CN107073085B - 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 - Google Patents

用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 Download PDF

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CN107073085B
CN107073085B CN201580057712.XA CN201580057712A CN107073085B CN 107073085 B CN107073085 B CN 107073085B CN 201580057712 A CN201580057712 A CN 201580057712A CN 107073085 B CN107073085 B CN 107073085B
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CN107073085A (zh
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R·肖沃尔特
R·阿尔马西
J·A·汤姆森
W·西森
W-J·西亚
L-C·陈
Y·李
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Polaris Pharmaceutical Group Co ltd
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Tdw Group
Polaris Group Cayman Islands
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580057712.XA 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 Active CN107073085B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210112607.3A CN114522225B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051182P 2014-09-16 2014-09-16
US62/051,182 2014-09-16
PCT/US2015/050354 WO2016044376A1 (en) 2014-09-16 2015-09-16 Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

Related Child Applications (1)

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CN202210112607.3A Division CN114522225B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

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CN107073085A CN107073085A (zh) 2017-08-18
CN107073085B true CN107073085B (zh) 2022-02-18

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CN202210112607.3A Active CN114522225B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

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US (1) US9789170B2 (enExample)
EP (2) EP3193913B1 (enExample)
JP (2) JP6782230B2 (enExample)
KR (1) KR102730989B1 (enExample)
CN (2) CN107073085B (enExample)
AU (1) AU2015317848B2 (enExample)
CA (1) CA2961602A1 (enExample)
ES (1) ES2915382T3 (enExample)
SG (2) SG10202002557SA (enExample)
TW (2) TWI708612B (enExample)
WO (1) WO2016044376A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2805360T3 (es) 2013-03-15 2021-02-11 Tdw Group Arginina desiminasa con reactividad cruzada reducida hacia anticuerpos para ADI - PEG 20 para el tratamiento del cáncer
US10463721B2 (en) 2014-03-18 2019-11-05 Tdw Group Engineered chimeric pegylated ADI and methods of use
SG10202002557SA (en) 2014-09-16 2020-04-29 Tdw Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
CN109414426B (zh) 2016-07-05 2024-12-20 北极星药业集团股份有限公司 使用精氨酸耗竭剂的组合癌症免疫疗法
WO2018035497A1 (en) 2016-08-18 2018-02-22 Meharry Medical College Inhibitors of intracellular invasion
WO2018063801A1 (en) * 2016-09-29 2018-04-05 Meharry Medical College Bacterial inhibitors
CA3039796A1 (en) * 2016-11-02 2018-05-11 Polaris Group Formulations of pegylated arginine deiminase
WO2018183671A1 (en) 2017-03-29 2018-10-04 Tdw Group Protein conjugates

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IT1298918B1 (it) 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
WO2002009741A1 (en) 2000-07-27 2002-02-07 Angiolab, Inc. The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis
AU2001289132A1 (en) 2000-11-28 2002-06-11 Phoenix Pharmacologics, Inc. Modified arginine deiminase
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CN1536079A (zh) * 2003-04-09 2004-10-13 上海复旦张江生物医药股份有限公司 修饰的精氨酸脱亚氨酶
CA2524173A1 (en) 2003-04-29 2004-11-11 Wyeth Methods for diagnosing aml and mds differential gene expression
WO2005052145A2 (en) 2003-10-07 2005-06-09 University Of Florida Recombinant alkaliizing bacteria
CN101002945B (zh) 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
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ES2805360T3 (es) * 2013-03-15 2021-02-11 Tdw Group Arginina desiminasa con reactividad cruzada reducida hacia anticuerpos para ADI - PEG 20 para el tratamiento del cáncer
US10463721B2 (en) * 2014-03-18 2019-11-05 Tdw Group Engineered chimeric pegylated ADI and methods of use
SG10202002557SA (en) 2014-09-16 2020-04-29 Tdw Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

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Publication number Publication date
TW202103730A (zh) 2021-02-01
SG10202002557SA (en) 2020-04-29
CN114522225A (zh) 2022-05-24
KR102730989B1 (ko) 2024-11-14
AU2015317848B2 (en) 2021-04-22
EP3193913A1 (en) 2017-07-26
CN107073085A (zh) 2017-08-18
TW201625295A (zh) 2016-07-16
JP2017529366A (ja) 2017-10-05
EP4104853A1 (en) 2022-12-21
WO2016044376A1 (en) 2016-03-24
CN114522225B (zh) 2025-07-25
TWI775160B (zh) 2022-08-21
US9789170B2 (en) 2017-10-17
US20160074487A1 (en) 2016-03-17
JP6782230B2 (ja) 2020-11-11
CA2961602A1 (en) 2016-03-24
EP3193913A4 (en) 2018-07-18
AU2015317848A1 (en) 2017-04-20
JP6961061B2 (ja) 2021-11-05
JP2021004268A (ja) 2021-01-14
SG11201702103XA (en) 2017-04-27
KR20170104986A (ko) 2017-09-18
TWI708612B (zh) 2020-11-01
ES2915382T3 (es) 2022-06-22
EP3193913B1 (en) 2022-05-11

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