TWI783978B - Tyk2抑制劑、其用途及生產方法 - Google Patents

Tyk2抑制劑、其用途及生產方法 Download PDF

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Publication number
TWI783978B
TWI783978B TW107107562A TW107107562A TWI783978B TW I783978 B TWI783978 B TW I783978B TW 107107562 A TW107107562 A TW 107107562A TW 107107562 A TW107107562 A TW 107107562A TW I783978 B TWI783978 B TW I783978B
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Taiwan
Prior art keywords
compound
compounds
tyk2
disease
ray diffraction
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TW107107562A
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English (en)
Chinese (zh)
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TW201840559A (zh
Inventor
傑諾米 羅伯特 葛林伍德
卡格 E 瑪斯
瓊 Ｐ 羅森
尚 巴蒂斯特 亞林
大衛 皮爾森
強納森 詹姆士 洛克雷
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美商林伯士拉克許米公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW107107562A 2017-03-08 2018-03-07 Tyk2抑制劑、其用途及生產方法 TWI783978B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762468688P 2017-03-08 2017-03-08
US62/468,688 2017-03-08

Publications (2)

Publication Number Publication Date
TW201840559A TW201840559A (zh) 2018-11-16
TWI783978B true TWI783978B (zh) 2022-11-21

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TW107107562A TWI783978B (zh) 2017-03-08 2018-03-07 Tyk2抑制劑、其用途及生產方法
TW111146722A TWI868528B (zh) 2017-03-08 2018-03-07 Ｔｙｋ２抑制劑之生產方法
TW113147070A TW202515876A (zh) 2017-03-08 2018-03-07 Tyk2抑制劑及其用途

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TW111146722A TWI868528B (zh) 2017-03-08 2018-03-07 Ｔｙｋ２抑制劑之生產方法
TW113147070A TW202515876A (zh) 2017-03-08 2018-03-07 Tyk2抑制劑及其用途

Country Status (10)

Country Link
US (2) US10336752B2 (enExample)
EP (2) EP4338802A3 (enExample)
JP (3) JP7160824B2 (enExample)
CN (1) CN110582501B (enExample)
AR (1) AR111233A1 (enExample)
AU (3) AU2018230737B2 (enExample)
CA (1) CA3055209A1 (enExample)
IL (1) IL269036B2 (enExample)
TW (3) TWI783978B (enExample)
WO (1) WO2018165240A1 (enExample)

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UY38144A (es) 2018-03-12 2019-10-31 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa
CN113271940A (zh) 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
FI3870579T3 (fi) * 2018-10-22 2025-01-02 Alumis Inc Tyk2-inhibiittoreita ja niiden käyttöjä
AU2020218267A1 (en) * 2019-02-07 2021-09-30 Ventyx Biosciences, Inc. TYK2 pseudokinase ligands
BR112021019070A2 (pt) 2019-03-26 2022-02-15 Ventyx Biosciences Inc Ligantes de pseudoquinase tyk2
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
IL287665A (en) * 2019-04-30 2022-07-01 Celgene Corp Combined treatments including apremilaste and tyk2 inhibitors
IL292785B2 (en) 2019-11-08 2025-09-01 Ventyx Biosciences Inc Tyk2 pseudokinase ligands
EP4404930A1 (en) * 2021-09-23 2024-07-31 Bristol-Myers Squibb Company Methods of treating hair-loss disorders with tyk2 inhibitors
AU2022378463A1 (en) 2021-10-25 2024-05-09 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2023183910A1 (en) * 2022-03-25 2023-09-28 Nimbus Lakshmi, Inc. Solid forms of tyk2 inhibitors and methods of use

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WO2016138352A1 (en) * 2015-02-27 2016-09-01 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

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Also Published As

Publication number Publication date
EP3592746A4 (en) 2020-11-25
TW202321243A (zh) 2023-06-01
CN110582501A (zh) 2019-12-17
AU2018230737A1 (en) 2019-09-19
US10336752B2 (en) 2019-07-02
CA3055209A1 (en) 2018-09-13
WO2018165240A1 (en) 2018-09-13
EP4338802A2 (en) 2024-03-20
IL269036A (en) 2019-10-31
JP2022185139A (ja) 2022-12-13
IL269036B (en) 2022-11-01
JP7535086B2 (ja) 2024-08-15
EP3592746B1 (en) 2024-01-24
EP3592746A1 (en) 2020-01-15
AU2024205575A1 (en) 2024-08-22
JP2024153877A (ja) 2024-10-29
IL269036B2 (en) 2023-03-01
US20180258086A1 (en) 2018-09-13
US20190337941A1 (en) 2019-11-07
AR111233A1 (es) 2019-06-19
TW202515876A (zh) 2025-04-16
JP7160824B2 (ja) 2022-10-25
AU2018230737B2 (en) 2022-09-22
TWI868528B (zh) 2025-01-01
AU2022256121A1 (en) 2022-11-17
JP2020511438A (ja) 2020-04-16
CN110582501B (zh) 2022-09-23
TW201840559A (zh) 2018-11-16
US11040967B2 (en) 2021-06-22
EP4338802A3 (en) 2024-09-04

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