TWI576106B - 雜芳基磺醯胺衍生物、其製備方法以及其於人類治療之用途 - Google Patents
雜芳基磺醯胺衍生物、其製備方法以及其於人類治療之用途 Download PDFInfo
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- TWI576106B TWI576106B TW100140099A TW100140099A TWI576106B TW I576106 B TWI576106 B TW I576106B TW 100140099 A TW100140099 A TW 100140099A TW 100140099 A TW100140099 A TW 100140099A TW I576106 B TWI576106 B TW I576106B
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- Prior art keywords
- phenyl
- sulfonamide
- thiazol
- pyridine
- piperidin
- Prior art date
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- 239000003814 drug Substances 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title description 4
- -1 8-quinolyl group Chemical group 0.000 claims description 79
- 239000000460 chlorine Substances 0.000 claims description 65
- 150000001875 compounds Chemical class 0.000 claims description 50
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 26
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- 239000001257 hydrogen Substances 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
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- 125000001424 substituent group Chemical group 0.000 claims description 9
- 241000009298 Trigla lyra Species 0.000 claims description 8
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| FR1059634A FR2967674B1 (fr) | 2010-11-23 | 2010-11-23 | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine |
Publications (2)
| Publication Number | Publication Date |
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| TW201225951A TW201225951A (en) | 2012-07-01 |
| TWI576106B true TWI576106B (zh) | 2017-04-01 |
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| TW100140099A TWI576106B (zh) | 2010-11-23 | 2011-11-03 | 雜芳基磺醯胺衍生物、其製備方法以及其於人類治療之用途 |
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| BR (1) | BR112013012615A2 (enExample) |
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| FR (1) | FR2967674B1 (enExample) |
| IL (1) | IL226495A (enExample) |
| MA (1) | MA34658B1 (enExample) |
| MX (1) | MX352396B (enExample) |
| MY (1) | MY168283A (enExample) |
| NZ (1) | NZ610700A (enExample) |
| RU (1) | RU2582995C2 (enExample) |
| TW (1) | TWI576106B (enExample) |
| UA (1) | UA109295C2 (enExample) |
| WO (1) | WO2012069503A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20120693A1 (es) | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| EP2704720B1 (en) * | 2011-05-03 | 2019-08-07 | Agios Pharmaceuticals, Inc. | Pyruvate kinase r activators for use in therapy |
| PT3406251T (pt) | 2011-05-03 | 2024-01-24 | Agios Pharmaceuticals Inc | Ativadores da piruvato-cinase para utilização em terapia |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| WO2015055447A1 (en) * | 2013-10-17 | 2015-04-23 | Basf Se | Process for preparing substituted isatoic acid anhydride compounds and derivatives thereof |
| WO2015095111A1 (en) * | 2013-12-18 | 2015-06-25 | Merck Sharp & Dohme Corp. | Diazepane orexin receptor antagonists |
| CN104292179A (zh) * | 2014-10-19 | 2015-01-21 | 湖南华腾制药有限公司 | 一种2-氯苯并[d]恶唑-5-甲醛的制备方法 |
| FR3029112A1 (fr) * | 2014-12-02 | 2016-06-03 | Pf Medicament | Dispersion solide a base de derives d'heteroarylsulfonamides a usage pharmaceutique |
| MX384883B (es) | 2015-06-11 | 2025-03-14 | Agios Pharmaceuticals Inc | Métodos para usar activadores de piruvato cinasa. |
| EP3601273B1 (en) * | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| CN107556266B (zh) * | 2017-09-12 | 2021-04-23 | 华南农业大学 | 一种2-巯基-4-取代-6-氟苯并噻唑及其制法、应用 |
| US20200131156A1 (en) * | 2018-10-30 | 2020-04-30 | H. Lundbeck A/S | ARYLSULFONYLPYROLECARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS |
| CN113200934B (zh) * | 2021-05-18 | 2022-05-31 | 郑州大学 | 含苯并吗啉酮-联苯骨架化合物及其制备方法和应用 |
| CN113912595B (zh) * | 2021-10-12 | 2024-03-15 | 中国药科大学 | 一类含有噻唑或噻二唑结构的化合物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149700A (en) * | 1990-05-30 | 1992-09-22 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
| US20050137200A1 (en) * | 2001-06-12 | 2005-06-23 | Aventis Pharma Deutschland Gmbh | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use |
