TWI733692B - 羧酸取代的(雜)芳環類衍生物及其製備方法和用途 - Google Patents
羧酸取代的(雜)芳環類衍生物及其製備方法和用途 Download PDFInfo
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- 125000002053 thietanyl group Chemical group 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 235000019303 thiodipropionic acid Nutrition 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
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- 229930192474 thiophene Natural products 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 230000032895 transmembrane transport Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229920011532 unplasticized polyvinyl chloride Polymers 0.000 description 1
- 229940005267 urate oxidase Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 239000008136 water-miscible vehicle Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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Classifications
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510560190 | 2015-09-02 | ||
| CN201510560190.7 | 2015-09-02 |
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| TW201710236A TW201710236A (zh) | 2017-03-16 |
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| CN110612286A (zh) * | 2017-02-28 | 2019-12-24 | 广东东阳光药业有限公司 | 氰基取代的稠合双环衍生物及其制备方法和用途 |
| ES2639863B1 (es) * | 2017-03-10 | 2018-09-20 | Universidad De Granada | Compuestos para el tratamiento de enfermedades causadas por la acumulación de oxalato |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| CN109503513B (zh) * | 2018-12-29 | 2020-09-25 | 嘉实(湖南)医药科技有限公司 | 一种非布司他中间体的“一锅法”合成方法 |
| CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
| JP7362916B2 (ja) * | 2019-10-30 | 2023-10-17 | ドンバオ・パープル・スター・(ハンジョウ)・バイオファーマシューティカル・カンパニー・リミテッド | キサンチンオキシダーゼ阻害剤としてのチオフェン誘導体およびその使用 |
| WO2021204884A1 (de) * | 2020-04-09 | 2021-10-14 | Bayer Aktiengesellschaft | 3-(4-alkenyl-phenyl)-3-pyrrolin-2-one und deren verwendung als herbizide |
| CN113105481A (zh) * | 2021-02-25 | 2021-07-13 | 浙江农林大学暨阳学院 | 一种双金属催化制备苯并-6,8-二氢异喹啉-1-亚硒砜基苯甲酰胺类化合物的方法 |
| JP7602065B2 (ja) * | 2021-04-29 | 2024-12-17 | ドンバオ パープル スター (ハンチョウ) バイオファーマシューティカル シーオー.,エルティーディー. | チオフェン誘導体の結晶及びその製造方法 |
| US20250282753A1 (en) * | 2022-04-27 | 2025-09-11 | Atom Bioscience America Corporation | Compounds useful for reducing uric acid |
| TW202342455A (zh) * | 2022-04-27 | 2023-11-01 | 大陸商江蘇新元素醫藥科技有限公司 | 可用於痛風的化合物 |
| CN115417804A (zh) * | 2022-09-16 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种7-甲基-1h-吲哚-5-羧酸的合成方法 |
| CN116375603A (zh) * | 2023-03-03 | 2023-07-04 | 大连理工大学 | 一种合成苯丙环丁烯衍生物的方法 |
| CN119492694B (zh) * | 2024-11-12 | 2025-09-30 | 科顺防水科技股份有限公司 | 化学阻根剂手性分布的测量方法 |
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| WO2010093191A2 (en) * | 2009-02-13 | 2010-08-19 | Lg Life Sciences Ltd. | Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same |
| WO2011043568A2 (en) * | 2009-10-07 | 2011-04-14 | Lg Life Sciences Ltd. | Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same |
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| AU642743B2 (en) | 1990-05-21 | 1993-10-28 | Smith Kline & French Laboratories Limited | Phenol and pyridinol derivatives as pharmaceuticals |
| JP2725886B2 (ja) * | 1990-11-30 | 1998-03-11 | 帝人株式会社 | 2―アリールチアゾール誘導体及びその医薬組成物 |
| SI2133332T1 (sl) | 2007-04-11 | 2014-02-28 | Kissei Pharmaceutical Co., Ltd. | (aza)indolinski derivat in njegova uporaba v medicinske namene |
| JP5587784B2 (ja) * | 2008-10-15 | 2014-09-10 | キッセイ薬品工業株式会社 | 縮合複素環誘導体及びその医薬用途 |
| US8263622B2 (en) | 2008-10-15 | 2012-09-11 | Kissei Pharmaceutical Co., Ltd. | Fused-ring derivative and medical application of same |
| SI2415771T1 (sl) | 2009-03-31 | 2013-12-31 | Kissei Pharmaceutical Co., Ltd. | Derivat indolizina in njegova uporaba v medicinske namene |
| JP5906191B2 (ja) | 2010-09-29 | 2016-04-20 | キッセイ薬品工業株式会社 | (アザ)インドリジン誘導体及びその医薬用途 |
| JP6377732B2 (ja) | 2013-06-21 | 2018-08-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 1,3−ジアミノシクロペンタンカルボキサミド誘導体 |
| JP2015214527A (ja) | 2014-05-13 | 2015-12-03 | 帝人ファーマ株式会社 | イミダゾール誘導体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010093191A2 (en) * | 2009-02-13 | 2010-08-19 | Lg Life Sciences Ltd. | Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same |
| WO2011043568A2 (en) * | 2009-10-07 | 2011-04-14 | Lg Life Sciences Ltd. | Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same |
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| RU2018111106A (ru) | 2019-10-07 |
| WO2017036404A1 (en) | 2017-03-09 |
| CN106478500B (zh) | 2020-02-11 |
| AR105893A1 (es) | 2017-11-22 |
| ES2839201T3 (es) | 2021-07-05 |
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| CA2994336C (en) | 2024-03-05 |
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| RU2733750C2 (ru) | 2020-10-06 |
| JP2018532698A (ja) | 2018-11-08 |
| AU2016316278A1 (en) | 2018-03-01 |
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| AU2016316278B2 (en) | 2020-06-04 |
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| DK3344604T3 (da) | 2020-12-07 |
| EP3344604B1 (en) | 2020-11-04 |
| HUE052608T2 (hu) | 2021-05-28 |
| CN106478500A (zh) | 2017-03-08 |
| US10266496B2 (en) | 2019-04-23 |
| EP3344604A1 (en) | 2018-07-11 |
| EP3344604A4 (en) | 2019-02-06 |
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