TWI780097B - 於活體外進行抗體之糖基化工程 - Google Patents

於活體外進行抗體之糖基化工程 Download PDF

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Publication number
TWI780097B
TWI780097B TW106144931A TW106144931A TWI780097B TW I780097 B TWI780097 B TW I780097B TW 106144931 A TW106144931 A TW 106144931A TW 106144931 A TW106144931 A TW 106144931A TW I780097 B TWI780097 B TW I780097B
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TW
Taiwan
Prior art keywords
antibody
glycosylation
antibodies
ligand
modified
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TW106144931A
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English (en)
Chinese (zh)
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TW201835333A (zh
Inventor
羅伯托 佛肯斯丹
赫科 渥齊
賽巴斯欽 莫理克
馬可 索曼
羅門 馬諦斯 凡赫 范
英格利 胥密特
羅藍 多恩
麥可 辛葛
Original Assignee
瑞士商赫孚孟拉羅股份公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60997429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI780097(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 瑞士商赫孚孟拉羅股份公司 filed Critical 瑞士商赫孚孟拉羅股份公司
Publication of TW201835333A publication Critical patent/TW201835333A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW106144931A 2016-12-21 2017-12-20 於活體外進行抗體之糖基化工程 TWI780097B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
??16205587.5 2016-12-21
EP16205587 2016-12-21
EP16205587.5 2016-12-21
??17157002.1 2017-02-20
EP17157002 2017-02-20
EP17157002.1 2017-02-20

Publications (2)

Publication Number Publication Date
TW201835333A TW201835333A (zh) 2018-10-01
TWI780097B true TWI780097B (zh) 2022-10-11

Family

ID=60997429

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106144931A TWI780097B (zh) 2016-12-21 2017-12-20 於活體外進行抗體之糖基化工程

Country Status (11)

Country Link
US (2) US20200165320A1 (https=)
EP (1) EP3559248B2 (https=)
JP (1) JP6850351B2 (https=)
KR (1) KR102317884B1 (https=)
CN (2) CN119685431A (https=)
AU (1) AU2017384276B9 (https=)
CA (1) CA3044920C (https=)
IL (1) IL267351A (https=)
MX (1) MX2019006266A (https=)
TW (1) TWI780097B (https=)
WO (1) WO2018114877A1 (https=)

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EP3559250A1 (en) 2016-12-21 2019-10-30 H. Hoffnabb-La Roche Ag Re-use of enzymes in in vitro glycoengineering of antibodies
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MX2019006123A (es) * 2016-12-21 2019-08-12 Hoffmann La Roche Metodo para glicomanipulacion in vitro de anticuerpos.
MA53122A (fr) 2018-07-13 2021-05-19 Genmab As Variants d'anticorps cd38 et leurs utilisations
JP7534281B2 (ja) 2018-07-13 2024-08-14 ジェンマブ エー／エス Ｃｄ３８抗体を使用したトロゴサイトーシスを介した治療
KR20220130724A (ko) 2020-01-16 2022-09-27 젠맵 에이/에스 Cd38 항체의 제제 및 그의 용도
KR20240051280A (ko) 2021-09-06 2024-04-19 젠맵 에이/에스 Cd27과 결합할 수 있는 항체, 그의 변이체 및 그의 용도
CN121285385A (zh) 2023-05-12 2026-01-06 金麦安博股份有限公司 能够与ox40结合的抗体、其变体及其用途
WO2025049881A1 (en) * 2023-09-01 2025-03-06 Catalent Pharma Solutions, Llc Dnase co-expression in host cells

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Also Published As

Publication number Publication date
BR112019010485A2 (pt) 2019-09-10
MX2019006266A (es) 2019-08-21
WO2018114877A1 (en) 2018-06-28
EP3559248B2 (en) 2024-11-20
US20200165320A1 (en) 2020-05-28
CN119685431A (zh) 2025-03-25
AU2017384276A1 (en) 2019-05-30
EP3559248B1 (en) 2021-11-17
AU2017384276B9 (en) 2020-11-26
KR20190082942A (ko) 2019-07-10
CA3044920C (en) 2022-06-28
EP3559248A1 (en) 2019-10-30
JP6850351B2 (ja) 2021-03-31
IL267351A (en) 2019-08-29
KR102317884B1 (ko) 2021-10-26
CA3044920A1 (en) 2018-06-28
TW201835333A (zh) 2018-10-01
AU2017384276B2 (en) 2020-07-02
CN110088291A (zh) 2019-08-02
US20240101643A1 (en) 2024-03-28
JP2020501577A (ja) 2020-01-23

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