TWI629061B - 包含右美托嘧啶（ｄｅｘｍｅｄｅｔｏｍｉｄｉｎｅ）經皮組成物之疼痛處理用方法及組成物 - Google Patents
包含右美托嘧啶（ｄｅｘｍｅｄｅｔｏｍｉｄｉｎｅ）經皮組成物之疼痛處理用方法及組成物 Download PDFInfo
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- TWI629061B TWI629061B TW103134523A TW103134523A TWI629061B TW I629061 B TWI629061 B TW I629061B TW 103134523 A TW103134523 A TW 103134523A TW 103134523 A TW103134523 A TW 103134523A TW I629061 B TWI629061 B TW I629061B
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| KR101827980B1 (ko) | 2013-10-07 | 2018-02-13 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법 |
| BR112016006848A2 (pt) | 2013-10-07 | 2017-08-01 | Teikoku Pharma Usa Inc | métodos e composições para distribuição transdérmica de uma quantidade não sedativa de dexmedetomidina |
| CA2924233C (en) | 2013-10-07 | 2018-10-23 | Teikoku Pharma Usa, Inc. | Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions |
| EP3054931B1 (en) * | 2013-10-07 | 2020-12-23 | Teikoku Pharma USA, Inc. | Transdermal delivery device for managing pain comprising dexmedetomidine transdermal compositions |
| TWI764951B (zh) * | 2016-10-31 | 2022-05-21 | 美商帝國製藥美國股份有限公司 | 用於處理疼痛之右美托咪啶經皮遞送裝置 |
| KR102793584B1 (ko) | 2016-12-31 | 2025-04-09 | 바이오엑셀 테라퓨틱스 인코포레이티드 | 불안의 치료를 위한 설하 덱스메데토미딘의 용도 |
| PL3813802T3 (pl) | 2018-06-27 | 2025-04-22 | Bioxcel Therapeutics, Inc. | Formulacje błony zawierające deksmedetomidynę i sposoby ich wytwarzania |
| US12472158B2 (en) | 2019-02-27 | 2025-11-18 | Vanderbilt University | Methods of treating trigeminal nerve pain |
| WO2020222192A1 (en) | 2019-05-01 | 2020-11-05 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| EP3962478A1 (en) | 2019-05-01 | 2022-03-09 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| EP3999058A4 (en) | 2019-07-19 | 2023-05-03 | Bioxcel Therapeutics, Inc. | NON-SEDATIVE DEXMEDETOMIDINE-BASED TREATMENT REGIMEN |
| WO2024037545A1 (zh) * | 2022-08-17 | 2024-02-22 | 宜昌人福药业有限责任公司 | 右美托咪定经皮组合物、透皮贴剂及其制备方法和应用 |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
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| CN1049450A (zh) * | 1989-08-18 | 1991-02-27 | 天鹅探究有限公司 | 右旋美托咪啶经皮肤使用的方法及用具 |
| US20130072532A1 (en) * | 2010-01-08 | 2013-03-21 | Recro Pharma, Inc. | Topical transdermal dexmedetomidine compositions and methods of use thereof |
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| GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
| GB2290964A (en) * | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
| CA2222133C (en) * | 1995-06-07 | 2002-12-24 | Cygnus, Inc. | Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
| NZ510771A (en) * | 1998-10-02 | 2003-08-29 | 3M Innovative Properties Co | Mucosal originated drug delivery systems |
| US7635488B2 (en) * | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| KR100511492B1 (ko) * | 2002-10-11 | 2005-08-31 | 주식회사 태평양 | 에페리손, 톨페리손 또는 그것들의 염을 포함하는경피흡수제제 |
| JP4694967B2 (ja) * | 2003-07-31 | 2011-06-08 | 久光製薬株式会社 | 貼付剤 |
| MXPA06002716A (es) * | 2003-09-12 | 2006-06-06 | Allergan Inc | Metodos y composiciones para el tratamiento de dolor y otras condiciones mediadas por adrenergicos de alfa-2. |
| KR101042490B1 (ko) * | 2004-07-15 | 2011-06-16 | 니뽄 다바코 산교 가부시키가이샤 | 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제 |
| US20070134310A1 (en) * | 2005-09-23 | 2007-06-14 | Nedberge Diane E | Transdermal risperidone delivery system |
| EP2308480B1 (en) * | 2005-09-23 | 2014-08-13 | ALZA Corporation | High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications |
| US20090258063A1 (en) * | 2006-09-11 | 2009-10-15 | Sekisui Chemical Co., Ltd. | Transdermal patch |
| US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
| JP5547065B2 (ja) * | 2008-05-15 | 2014-07-09 | 久光製薬株式会社 | パロノセトロンを含有する経皮吸収製剤 |
| EP2330903A4 (en) * | 2008-07-28 | 2011-10-12 | Endogenx Inc | METHOD FOR TREATING PAIN USING AN ALPHA-2 ADRENEER AGONIST AND AN ENDOTHELINE ANTAGONIST |
| US9308203B2 (en) * | 2008-10-01 | 2016-04-12 | Taiwan Biotech Co., Ltd. | Pressure sensitive adhesive matrix device or system for the treatment or prevention of onychomycosis or tinea pedis |
| US8563031B2 (en) * | 2010-05-27 | 2013-10-22 | Absize, Inc. | Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith |
| CN103200944B (zh) * | 2010-11-17 | 2016-05-04 | 赫克萨尔股份公司 | 包含丁丙诺啡的经皮治疗系统 |
| US20130096170A1 (en) * | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| EP3054931B1 (en) * | 2013-10-07 | 2020-12-23 | Teikoku Pharma USA, Inc. | Transdermal delivery device for managing pain comprising dexmedetomidine transdermal compositions |
-
2014
- 2014-10-03 EP EP14851606.5A patent/EP3054931B1/en active Active
- 2014-10-03 JP JP2016520593A patent/JP6188934B2/ja active Active
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- 2014-10-03 WO PCT/US2014/059057 patent/WO2015054062A2/en not_active Ceased
- 2014-10-03 KR KR1020187023714A patent/KR20180095733A/ko not_active Ceased
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2024
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1049450A (zh) * | 1989-08-18 | 1991-02-27 | 天鹅探究有限公司 | 右旋美托咪啶经皮肤使用的方法及用具 |
| US20130072532A1 (en) * | 2010-01-08 | 2013-03-21 | Recro Pharma, Inc. | Topical transdermal dexmedetomidine compositions and methods of use thereof |
Also Published As
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| CA2924188C (en) | 2018-12-18 |
| EP3054931A2 (en) | 2016-08-17 |
| US20240245652A1 (en) | 2024-07-25 |
| JP2018008984A (ja) | 2018-01-18 |
| EP3054931A4 (en) | 2017-04-05 |
| ES2855103T3 (es) | 2021-09-23 |
| RU2654702C2 (ru) | 2018-05-22 |
| TW201524506A (zh) | 2015-07-01 |
| JP6188934B2 (ja) | 2017-08-30 |
| RU2016109631A (ru) | 2017-11-15 |
| KR20180095733A (ko) | 2018-08-27 |
| BR112016007327A2 (pt) | 2017-08-01 |
| CN105764495A (zh) | 2016-07-13 |
| EP3054931B1 (en) | 2020-12-23 |
| JP6522062B2 (ja) | 2019-05-29 |
| KR101891186B1 (ko) | 2018-08-24 |
| JP2016532645A (ja) | 2016-10-20 |
| KR20160062159A (ko) | 2016-06-01 |
| CN110604728A (zh) | 2019-12-24 |
| WO2015054062A2 (en) | 2015-04-16 |
| CA2924188A1 (en) | 2015-04-16 |
| US20150098982A1 (en) | 2015-04-09 |
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