TWI780847B - 新穎之ｃｈｏ整合位點及其用途 - Google Patents
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| WO2017184831A1 (en) | 2016-04-20 | 2017-10-26 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| AR109451A1 (es) | 2016-04-20 | 2018-12-12 | Regeneron Pharma | Composiciones y métodos para preparar anticuerpos basados en el uso de loci mejoradores de expresión |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| EP4130280A3 (en) * | 2016-12-20 | 2023-04-19 | Development Center for Biotechnology | Targeted integration sites in chinese hamster ovary cell genome |
| US20210309988A1 (en) * | 2017-02-07 | 2021-10-07 | Sigma-Aldrich Co. Llc | Stable targeted integration |
| KR20240154089A (ko) * | 2017-02-17 | 2024-10-24 | 론자 리미티드 | 아데노-관련 바이러스 생산을 위한 포유동물 세포 |
| EP3601542A4 (en) * | 2017-03-19 | 2021-01-13 | Applied Stemcell, Inc. | NEW INTEGRATION SITES AND THEIR USES |
| CA3068779A1 (en) | 2017-08-11 | 2019-02-14 | Boehringer Ingelheim International Gmbh | Integration sites in cho cells |
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| IL275462B1 (en) * | 2017-12-22 | 2025-09-01 | Genentech Inc | Targeted integration of nucleic acids |
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| CN109321604B (zh) * | 2018-10-30 | 2021-07-06 | 江南大学 | 一种cho细胞基因组内nw_006882077-1稳定表达蛋白质的应用 |
| CN109136193B (zh) * | 2018-10-30 | 2021-07-06 | 江南大学 | 一种cho细胞基因组内nw_006884764-1稳定表达蛋白质的应用 |
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| TW202216991A (zh) * | 2020-06-24 | 2022-05-01 | 美商建南德克公司 | 核酸之靶向整合 |
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| AU2022373655A1 (en) | 2021-10-18 | 2024-05-09 | Regeneron Pharmaceuticals, Inc. | Mammalian cells comprising integrated cas9 genes to produce stable integration sites, and mammalian cells comprising stable integration sites and other sites |
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| EP4468859A2 (en) * | 2022-01-28 | 2024-12-04 | The Trustees Of Columbia University In The City Of New York | Genetic modifications for xenotransplantation |
| CN117305334B (zh) * | 2022-06-21 | 2024-11-08 | 深圳太力生物技术有限责任公司 | 靶向整合细胞及其制备方法、生产目标基因表达产物的方法 |
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| CN118726475B (zh) * | 2023-03-28 | 2025-07-08 | 深圳太力生物技术有限责任公司 | 核酸、重组载体、靶向整合细胞、基因表达方法和应用 |
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| KR102243243B1 (ko) | 2021-04-22 |
| MY184103A (en) | 2021-03-18 |
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| CN107109434A (zh) | 2017-08-29 |
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| CA2965495C (en) | 2022-05-24 |
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