FR2967674B1 - Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine - Google Patents

Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine

Info

Publication number
FR2967674B1
FR2967674B1 FR1059634A FR1059634A FR2967674B1 FR 2967674 B1 FR2967674 B1 FR 2967674B1 FR 1059634 A FR1059634 A FR 1059634A FR 1059634 A FR1059634 A FR 1059634A FR 2967674 B1 FR2967674 B1 FR 2967674B1
Authority
FR
France
Prior art keywords
preparation
application
human therapeutics
heteroarylsulfonamide
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1059634A
Other languages
English (en)
French (fr)
Other versions
FR2967674A1 (fr
Inventor
Passelaigue Elisabeth Dupont
Roy Isabelle Le
Christophe Pignier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR1059634A priority Critical patent/FR2967674B1/fr
Priority to TW100140099A priority patent/TWI576106B/zh
Priority to ARP110104287A priority patent/AR083903A1/es
Priority to US13/822,406 priority patent/US8846930B2/en
Priority to CA2817531A priority patent/CA2817531A1/en
Priority to JP2013540331A priority patent/JP5837085B2/ja
Priority to CN201180055123.XA priority patent/CN103209980B/zh
Priority to UAA201307746A priority patent/UA109295C2/uk
Priority to PCT/EP2011/070736 priority patent/WO2012069503A1/en
Priority to RU2013126251/04A priority patent/RU2582995C2/ru
Priority to MX2013005734A priority patent/MX352396B/es
Priority to HK14100374.0A priority patent/HK1187345B/xx
Priority to KR1020137015172A priority patent/KR101838326B1/ko
Priority to AU2011333772A priority patent/AU2011333772B2/en
Priority to EP11785690.6A priority patent/EP2643318A1/en
Priority to MYPI2013001836A priority patent/MY168283A/en
Priority to NZ610700A priority patent/NZ610700A/en
Priority to BR112013012615A priority patent/BR112013012615A2/pt
Publication of FR2967674A1 publication Critical patent/FR2967674A1/fr
Application granted granted Critical
Publication of FR2967674B1 publication Critical patent/FR2967674B1/fr
Priority to MA35892A priority patent/MA34658B1/fr
Priority to IL226495A priority patent/IL226495A/en
Priority to US14/460,951 priority patent/US9156834B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR1059634A 2010-11-23 2010-11-23 Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine Active FR2967674B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR1059634A FR2967674B1 (fr) 2010-11-23 2010-11-23 Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine
TW100140099A TWI576106B (zh) 2010-11-23 2011-11-03 雜芳基磺醯胺衍生物、其製備方法以及其於人類治療之用途
ARP110104287A AR083903A1 (es) 2010-11-23 2011-11-17 Derivados de benzooxazol y benzotiazol sulfonamidas, utiles para tratar trastornos del ritmo cardiaco y cancer, composiciones farmaceuticas que los contienen y metodo para prepararlos
EP11785690.6A EP2643318A1 (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
JP2013540331A JP5837085B2 (ja) 2010-11-23 2011-11-23 ヘテロアリールスルホンアミド誘導体、それらの製造およびヒト治療におけるそれらの応用
CN201180055123.XA CN103209980B (zh) 2010-11-23 2011-11-23 杂芳基磺酰胺类衍生物,其制备及其在人类治疗中的应用
UAA201307746A UA109295C2 (uk) 2010-11-23 2011-11-23 Похідні гетероарилсульфонамідів, їх одержання і застосування для лікування людини
PCT/EP2011/070736 WO2012069503A1 (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
RU2013126251/04A RU2582995C2 (ru) 2010-11-23 2011-11-23 Производные гетероарилсульфонамидов, их получение и применение для лечения человека
MX2013005734A MX352396B (es) 2010-11-23 2011-11-23 Derivados de heteroarilsulfonamidas, su preparacion y su aplicacion en terapia humana.
US13/822,406 US8846930B2 (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
KR1020137015172A KR101838326B1 (ko) 2010-11-23 2011-11-23 헤테로아릴술폰아미드 유도체, 이의 제조방법 및 인간치료에서의 용도
AU2011333772A AU2011333772B2 (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
CA2817531A CA2817531A1 (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
MYPI2013001836A MY168283A (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
NZ610700A NZ610700A (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
BR112013012615A BR112013012615A2 (pt) 2010-11-23 2011-11-23 derivados de heteroarilsulfonamidas, sua preparação e sua aplicação em terapia humana
HK14100374.0A HK1187345B (en) 2010-11-23 2011-11-23 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy
MA35892A MA34658B1 (fr) 2010-11-23 2013-05-13 Dérivés d'hétéroarylsulfonamides, leur préparation et leur application en thérapie humaine
IL226495A IL226495A (en) 2010-11-23 2013-05-21 Derivatives of the Terroylsulfonamides, their preparation and their application in human therapy
US14/460,951 US9156834B2 (en) 2010-11-23 2014-08-15 Derivatives of heteroarylsulfonamides, their preparation and their application in human therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059634A FR2967674B1 (fr) 2010-11-23 2010-11-23 Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine

Publications (2)

Publication Number Publication Date
FR2967674A1 FR2967674A1 (fr) 2012-05-25
FR2967674B1 true FR2967674B1 (fr) 2012-12-14

Family

ID=44246390

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1059634A Active FR2967674B1 (fr) 2010-11-23 2010-11-23 Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine

