TWI668010B - 使用ｇｌｐ－１及抗ｉｌ－２１治療糖尿病 - Google Patents

使用ｇｌｐ－１及抗ｉｌ－２１治療糖尿病 Download PDF

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Publication number
TWI668010B
TWI668010B TW104114239A TW104114239A TWI668010B TW I668010 B TWI668010 B TW I668010B TW 104114239 A TW104114239 A TW 104114239A TW 104114239 A TW104114239 A TW 104114239A TW I668010 B TWI668010 B TW I668010B
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TW
Taiwan
Prior art keywords
glp
agonist
peptide
specific example
function inhibitor
Prior art date
Application number
TW104114239A
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English (en)
Chinese (zh)
Other versions
TW201625289A (zh
Inventor
肯 考匹特斯
Ken COPPIETERS
海拉斯 馬提亞斯 馮
Matthias Von Herrath
塔馬 保爾拉倫
Tamar BOURSALIAN
Original Assignee
丹麥商諾佛 儂迪克股份有限公司
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 丹麥商諾佛 儂迪克股份有限公司, Novo Nordisk A/S filed Critical 丹麥商諾佛 儂迪克股份有限公司
Publication of TW201625289A publication Critical patent/TW201625289A/zh
Application granted granted Critical
Publication of TWI668010B publication Critical patent/TWI668010B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW104114239A 2014-05-07 2015-05-05 使用ｇｌｐ－１及抗ｉｌ－２１治療糖尿病 TWI668010B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461989841P 2014-05-07 2014-05-07
US61/989,841 2014-05-07
EP14169596 2014-05-23
EP14169596.5 2014-05-23
EP14189732.2 2014-10-21
EP14189732 2014-10-21

Publications (2)

Publication Number Publication Date
TW201625289A TW201625289A (zh) 2016-07-16
TWI668010B true TWI668010B (zh) 2019-08-11

Family

ID=54392180

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104114239A TWI668010B (zh) 2014-05-07 2015-05-05 使用ｇｌｐ－１及抗ｉｌ－２１治療糖尿病

Country Status (9)

Country Link
US (1) US10105442B2 (https=)
EP (1) EP3139948B1 (https=)
JP (1) JP6672175B2 (https=)
CN (1) CN106999553B (https=)
PL (1) PL3139948T3 (https=)
RS (1) RS60316B1 (https=)
SI (1) SI3139948T1 (https=)
TW (1) TWI668010B (https=)
WO (1) WO2015169789A1 (https=)

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WO2017149109A1 (en) * 2016-03-04 2017-09-08 Novo Nordisk A/S Liraglutide in diabetic foot ulcer
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
WO2025257327A1 (en) 2024-06-13 2025-12-18 Almirall, S.A. Therapeutic approaches for the management of hidradenitis suppurativa

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CN102711805A (zh) * 2009-11-13 2012-10-03 赛诺菲-安万特德国有限公司 包含glp-1激动剂、胰岛素和甲硫氨酸的药物组合物

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AU2002316811A1 (en) * 2001-06-28 2003-03-03 Novo Nordisk A/S Stable formulation of modified glp-1
ES2629395T3 (es) * 2001-10-04 2017-08-09 Genetics Institute, Llc Métodos y composiciones para modular la actividad de la interleucina-21
EP1515749B1 (en) 2002-06-14 2012-08-15 Novo Nordisk A/S Combined use of a modulator of cd3 and a glp-1 compound
WO2005023291A2 (en) * 2003-09-11 2005-03-17 Novo Nordisk A/S Use of glp1-agonists in the treatment of patients with type i diabetes
CN100444898C (zh) * 2003-09-19 2008-12-24 诺沃挪第克公司 治疗肽的清蛋白结合型衍生物
ATE498404T1 (de) * 2003-12-09 2011-03-15 Novo Nordisk As Regulierung der nahrungspräferenz mit glp-1- agonisten
EP1841448A2 (en) 2004-12-30 2007-10-10 Diakine Therapeutics, Inc. Pharmaceutical compositions and methods for restoring beta-cell mass and function
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
EP1883417A2 (en) 2005-05-25 2008-02-06 Curedm Inc. Peptides, derivatives and analogs thereof, and methods of using same
MX2008001468A (es) * 2005-06-30 2008-04-07 Sod Conseils Rech Applic Composiciones farmaceuticas del peptido similar al glucagon-1.
CA2658678A1 (en) 2005-08-06 2007-02-15 Gerald J. Prud'homme Composition and method for prevention and treatment of type i diabetes
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Also Published As

Publication number Publication date
JP2017514860A (ja) 2017-06-08
RS60316B1 (sr) 2020-07-31
TW201625289A (zh) 2016-07-16
PL3139948T3 (pl) 2020-08-10
US20170043014A1 (en) 2017-02-16
CN106999553A (zh) 2017-08-01
CN106999553B (zh) 2021-11-26
JP6672175B2 (ja) 2020-03-25
US10105442B2 (en) 2018-10-23
EP3139948B1 (en) 2020-03-04
WO2015169789A1 (en) 2015-11-12
EP3139948A1 (en) 2017-03-15
SI3139948T1 (sl) 2020-07-31

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