TWI689514B - 化合物、組合物及用於治療疾病之方法 - Google Patents

化合物、組合物及用於治療疾病之方法 Download PDF

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TWI689514B
TWI689514B TW106122757A TW106122757A TWI689514B TW I689514 B TWI689514 B TW I689514B TW 106122757 A TW106122757 A TW 106122757A TW 106122757 A TW106122757 A TW 106122757A TW I689514 B TWI689514 B TW I689514B
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alkyl
compound
aryl
cancer
pharmaceutically acceptable
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TW201805295A (zh
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拉德哈克里西南 P 埃伊爾
安珍妮尤路 希里
西莎拉梅伊爾 帕德曼亞伯汗
吉塔 米賀
勝華 周
斯理魯帕 查拉
雷蒙 H 吉米
迪龍 克萊瑞
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美商史貝羅威生物科學有限公司
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/16—Purine radicals
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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TW106122757A 2016-07-06 2017-07-06 化合物、組合物及用於治療疾病之方法 TWI689514B (zh)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US201662359039P 2016-07-06 2016-07-06
US62/359,039 2016-07-06
US201662363118P 2016-07-15 2016-07-15
US62/363,118 2016-07-15
US201662403530P 2016-10-03 2016-10-03
US62/403,530 2016-10-03
US201662411424P 2016-10-21 2016-10-21
US62/411,424 2016-10-21
US201762444141P 2017-01-09 2017-01-09
US62/444,141 2017-01-09
US201762462679P 2017-02-23 2017-02-23
US62/462,679 2017-02-23
US201762470746P 2017-03-13 2017-03-13
US62/470,746 2017-03-13
US201762508846P 2017-05-19 2017-05-19
US62/508,846 2017-05-19

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TW201805295A TW201805295A (zh) 2018-02-16
TWI689514B true TWI689514B (zh) 2020-04-01

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EP (1) EP3481402A4 (cg-RX-API-DMAC7.html)
JP (3) JP7100227B2 (cg-RX-API-DMAC7.html)
KR (1) KR102569881B1 (cg-RX-API-DMAC7.html)
CN (1) CN109843302B (cg-RX-API-DMAC7.html)
AU (1) AU2017293781B2 (cg-RX-API-DMAC7.html)
CA (1) CA3029644A1 (cg-RX-API-DMAC7.html)
IL (1) IL264049B2 (cg-RX-API-DMAC7.html)
MX (2) MX392605B (cg-RX-API-DMAC7.html)
MY (1) MY199689A (cg-RX-API-DMAC7.html)
NZ (1) NZ750055A (cg-RX-API-DMAC7.html)
SG (1) SG11201811709WA (cg-RX-API-DMAC7.html)
TW (1) TWI689514B (cg-RX-API-DMAC7.html)
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