Country Status (19)

Country Link
US (2) US8846930B2 (enExample)
EP (1) EP2643318A1 (enExample)
JP (1) JP5837085B2 (enExample)
KR (1) KR101838326B1 (enExample)
CN (1) CN103209980B (enExample)
AR (1) AR083903A1 (enExample)
AU (1) AU2011333772B2 (enExample)
BR (1) BR112013012615A2 (enExample)
CA (1) CA2817531A1 (enExample)
FR (1) FR2967674B1 (enExample)
IL (1) IL226495A (enExample)
MA (1) MA34658B1 (enExample)
MX (1) MX352396B (enExample)
MY (1) MY168283A (enExample)
NZ (1) NZ610700A (enExample)
RU (1) RU2582995C2 (enExample)
TW (1) TWI576106B (enExample)
UA (1) UA109295C2 (enExample)
WO (1) WO2012069503A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120693A1 (es) 2009-06-29 2012-07-04 Agios Pharmaceuticals Inc Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)
EP2704720B1 (en) * 2011-05-03 2019-08-07 Agios Pharmaceuticals, Inc. Pyruvate kinase r activators for use in therapy
PT3406251T (pt) 2011-05-03 2024-01-24 Agios Pharmaceuticals Inc Ativadores da piruvato-cinase para utilização em terapia
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
WO2015055447A1 (en) * 2013-10-17 2015-04-23 Basf Se Process for preparing substituted isatoic acid anhydride compounds and derivatives thereof
WO2015095111A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
CN104292179A (zh) * 2014-10-19 2015-01-21 湖南华腾制药有限公司 一种2-氯苯并[d]恶唑-5-甲醛的制备方法
FR3029112A1 (fr) * 2014-12-02 2016-06-03 Pf Medicament Dispersion solide a base de derives d'heteroarylsulfonamides a usage pharmaceutique
MX384883B (es) 2015-06-11 2025-03-14 Agios Pharmaceuticals Inc Métodos para usar activadores de piruvato cinasa.
EP3601273B1 (en) * 2017-03-24 2021-12-01 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
CN107556266B (zh) * 2017-09-12 2021-04-23 华南农业大学 一种2-巯基-4-取代-6-氟苯并噻唑及其制法、应用
US20200131156A1 (en) * 2018-10-30 2020-04-30 H. Lundbeck A/S ARYLSULFONYLPYROLECARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS
CN113200934B (zh) * 2021-05-18 2022-05-31 郑州大学 含苯并吗啉酮-联苯骨架化合物及其制备方法和应用
CN113912595B (zh) * 2021-10-12 2024-03-15 中国药科大学 一类含有噻唑或噻二唑结构的化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149700A (en) * 1990-05-30 1992-09-22 American Home Products Corporation Substituted arylsulfonamides and benzamides
DE10128331A1 (de) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
PL1828154T3 (pl) * 2004-12-09 2009-10-30 Hoffmann La Roche Pochodne fenylopiperazynometanonu
EP1902051A1 (en) * 2005-06-09 2008-03-26 Merck Frosst Canada Ltd. Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
CN101296914B (zh) * 2005-08-26 2012-07-18 盐野义制药株式会社 具有ppar激动活性的衍生物
CA2702772A1 (en) * 2007-10-25 2009-04-30 Boehringer Ingelheim International Gmbh Diazepane compounds which modulate the cb2 receptor
CA2727780A1 (en) * 2008-06-13 2009-12-17 Bionomics Limited Novel potassium channel blockers and uses thereof
GB0815781D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
CN101503392B (zh) * 2009-03-31 2010-12-29 中国药科大学 芳甲胺类化合物、其制备方法及其医药用途
WO2010130638A1 (en) * 2009-05-14 2010-11-18 Evotec Ag Sulfonamide compounds, pharmaceutical compositions and uses thereof
PE20120693A1 (es) * 2009-06-29 2012-07-04 Agios Pharmaceuticals Inc Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2)

Also Published As

Publication number Publication date
KR101838326B1 (ko) 2018-03-13
NZ610700A (en) 2014-12-24
HK1187345A1 (en) 2014-04-04
IL226495A0 (en) 2013-07-31
BR112013012615A2 (pt) 2016-09-06
MX2013005734A (es) 2013-08-01
US8846930B2 (en) 2014-09-30
AR083903A1 (es) 2013-04-10
CA2817531A1 (en) 2012-05-31
UA109295C2 (uk) 2015-08-10
CN103209980B (zh) 2015-06-03
CN103209980A (zh) 2013-07-17
RU2582995C2 (ru) 2016-04-27
AU2011333772A1 (en) 2013-06-06
US20140357624A1 (en) 2014-12-04
RU2013126251A (ru) 2014-12-27
TW201225951A (en) 2012-07-01
US20130172326A1 (en) 2013-07-04
US9156834B2 (en) 2015-10-13
IL226495A (en) 2017-06-29
MA34658B1 (fr) 2013-11-02
AU2011333772B2 (en) 2016-08-18
EP2643318A1 (en) 2013-10-02
KR20130119943A (ko) 2013-11-01
MX352396B (es) 2017-11-22
FR2967674A1 (fr) 2012-05-25
JP5837085B2 (ja) 2015-12-24
WO2012069503A1 (en) 2012-05-31
JP2014502268A (ja) 2014-01-30
MY168283A (en) 2018-10-19
TWI576106B (zh) 2017-04-01

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