TWI777260B - 芋螺毒素(conotoxin)肽之修飾及用途 - Google Patents
芋螺毒素(conotoxin)肽之修飾及用途 Download PDFInfo
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- TWI777260B TWI777260B TW109134130A TW109134130A TWI777260B TW I777260 B TWI777260 B TW I777260B TW 109134130 A TW109134130 A TW 109134130A TW 109134130 A TW109134130 A TW 109134130A TW I777260 B TWI777260 B TW I777260B
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- pain
- peptide
- variant
- conotoxin peptide
- pharmaceutically acceptable
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- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
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- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| TW104136722A TWI708790B (zh) | 2014-11-07 | 2015-11-06 | 芋螺毒素（ｃｏｎｏｔｏｘｉｎ）肽之修飾及用途 |
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| ES (1) | ES2950901T3 (enExample) |
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| IL (2) | IL284236B2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107249616A (zh) | 2014-11-07 | 2017-10-13 | 奇尼塔慢性疼痛有限责任公司 | 芋螺毒素(conotoxin)肽的修饰和用途 |
| RU2731217C2 (ru) * | 2016-11-28 | 2020-08-31 | Общество с ограниченной ответственностью "Синейро" | Аналог альфа-конотоксина RgIA для лечения боли |
| US10947274B1 (en) * | 2018-05-01 | 2021-03-16 | University Of Utah Research Foundation | Synthetic analgesic peptides of RgIA analogs |
| KR102117106B1 (ko) | 2018-09-14 | 2020-06-01 | 대한민국(환경부 국립생물자원관장) | N형 칼슘채널 차단 활성을 갖는 긴호랑거미 유래 알지신-ⅰ 펩타이드 및 이의 용도 |
| SG11202106847SA (en) * | 2019-01-04 | 2021-07-29 | Kineta Chronic Pain Llc | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
| US11612661B2 (en) | 2019-01-04 | 2023-03-28 | Kineta Chronic Pain, Llc | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
| WO2021207408A2 (en) * | 2020-04-09 | 2021-10-14 | Glo Pharma, Inc. | Peptide compositions and methods for inhibiting nicotinic acetylcholine receptor activity |
| CN116528884A (zh) * | 2020-06-03 | 2023-08-01 | 犹他大学研究基金会 | 构象受限的α-RGIA类似物 |
| CN114805492B (zh) * | 2022-03-15 | 2025-07-22 | 上海元炘执药科技有限公司 | 一种用于抑制电压门控钠离子通道1.4的芋螺毒素kiiia突变体及其制备方法和应用 |
| CN115286700B (zh) * | 2022-08-22 | 2024-11-19 | 中国海洋大学 | 一种具有血浆稳定性的镇痛多肽 |
| CN118184744A (zh) * | 2024-03-29 | 2024-06-14 | 广西大学 | 一种靶向神经型乙酰胆碱受体的多肽分子及其制备方法和应用 |
| CN119912549A (zh) * | 2024-12-29 | 2025-05-02 | 中国人民解放军军事科学院防化研究院 | 一类脂肪醛修饰的芋螺肽及其制备方法 |
| CN121471320B (zh) * | 2026-01-12 | 2026-03-17 | 中国海洋大学 | 一种靶向trpv1的多肽及其应用 |
Citations (1)
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| US20120220539A1 (en) * | 2006-07-18 | 2012-08-30 | University Of Utah Research Foundation | Conotoxin peptides |
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| US5595972A (en) | 1993-06-29 | 1997-01-21 | University Of Utah Research Foundation | Conotoxin peptides |
| US6797808B1 (en) | 1999-01-29 | 2004-09-28 | University Of Utah Research Foundation | α-conotoxin peptides |
| KR20020047245A (ko) | 1999-10-18 | 2002-06-21 | 에프.지.엠. 헤르만스 ; 이.에이치. 리링크 | 면역요법에 사용하기 위한 수정 펩티드 및 펩티드모방체 |
| US7507717B2 (en) | 2002-12-02 | 2009-03-24 | Xenome Ltd. | Type II chi-conotoxin peptides (noradrenaline transporter inhibitors) |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| EP1770099A1 (en) * | 2005-09-28 | 2007-04-04 | University of Geneva | Method of producing a modified (poly)peptide |
| US7745573B2 (en) | 2006-02-17 | 2010-06-29 | Polychip Pharmaceuticals Pty Ltd. | Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides |
| EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
| CA2566832A1 (en) * | 2006-04-13 | 2007-10-13 | The University Of Queensland | Cyclised alpha-conotoxin peptides |
| KR20090060294A (ko) * | 2006-09-08 | 2009-06-11 | 암브룩스, 인코포레이티드 | 변형된 인간 혈장 폴리펩티드 또는 Ｆｃ 스캐폴드 및 그의 용도 |
| US20090326192A1 (en) * | 2008-04-08 | 2009-12-31 | Aileron Therapeutics, Inc. | Biologically active peptidomimetic macrocycles |
| DE102009050885A1 (de) * | 2009-10-27 | 2011-04-28 | Behr Gmbh & Co. Kg | Luftausströmer |
| JP6681826B2 (ja) | 2013-05-31 | 2020-04-15 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | コノトキシンペプチド、医薬組成物およびそれらの使用 |
| CN107249616A (zh) | 2014-11-07 | 2017-10-13 | 奇尼塔慢性疼痛有限责任公司 | 芋螺毒素(conotoxin)肽的修饰和用途 |
| US11612661B2 (en) | 2019-01-04 | 2023-03-28 | Kineta Chronic Pain, Llc | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
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|---|---|---|---|---|
| US20120220539A1 (en) * | 2006-07-18 | 2012-08-30 | University Of Utah Research Foundation | Conotoxin peptides |
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Balazs Hargittai et al.Chemical Syntheses and Biological Activities of Lactam Analogues of α-Conotoxin SI. J. Med. Chem. 2000, 43, 4787- 4792. * |
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| EP3215172A4 (en) | 2018-07-25 |
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