TWI669131B - Ｐｃｓｋ９抑制劑用於治療高血脂症的用途 - Google Patents
Ｐｃｓｋ９抑制劑用於治療高血脂症的用途 Download PDFInfo
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361890154P | 2013-10-11 | 2013-10-11 | |
| US61/890,154 | 2013-10-11 | ||
| US201461923103P | 2014-01-02 | 2014-01-02 | |
| US61/923,103 | 2014-01-02 | ||
| US201461955514P | 2014-03-19 | 2014-03-19 | |
| US61/955,514 | 2014-03-19 | ||
| US201462004620P | 2014-05-29 | 2014-05-29 | |
| US62/004,620 | 2014-05-29 | ||
| US201462025104P | 2014-07-16 | 2014-07-16 | |
| US62/025,104 | 2014-07-16 | ||
| EP14306221 | 2014-07-31 | ||
| EP14306221.4 | 2014-07-31 | ||
| US201462054571P | 2014-09-24 | 2014-09-24 | |
| US62/054,571 | 2014-09-24 | ||
| EP14306584 | 2014-10-09 | ||
| EP14306584.5 | 2014-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201605475A TW201605475A (zh) | 2016-02-16 |
| TWI669131B true TWI669131B (zh) | 2019-08-21 |
Family
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Family Applications (1)
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| TW103135495A TWI669131B (zh) | 2013-10-11 | 2014-10-13 | Ｐｃｓｋ９抑制劑用於治療高血脂症的用途 |
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Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| MX366458B (es) | 2011-01-28 | 2019-07-10 | Sanofi Biotechnology | Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9. |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| MX363642B (es) | 2011-09-16 | 2019-03-28 | Regeneron Pharma | Metodos para reducir los niveles de lipoproteina (a) administrando un inhibidor de proproteina convertasa subtilisina kexina-9 (pcsk9). |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| US10058630B2 (en) * | 2012-10-22 | 2018-08-28 | Concievalve, Llc | Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| CN105705521A (zh) | 2013-06-07 | 2016-06-22 | 再生元制药公司 | 通过施用pcsk9抑制剂抑制动脉粥样硬化的方法 |
| MX2016006226A (es) | 2013-11-12 | 2016-09-07 | Sanofi Biotechnology | Regimenes de dosificacion para uso con inhibidores de pcsk9. |
| EP3169710A1 (en) * | 2014-07-14 | 2017-05-24 | Amgen Inc. | Crystalline antibody formulations |
| RU2735521C2 (ru) | 2014-07-16 | 2020-11-03 | Санофи Байотекнолоджи | Способы лечения пациентов с гетерозиготной семейной гиперхолестеринемией (hefh) |
| EP3283012A4 (en) * | 2015-04-15 | 2018-11-21 | Concievalve LLC | Devices and methods for inhibiting stenosis, obstruction, or calcification of a native heart valve, stented heart valve or bioprosthesis |
| CN104861071B (zh) * | 2015-04-27 | 2019-04-12 | 南京师范大学 | 针对pcsk9的全人源单克隆抗体的可变区基因及其应用 |
| EA201890519A1 (ru) * | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| JP2020502991A (ja) | 2016-09-20 | 2020-01-30 | ウーシー バイオロジクス アイルランド リミテッド | 新規抗ｐｃｓｋ９抗体 |
| US11325945B2 (en) | 2017-04-12 | 2022-05-10 | Cadila Healthcare Limited | Peptide based PCSK9 vaccine |
| EP3615694B1 (en) | 2017-04-25 | 2022-03-30 | The Brigham and Women's Hospital, Inc. | Il-8, il-6, il-1b and tet2 and dnmt3a in atherosclerosis |
| CN107090474A (zh) * | 2017-05-22 | 2017-08-25 | 山东大学 | 一种腹主动脉瘤疾病动物模型的制备方法 |
| CN109963877B (zh) * | 2017-06-14 | 2023-01-20 | 江苏恒瑞医药股份有限公司 | Pcsk9抗体、其抗原结合片段及其医药用途 |
| CN113015543A (zh) * | 2018-03-06 | 2021-06-22 | 赛诺菲生物技术公司 | Pcsk9抑制剂用于降低心血管风险的用途 |
| JOP20190150A1 (ar) | 2018-06-21 | 2019-12-21 | Merck Sharp & Dohme | مركبات مناهضة لـ pcsk9 |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| IL323016A (en) * | 2019-11-18 | 2025-10-01 | Ad Pharmaceuticals Co Ltd | Anti-pcsk9 antibody and its use |
| US20230272112A1 (en) * | 2019-12-10 | 2023-08-31 | Regeneron Pharmaceuticals, Inc. | Use of a pcsk9 inhibitor to treat homozygous familial hypercholesterolemia |
| CN114277032A (zh) * | 2021-12-31 | 2022-04-05 | 华中科技大学同济医学院附属协和医院 | 一种低密度脂蛋白受体基因突变体及其应用 |
| CN116983434B (zh) * | 2023-09-28 | 2024-03-15 | 康霖生物科技（杭州）有限公司 | 用于基因治疗的核酸构建体及其用途 |
Citations (3)
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|---|---|---|---|---|
| WO2012101253A1 (en) * | 2011-01-28 | 2012-08-02 | Sanofi | Pharmaceutical compositions comprising human antibodies to pcsk9 |
| US20130064825A1 (en) * | 2011-05-10 | 2013-03-14 | Amgen Inc. | Methods of treating or preventing cholesterol related disorders |
| US20130064834A1 (en) * | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JO3672B1 (ar) * | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US8357371B2 (en) * | 2008-12-15 | 2013-01-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to PCSK9 |
| US20130006482A1 (en) * | 2011-06-30 | 2013-01-03 | Ramadev Burigsay Hukkeri | Guidance system for a mobile machine |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| MX363642B (es) * | 2011-09-16 | 2019-03-28 | Regeneron Pharma | Metodos para reducir los niveles de lipoproteina (a) administrando un inhibidor de proproteina convertasa subtilisina kexina-9 (pcsk9). |
| TWI682780B (zh) * | 2013-05-30 | 2020-01-21 | 美商再生元醫藥公司 | 醫藥組成物用於製造治療與ｐｃｓｋ９功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途 |
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2014
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- 2014-10-10 KR KR1020237026483A patent/KR20230119045A/ko not_active Ceased
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- 2014-10-10 CN CN202210762455.1A patent/CN115192704A/zh active Pending
- 2014-10-10 EA EA201690754A patent/EA037526B1/ru unknown
- 2014-10-10 PL PL14802527T patent/PL3055333T4/pl unknown
- 2014-10-10 EP EP14802527.3A patent/EP3055333B1/en active Active
- 2014-10-10 US US14/511,975 patent/US20150140002A1/en not_active Abandoned
- 2014-10-10 CA CA2926942A patent/CA2926942A1/en active Pending
- 2014-10-10 EP EP19210918.9A patent/EP3689913B1/en active Active
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- 2014-10-10 KR KR1020167012099A patent/KR20160062166A/ko not_active Ceased
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- 2014-10-10 WO PCT/US2014/060109 patent/WO2015054619A2/en not_active Ceased
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2019
- 2019-08-09 JP JP2019146940A patent/JP6994484B2/ja active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064834A1 (en) * | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| WO2012101253A1 (en) * | 2011-01-28 | 2012-08-02 | Sanofi | Pharmaceutical compositions comprising human antibodies to pcsk9 |
| US20130064825A1 (en) * | 2011-05-10 | 2013-03-14 | Amgen Inc. | Methods of treating or preventing cholesterol related disorders |
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