TWI620578B - 用以減少眼用類固醇的倂發症之藥學組成物 - Google Patents

用以減少眼用類固醇的倂發症之藥學組成物 Download PDF

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Publication number
TWI620578B
TWI620578B TW102105245A TW102105245A TWI620578B TW I620578 B TWI620578 B TW I620578B TW 102105245 A TW102105245 A TW 102105245A TW 102105245 A TW102105245 A TW 102105245A TW I620578 B TWI620578 B TW I620578B
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TW
Taiwan
Prior art keywords
pharmaceutical composition
phospholipids
μmol
ophthalmic
mixture
Prior art date
Application number
TW102105245A
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English (en)
Chinese (zh)
Other versions
TW201338806A (zh
Inventor
洪基隆
郭松聲
施雪芳
張博鈞
蔡志強
林宏輝
曾雲龍
Original Assignee
台灣微脂體股份有限公司
Tlc生物醫藥公司
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Publication of TW201338806A publication Critical patent/TW201338806A/zh
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Publication of TWI620578B publication Critical patent/TWI620578B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW102105245A 2012-02-10 2013-02-08 用以減少眼用類固醇的倂發症之藥學組成物 TWI620578B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261597189P 2012-02-10 2012-02-10
US61/597,189 2012-02-10

Publications (2)

Publication Number Publication Date
TW201338806A TW201338806A (zh) 2013-10-01
TWI620578B true TWI620578B (zh) 2018-04-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW102105245A TWI620578B (zh) 2012-02-10 2013-02-08 用以減少眼用類固醇的倂發症之藥學組成物

Country Status (18)

Country Link
US (2) US10058616B2 (enExample)
EP (1) EP2797601B1 (enExample)
JP (1) JP6231995B2 (enExample)
KR (1) KR102060210B1 (enExample)
CN (2) CN104125830B (enExample)
AU (1) AU2013216861B2 (enExample)
BR (1) BR112014018393B1 (enExample)
CA (1) CA2862055C (enExample)
CY (1) CY1120323T1 (enExample)
DK (1) DK2797601T3 (enExample)
ES (1) ES2673330T3 (enExample)
IN (1) IN2014MN01571A (enExample)
NZ (1) NZ628124A (enExample)
PT (1) PT2797601T (enExample)
RU (1) RU2660585C2 (enExample)
TR (1) TR201808592T4 (enExample)
TW (1) TWI620578B (enExample)
WO (1) WO2013119988A1 (enExample)

Families Citing this family (11)

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SG11201809136UA (en) * 2016-04-19 2018-11-29 Univ Nanyang Tech Subconjuctival depot forming formulations for ocular drug delivery
US11766421B2 (en) 2017-09-25 2023-09-26 Surface Ophthalmics, Inc. Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
CA3080166A1 (en) 2017-11-21 2019-05-31 Axerovision, Inc. Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
EP3820479B1 (en) 2018-07-09 2026-03-11 Taiwan Liposome Co., Ltd. Methods to reduce complications of intra-articular steroid
IL281513B1 (en) 2018-09-16 2026-07-01 Tlc Biopharmaceuticals Inc Preparations for the treatment of joint pain
JP2022516099A (ja) 2018-12-27 2022-02-24 サーフィス オフサルミクス,インコーポレイテッド 眼科用医薬組成物及び癌表面疾患の処置方法
RU2716429C1 (ru) * 2019-05-29 2020-03-11 федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения рецидивирующей эрозии роговицы различного генеза
CN111415822A (zh) * 2020-03-05 2020-07-14 沈阳农业大学 一种洋葱碳/二氧化锰阵列电极及其制备方法和应用
US20240156839A1 (en) * 2021-03-05 2024-05-16 Taiwan Liposome Company, Ltd. Pharmaceutical compositions with reduced side effect and methods of using the same
CN117979951A (zh) 2021-05-10 2024-05-03 瑟菲斯眼科股份有限公司 一种用于缓解眼部疼痛的硫酸软骨素的用途
US12440510B2 (en) 2021-05-10 2025-10-14 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain

Citations (1)

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TW201105350A (en) * 2009-08-10 2011-02-16 Taiwan Liposome Co Ltd Ophthalmic drug delivery system containing phospholipid and cholesterol

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US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
IL103907A0 (en) * 1992-11-27 1993-04-04 Pharmos Corp Ophthalmic compositions
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
EP1590006B1 (en) 2003-02-04 2010-09-08 Bracco Suisse SA Ultrasound contrast agents and process for the preparation thereof
KR100862930B1 (ko) * 2004-06-23 2008-10-13 시리온 테라퓨틱스, 인크. 레티닐 유도체를 사용하여 안 증상을 치료하기 위한 방법및 조성물
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
EP1864668B1 (en) * 2006-06-01 2012-11-21 Novagali Pharma S.A. Use of prodrugs for ocular intravitreous administration
AU2007260872A1 (en) * 2006-06-22 2007-12-27 Sirion Therapeutics, Inc Methods and compositions for treating ophthalmic conditions via modulation of megalin activity
US20080118500A1 (en) * 2006-11-16 2008-05-22 Taiwan Liposome Company Sustained releasing composition via local injection for treating eye diseases
WO2009107753A1 (ja) * 2008-02-29 2009-09-03 財団法人 名古屋産業科学研究所 後眼部到達用リポソーム及び後眼部疾患用医薬組成物
CN101502485A (zh) * 2009-03-20 2009-08-12 中国药科大学 地塞米松眼用纳米立方液晶制剂及其制备方法
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Also Published As

Publication number Publication date
US20180193461A1 (en) 2018-07-12
NZ628124A (en) 2016-06-24
ES2673330T3 (es) 2018-06-21
BR112014018393A2 (enExample) 2017-06-20
EP2797601A1 (en) 2014-11-05
JP2015506983A (ja) 2015-03-05
WO2013119988A1 (en) 2013-08-15
PT2797601T (pt) 2018-06-27
CN104125830B (zh) 2018-01-16
CN104125830A (zh) 2014-10-29
BR112014018393A8 (pt) 2017-07-11
CN107260679B (zh) 2020-07-31
RU2660585C2 (ru) 2018-07-06
KR20150008844A (ko) 2015-01-23
DK2797601T3 (en) 2018-06-14
RU2014132553A (ru) 2016-02-27
TR201808592T4 (tr) 2018-07-23
EP2797601B1 (en) 2018-03-21
JP6231995B2 (ja) 2017-11-15
AU2013216861B2 (en) 2017-05-18
KR102060210B1 (ko) 2019-12-27
CY1120323T1 (el) 2019-07-10
CA2862055A1 (en) 2013-08-15
US10350294B2 (en) 2019-07-16
TW201338806A (zh) 2013-10-01
CA2862055C (en) 2020-03-10
BR112014018393B1 (pt) 2020-09-15
IN2014MN01571A (enExample) 2015-05-15
US10058616B2 (en) 2018-08-28
US20150011520A1 (en) 2015-01-08
CN107260679A (zh) 2017-10-20
AU2013216861A1 (en) 2014-08-07
HK1201723A1 (en) 2015-09-11
EP2797601A4 (en) 2015-06-03

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