TWI593417B - 使用臍帶血細胞的腦損傷治療 - Google Patents

使用臍帶血細胞的腦損傷治療 Download PDF

Info

Publication number
TWI593417B
TWI593417B TW098110103A TW98110103A TWI593417B TW I593417 B TWI593417 B TW I593417B TW 098110103 A TW098110103 A TW 098110103A TW 98110103 A TW98110103 A TW 98110103A TW I593417 B TWI593417 B TW I593417B
Authority
TW
Taiwan
Prior art keywords
cord blood
blood cell
cell population
cells
isolated
Prior art date
Application number
TW098110103A
Other languages
English (en)
Chinese (zh)
Other versions
TW200948370A (en
Inventor
林欣榮
徐偉成
李鴻
Original Assignee
永生臍帶血銀行
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 永生臍帶血銀行 filed Critical 永生臍帶血銀行
Publication of TW200948370A publication Critical patent/TW200948370A/zh
Application granted granted Critical
Publication of TWI593417B publication Critical patent/TWI593417B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/51Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW098110103A 2008-03-28 2009-03-27 使用臍帶血細胞的腦損傷治療 TWI593417B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7217308P 2008-03-28 2008-03-28

Publications (2)

Publication Number Publication Date
TW200948370A TW200948370A (en) 2009-12-01
TWI593417B true TWI593417B (zh) 2017-08-01

Family

ID=41114539

Family Applications (2)

Application Number Title Priority Date Filing Date
TW098110103A TWI593417B (zh) 2008-03-28 2009-03-27 使用臍帶血細胞的腦損傷治療
TW105122319A TW201636033A (zh) 2008-03-28 2009-03-27 使用臍帶血細胞的腦損傷治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW105122319A TW201636033A (zh) 2008-03-28 2009-03-27 使用臍帶血細胞的腦損傷治療

Country Status (10)

Country Link
US (1) US11318170B2 (https=)
EP (1) EP2282748B1 (https=)
JP (4) JP2011515470A (https=)
CN (1) CN102036671A (https=)
AU (1) AU2009229153B2 (https=)
CA (1) CA2719740C (https=)
IL (1) IL208406A0 (https=)
SG (1) SG191701A1 (https=)
TW (2) TWI593417B (https=)
WO (1) WO2009120368A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694038B2 (en) * 2000-04-06 2017-07-04 Wayne P. Franco Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs
PL2790712T3 (pl) * 2011-12-14 2017-04-28 Yeda Research And Development Co. Ltd. Podpopulacja ludzkich monocytów do leczenia uszkodzenia ośrodkowego układu nerwowego
CN103599129A (zh) * 2013-11-07 2014-02-26 唐明淇 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途
WO2015174087A1 (ja) * 2014-05-16 2015-11-19 公益財団法人先端医療振興財団 脳梗塞の予防及び/又は治療の為の医薬
WO2017204231A1 (ja) * 2016-05-24 2017-11-30 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
CN108269615A (zh) * 2018-03-14 2018-07-10 南宁市第人民医院 一种脐血pH值与婴幼儿脑损伤的关系评价方法
EP4017507A4 (en) * 2019-08-20 2023-09-06 Stemcyte, Inc. TREATMENT OF CARDIOVASCULAR DISEASES

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5087570A (en) 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US7160724B2 (en) 2000-03-09 2007-01-09 University Of South Florida Human cord blood as a source of neural tissue for repair of the brain and spinal cord
WO2001075094A1 (en) * 2000-04-04 2001-10-11 Thomas Jefferson University Application of myeloid-origin cells to the nervous system
US8062837B2 (en) 2002-02-14 2011-11-22 Stemcyte, Inc. Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
DE10330216A1 (de) * 2003-07-03 2005-01-20 Jensen, Arne Wilhelm Oluf, Prof. Dr. Verwendung von Stammzellen aus Nabelschnurblut zur Verhinderung von Hirnschäden infolge Sauerstoffmangel und zur Neuroprotektion
US8309070B2 (en) * 2004-05-17 2012-11-13 Regents Of The University Of Minnesota Use of umbilical cord blood stem cells to treat ischemic event
US20060264365A1 (en) 2005-05-18 2006-11-23 Hung Li Treatment of brain tissue damage
US7569545B2 (en) 2005-05-20 2009-08-04 Academia Sinica Methods of increasing neurotrophic factor expression
KR101536239B1 (ko) 2005-09-23 2015-07-13 셀레릭스, 에스.엘. 면역조절활성을 갖는 세포 개체군, 분리 방법 및 용도
US7427597B2 (en) 2005-11-21 2008-09-23 Academia Sinica Method of treating brain tissue damages
US8329166B2 (en) 2005-12-16 2012-12-11 Academia Sinica Pluripotent olfactory stem cells
CA2762853A1 (en) 2009-05-21 2010-11-25 Stemcyte Inc. Cell therapy for brain tissue damage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Medical Hypotheses and Research, Vol. 3, No. 2, April 2006 BMC Cell Biology 2006, 7:30, p1-10 *

Also Published As

Publication number Publication date
TW201636033A (zh) 2016-10-16
EP2282748A4 (en) 2012-01-11
CA2719740C (en) 2018-11-20
SG191701A1 (en) 2013-07-31
US11318170B2 (en) 2022-05-03
AU2009229153B2 (en) 2015-06-11
JP6138090B2 (ja) 2017-05-31
JP6655123B2 (ja) 2020-02-26
CA2719740A1 (en) 2009-10-01
AU2009229153A1 (en) 2009-10-01
EP2282748B1 (en) 2016-11-09
JP2011515470A (ja) 2011-05-19
TW200948370A (en) 2009-12-01
JP2014237677A (ja) 2014-12-18
JP2017031158A (ja) 2017-02-09
CN102036671A (zh) 2011-04-27
WO2009120368A2 (en) 2009-10-01
IL208406A0 (en) 2010-12-30
US20110256107A1 (en) 2011-10-20
WO2009120368A3 (en) 2010-01-07
EP2282748A2 (en) 2011-02-16
JP6401757B2 (ja) 2018-10-10
JP2018154634A (ja) 2018-10-04

Similar Documents

Publication Publication Date Title
JP6401757B2 (ja) 臍帯血細胞を用いた脳損傷の処置
US20210213068A1 (en) Pluripotent stem cell for treatment of cerebral infarction
JP5649786B2 (ja) ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
US20030211085A1 (en) Cell therapy for chronic stroke
JP6604492B2 (ja) 脳梗塞治療のための多能性幹細胞
HK1153663A (en) Treatment of brain damage using umbilical cord blood cells
HK1153663B (en) Treatment of brain damage using umbilical cord blood cells
US20250144150A1 (en) Preparation method of pharmaceutical composition for treating chronic stroke
KR101423659B1 (ko) 초기 분화된 양수 줄기세포를 포함하는 요실금 치료제
US20230233613A1 (en) Pharmaceutical composition for treating chronic stroke
EP1180036B1 (en) Cell therapy for chronic stroke
JP2025123077A (ja) 脊髄梗塞治療のための多能性幹細胞
England Mobilisation of endogenous haematopoietic stem cells and their use as treatment for subacute stroke
Bonab et al. Mesenchymal stem cell therapy for multiple sclerosis
Banfi et al. A CASE OF CHRONIC IMMUNE SENSORY POLIRADICU-LOPATHY (CISP) RESPONSIVE TO IMMUNE MODULATING TREATMENT
Zalewska Investigation of corticosterone impact on the sub-acute stage of recovery after photothrombotic stroke induction

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees