EA036434B1 - Способ лечения рака легких с применением комбинации ингибитора киназы аврора и паклитаксела - Google Patents

Способ лечения рака легких с применением комбинации ингибитора киназы аврора и паклитаксела Download PDF

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Publication number
EA036434B1
EA036434B1 EA201491727A EA201491727A EA036434B1 EA 036434 B1 EA036434 B1 EA 036434B1 EA 201491727 A EA201491727 A EA 201491727A EA 201491727 A EA201491727 A EA 201491727A EA 036434 B1 EA036434 B1 EA 036434B1
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EA
Eurasian Patent Office
Prior art keywords
aurora
cancer
paclitaxel
dose
kinase inhibitor
Prior art date
Application number
EA201491727A
Other languages
English (en)
Russian (ru)
Other versions
EA201491727A1 (ru
Inventor
Ариджит Чакраварти
Джеффри А. Эксиди
Роберт В. Клейнфилд
Кха Н. Ли
Вен Чуи Шю
Картхик Венкатакришнан
Original Assignee
Милленниум Фармасьютикалз, Инк.
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Application filed by Милленниум Фармасьютикалз, Инк. filed Critical Милленниум Фармасьютикалз, Инк.
Publication of EA201491727A1 publication Critical patent/EA201491727A1/ru
Publication of EA036434B1 publication Critical patent/EA036434B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201491727A 2012-03-20 2013-03-19 Способ лечения рака легких с применением комбинации ингибитора киназы аврора и паклитаксела EA036434B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261613258P 2012-03-20 2012-03-20
PCT/US2013/032962 WO2013142491A1 (en) 2012-03-20 2013-03-19 Methods of treating cancer using aurora kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201491727A1 EA201491727A1 (ru) 2015-01-30
EA036434B1 true EA036434B1 (ru) 2020-11-10

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EA201491727A EA036434B1 (ru) 2012-03-20 2013-03-19 Способ лечения рака легких с применением комбинации ингибитора киназы аврора и паклитаксела

Country Status (24)

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US (2) US20130303519A1 (enExample)
EP (1) EP2827855B1 (enExample)
JP (1) JP6373252B2 (enExample)
KR (1) KR102128866B1 (enExample)
CN (1) CN104271129A (enExample)
AU (1) AU2013235275B2 (enExample)
CA (1) CA2868024A1 (enExample)
EA (1) EA036434B1 (enExample)
ES (1) ES2746946T3 (enExample)
GE (1) GEP20186900B (enExample)
IL (1) IL234686B (enExample)
IN (1) IN2014DN08477A (enExample)
JO (1) JO3630B1 (enExample)
MA (1) MA37438A1 (enExample)
MX (1) MX358411B (enExample)
MY (1) MY175225A (enExample)
NZ (1) NZ700744A (enExample)
PH (1) PH12014502109A1 (enExample)
SG (2) SG11201405621UA (enExample)
TN (1) TN2014000387A1 (enExample)
TW (1) TWI649082B (enExample)
UA (1) UA117455C2 (enExample)
WO (1) WO2013142491A1 (enExample)
ZA (1) ZA201407551B (enExample)

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JP6786530B2 (ja) * 2015-07-02 2020-11-18 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. オーロラaキナーゼの選択的インヒビターに対する応答のバイオマーカー
CN114681455A (zh) * 2018-08-17 2022-07-01 深圳微芯生物科技股份有限公司 组蛋白去乙酰化酶抑制剂与蛋白激酶抑制剂之组合及其制药用途

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Also Published As

Publication number Publication date
KR102128866B1 (ko) 2020-07-01
IN2014DN08477A (enExample) 2015-05-08
WO2013142491A1 (en) 2013-09-26
MA37438A1 (fr) 2016-05-31
JP6373252B2 (ja) 2018-08-15
ES2746946T3 (es) 2020-03-09
MX2014011324A (es) 2014-12-05
UA117455C2 (uk) 2018-08-10
IL234686B (en) 2020-01-30
US10213436B2 (en) 2019-02-26
US20160193224A1 (en) 2016-07-07
ZA201407551B (en) 2019-01-30
PH12014502109A1 (en) 2014-12-10
GEP20186900B (en) 2018-10-10
HK1206253A1 (en) 2016-01-08
JO3630B1 (ar) 2020-08-27
US20130303519A1 (en) 2013-11-14
TN2014000387A1 (en) 2015-12-21
TWI649082B (zh) 2019-02-01
NZ700744A (en) 2016-09-30
KR20140144215A (ko) 2014-12-18
IL234686A0 (en) 2014-11-30
CA2868024A1 (en) 2013-09-26
EA201491727A1 (ru) 2015-01-30
TW201343169A (zh) 2013-11-01
AU2013235275A1 (en) 2014-10-23
MY175225A (en) 2020-06-16
CN104271129A (zh) 2015-01-07
AU2013235275B2 (en) 2017-12-07
SG10201607741RA (en) 2016-11-29
MX358411B (es) 2018-08-20
EP2827855A1 (en) 2015-01-28
EP2827855B1 (en) 2019-06-26
SG11201405621UA (en) 2014-10-30
JP2015510945A (ja) 2015-04-13

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