CN110582501B - Tyk2抑制剂、其用途和生产方法 - Google Patents

Tyk2抑制剂、其用途和生产方法 Download PDF

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Publication number
CN110582501B
CN110582501B CN201880028375.5A CN201880028375A CN110582501B CN 110582501 B CN110582501 B CN 110582501B CN 201880028375 A CN201880028375 A CN 201880028375A CN 110582501 B CN110582501 B CN 110582501B
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compound
disorder
crystalline form
powder
ray diffraction
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CN110582501A (zh
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J·R·葛林伍德
C·E·玛斯
J·P·劳森
J-B·阿林
D·皮尔逊
J·J·罗格雷
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Takeda Pharmaceutical Co Ltd
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Nimbus Lakshmi Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880028375.5A 2017-03-08 2018-03-07 Tyk2抑制剂、其用途和生产方法 Active CN110582501B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762468688P 2017-03-08 2017-03-08
US62/468,688 2017-03-08
PCT/US2018/021265 WO2018165240A1 (en) 2017-03-08 2018-03-07 Tyk2 inhibitors, uses, and methods for production thereof

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CN110582501A CN110582501A (zh) 2019-12-17
CN110582501B true CN110582501B (zh) 2022-09-23

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US (2) US10336752B2 (enExample)
EP (2) EP4338802A3 (enExample)
JP (3) JP7160824B2 (enExample)
CN (1) CN110582501B (enExample)
AR (1) AR111233A1 (enExample)
AU (3) AU2018230737B2 (enExample)
CA (1) CA3055209A1 (enExample)
IL (1) IL269036B2 (enExample)
TW (3) TWI783978B (enExample)
WO (1) WO2018165240A1 (enExample)

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CN113271940A (zh) 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
FI3870579T3 (fi) * 2018-10-22 2025-01-02 Alumis Inc Tyk2-inhibiittoreita ja niiden käyttöjä
AU2020218267A1 (en) * 2019-02-07 2021-09-30 Ventyx Biosciences, Inc. TYK2 pseudokinase ligands
BR112021019070A2 (pt) 2019-03-26 2022-02-15 Ventyx Biosciences Inc Ligantes de pseudoquinase tyk2
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
IL287665A (en) * 2019-04-30 2022-07-01 Celgene Corp Combined treatments including apremilaste and tyk2 inhibitors
IL292785B2 (en) 2019-11-08 2025-09-01 Ventyx Biosciences Inc Tyk2 pseudokinase ligands
EP4404930A1 (en) * 2021-09-23 2024-07-31 Bristol-Myers Squibb Company Methods of treating hair-loss disorders with tyk2 inhibitors
AU2022378463A1 (en) 2021-10-25 2024-05-09 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2023183910A1 (en) * 2022-03-25 2023-09-28 Nimbus Lakshmi, Inc. Solid forms of tyk2 inhibitors and methods of use

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Also Published As

Publication number Publication date
EP3592746A4 (en) 2020-11-25
TWI783978B (zh) 2022-11-21
TW202321243A (zh) 2023-06-01
CN110582501A (zh) 2019-12-17
AU2018230737A1 (en) 2019-09-19
US10336752B2 (en) 2019-07-02
CA3055209A1 (en) 2018-09-13
WO2018165240A1 (en) 2018-09-13
EP4338802A2 (en) 2024-03-20
IL269036A (en) 2019-10-31
JP2022185139A (ja) 2022-12-13
IL269036B (en) 2022-11-01
JP7535086B2 (ja) 2024-08-15
EP3592746B1 (en) 2024-01-24
EP3592746A1 (en) 2020-01-15
AU2024205575A1 (en) 2024-08-22
JP2024153877A (ja) 2024-10-29
IL269036B2 (en) 2023-03-01
US20180258086A1 (en) 2018-09-13
US20190337941A1 (en) 2019-11-07
AR111233A1 (es) 2019-06-19
TW202515876A (zh) 2025-04-16
JP7160824B2 (ja) 2022-10-25
AU2018230737B2 (en) 2022-09-22
TWI868528B (zh) 2025-01-01
AU2022256121A1 (en) 2022-11-17
JP2020511438A (ja) 2020-04-16
TW201840559A (zh) 2018-11-16
US11040967B2 (en) 2021-06-22
EP4338802A3 (en) 2024-09-04

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Effective date of registration: 20231129

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Patentee before: NIMBUS LAKSHMI, Inc.

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