TWI666212B - 作為類鐸受體７（ｔｏｌｌ－ｌｉｋｅ ｒｅｃｅｐｔｏｒ ７）促效劑之化合物及組合物 - Google Patents

作為類鐸受體７（ｔｏｌｌ－ｌｉｋｅ ｒｅｃｅｐｔｏｒ ７）促效劑之化合物及組合物 Download PDF

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TWI666212B
TWI666212B TW104113993A TW104113993A TWI666212B TW I666212 B TWI666212 B TW I666212B TW 104113993 A TW104113993 A TW 104113993A TW 104113993 A TW104113993 A TW 104113993A TW I666212 B TWI666212 B TW I666212B
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pyrrolo
formula
amino
methyl
compound
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TW104113993A
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TW201623309A (zh
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永愷 李
莫婷婷
波瑞諾 娃
湯姆 瑤 欣 吳
張曉躍
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瑞士商諾華公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW104113993A 2014-05-01 2015-04-30 作為類鐸受體７（ｔｏｌｌ－ｌｉｋｅ ｒｅｃｅｐｔｏｒ ７）促效劑之化合物及組合物 TWI666212B (zh)

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US201461987321P 2014-05-01 2014-05-01
US61/987,321 2014-05-01

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TW201623309A TW201623309A (zh) 2016-07-01
TWI666212B true TWI666212B (zh) 2019-07-21

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US (1) US9902730B2 (https=)
EP (1) EP3137470B1 (https=)
JP (1) JP6484253B2 (https=)
KR (1) KR102139847B1 (https=)
CN (1) CN106232603B (https=)
AP (1) AP2016009485A0 (https=)
AR (1) AR100244A1 (https=)
AU (1) AU2015253215B2 (https=)
BR (1) BR112016025423A2 (https=)
CA (1) CA2946408C (https=)
CL (1) CL2016002751A1 (https=)
CR (1) CR20160512A (https=)
CU (1) CU24401B1 (https=)
DO (1) DOP2016000295A (https=)
EA (1) EA030603B1 (https=)
ES (1) ES2877050T3 (https=)
GT (1) GT201600233A (https=)
IL (1) IL248347B (https=)
MX (1) MX362341B (https=)
NI (1) NI201600164A (https=)
NZ (1) NZ724792A (https=)
PE (1) PE20170325A1 (https=)
PH (1) PH12016501966A1 (https=)
PL (1) PL3137470T3 (https=)
PT (1) PT3137470T (https=)
SG (1) SG11201608161VA (https=)
SV (1) SV2016005311A (https=)
TW (1) TWI666212B (https=)
UY (1) UY36103A (https=)
WO (1) WO2015168269A1 (https=)

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