TWI708612B - 用於治療癌症之與 adi-peg 20 抗體具有降低之交叉反應性的精胺酸脫亞胺酶 - Google Patents

用於治療癌症之與 adi-peg 20 抗體具有降低之交叉反應性的精胺酸脫亞胺酶 Download PDF

Info

Publication number
TWI708612B
TWI708612B TW104130733A TW104130733A TWI708612B TW I708612 B TWI708612 B TW I708612B TW 104130733 A TW104130733 A TW 104130733A TW 104130733 A TW104130733 A TW 104130733A TW I708612 B TWI708612 B TW I708612B
Authority
TW
Taiwan
Prior art keywords
peg
adi
adir
cancer
patent application
Prior art date
Application number
TW104130733A
Other languages
English (en)
Chinese (zh)
Other versions
TW201625295A (zh
Inventor
理查 夏華特
羅柏特 亞瑪西
詹姆士Ａ 湯瑪森
衛斯 希森
夏偉中
立章 陳
李洋
Original Assignee
開曼群島商瑞華藥業集團
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 開曼群島商瑞華藥業集團 filed Critical 開曼群島商瑞華藥業集團
Publication of TW201625295A publication Critical patent/TW201625295A/zh
Application granted granted Critical
Publication of TWI708612B publication Critical patent/TWI708612B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW104130733A 2014-09-16 2015-09-16 用於治療癌症之與 adi-peg 20 抗體具有降低之交叉反應性的精胺酸脫亞胺酶 TWI708612B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462051182P 2014-09-16 2014-09-16
US62/051,182 2014-09-16

Publications (2)

Publication Number Publication Date
TW201625295A TW201625295A (zh) 2016-07-16
TWI708612B true TWI708612B (zh) 2020-11-01

Family

ID=55453727

Family Applications (2)

Application Number Title Priority Date Filing Date
TW104130733A TWI708612B (zh) 2014-09-16 2015-09-16 用於治療癌症之與 adi-peg 20 抗體具有降低之交叉反應性的精胺酸脫亞胺酶
TW109133681A TWI775160B (zh) 2014-09-16 2015-09-16 用於治療癌症之與adi-peg 20抗體具有降低之交叉反應性的精胺酸脫亞胺酶

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW109133681A TWI775160B (zh) 2014-09-16 2015-09-16 用於治療癌症之與adi-peg 20抗體具有降低之交叉反應性的精胺酸脫亞胺酶

Country Status (11)

Country Link
US (1) US9789170B2 (enExample)
EP (2) EP3193913B1 (enExample)
JP (2) JP6782230B2 (enExample)
KR (1) KR102730989B1 (enExample)
CN (2) CN107073085B (enExample)
AU (1) AU2015317848B2 (enExample)
CA (1) CA2961602A1 (enExample)
ES (1) ES2915382T3 (enExample)
SG (2) SG10202002557SA (enExample)
TW (2) TWI708612B (enExample)
WO (1) WO2016044376A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2805360T3 (es) 2013-03-15 2021-02-11 Tdw Group Arginina desiminasa con reactividad cruzada reducida hacia anticuerpos para ADI - PEG 20 para el tratamiento del cáncer
US10463721B2 (en) 2014-03-18 2019-11-05 Tdw Group Engineered chimeric pegylated ADI and methods of use
SG10202002557SA (en) 2014-09-16 2020-04-29 Tdw Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
CN109414426B (zh) 2016-07-05 2024-12-20 北极星药业集团股份有限公司 使用精氨酸耗竭剂的组合癌症免疫疗法
WO2018035497A1 (en) 2016-08-18 2018-02-22 Meharry Medical College Inhibitors of intracellular invasion
WO2018063801A1 (en) * 2016-09-29 2018-04-05 Meharry Medical College Bacterial inhibitors
CA3039796A1 (en) * 2016-11-02 2018-05-11 Polaris Group Formulations of pegylated arginine deiminase
WO2018183671A1 (en) 2017-03-29 2018-10-04 Tdw Group Protein conjugates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083774A2 (en) 2000-05-04 2001-11-08 Phoenix Pharmacologics, Inc. Novel mutated form of arginine deiminase

