TWI733692B - 羧酸取代的(雜)芳環類衍生物及其製備方法和用途 - Google Patents

羧酸取代的(雜)芳環類衍生物及其製備方法和用途 Download PDF

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TWI733692B
TWI733692B TW105128309A TW105128309A TWI733692B TW I733692 B TWI733692 B TW I733692B TW 105128309 A TW105128309 A TW 105128309A TW 105128309 A TW105128309 A TW 105128309A TW I733692 B TWI733692 B TW I733692B
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reaction mixture
compound
added
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TW201710236A (zh
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楊新業
黃常偉
馬發城
霽 張
王曉軍
張英俊
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大陸商廣東東陽光藥業有限公司
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ES2639863B1 (es) * 2017-03-10 2018-09-20 Universidad De Granada Compuestos para el tratamiento de enfermedades causadas por la acumulación de oxalato
WO2019057946A1 (en) 2017-09-25 2019-03-28 F. Hoffmann-La Roche Ag MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
CN109503513B (zh) * 2018-12-29 2020-09-25 嘉实（湖南）医药科技有限公司 一种非布司他中间体的“一锅法”合成方法
CN111943957B (zh) * 2019-05-17 2023-01-06 中国医学科学院药物研究所 喹啉甲酰胺类化合物及其制备方法和用途
WO2021083319A1 (zh) * 2019-10-30 2021-05-06 南京明德新药研发有限公司 作为黄嘌呤氧化酶抑制剂的噻吩衍生物及其应用
WO2021204884A1 (de) * 2020-04-09 2021-10-14 Bayer Aktiengesellschaft 3-(4-alkenyl-phenyl)-3-pyrrolin-2-one und deren verwendung als herbizide
CN113105481A (zh) * 2021-02-25 2021-07-13 浙江农林大学暨阳学院 一种双金属催化制备苯并-6，8-二氢异喹啉-1-亚硒砜基苯甲酰胺类化合物的方法
MX2023012804A (es) * 2021-04-29 2023-11-08 Dongbao Purple Star Hangzhou Biopharmaceutical Co Ltd Forma cristalina de derivado de tiofeno y metodo de preparacion de la misma.
JP7792730B2 (ja) * 2022-04-27 2025-12-26 杭州新元素▲薬▼▲業▼有限公司 尿酸を降下させるために使用できる化合物
TWI922802B (zh) * 2022-04-27 2026-04-21 大陸商杭州新元素藥業股份有限公司 可用於痛風的化合物
CN115417804A (zh) * 2022-09-16 2022-12-02 天津药明康德新药开发有限公司 一种7-甲基-1h-吲哚-5-羧酸的合成方法
CN116375603A (zh) * 2023-03-03 2023-07-04 大连理工大学 一种合成苯丙环丁烯衍生物的方法
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WO2025223330A1 (zh) * 2024-04-23 2025-10-30 深壶制药(山东)有限公司 吲哚并饱和环类化合物或其衍生物及其应用
CN119492694B (zh) * 2024-11-12 2025-09-30 科顺防水科技股份有限公司 化学阻根剂手性分布的测量方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093191A2 (en) * 2009-02-13 2010-08-19 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2011043568A2 (en) * 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU642743B2 (en) 1990-05-21 1993-10-28 Smith Kline & French Laboratories Limited Phenol and pyridinol derivatives as pharmaceuticals
CA2073981C (en) * 1990-11-30 2002-01-08 Shiro Kondo 2-arylthiazole derivatives and pharmaceutical composition thereof
CN101679251B (zh) 2007-04-11 2013-10-02 橘生药品工业株式会社 (氮杂)吲哚衍生物及其医药用途
CA2739060C (en) * 2008-10-15 2016-08-23 Kissei Pharmaceutical Co., Ltd. Fused-ring derivative and medical application of same
WO2010044404A1 (ja) 2008-10-15 2010-04-22 キッセイ薬品工業株式会社 縮合複素環誘導体及びその医薬用途
BRPI1013432B1 (pt) 2009-03-31 2019-12-17 Kissei Pharmaceutical derivado de indolizina e composição farmacêutica
KR20130099064A (ko) * 2010-09-29 2013-09-05 깃세이 야쿠힌 고교 가부시키가이샤 (아자)인돌리진 유도체 및 그 의약용도
EP3010916B1 (en) 2013-06-21 2017-09-27 Merck Patent GmbH 1,3-diaminocyclopentane carboxamide derivatives
JP2015214527A (ja) * 2014-05-13 2015-12-03 帝人ファーマ株式会社 イミダゾール誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093191A2 (en) * 2009-02-13 2010-08-19 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2011043568A2 (en) * 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

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