色 | 無色透明 | 無色透明 | |
60℃ | 2週pH | 5.13 | 4.70 |
4週pH | 5.09 | 4.46 | |
4週外觀 | 無色透明 | 黃色 | |
光照 | 2週pH | 5.22 | 5.12 |
4週pH | 5.07 | 4.19 | |
4週外觀 | 無色透明 | 黃色 | |
窗臺 | 2週pH | 5.10 | 4.76 |
4週pH | 5.09 | 4.19 | |
4週外觀 | 無色透明 | 黃色 | |
室溫 | 2週pH | 5.22 | 5.02 |
4週pH | 5.20 | 4.73 | |
4週外觀 | 無色透明 | 無色透明 |
從上述結果可以看到,添加pH穩定劑的化妝品組合物N在各種條件下的pH均無明顯變化,同時其顏色外觀亦無明顯改變,參見附圖2;對比之下,添加抗氧化劑維生素C的化妝品組合物O在高溫和光照下顏色開始明顯變黃,常溫條件下也有輕微變黃,參見附圖2。該結果表明,pH穩定劑對含有對羥基苯乙酮的化妝品組合物顏色和pH的穩定作用顯著優於先前專利技術中使用抗氧化劑的技術方案。
實施例3:製備和考察了不同的pH穩定劑對含對羥基苯乙酮的化妝品組合物J-M的pH穩定性和顏色穩定性的影響
化妝品組合物J-M的配方如下表5所示。
表5
成分% | 化妝品組合物J | 化妝品組合物K | 化妝品組合物L | 化妝品組合物M |
水 | 89.25 | 89.2 | 89.05 | 89.05 |
甘油 | 3 | 3 | 3 | 3 |
甜菜鹼 | 2 | 2 | 2 | 2 |
1,3-丙二醇 | 5 | 5 | 5 | 5 |
對羥基苯乙酮 | 0.3 | 0.3 | 0.3 | 0.3 |
羥苯甲酯 | 0.15 | 0.15 | 0.15 | 0.15 |
檸檬酸 | 0.1 | 0 | 0 | 0 |
檸檬酸鈉 | 0.2 | 0 | 0 | 0 |
乳酸 | 0 | 0.05 | 0 | 0 |
乳酸鈉 | 0 | 0.3 | 0 | 0 |
檸檬酸三乙酯 | 0 | 0 | 0.5 | 0 |
泛內酯 | 0 | 0 | 0 | 0.5 |
測試了化妝品組合物J-M的初始pH,並對其外觀進行拍照,參見附圖3;隨後將各化妝品組合物分裝,並分別置於室溫、窗臺、光照和高溫(48℃和60℃)下2週和4週,觀察並測試在不同條件下的pH變化和顏色變化。結果如下表6所示。
表6
放置條件 | 測試 指標 | 化妝品組合物 J | 化妝品組合物 K | 化妝品組合物 L | 化妝品組合物 M |
初始 | 初始pH | 4.77 | 4.37 | 4.58 | 5.10 |
初始顏色 | 無色 透明 | 無色 透明 | 無色 透明 | 無色 透明 | |
60℃ | 2週pH | 4.76 | 4.23 | 4.03 | 3.93 |
4週pH | 4.77 | 4.24 | 3.64 | 3.79 | |
4週外觀 | 無色透明 | 無色透明 | 無色透明 | 無色透明 | |
光照 | 2週pH | 4.82 | 4.36 | 4.57 | 4.53 |
4週pH | 4.71 | 4.24 | 4.27 | 4.13 | |
4週外觀 | 無色透明 | 無色透明 | 無色透明 | 無色透明 | |
窗臺 | 2週pH | 4.78 | 4.32 | 4.44 | 4.56 |
4週pH | 4.77 | 4.29 | 4.34 | 4.32 | |
4週外觀 | 無色透明 | 無色透明 | 無色透明 | 無色透明 | |
室溫 | 2週pH | 4.81 | 4.39 | 4.56 | 4.65 |
4週pH | 4.76 | 4.30 | 4.45 | 4.37 | |
4週外觀 | 無色透明 | 無色透明 | 無色透明 | 無色透明 |
上述結果表明,本發明範圍內的pH穩定劑均顯著提高了對羥基苯乙酮在化妝品組合物中的穩定性,且在4週後組合物的顏色沒有明顯變化,參見附圖3。
以上所述實施例的技術方案是本發明較佳實施方式,除此之外,本發明的pH穩定劑可以應用於添加有對羥基苯乙酮的精華、乳、霜、粉底、防曬等各種化妝品的顏色穩定性的改善,在不脫離本發明原理的前提下還可以進行若干改進和變換,這些改進和變化也應視為在本發明的保護範圍內。
無
圖1是組合物A-I在初始和各種條件下儲存4週後的外觀的照片。
圖2是組合物N和O在初始和各種條件下儲存4週後的外觀的照片。
圖3是組合物J-M在初始和各種條件下儲存4週後的外觀的照片。
Claims (5)
- 一種提高對羥基苯乙酮在化妝品組合物中的穩定性的方法,包括將一pH穩定劑加入到含有對羥基苯乙酮的化妝品組合物中,其中該pH穩定劑選自γ-壬內酯、泛內酯、柠檬酸三乙酯、和弱酸及其鹽的混合物,該弱酸選自乙酸、乙醯丙酸、乳酸、鄰苯二甲酸、碳酸、磷酸、偏磷酸、亞硫酸、氫氟酸、氫硫酸和次氯酸,和該鹽包括鹼金屬鹽;其中該pH穩定劑在該化妝品組合物中的含量為0.01-3%,基於該化妝品組合物的總重量;其中該pH穩定劑使組合物在整個保質期內的pH保持在4-7;和其中對羥基苯乙酮在該化妝品組合物中的含量為0.01-1%。
- 如請求項1所述的方法,其中該pH穩定劑是乙醯丙酸及其鹼金屬鹽的混合物。
- 如請求項1至請求項2中任一項所述的方法,其中該pH穩定劑在該化妝品組合物中的含量為0.05-2%,基於該化妝品組合物的總重量。
- 如請求項1至請求項2中任一項所述的方法,其中該pH穩定劑使組合物在整個保存期限內的pH保持在5-7。
- 如請求項1至請求項2中任一項所述的方法,其中對羥基苯乙酮在該化妝品組合物中的含量為0.05-0.8%,基於該化妝品組合物的總重量。
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