TWI823213B - Cdk2抑制劑之固體形式 - Google Patents

Cdk2抑制劑之固體形式 Download PDF

Info

Publication number
TWI823213B
TWI823213B TW110148386A TW110148386A TWI823213B TW I823213 B TWI823213 B TW I823213B TW 110148386 A TW110148386 A TW 110148386A TW 110148386 A TW110148386 A TW 110148386A TW I823213 B TWI823213 B TW I823213B
Authority
TW
Taiwan
Prior art keywords
cancer
ppm
crystalline
values
monohydrate
Prior art date
Application number
TW110148386A
Other languages
English (en)
Chinese (zh)
Other versions
TW202233606A (zh
Inventor
鳳娟 曹
凱文 法蘭西斯 迪波亞斯
麥可 席博雷恩
Original Assignee
美商輝瑞大藥廠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商輝瑞大藥廠 filed Critical 美商輝瑞大藥廠
Publication of TW202233606A publication Critical patent/TW202233606A/zh
Application granted granted Critical
Publication of TWI823213B publication Critical patent/TWI823213B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cereal-Derived Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110148386A 2020-12-24 2021-12-23 Cdk2抑制劑之固體形式 TWI823213B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063130530P 2020-12-24 2020-12-24
US63/130,530 2020-12-24

Publications (2)

Publication Number Publication Date
TW202233606A TW202233606A (zh) 2022-09-01
TWI823213B true TWI823213B (zh) 2023-11-21

Family

ID=79283019

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110148386A TWI823213B (zh) 2020-12-24 2021-12-23 Cdk2抑制劑之固體形式

Country Status (10)

Country Link
US (1) US20240076287A1 (enExample)
EP (1) EP4267563A1 (enExample)
JP (2) JP2024503235A (enExample)
KR (1) KR20230122100A (enExample)
CN (1) CN116723837B (enExample)
AU (1) AU2021404974B2 (enExample)
CA (1) CA3206153A1 (enExample)
MX (1) MX2023007699A (enExample)
TW (1) TWI823213B (enExample)
WO (1) WO2022137106A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3217792A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc Cdk2 degraders and uses thereof
US20250127759A1 (en) * 2021-12-02 2025-04-24 Pfizer Inc. Methods and dosing regimens comprising a cdk2 inhibitor for the treatment of cancer
CN118679150A (zh) * 2022-01-27 2024-09-20 益方生物科技(上海)股份有限公司 Cdk2抑制剂及其制备方法和用途
WO2024046443A1 (en) * 2022-09-01 2024-03-07 Nutshell Biotech (Shanghai) Co., Ltd. Macrocyclic compounds as selective cdk inhibitors
WO2025191482A1 (en) 2024-03-15 2025-09-18 Pfizer Inc. Synthesis of (1h-pyrazol-5-yl)cyclopentyl carbamate compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020157652A2 (en) * 2019-01-31 2020-08-06 Pfizer Inc. Cdk2 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020157652A2 (en) * 2019-01-31 2020-08-06 Pfizer Inc. Cdk2 inhibitors

Also Published As

Publication number Publication date
MX2023007699A (es) 2023-07-10
KR20230122100A (ko) 2023-08-22
TW202233606A (zh) 2022-09-01
AU2021404974A1 (en) 2023-07-06
JP2026123057A (ja) 2026-07-29
AU2021404974B2 (en) 2024-11-28
WO2022137106A1 (en) 2022-06-30
JP2024503235A (ja) 2024-01-25
EP4267563A1 (en) 2023-11-01
CN116723837B (zh) 2026-05-26
CN116723837A (zh) 2023-09-08
CA3206153A1 (en) 2022-06-30
AU2021404974A9 (en) 2025-04-10
US20240076287A1 (en) 2024-03-07

Similar Documents

Publication Publication Date Title
JP7291839B2 (ja) 固体形態のcdk4阻害薬
AU2021404974B2 (en) Solid forms of a cdk2 inhibitor
JP6946194B2 (ja) キナーゼを調節する化合物の固体形態
KR20230121756A (ko) Fgfr 억제제 및 이의 제조 및 사용 방법
TW200808746A (en) Triazole compounds that modulate HSP90 activity
CN109819649B (zh) 氨基嘌呤化合物的固体形式及其使用方法
US20230321042A1 (en) Combination therapy
CN117337293A (zh) 固体形式的eif4e抑制剂
KR20240145475A (ko) 고형 종양의 치료를 위한 유비퀴틴-특이적-프로세싱 프로테아제 1 (usp1) 억제제
ES3032458T3 (en) Crystalline form of the hydrochloride salt of 2-((1r,4r)-4-((3-(3-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
JP2017529356A (ja) チロシンキナーゼ阻害剤及びその塩の結晶形態
CA3195063C (en) Solid forms of the cdk4 inhibitor pf-07220060
RU2850825C1 (ru) Твердые формы ингибитора cdk2
RU2856216C1 (ru) Твердые формы ингибитора cdk4
HK40096368A (en) Solid forms of a cdk2 inhibitor
BR112023004713B1 (pt) Formas sólidas de um inibidor de cdk4 e sua composição farmacêutica
HK40087859A (en) Solid forms of a cdk4 inhibitor
HK40131055A (en) A pharmaceutical combination and use thereof
HK40125945A (en) Fumarate, tartrate, malate, and citrate salts of an egfr inhibitor
EA049394B1 (ru) Ингибиторы fgfr и способы их получения и применения