JP6231995B2 - 眼の疾患の合併症を低減するための薬学的組成物 - Google Patents

眼の疾患の合併症を低減するための薬学的組成物 Download PDF

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JP6231995B2
JP6231995B2 JP2014556741A JP2014556741A JP6231995B2 JP 6231995 B2 JP6231995 B2 JP 6231995B2 JP 2014556741 A JP2014556741 A JP 2014556741A JP 2014556741 A JP2014556741 A JP 2014556741A JP 6231995 B2 JP6231995 B2 JP 6231995B2
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pharmaceutical composition
composition according
steroid
group
lipid cake
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JP2015506983A5 (enExample
JP2015506983A (ja
Inventor
クールン ホン，
クールン ホン，
ルーク エス．エス． グオ，
ルーク エス．エス． グオ，
ユン−ロン ツェン，
ユン−ロン ツェン，
シェウ−ファン シー，
シェウ−ファン シー，
ポ−チュン チャン，
ポ−チュン チャン，
チー−チャン ツァイ，
チー−チャン ツァイ，
ホン−フイ リン，
ホン−フイ リン，
Original Assignee
タイワン リポソーム カンパニー リミテッド
タイワン リポソーム カンパニー リミテッド
ティーエルシー バイオファーマシューティカルズ、インク．
ティーエルシー バイオファーマシューティカルズ、インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014556741A 2012-02-10 2013-02-08 眼の疾患の合併症を低減するための薬学的組成物 Active JP6231995B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261597189P 2012-02-10 2012-02-10
US61/597,189 2012-02-10
PCT/US2013/025390 WO2013119988A1 (en) 2012-02-10 2013-02-08 Pharmaceutical compositions to reduce complications of ocular steroid

Publications (3)

Publication Number Publication Date
JP2015506983A JP2015506983A (ja) 2015-03-05
JP2015506983A5 JP2015506983A5 (enExample) 2016-03-24
JP6231995B2 true JP6231995B2 (ja) 2017-11-15

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JP2014556741A Active JP6231995B2 (ja) 2012-02-10 2013-02-08 眼の疾患の合併症を低減するための薬学的組成物

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Country Link
US (2) US10058616B2 (enExample)
EP (1) EP2797601B1 (enExample)
JP (1) JP6231995B2 (enExample)
KR (1) KR102060210B1 (enExample)
CN (2) CN104125830B (enExample)
AU (1) AU2013216861B2 (enExample)
BR (1) BR112014018393B1 (enExample)
CA (1) CA2862055C (enExample)
CY (1) CY1120323T1 (enExample)
DK (1) DK2797601T3 (enExample)
ES (1) ES2673330T3 (enExample)
IN (1) IN2014MN01571A (enExample)
NZ (1) NZ628124A (enExample)
PT (1) PT2797601T (enExample)
RU (1) RU2660585C2 (enExample)
TR (1) TR201808592T4 (enExample)
TW (1) TWI620578B (enExample)
WO (1) WO2013119988A1 (enExample)

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EP3445335A4 (en) * 2016-04-19 2020-03-04 Nanyang Technological University FORMULATIONS FORMING A SUB-CONJUNCTIVAL DEPOSIT FOR THE ADMINISTRATION OF MEDICATION AT THE EYE LEVEL
US11766421B2 (en) 2017-09-25 2023-09-26 Surface Ophthalmics, Inc. Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
KR102712798B1 (ko) * 2017-11-21 2024-10-04 씨에스 파마슈티컬스 리미티드 안구주위 분비선 또는 안구 표면에서의 이상 염증을 치료하기 위한 조성물 및 사용 방법
US11759472B2 (en) 2017-11-21 2023-09-19 Cs Pharmaceuticals Limited Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
EP3820479A1 (en) * 2018-07-09 2021-05-19 Taiwan Liposome Co., Ltd. Methods to reduce complications of intra-articular steroid
BR112021004880A2 (pt) 2018-09-16 2021-06-01 Tlc Biopharmaceuticals, Inc. composições farmacêuticas adequadas para entrega articular e uso das mesmas no tratamento de dor nas articulações
KR20210141448A (ko) 2018-12-27 2021-11-23 서피스 아프샐믹스 인코포레이티드 안구 표면 질환을 치료하기 위한 안과용 약학 조성물 및 방법
RU2716429C1 (ru) * 2019-05-29 2020-03-11 федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения рецидивирующей эрозии роговицы различного генеза
CN111415822A (zh) * 2020-03-05 2020-07-14 沈阳农业大学 一种洋葱碳/二氧化锰阵列电极及其制备方法和应用
US12440510B2 (en) 2021-05-10 2025-10-14 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
CN117979951A (zh) 2021-05-10 2024-05-03 瑟菲斯眼科股份有限公司 一种用于缓解眼部疼痛的硫酸软骨素的用途

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SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
IL103907A0 (en) * 1992-11-27 1993-04-04 Pharmos Corp Ophthalmic compositions
CN100367932C (zh) * 2002-11-26 2008-02-13 吉里德科学公司 借助梯度的脂质体中药物装填的方法
CN100374165C (zh) 2003-02-04 2008-03-12 伯拉考国际股份公司 超声造影剂及其制备方法
EP1768657B1 (en) * 2004-06-23 2008-08-13 Sirion Therapeutics, Inc. Methods and compositions for treating ophthalmic conditions with retinyl derivates
US7767217B2 (en) * 2006-03-14 2010-08-03 Foresight Biotherapeutics Ophthalmic compositions comprising povidone-iodine
US20070280902A1 (en) * 2006-06-01 2007-12-06 Laura Rabinovich-Guilatt Method for treating eye disease or conditions affecting the posterior segment of the eye
KR20090029814A (ko) * 2006-06-22 2009-03-23 시리온 테라퓨틱스, 인크. 메갈린 활성의 조절을 통한 안질환의 치료 방법 및 조성물
US20080118500A1 (en) * 2006-11-16 2008-05-22 Taiwan Liposome Company Sustained releasing composition via local injection for treating eye diseases
US9114070B2 (en) 2008-02-29 2015-08-25 Nagoya Industrial Science Research Institute Liposome for delivery to posterior segment of eye and pharmaceutical composition for disease in posterior segment of eye
CN101502485A (zh) * 2009-03-20 2009-08-12 中国药科大学 地塞米松眼用纳米立方液晶制剂及其制备方法
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Also Published As

Publication number Publication date
EP2797601A1 (en) 2014-11-05
BR112014018393B1 (pt) 2020-09-15
US10058616B2 (en) 2018-08-28
CN104125830B (zh) 2018-01-16
TWI620578B (zh) 2018-04-11
AU2013216861B2 (en) 2017-05-18
US10350294B2 (en) 2019-07-16
BR112014018393A8 (pt) 2017-07-11
CY1120323T1 (el) 2019-07-10
CN107260679B (zh) 2020-07-31
KR102060210B1 (ko) 2019-12-27
BR112014018393A2 (enExample) 2017-06-20
TW201338806A (zh) 2013-10-01
JP2015506983A (ja) 2015-03-05
US20180193461A1 (en) 2018-07-12
AU2013216861A1 (en) 2014-08-07
RU2014132553A (ru) 2016-02-27
CA2862055A1 (en) 2013-08-15
CA2862055C (en) 2020-03-10
KR20150008844A (ko) 2015-01-23
EP2797601B1 (en) 2018-03-21
ES2673330T3 (es) 2018-06-21
PT2797601T (pt) 2018-06-27
DK2797601T3 (en) 2018-06-14
CN107260679A (zh) 2017-10-20
IN2014MN01571A (enExample) 2015-05-15
TR201808592T4 (tr) 2018-07-23
RU2660585C2 (ru) 2018-07-06
US20150011520A1 (en) 2015-01-08
NZ628124A (en) 2016-06-24
WO2013119988A1 (en) 2013-08-15
CN104125830A (zh) 2014-10-29
EP2797601A4 (en) 2015-06-03
HK1201723A1 (en) 2015-09-11

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