JP7160824B2 - Tyk2阻害剤、使用およびその製造のための方法 - Google Patents

Tyk2阻害剤、使用およびその製造のための方法 Download PDF

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JP7160824B2
JP7160824B2 JP2019548301A JP2019548301A JP7160824B2 JP 7160824 B2 JP7160824 B2 JP 7160824B2 JP 2019548301 A JP2019548301 A JP 2019548301A JP 2019548301 A JP2019548301 A JP 2019548301A JP 7160824 B2 JP7160824 B2 JP 7160824B2
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JP2020511438A5 (enExample
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ジェレミー ロバート グリーンウッド,
クレッグ イー. マッセ,
ジョン ピー. ローソン,
ジャン-バティスト アルリン,
デイビッド ピアソン,
ジョナサン ジェイムズ ラフリー,
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ニンバス ラクシュミ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical Kinetics & Catalysis (AREA)
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  • Biomedical Technology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019548301A 2017-03-08 2018-03-07 Tyk2阻害剤、使用およびその製造のための方法 Active JP7160824B2 (ja)

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JP2022164799A JP7535086B2 (ja) 2017-03-08 2022-10-13 Tyk2阻害剤、使用およびその製造のための方法
JP2024127741A JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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US201762468688P 2017-03-08 2017-03-08
US62/468,688 2017-03-08
PCT/US2018/021265 WO2018165240A1 (en) 2017-03-08 2018-03-07 Tyk2 inhibitors, uses, and methods for production thereof

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JP7160824B2 true JP7160824B2 (ja) 2022-10-25

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JP2019548301A Active JP7160824B2 (ja) 2017-03-08 2018-03-07 Tyk2阻害剤、使用およびその製造のための方法
JP2022164799A Active JP7535086B2 (ja) 2017-03-08 2022-10-13 Tyk2阻害剤、使用およびその製造のための方法
JP2024127741A Pending JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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JP2024127741A Pending JP2024153877A (ja) 2017-03-08 2024-08-02 Tyk2阻害剤、使用およびその製造のための方法

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US (2) US10336752B2 (enExample)
EP (2) EP4338802A3 (enExample)
JP (3) JP7160824B2 (enExample)
CN (1) CN110582501B (enExample)
AR (1) AR111233A1 (enExample)
AU (3) AU2018230737B2 (enExample)
CA (1) CA3055209A1 (enExample)
IL (1) IL269036B2 (enExample)
TW (3) TWI783978B (enExample)
WO (1) WO2018165240A1 (enExample)

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EP4327809A3 (en) 2015-09-02 2024-04-17 Takeda Pharmaceutical Company Limited Tyk2 inhibitors and uses thereof
AU2017345736B2 (en) 2016-10-21 2022-04-07 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
DK3658557T3 (da) 2017-07-28 2024-07-29 Takeda Pharmaceuticals Co Tyk2-inhibitorer og anvendelser deraf
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AU2020218267A1 (en) * 2019-02-07 2021-09-30 Ventyx Biosciences, Inc. TYK2 pseudokinase ligands
BR112021019070A2 (pt) 2019-03-26 2022-02-15 Ventyx Biosciences Inc Ligantes de pseudoquinase tyk2
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
IL287665A (en) * 2019-04-30 2022-07-01 Celgene Corp Combined treatments including apremilaste and tyk2 inhibitors
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AU2022378463A1 (en) 2021-10-25 2024-05-09 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2023183910A1 (en) * 2022-03-25 2023-09-28 Nimbus Lakshmi, Inc. Solid forms of tyk2 inhibitors and methods of use

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Also Published As

Publication number Publication date
EP3592746A4 (en) 2020-11-25
TWI783978B (zh) 2022-11-21
TW202321243A (zh) 2023-06-01
CN110582501A (zh) 2019-12-17
AU2018230737A1 (en) 2019-09-19
US10336752B2 (en) 2019-07-02
CA3055209A1 (en) 2018-09-13
WO2018165240A1 (en) 2018-09-13
EP4338802A2 (en) 2024-03-20
IL269036A (en) 2019-10-31
JP2022185139A (ja) 2022-12-13
IL269036B (en) 2022-11-01
JP7535086B2 (ja) 2024-08-15
EP3592746B1 (en) 2024-01-24
EP3592746A1 (en) 2020-01-15
AU2024205575A1 (en) 2024-08-22
JP2024153877A (ja) 2024-10-29
IL269036B2 (en) 2023-03-01
US20180258086A1 (en) 2018-09-13
US20190337941A1 (en) 2019-11-07
AR111233A1 (es) 2019-06-19
TW202515876A (zh) 2025-04-16
AU2018230737B2 (en) 2022-09-22
TWI868528B (zh) 2025-01-01
AU2022256121A1 (en) 2022-11-17
JP2020511438A (ja) 2020-04-16
CN110582501B (zh) 2022-09-23
TW201840559A (zh) 2018-11-16
US11040967B2 (en) 2021-06-22
EP4338802A3 (en) 2024-09-04

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