TWI737583B - 用於長效型干擾素之劑量方案 - Google Patents

用於長效型干擾素之劑量方案 Download PDF

Info

Publication number
TWI737583B
TWI737583B TW104136693A TW104136693A TWI737583B TW I737583 B TWI737583 B TW I737583B TW 104136693 A TW104136693 A TW 104136693A TW 104136693 A TW104136693 A TW 104136693A TW I737583 B TWI737583 B TW I737583B
Authority
TW
Taiwan
Prior art keywords
interferon
administered
treatment period
period
weeks
Prior art date
Application number
TW104136693A
Other languages
English (en)
Chinese (zh)
Other versions
TW201618808A (zh
Inventor
國鐘 林
克里斯托夫 克勞德
歐雷 札格里茲裘克
Original Assignee
藥華醫藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 藥華醫藥股份有限公司 filed Critical 藥華醫藥股份有限公司
Publication of TW201618808A publication Critical patent/TW201618808A/zh
Application granted granted Critical
Publication of TWI737583B publication Critical patent/TWI737583B/zh

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
TW104136693A 2014-11-06 2015-11-06 用於長效型干擾素之劑量方案 TWI737583B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14192114 2014-11-06
EP14192114.8 2014-11-06

Publications (2)

Publication Number Publication Date
TW201618808A TW201618808A (zh) 2016-06-01
TWI737583B true TWI737583B (zh) 2021-09-01

Family

ID=51945707

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104136693A TWI737583B (zh) 2014-11-06 2015-11-06 用於長效型干擾素之劑量方案

Country Status (32)

Country Link
US (3) US11559567B2 (enExample)
EP (2) EP4282485A3 (enExample)
JP (2) JP6820841B2 (enExample)
KR (2) KR102724837B1 (enExample)
CN (1) CN107530403A (enExample)
AU (1) AU2015342908B2 (enExample)
BR (1) BR112017009193A2 (enExample)
CA (1) CA2964390A1 (enExample)
CL (1) CL2017001088A1 (enExample)
DK (1) DK3215193T3 (enExample)
EA (1) EA037151B1 (enExample)
ES (1) ES2966888T3 (enExample)
FI (1) FI3215193T3 (enExample)
HK (1) HK1243627A1 (enExample)
HR (1) HRP20231732T1 (enExample)
HU (1) HUE064909T2 (enExample)
IL (1) IL251627B (enExample)
LT (1) LT3215193T (enExample)
MX (1) MX389844B (enExample)
MY (1) MY191506A (enExample)
NZ (1) NZ730924A (enExample)
PH (1) PH12017500617B1 (enExample)
PL (1) PL3215193T3 (enExample)
PT (1) PT3215193T (enExample)
RS (1) RS65015B1 (enExample)
SG (1) SG11201702798PA (enExample)
SI (1) SI3215193T1 (enExample)
SM (1) SMT202400028T1 (enExample)
TW (1) TWI737583B (enExample)
UA (1) UA122867C2 (enExample)
WO (1) WO2016073825A1 (enExample)
ZA (1) ZA201702704B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018134260A1 (en) * 2017-01-18 2018-07-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment patients suffering from myeloproliferative disorders
US11414698B2 (en) * 2018-03-22 2022-08-16 Chang Gung Medical Foundation Chang Gung Memorial Hospital At Chiayi Method of quantifying mutant allele burden of target gene
CN115968291A (zh) * 2020-04-22 2023-04-14 南湖制药公司 聚乙二醇化干扰素tau及其组合物和方法
AU2022221496A1 (en) * 2021-08-29 2023-03-16 Pharmaessentia Corporation Method of Using Pegylated Interferon-alpha

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5738846A (en) 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US6824768B2 (en) * 1998-12-18 2004-11-30 Schering Corporation Ribavirin-pegylated interferon alfa induction HCV combination therapy
RU2002105485A (ru) * 1999-08-13 2004-01-27 Ф.Хоффманн-Ля Рош Аг (Ch) Применение микофенолята мофетила в сочетании с ПЭГ-интерфероном-α (ПЭГ-IFN-α)
BR0013638A (pt) 1999-08-27 2002-05-14 Maxygen Aps Novas moléculas semelhantes a interferon beta
PL356007A1 (en) 1999-11-12 2004-05-31 Maxygen Holdings Ltd Interferon gamma conjugates
US7125843B2 (en) 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
RS53104A (sr) 2001-11-20 2006-10-27 Pharmacia Corporation Hemijski modifikovani konjugati humanog hormona rasta
US20030171285A1 (en) 2001-11-20 2003-09-11 Finn Rory F. Chemically-modified human growth hormone conjugates
CA2753899C (en) 2002-01-18 2014-03-25 Biogen Idec Ma Inc. Polyalkylene glycol with moiety for conjugating biologically active compounds
US7345150B2 (en) 2002-03-26 2008-03-18 Medical University Of Toledo Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
JP4764630B2 (ja) 2002-09-09 2011-09-07 ネクター セラピューティックス 水溶性ポリマーアルカナール
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
MXPA05006945A (es) 2002-12-26 2005-12-14 Mountain View Pharmaceuticals Conjugados polimericos de citoquinas, quimiocinas, factores de crecimiento, hormonas polipeptidicas y sus antagonistas con actividad conservada de union al receptor.
PT2644206T (pt) 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
KR20060120141A (ko) 2003-11-24 2006-11-24 네오스 테크놀로지스, 인크. 글리코페질화 에리트로포이에틴
BRPI0515118A (pt) 2004-08-31 2008-07-01 Pharmacia & Upjohn Co Llc conjugados de hormÈnio do crescimento humano com polietileno glicol
US7365127B2 (en) 2005-02-04 2008-04-29 Enzon Pharmaceuticals, Inc. Process for the preparation of polymer conjugates
EP1869079A2 (en) 2005-03-11 2007-12-26 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
WO2006094530A1 (en) 2005-03-11 2006-09-14 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
CN101002944B (zh) 2006-01-17 2012-07-25 中国科学院过程工程研究所 支链聚乙二醇-干扰素结合物及其制备方法
EP1834963A1 (en) 2006-03-13 2007-09-19 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
CN101104078B (zh) 2006-07-11 2011-11-02 北京美倍他药物研究有限公司 多肽及蛋白药物的聚乙二醇偶合物
CN101108895B (zh) 2006-07-19 2011-10-26 北京键凯科技有限公司 聚乙二醇乙醛衍生物及其与药物的结合物
WO2008021487A1 (en) 2006-08-18 2008-02-21 Pepgen Corporation Combination treatment method with interferon-tau
CN1966547B (zh) 2006-11-06 2011-11-09 中国药科大学 双链结构的聚乙二醇衍生物的制备及其与药物分子的结合
CN1970572A (zh) 2006-12-21 2007-05-30 北京三元基因工程有限公司 干扰素α突变体及其聚乙二醇衍生物
CL2008002399A1 (es) 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
WO2009030066A1 (en) * 2007-09-04 2009-03-12 Biosteed Gene Expression Tech. Co., Ltd. Polyethylene glycol modified interferon alpha 2b and preparation method and applicatioins thereof
PL2196475T3 (pl) 2007-09-04 2012-10-31 Biosteed Gene Expression Tech Co Ltd Interferon alfa 2a zmodyfikowany rozgałęzioną cząsteczką glikolu polietylenowego, sposób jego syntezy i zastosowanie
CN101491682A (zh) 2008-04-30 2009-07-29 北京凯正生物工程发展有限责任公司 聚乙二醇化重组人干扰素ω偶合物及其制备工艺
AU2009276458B2 (en) 2008-07-31 2014-06-19 Pharmaessentia Corp. Peptide-polymer conjugates
CN101671390B (zh) 2008-09-10 2012-10-03 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物的制备和用途
CN101514229B (zh) 2009-04-03 2012-05-09 海南四环心脑血管药物研究院有限公司 人干扰素α衍生物及其聚乙二醇化修饰物
UA109646C2 (uk) * 2009-12-10 2015-09-25 Терапевтичне застосування кон'югатів білка з полімером
JP2014504184A (ja) * 2010-12-01 2014-02-20 スパイナル・モデュレーション・インコーポレイテッド 神経構造への薬剤の直接送達

Also Published As

Publication number Publication date
TW201618808A (zh) 2016-06-01
PL3215193T3 (pl) 2024-03-18
KR20230079520A (ko) 2023-06-07
LT3215193T (lt) 2024-01-25
HUE064909T2 (hu) 2024-04-28
IL251627A0 (en) 2017-06-29
AU2015342908A1 (en) 2017-05-04
BR112017009193A2 (pt) 2018-01-30
HRP20231732T1 (hr) 2024-03-15
AU2015342908B2 (en) 2021-06-24
CL2017001088A1 (es) 2018-01-12
MX389844B (es) 2025-03-04
ZA201702704B (en) 2020-10-28
EP3215193A4 (en) 2018-07-25
FI3215193T3 (fi) 2023-12-28
KR20170083074A (ko) 2017-07-17
JP2021001184A (ja) 2021-01-07
EP4282485A2 (en) 2023-11-29
EP4282485A3 (en) 2024-01-17
SI3215193T1 (sl) 2024-02-29
JP2017533192A (ja) 2017-11-09
EA201790991A1 (ru) 2017-11-30
HK1243627A1 (zh) 2018-07-20
PH12017500617A1 (en) 2017-09-04
KR102540109B1 (ko) 2023-06-02
EA037151B1 (ru) 2021-02-11
US20230131552A1 (en) 2023-04-27
NZ730924A (en) 2022-04-29
RS65015B1 (sr) 2024-01-31
ES2966888T3 (es) 2024-04-24
CN107530403A (zh) 2018-01-02
US12343381B2 (en) 2025-07-01
PT3215193T (pt) 2023-12-15
SMT202400028T1 (it) 2024-03-13
EP3215193A1 (en) 2017-09-13
IL251627B (en) 2021-12-01
MY191506A (en) 2022-06-28
US11559567B2 (en) 2023-01-24
UA122867C2 (uk) 2021-01-13
DK3215193T3 (da) 2024-01-08
WO2016073825A1 (en) 2016-05-12
MX2017005244A (es) 2017-08-18
PH12017500617B1 (en) 2024-07-03
US20170326206A1 (en) 2017-11-16
EP3215193B1 (en) 2023-10-04
KR102724837B1 (ko) 2024-10-31
SG11201702798PA (en) 2017-05-30
US20250186552A1 (en) 2025-06-12
JP6820841B2 (ja) 2021-01-27
CA2964390A1 (en) 2016-05-12

Similar Documents

Publication Publication Date Title
US12343381B2 (en) Dosage regimen for pegylated interferon
TWI272948B (en) HSA-free stabilized interferon liquid formulations
US20180207237A1 (en) Il-12 formulations for enhancing hematopoiesis
JP2015038083A (ja) 造血におけるil−12の使用
CN100536910C (zh) 胸腺素α1肽/聚合物结合物
KR20200047524A (ko) B형 간염 바이러스 감염을 치료 및/또는 예방하기 위한 조성물 및 이의 용도
EP3484500A1 (en) Uses of il-12 as a replacement immunotherapeutic
JPH06340549A (ja) ネコの呼吸器疾患治療剤とその治療剤を用いる治療方法
JP2013543872A (ja) インターフェロン−βの安定に保存される組成物
RU2554761C1 (ru) Противоэнтеровирусное и иммуностимулирующее средство
US20240423983A1 (en) Enhancement of cd47 blockade therapy with dhfr inhibitors
CN114028544A (zh) 一种动员淋巴瘤和骨髓瘤干细胞的药物组合物
WO2014130811A1 (en) Interferon beta formulation
JP2013018729A (ja) アルツハイマー病治療剤の作用増強経口用剤