TWI747929B - 一種人胰島素或其類似物的醯化衍生物 - Google Patents

一種人胰島素或其類似物的醯化衍生物 Download PDF

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Publication number
TWI747929B
TWI747929B TW106125882A TW106125882A TWI747929B TW I747929 B TWI747929 B TW I747929B TW 106125882 A TW106125882 A TW 106125882A TW 106125882 A TW106125882 A TW 106125882A TW I747929 B TWI747929 B TW I747929B
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TW
Taiwan
Prior art keywords
patent application
scope
human insulin
item
zinc complex
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TW106125882A
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English (en)
Chinese (zh)
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TW201805300A (zh
Inventor
劉德玉
王宏偉
趙亮
王菲菲
曾翔
王濤
王亞里
戴雨璐
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大陸商江蘇恆瑞醫藥股份有限公司
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Publication of TW201805300A publication Critical patent/TW201805300A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
TW106125882A 2016-08-02 2017-08-01 一種人胰島素或其類似物的醯化衍生物 TWI747929B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
??201610625257.5 2016-08-02
CN201610625257 2016-08-02
CN201610625257.5 2016-08-02
??201610779132.8 2016-08-31
CN201610779132 2016-08-31
CN201610779132.8 2016-08-31

Publications (2)

Publication Number Publication Date
TW201805300A TW201805300A (zh) 2018-02-16
TWI747929B true TWI747929B (zh) 2021-12-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW106125882A TWI747929B (zh) 2016-08-02 2017-08-01 一種人胰島素或其類似物的醯化衍生物

Country Status (6)

Country Link
US (1) US10815287B2 (cg-RX-API-DMAC7.html)
EP (1) EP3495384A4 (cg-RX-API-DMAC7.html)
JP (2) JP7432361B2 (cg-RX-API-DMAC7.html)
CN (2) CN114478747B (cg-RX-API-DMAC7.html)
TW (1) TWI747929B (cg-RX-API-DMAC7.html)
WO (1) WO2018024186A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210040171A1 (en) * 2018-02-01 2021-02-11 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition comprising acylated derivative of human insulin analog and preparation method thereof
CA3086618A1 (en) 2018-02-09 2019-08-15 Jiangsu Hengrul Medicine Co., Ltd. Codon optimized precursor gene and signal peptide gene of human insulin analogue
CA3100869A1 (en) 2018-05-24 2019-11-28 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing precursor of recombinant human insulin or analogue thereof
EP3893934B1 (en) 2018-12-11 2025-09-10 Sanofi Insulin conjugates
CN118666989A (zh) 2019-12-30 2024-09-20 甘李药业股份有限公司 胰岛素衍生物
TW202229324A (zh) * 2020-11-27 2022-08-01 大陸商江蘇恒瑞醫藥股份有限公司 製備胰島素或其類似物的醯化衍生物的方法
CN112939771A (zh) * 2021-01-28 2021-06-11 宁夏蓝博思化学技术有限公司 长链烷基二酸单叔丁酯的制备方法
WO2022247773A1 (en) * 2021-05-24 2022-12-01 Sunshine Lake Pharma Co., Ltd. A novel acylated insulin analog
WO2022268208A1 (zh) 2021-06-25 2022-12-29 甘李药业股份有限公司 含酰化胰岛素的药物组合物
WO2023143458A1 (zh) 2022-01-28 2023-08-03 甘李药业股份有限公司 酰化胰岛素
CN117756914B (zh) * 2023-12-15 2024-09-03 瀚晖制药有限公司 依柯胰岛素的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012347A2 (en) * 2003-08-05 2005-02-10 Novo Nordisk A/S Novel insulin derivatives
TW201323439A (zh) * 2011-12-15 2013-06-16 Shanghai Hengrui Pharm Co Ltd 人胰島素類似物及其醯化衍生物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
PT792290E (pt) 1993-09-17 2002-01-30 Novo Nordisk As Insulina acilada
CN1163574A (zh) * 1994-11-17 1997-10-29 伊莱利利公司 酰化的胰岛素类似物
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
WO2003075950A1 (en) * 2002-03-13 2003-09-18 Novo Nordisk A/S Minimising body weight gain in insulin treatment
EP2287184A3 (en) 2003-08-05 2011-08-10 Novo Nordisk A/S Novel insulin derivatives
DK1969004T3 (da) * 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
EP2178910B1 (en) 2007-08-15 2014-10-08 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
DK2910570T3 (en) * 2008-03-18 2017-01-30 Novo Nordisk As Protease-stabilized acylated insulin analogues.
US8935928B2 (en) * 2011-10-10 2015-01-20 Lockheed Martin Corporation Integrated air-cycle refrigeration and power generation system
CN106496322A (zh) * 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 人胰岛素或其类似物的酰化衍生物的制备方法
CA3013623A1 (en) * 2016-02-05 2017-08-10 Memorial Sloan-Ketering Cancer Center Methods of differentiating stem cell-derived ectodermal lineage precursors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012347A2 (en) * 2003-08-05 2005-02-10 Novo Nordisk A/S Novel insulin derivatives
TW201323439A (zh) * 2011-12-15 2013-06-16 Shanghai Hengrui Pharm Co Ltd 人胰島素類似物及其醯化衍生物

Also Published As

Publication number Publication date
CN114478747B (zh) 2024-06-14
WO2018024186A1 (zh) 2018-02-08
JP2019526537A (ja) 2019-09-19
US10815287B2 (en) 2020-10-27
JP2022095872A (ja) 2022-06-28
TW201805300A (zh) 2018-02-16
CN114478747A (zh) 2022-05-13
EP3495384A4 (en) 2020-02-26
CN108463468B (zh) 2022-03-04
US20190169257A1 (en) 2019-06-06
CN108463468A (zh) 2018-08-28
EP3495384A1 (en) 2019-06-12
JP7432361B2 (ja) 2024-02-16

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