TWI727427B - 用於治療腫瘤的抗pd-1組合 - Google Patents

用於治療腫瘤的抗pd-1組合 Download PDF

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TWI727427B
TWI727427B TW108134121A TW108134121A TWI727427B TW I727427 B TWI727427 B TW I727427B TW 108134121 A TW108134121 A TW 108134121A TW 108134121 A TW108134121 A TW 108134121A TW I727427 B TWI727427 B TW I727427B
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alkyl
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cancer
specific embodiments
cells
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TW108134121A
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TW202026013A (zh
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李立新
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英屬開曼群島商博笛生物科技有限公司
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Priority claimed from CN201410325480.9A external-priority patent/CN105233291A/zh
Priority claimed from CN201410440824.0A external-priority patent/CN105440135A/zh
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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TW108134121A 2014-07-09 2015-07-08 用於治療腫瘤的抗pd-1組合 TWI727427B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201410325480.9A CN105233291A (zh) 2014-07-09 2014-07-09 用于治疗癌症的联合治疗组合物和联合治疗方法
CN201410325480.9 2014-07-09
CN201410440824.0 2014-09-01
CN201410440824.0A CN105440135A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物

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TW202026013A TW202026013A (zh) 2020-07-16
TWI727427B true TWI727427B (zh) 2021-05-11

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TW108134121A TWI727427B (zh) 2014-07-09 2015-07-08 用於治療腫瘤的抗pd-1組合
TW104122202A TWI691335B (zh) 2014-07-09 2015-07-08 用於治療腫瘤的抗pd-l1組合

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EP (2) EP4001311B1 (enExample)
JP (4) JP6760919B2 (enExample)
KR (1) KR102462743B1 (enExample)
CN (1) CN107074958A (enExample)
AR (1) AR132604A2 (enExample)
AU (3) AU2015286043B2 (enExample)
CA (1) CA2954446A1 (enExample)
DK (1) DK3166976T3 (enExample)
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010077634A1 (en) 2008-12-09 2010-07-08 Genentech, Inc. Anti-pd-l1 antibodies and their use to enhance t-cell function
CN103566377A (zh) 2012-07-18 2014-02-12 上海博笛生物科技有限公司 癌症的靶向免疫治疗
CA2936377A1 (en) 2014-01-10 2015-07-16 Shanghai Birdie Biotech, Inc. Compounds and compositions for treating egfr expressing tumors
CA2974651A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
RU2016142476A (ru) 2014-03-31 2018-05-07 Дженентек, Инк. Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40
EP4001311B1 (en) * 2014-07-09 2025-11-05 Birdie Biopharmaceuticals Inc. Anti-pd-l1/pd-1 combinations for treating tumors
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