TWI789369B - 抗c5抗體及使用方法 - Google Patents

抗c5抗體及使用方法 Download PDF

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Publication number
TWI789369B
TWI789369B TW106141573A TW106141573A TWI789369B TW I789369 B TWI789369 B TW I789369B TW 106141573 A TW106141573 A TW 106141573A TW 106141573 A TW106141573 A TW 106141573A TW I789369 B TWI789369 B TW I789369B
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TW
Taiwan
Prior art keywords
antibody
amino acid
seq
acid sequence
hvr
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TW106141573A
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English (en)
Chinese (zh)
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TW201809000A (zh
Inventor
類家慶直
三瓶全次郎
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日商中外製藥股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW106141573A 2016-06-17 2017-06-16 抗c5抗體及使用方法 TWI789369B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016-120325 2016-06-17
JP2016120325 2016-06-17

Publications (2)

Publication Number Publication Date
TW201809000A TW201809000A (zh) 2018-03-16
TWI789369B true TWI789369B (zh) 2023-01-11

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Family Applications (4)

Application Number Title Priority Date Filing Date
TW106141573A TWI789369B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW112120479A TW202337903A (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW111107923A TWI807666B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW106120143A TWI610941B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法

Family Applications After (3)

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TW112120479A TW202337903A (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW111107923A TWI807666B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法
TW106120143A TWI610941B (zh) 2016-06-17 2017-06-16 抗c5抗體及使用方法

Country Status (19)

Country Link
EP (1) EP3472316A4 (uk)
JP (3) JP6202774B1 (uk)
KR (2) KR102226975B1 (uk)
CN (3) CN115960223A (uk)
AU (1) AU2017285763B2 (uk)
BR (1) BR112018075688A2 (uk)
CA (1) CA3021956A1 (uk)
CL (1) CL2018003573A1 (uk)
CR (1) CR20190013A (uk)
EA (1) EA201990018A1 (uk)
IL (2) IL300611A (uk)
MX (2) MX2018015030A (uk)
MY (1) MY187848A (uk)
PE (2) PE20190394A1 (uk)
PH (1) PH12018502354A1 (uk)
SG (2) SG11201705584VA (uk)
TW (4) TWI789369B (uk)
UA (1) UA126561C2 (uk)
WO (1) WO2017217524A1 (uk)

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US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
CN107551270A (zh) 2008-04-11 2018-01-09 中外制药株式会社 与多个分子的抗原反复结合的抗原结合分子
RU2658504C9 (ru) 2010-11-30 2018-08-21 Чугаи Сейяку Кабусики Кайся Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул
TW201809008A (zh) 2014-12-19 2018-03-16 日商中外製藥股份有限公司 抗c5抗體及使用方法
DK3468990T3 (da) 2016-06-14 2024-06-24 Regeneron Pharmaceuticals Inc Anti-C5-antistoffer og anvendelser deraf
MX2018015030A (es) * 2016-06-17 2019-04-22 Chugai Pharmaceutical Co Ltd Anticuerpos anti-c5 y metodos de uso.
SG11201801024XA (en) 2016-08-05 2018-05-30 Chugai Pharmaceutical Co Ltd Therapeutic or preventive compositions for il-8-related diseases
BR112020006692A2 (pt) * 2017-10-04 2020-10-06 Alexion Pharmaceuticals, Inc. dosagem e administração de anticorpos anti-c5 para o tratamento de pacientes com glomerulonefrite membranoproliferativa
JP2021506241A (ja) 2017-12-13 2021-02-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 抗c5抗体組み合わせ物およびその使用
CN113038967A (zh) * 2018-09-06 2021-06-25 宾夕法尼亚大学理事会 人源化抗c5抗体及其用途
CA3137907A1 (en) * 2019-04-24 2020-10-29 The Trustees Of The University Of Pennsylvania Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof
CN113563467A (zh) * 2020-04-28 2021-10-29 上海普铭生物科技有限公司 针对人补体蛋白c5的抗体及其应用
JP7494413B2 (ja) 2020-07-15 2024-06-04 ビオシオン インコーポレイテッド C5に結合する抗体及びその用途

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CA2899589A1 (en) * 2013-01-31 2014-08-07 Seoul National University R & Db Foundation C5 antibody and method for preventing and treating complement-related diseases
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TWI610941B (zh) * 2016-06-17 2018-01-11 中外製藥股份有限公司 抗c5抗體及使用方法
TWI617580B (zh) * 2014-12-19 2018-03-11 中外製藥股份有限公司 抗c5抗體及使用方法

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TW201206466A (en) * 2010-03-11 2012-02-16 Rinat Neuroscience Corp Antibodies with pH dependent antigen binding
CA2899589A1 (en) * 2013-01-31 2014-08-07 Seoul National University R & Db Foundation C5 antibody and method for preventing and treating complement-related diseases
TWI617580B (zh) * 2014-12-19 2018-03-11 中外製藥股份有限公司 抗c5抗體及使用方法
TWI597292B (zh) * 2015-12-18 2017-09-01 中外製藥股份有限公司 抗c5抗體及使用方法
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TWI610941B (zh) * 2016-06-17 2018-01-11 中外製藥股份有限公司 抗c5抗體及使用方法

Also Published As

Publication number Publication date
AU2017285763B2 (en) 2024-02-01
BR112018075688A2 (pt) 2019-04-02
IL263657A (en) 2019-01-31
PH12018502354A1 (en) 2019-09-23
TWI610941B (zh) 2018-01-11
WO2017217524A1 (en) 2017-12-21
EP3472316A4 (en) 2020-01-08
KR20190009273A (ko) 2019-01-28
CR20190013A (es) 2019-03-05
EP3472316A1 (en) 2019-04-24
KR102226975B1 (ko) 2021-03-11
MY187848A (en) 2021-10-26
CL2018003573A1 (es) 2019-02-01
CN109312326A (zh) 2019-02-05
MX2023001360A (es) 2023-02-27
TWI807666B (zh) 2023-07-01
TW202337903A (zh) 2023-10-01
CA3021956A1 (en) 2017-12-21
JP2022091748A (ja) 2022-06-21
AU2017285763A1 (en) 2018-11-08
TW201808996A (zh) 2018-03-16
SG11201705584VA (en) 2018-05-30
RU2019100222A (ru) 2020-07-17
RU2019100222A3 (uk) 2020-11-05
JP6202774B1 (ja) 2017-09-27
CN115960223A (zh) 2023-04-14
CN109312326B (zh) 2022-09-09
KR101852739B1 (ko) 2018-04-30
JP2018009021A (ja) 2018-01-18
MX2018015030A (es) 2019-04-22
PE20240825A1 (es) 2024-04-18
EA201990018A1 (ru) 2019-08-30
TW202239766A (zh) 2022-10-16
IL300611A (en) 2023-04-01
TW201809000A (zh) 2018-03-16
UA126561C2 (uk) 2022-11-02
PE20190394A1 (es) 2019-03-13
JP2017226655A (ja) 2017-12-28
SG10201800265UA (en) 2018-02-27
JP7032077B2 (ja) 2022-03-08
CN115925922A (zh) 2023-04-07

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