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5804183A (en) 1997-01-31 1998-09-08 Enzon, Inc. Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
US6183738B1 (en) 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
US6180387B1 (en) 1997-08-11 2001-01-30 Smithkline Beecham Corporation Arginine deiminase
IT1298918B1 (it) 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
WO2002009741A1 (en) 2000-07-27 2002-02-07 Angiolab, Inc. The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis
AU2001289132A1 (en) 2000-11-28 2002-06-11 Phoenix Pharmacologics, Inc. Modified arginine deiminase
CA2506244C (en) 2002-11-18 2012-10-30 Phoenix Pharmacologics, Inc. Methods for inhibiting viral replication in vivo
CN1536079A (zh) * 2003-04-09 2004-10-13 上海复旦张江生物医药股份有限公司 修饰的精氨酸脱亚氨酶
CA2524173A1 (en) 2003-04-29 2004-11-11 Wyeth Methods for diagnosing aml and mds differential gene expression
WO2005052145A2 (en) 2003-10-07 2005-06-09 University Of Florida Recombinant alkaliizing bacteria
CN101002945B (zh) 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
EP2173732A4 (en) 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
US20090238813A1 (en) 2007-12-28 2009-09-24 Board Of Regents, The University Of Texas System Compositions And Methods For Engineered Human Arginine Deiminases
WO2010083312A2 (en) 2009-01-14 2010-07-22 The Trustees Of The University Of Pennsylvania Micro-rna biomarker in cancer
CN101591649B (zh) * 2009-07-10 2013-02-13 江苏泰康生物医药有限公司 甲氧基聚乙二醇修饰的精氨酸脱亚氨酶及其制备与应用
US20110111403A1 (en) 2009-10-30 2011-05-12 Life Technologies Corporation Multi-primer assay for mycoplasma detection
CN101812438B (zh) * 2010-03-25 2014-08-27 江苏泰康生物医药有限公司 一种精氨酸脱亚氨酶突变体及其制备与应用
WO2011151704A2 (en) 2010-06-02 2011-12-08 Fresenius Kabi Oncology Ltd. Stable pharmaceutical compositions of rapamycin esters
US20120148559A1 (en) 2010-12-01 2012-06-14 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
US8663967B2 (en) 2011-08-22 2014-03-04 Jiangsu T-Mab Biopharma Co., Ltd. Arginine deiminase mutant and preparation and application thereof
CN103797025B (zh) 2012-04-04 2018-03-23 波拉里集团 用精氨酸脱亚氨酶治疗的方法
ES2805360T3 (es) * 2013-03-15 2021-02-11 Tdw Group Arginina desiminasa con reactividad cruzada reducida hacia anticuerpos para ADI - PEG 20 para el tratamiento del cáncer
US10463721B2 (en) * 2014-03-18 2019-11-05 Tdw Group Engineered chimeric pegylated ADI and methods of use
SG10202002557SA (en) 2014-09-16 2020-04-29 Tdw Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001083774A2 (en) 2000-05-04 2001-11-08 Phoenix Pharmacologics, Inc. Novel mutated form of arginine deiminase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NCBI Reference Sequence: WP_029512517.1
T-S Yang et al., "A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients", Br J Cancer, 2010 Sep 28; 103(7): 954–960.
T-S Yang et al., "A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients", Br J Cancer, 2010 Sep 28; 103(7): 954–960. NCBI Reference Sequence: WP_029512517.1 *

Also Published As

Publication number Publication date
TW202103730A (zh) 2021-02-01
CN107073085B (zh) 2022-02-18
SG10202002557SA (en) 2020-04-29
CN114522225A (zh) 2022-05-24
KR102730989B1 (ko) 2024-11-14
AU2015317848B2 (en) 2021-04-22
EP3193913A1 (en) 2017-07-26
CN107073085A (zh) 2017-08-18
TW201625295A (zh) 2016-07-16
JP2017529366A (ja) 2017-10-05
EP4104853A1 (en) 2022-12-21
WO2016044376A1 (en) 2016-03-24
CN114522225B (zh) 2025-07-25
TWI775160B (zh) 2022-08-21
US9789170B2 (en) 2017-10-17
US20160074487A1 (en) 2016-03-17
JP6782230B2 (ja) 2020-11-11
CA2961602A1 (en) 2016-03-24
EP3193913A4 (en) 2018-07-18
AU2015317848A1 (en) 2017-04-20
JP6961061B2 (ja) 2021-11-05
JP2021004268A (ja) 2021-01-14
SG11201702103XA (en) 2017-04-27
KR20170104986A (ko) 2017-09-18
ES2915382T3 (es) 2022-06-22
EP3193913B1 (en) 2022-05-11

Similar Documents

Publication Publication Date Title
TWI708612B (zh) 用於治療癌症之與 adi-peg 20 抗體具有降低之交叉反應性的精胺酸脫亞胺酶
KR102353046B1 (ko) 조작된 키메라성 페길화된 ａｄｉ 및 사용 방법
KR102263038B1 (ko) 암치료를 위한 ａｄｉ-ｐｅｇ 20 항체에 대해 감소된 교차반응성을 지니는 아르기닌 탈이민효소
TWI676683B (zh) 用於癌症治療之對ａｄｉ－ｐｅｇ２０抗體交叉反應性降低之精胺酸去亞胺酶
HK40075284A (en) Arginine deiminases with reduced cross reactivity to adi-peg20 antibodies for cancer therapy
TWI699210B (zh) 工程化之嵌合聚乙二醇化ａｄｉ及使用方法
HK1219232B (en) Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
HK1227767B (en) Engineered chimeric pegylated adi and methods of use
HK1227767A1 (en) Engineered chimeric pegylated adi and methods of use