| WO2006130986A1 (en) * | 2005-06-09 | 2006-12-14 | Merck Frosst Canada Ltd. | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2010023445A1 (en) * | 2008-08-29 | 2010-03-04 | Xention Limited | Novel potassium channel blocker |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1828154T3 (pl) * | 2004-12-09 | 2009-10-30 | Hoffmann La Roche | Pochodne fenylopiperazynometanonu |
| CN101296914B (zh) * | 2005-08-26 | 2012-07-18 | 盐野义制药株式会社 | 具有ppar激动活性的衍生物 |
| CA2702772A1 (en) * | 2007-10-25 | 2009-04-30 | Boehringer Ingelheim International Gmbh | Diazepane compounds which modulate the cb2 receptor |
| CA2727780A1 (en) * | 2008-06-13 | 2009-12-17 | Bionomics Limited | Novel potassium channel blockers and uses thereof |
| CN101503392B (zh) * | 2009-03-31 | 2010-12-29 | 中国药科大学 | 芳甲胺类化合物、其制备方法及其医药用途 |
| WO2010130638A1 (en) * | 2009-05-14 | 2010-11-18 | Evotec Ag | Sulfonamide compounds, pharmaceutical compositions and uses thereof |
| PE20120693A1 (es) * | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
-
2010
- 2010-11-23 FR FR1059634A patent/FR2967674B1/fr active Active
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2011
- 2011-11-03 TW TW100140099A patent/TWI576106B/zh not_active IP Right Cessation
- 2011-11-17 AR ARP110104287A patent/AR083903A1/es unknown
- 2011-11-23 US US13/822,406 patent/US8846930B2/en not_active Expired - Fee Related
- 2011-11-23 NZ NZ610700A patent/NZ610700A/en not_active IP Right Cessation
- 2011-11-23 JP JP2013540331A patent/JP5837085B2/ja not_active Expired - Fee Related
- 2011-11-23 WO PCT/EP2011/070736 patent/WO2012069503A1/en not_active Ceased
- 2011-11-23 AU AU2011333772A patent/AU2011333772B2/en not_active Ceased
- 2011-11-23 CA CA2817531A patent/CA2817531A1/en not_active Abandoned
- 2011-11-23 MY MYPI2013001836A patent/MY168283A/en unknown
- 2011-11-23 MX MX2013005734A patent/MX352396B/es active IP Right Grant
- 2011-11-23 EP EP11785690.6A patent/EP2643318A1/en not_active Withdrawn
- 2011-11-23 KR KR1020137015172A patent/KR101838326B1/ko not_active Expired - Fee Related
- 2011-11-23 BR BR112013012615A patent/BR112013012615A2/pt not_active IP Right Cessation
- 2011-11-23 RU RU2013126251/04A patent/RU2582995C2/ru not_active IP Right Cessation
- 2011-11-23 CN CN201180055123.XA patent/CN103209980B/zh not_active Expired - Fee Related
- 2011-11-23 UA UAA201307746A patent/UA109295C2/uk unknown
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2013
- 2013-05-13 MA MA35892A patent/MA34658B1/fr unknown
- 2013-05-21 IL IL226495A patent/IL226495A/en active IP Right Grant
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2014
- 2014-08-15 US US14/460,951 patent/US9156834B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149700A (en) * | 1990-05-30 | 1992-09-22 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
| US20050137200A1 (en) * | 2001-06-12 | 2005-06-23 | Aventis Pharma Deutschland Gmbh | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use |
| WO2006130986A1 (en) * | 2005-06-09 | 2006-12-14 | Merck Frosst Canada Ltd. | Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2010023445A1 (en) * | 2008-08-29 | 2010-03-04 | Xention Limited | Novel potassium channel blocker |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101838326B1 (ko) | 2018-03-13 |
| NZ610700A (en) | 2014-12-24 |
| HK1187345A1 (en) | 2014-04-04 |
| IL226495A0 (en) | 2013-07-31 |
| BR112013012615A2 (pt) | 2016-09-06 |
| MX2013005734A (es) | 2013-08-01 |
| US8846930B2 (en) | 2014-09-30 |
| AR083903A1 (es) | 2013-04-10 |
| CA2817531A1 (en) | 2012-05-31 |
| FR2967674B1 (fr) | 2012-12-14 |
| UA109295C2 (uk) | 2015-08-10 |
| CN103209980B (zh) | 2015-06-03 |
| CN103209980A (zh) | 2013-07-17 |
| RU2582995C2 (ru) | 2016-04-27 |
| AU2011333772A1 (en) | 2013-06-06 |
| US20140357624A1 (en) | 2014-12-04 |
| RU2013126251A (ru) | 2014-12-27 |
| TW201225951A (en) | 2012-07-01 |
| US20130172326A1 (en) | 2013-07-04 |
| US9156834B2 (en) | 2015-10-13 |
| IL226495A (en) | 2017-06-29 |
| MA34658B1 (fr) | 2013-11-02 |
| AU2011333772B2 (en) | 2016-08-18 |
| EP2643318A1 (en) | 2013-10-02 |
| KR20130119943A (ko) | 2013-11-01 |
| MX352396B (es) | 2017-11-22 |
| FR2967674A1 (fr) | 2012-05-25 |
| JP5837085B2 (ja) | 2015-12-24 |
| WO2012069503A1 (en) | 2012-05-31 |
| JP2014502268A (ja) | 2014-01-30 |
| MY168283A (en) | 2018-10-19 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |