CN102036671A - 使用脐带血细胞治疗脑损伤 - Google Patents

使用脐带血细胞治疗脑损伤 Download PDF

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Publication number
CN102036671A
CN102036671A CN2009801155168A CN200980115516A CN102036671A CN 102036671 A CN102036671 A CN 102036671A CN 2009801155168 A CN2009801155168 A CN 2009801155168A CN 200980115516 A CN200980115516 A CN 200980115516A CN 102036671 A CN102036671 A CN 102036671A
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China
Prior art keywords
cord blood
cells
blood cells
isolated population
administered
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Pending
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CN2009801155168A
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English (en)
Chinese (zh)
Inventor
S-Z·林
W-C·徐
H·李
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StemCyte Inc
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StemCyte Inc
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Publication of CN102036671A publication Critical patent/CN102036671A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN2009801155168A 2008-03-28 2009-03-26 使用脐带血细胞治疗脑损伤 Pending CN102036671A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7217308P 2008-03-28 2008-03-28
US61/072,173 2008-03-28
PCT/US2009/001915 WO2009120368A2 (en) 2008-03-28 2009-03-26 Treatment of brain damage using umbilical cord blood cells

Publications (1)

Publication Number Publication Date
CN102036671A true CN102036671A (zh) 2011-04-27

Family

ID=41114539

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801155168A Pending CN102036671A (zh) 2008-03-28 2009-03-26 使用脐带血细胞治疗脑损伤

Country Status (10)

Country Link
US (1) US11318170B2 (https=)
EP (1) EP2282748B1 (https=)
JP (4) JP2011515470A (https=)
CN (1) CN102036671A (https=)
AU (1) AU2009229153B2 (https=)
CA (1) CA2719740C (https=)
IL (1) IL208406A0 (https=)
SG (1) SG191701A1 (https=)
TW (2) TW201636033A (https=)
WO (1) WO2009120368A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599129A (zh) * 2013-11-07 2014-02-26 唐明淇 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途
CN108269615A (zh) * 2018-03-14 2018-07-10 南宁市第人民医院 一种脐血pH值与婴幼儿脑损伤的关系评价方法
CN114466655A (zh) * 2019-08-20 2022-05-10 永生生技股份有限公司 心血管疾病的治疗

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694038B2 (en) * 2000-04-06 2017-07-04 Wayne P. Franco Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs
EP2790712B1 (en) * 2011-12-14 2016-08-31 Yeda Research and Development Co. Ltd. Human monocyte sub-population for treatment of central nervous system injury
JPWO2015174087A1 (ja) * 2014-05-16 2017-04-20 公益財団法人先端医療振興財団 脳梗塞の予防及び／又は治療の為の医薬
JP7126703B2 (ja) * 2016-05-24 2022-08-29 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤

Family Cites Families (16)

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US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5087570A (en) 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
EP1263930A4 (en) 2000-03-09 2004-07-21 Saneron Ccel Therapeutics Inc HUMAN CORD BLOOD BLOOD AS A SOURCE FOR NEURAL TISSUE FOR HEALING THE BRAIN AND BACK MARK
US20010038836A1 (en) * 2000-04-04 2001-11-08 Matthew During Application of myeloid-origin cells to the nervous system
US8062837B2 (en) 2002-02-14 2011-11-22 Stemcyte, Inc. Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
DE10330216A1 (de) 2003-07-03 2005-01-20 Jensen, Arne Wilhelm Oluf, Prof. Dr. Verwendung von Stammzellen aus Nabelschnurblut zur Verhinderung von Hirnschäden infolge Sauerstoffmangel und zur Neuroprotektion
US8309070B2 (en) 2004-05-17 2012-11-13 Regents Of The University Of Minnesota Use of umbilical cord blood stem cells to treat ischemic event
US20060264365A1 (en) 2005-05-18 2006-11-23 Hung Li Treatment of brain tissue damage
US7569545B2 (en) 2005-05-20 2009-08-04 Academia Sinica Methods of increasing neurotrophic factor expression
EP3184630B1 (en) 2005-09-23 2019-07-17 TiGenix, S.A.U. Cell populations having immunoregulatory activity, method for isolation and uses
US7427597B2 (en) 2005-11-21 2008-09-23 Academia Sinica Method of treating brain tissue damages
US8329166B2 (en) 2005-12-16 2012-12-11 Academia Sinica Pluripotent olfactory stem cells
US20100310530A1 (en) 2009-05-21 2010-12-09 Stemcyte Inc. Cell Therapy for Brain Tissue Damage

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JIELI CHEN等: "《Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats》", 《STROKE》 *
LU D等: "《Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury》", 《CELL TRANSPLANT》 *
郝思国等: "《人脐血CD133＋细胞体外短期培养中生物学特性的变化》", 《中国实验血液学杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599129A (zh) * 2013-11-07 2014-02-26 唐明淇 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途
CN108269615A (zh) * 2018-03-14 2018-07-10 南宁市第人民医院 一种脐血pH值与婴幼儿脑损伤的关系评价方法
CN114466655A (zh) * 2019-08-20 2022-05-10 永生生技股份有限公司 心血管疾病的治疗

Also Published As

Publication number Publication date
JP2017031158A (ja) 2017-02-09
EP2282748B1 (en) 2016-11-09
TW200948370A (en) 2009-12-01
EP2282748A2 (en) 2011-02-16
WO2009120368A2 (en) 2009-10-01
JP6655123B2 (ja) 2020-02-26
WO2009120368A3 (en) 2010-01-07
AU2009229153B2 (en) 2015-06-11
JP2014237677A (ja) 2014-12-18
TWI593417B (zh) 2017-08-01
CA2719740A1 (en) 2009-10-01
JP6138090B2 (ja) 2017-05-31
IL208406A0 (en) 2010-12-30
JP2018154634A (ja) 2018-10-04
CA2719740C (en) 2018-11-20
US11318170B2 (en) 2022-05-03
SG191701A1 (en) 2013-07-31
AU2009229153A1 (en) 2009-10-01
TW201636033A (zh) 2016-10-16
JP6401757B2 (ja) 2018-10-10
JP2011515470A (ja) 2011-05-19
US20110256107A1 (en) 2011-10-20
EP2282748A4 (en) 2012-01-11

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Application publication date: 20110427