TWI649082B - 使用奧諾拉(aurora)激酶抑制劑治療癌症的方法 - Google Patents

使用奧諾拉(aurora)激酶抑制劑治療癌症的方法 Download PDF

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Publication number
TWI649082B
TWI649082B TW102109912A TW102109912A TWI649082B TW I649082 B TWI649082 B TW I649082B TW 102109912 A TW102109912 A TW 102109912A TW 102109912 A TW102109912 A TW 102109912A TW I649082 B TWI649082 B TW I649082B
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Taiwan
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cancer
onora
kinase
paclitaxel
cell
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TW102109912A
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English (en)
Chinese (zh)
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TW201343169A (zh
Inventor
亞里吉特 查卡瓦堤
傑佛瑞A 艾克塞迪
羅伯特W 克林佛德
哈N 李
徐文起
卡席克 凡卡達克里斯漢
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美商千禧製藥公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW102109912A 2012-03-20 2013-03-20 使用奧諾拉(aurora)激酶抑制劑治療癌症的方法 TWI649082B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261613258P 2012-03-20 2012-03-20
US61/613,258 2012-03-20

Publications (2)

Publication Number Publication Date
TW201343169A TW201343169A (zh) 2013-11-01
TWI649082B true TWI649082B (zh) 2019-02-01

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TW102109912A TWI649082B (zh) 2012-03-20 2013-03-20 使用奧諾拉(aurora)激酶抑制劑治療癌症的方法

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US (2) US20130303519A1 (enExample)
EP (1) EP2827855B1 (enExample)
JP (1) JP6373252B2 (enExample)
KR (1) KR102128866B1 (enExample)
CN (1) CN104271129A (enExample)
AU (1) AU2013235275B2 (enExample)
CA (1) CA2868024A1 (enExample)
EA (1) EA036434B1 (enExample)
ES (1) ES2746946T3 (enExample)
GE (1) GEP20186900B (enExample)
IL (1) IL234686B (enExample)
IN (1) IN2014DN08477A (enExample)
JO (1) JO3630B1 (enExample)
MA (1) MA37438A1 (enExample)
MX (1) MX358411B (enExample)
MY (1) MY175225A (enExample)
NZ (1) NZ700744A (enExample)
PH (1) PH12014502109A1 (enExample)
SG (2) SG11201405621UA (enExample)
TN (1) TN2014000387A1 (enExample)
TW (1) TWI649082B (enExample)
UA (1) UA117455C2 (enExample)
WO (1) WO2013142491A1 (enExample)
ZA (1) ZA201407551B (enExample)

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Also Published As

Publication number Publication date
KR102128866B1 (ko) 2020-07-01
IN2014DN08477A (enExample) 2015-05-08
EA036434B1 (ru) 2020-11-10
WO2013142491A1 (en) 2013-09-26
MA37438A1 (fr) 2016-05-31
JP6373252B2 (ja) 2018-08-15
ES2746946T3 (es) 2020-03-09
MX2014011324A (es) 2014-12-05
UA117455C2 (uk) 2018-08-10
IL234686B (en) 2020-01-30
US10213436B2 (en) 2019-02-26
US20160193224A1 (en) 2016-07-07
ZA201407551B (en) 2019-01-30
PH12014502109A1 (en) 2014-12-10
GEP20186900B (en) 2018-10-10
HK1206253A1 (en) 2016-01-08
JO3630B1 (ar) 2020-08-27
US20130303519A1 (en) 2013-11-14
TN2014000387A1 (en) 2015-12-21
NZ700744A (en) 2016-09-30
KR20140144215A (ko) 2014-12-18
IL234686A0 (en) 2014-11-30
CA2868024A1 (en) 2013-09-26
EA201491727A1 (ru) 2015-01-30
TW201343169A (zh) 2013-11-01
AU2013235275A1 (en) 2014-10-23
MY175225A (en) 2020-06-16
CN104271129A (zh) 2015-01-07
AU2013235275B2 (en) 2017-12-07
SG10201607741RA (en) 2016-11-29
MX358411B (es) 2018-08-20
EP2827855A1 (en) 2015-01-28
EP2827855B1 (en) 2019-06-26
SG11201405621UA (en) 2014-10-30
JP2015510945A (ja) 2015-04-13

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