TWI814187B - 使用ACTRII配位體捕捉以治療β-地中海型貧血 - Google Patents

使用ACTRII配位體捕捉以治療β-地中海型貧血 Download PDF

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Publication number
TWI814187B
TWI814187B TW110148304A TW110148304A TWI814187B TW I814187 B TWI814187 B TW I814187B TW 110148304 A TW110148304 A TW 110148304A TW 110148304 A TW110148304 A TW 110148304A TW I814187 B TWI814187 B TW I814187B
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Taiwan
Prior art keywords
certain embodiments
actriib
individual
signaling inhibitor
seq
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TW110148304A
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English (en)
Chinese (zh)
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TW202231294A (zh
Inventor
肯尼斯 M 艾堤
艾德拉曼 拉丹
拉傑許 喬普拉
傑 貝克斯壯
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美商西建公司
美商艾瑟勒朗法瑪公司
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Publication of TW202231294A publication Critical patent/TW202231294A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110148304A 2015-05-13 2016-05-12 使用ACTRII配位體捕捉以治療β-地中海型貧血 TWI814187B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562161136P 2015-05-13 2015-05-13
US62/161,136 2015-05-13
US201562173836P 2015-06-10 2015-06-10
US62/173,836 2015-06-10
US201562243457P 2015-10-19 2015-10-19
US62/243,457 2015-10-19

Publications (2)

Publication Number Publication Date
TW202231294A TW202231294A (zh) 2022-08-16
TWI814187B true TWI814187B (zh) 2023-09-01

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Family Applications (2)

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TW110148304A TWI814187B (zh) 2015-05-13 2016-05-12 使用ACTRII配位體捕捉以治療β-地中海型貧血
TW105114763A TWI762444B (zh) 2015-05-13 2016-05-12 使用ＡＣＴＲＩＩ配位體捕捉以治療β-地中海型貧血

Family Applications After (1)

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TW105114763A TWI762444B (zh) 2015-05-13 2016-05-12 使用ＡＣＴＲＩＩ配位體捕捉以治療β-地中海型貧血

Country Status (15)

Country Link
US (1) US20180125928A1 (enExample)
EP (1) EP3294320A4 (enExample)
JP (2) JP6976859B2 (enExample)
KR (1) KR102640198B1 (enExample)
CN (1) CN107847562A (enExample)
AU (2) AU2016261913B2 (enExample)
CA (1) CA2985777A1 (enExample)
HK (1) HK1251157A1 (enExample)
IL (2) IL284686B2 (enExample)
JO (1) JOP20160092B1 (enExample)
MY (1) MY189601A (enExample)
PH (1) PH12017502079A1 (enExample)
TN (1) TN2017000468A1 (enExample)
TW (2) TWI814187B (enExample)
WO (1) WO2016183280A1 (enExample)

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IL284686A (en) 2021-08-31
TN2017000468A1 (en) 2019-04-12
AU2016261913B2 (en) 2021-08-12
IL255527B (en) 2021-07-29
CN107847562A (zh) 2018-03-27
CA2985777A1 (en) 2016-11-17
HK1251157A1 (zh) 2019-01-25
WO2016183280A1 (en) 2016-11-17
TW201709927A (zh) 2017-03-16
IL284686B (en) 2023-01-01
EP3294320A4 (en) 2018-12-26
JOP20160092B1 (ar) 2023-03-28
EP3294320A1 (en) 2018-03-21
US20180125928A1 (en) 2018-05-10
TWI762444B (zh) 2022-05-01
IL255527A (en) 2018-01-31
KR102640198B1 (ko) 2024-02-23
JP2021191755A (ja) 2021-12-16
IL284686B2 (en) 2023-05-01
AU2021258087B2 (en) 2023-04-27
MY189601A (en) 2022-02-18
TW202231294A (zh) 2022-08-16
JP2018520094A (ja) 2018-07-26
NZ737043A (en) 2025-02-28
JP6976859B2 (ja) 2021-12-08
AU2016261913A1 (en) 2017-11-30
KR20180006437A (ko) 2018-01-17
PH12017502079A1 (en) 2018-06-11
AU2021258087A1 (en) 2021-11-25

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