TWI561522B - Substituted imidazopyridinyl-aminopyridine compounds - Google Patents

Substituted imidazopyridinyl-aminopyridine compounds

Info

Publication number
TWI561522B
TWI561522B TW101122473A TW101122473A TWI561522B TW I561522 B TWI561522 B TW I561522B TW 101122473 A TW101122473 A TW 101122473A TW 101122473 A TW101122473 A TW 101122473A TW I561522 B TWI561522 B TW I561522B
Authority
TW
Taiwan
Prior art keywords
substituted imidazopyridinyl
aminopyridine compounds
aminopyridine
compounds
imidazopyridinyl
Prior art date
Application number
TW101122473A
Other languages
English (en)
Other versions
TW201311687A (zh
Inventor
Mark A Ashwell
Chris Brassard
Anton Filikov
Jason Hill
Steffi Koerner
Jean-Marc Lapierre
Yanbin Liu
Nivedita Namdev
Robert Nicewonger
Rocio Palma
Manish Tandon
David Vensel
Akihisa Matsuda
Shin Iimura
Kenichi Yoshida
Takanori Yamazaki
Takahiro Kitamura
Takeshi Isoyama
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of TW201311687A publication Critical patent/TW201311687A/zh
Application granted granted Critical
Publication of TWI561522B publication Critical patent/TWI561522B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW101122473A 2011-06-24 2012-06-22 Substituted imidazopyridinyl-aminopyridine compounds TWI561522B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161500889P 2011-06-24 2011-06-24

Publications (2)

Publication Number Publication Date
TW201311687A TW201311687A (zh) 2013-03-16
TWI561522B true TWI561522B (en) 2016-12-11

Family

ID=47362419

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101122473A TWI561522B (en) 2011-06-24 2012-06-22 Substituted imidazopyridinyl-aminopyridine compounds

Country Status (17)

Country Link
US (2) US8609688B2 (zh)
EP (1) EP2723741B8 (zh)
JP (1) JP6046710B2 (zh)
KR (2) KR20190015600A (zh)
CN (1) CN103748093B (zh)
AU (2) AU2012272937B2 (zh)
BR (1) BR112013033182A2 (zh)
CA (1) CA2837727C (zh)
DK (1) DK2723741T3 (zh)
ES (1) ES2579855T3 (zh)
HK (1) HK1196371A1 (zh)
IL (3) IL229719A0 (zh)
MX (1) MX339862B (zh)
PH (1) PH12013502565B1 (zh)
TW (1) TWI561522B (zh)
WO (1) WO2012177844A2 (zh)
ZA (1) ZA201308929B (zh)

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US11202759B2 (en) 2010-10-06 2021-12-21 President And Fellows Of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
EP2701753B1 (en) 2011-04-27 2018-12-26 President and Fellows of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
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JP6062426B2 (ja) 2011-06-03 2017-01-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー抗原生成癌ワクチン
CA2837727C (en) * 2011-06-24 2019-12-03 Arqule, Inc. Substituted imidazopyridinyl-aminopyridine compounds
SI2838515T1 (sl) 2012-04-16 2020-07-31 President And Fellows Of Harvard College Mezoporozni sestavki iz silicijevega dioksida za moduliranje imunskih odgovorov
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CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
CN111499627A (zh) 2014-04-22 2020-08-07 艾科尔公司 取代的咪唑并吡啶基-氨基吡啶化合物的盐和多晶型
US10682400B2 (en) 2014-04-30 2020-06-16 President And Fellows Of Harvard College Combination vaccine devices and methods of killing cancer cells
ES2955926T3 (es) 2014-09-05 2023-12-11 Arqule Inc Composiciones y métodos para tratar trastornos proliferativos
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
CN105315161B (zh) * 2015-06-05 2017-08-04 厦门医学院 一类PKB/Akt抑制剂的关键中间体的制备方法
CN109072197A (zh) 2016-02-06 2018-12-21 哈佛学院校长同事会 重塑造血巢以重建免疫
US11352328B2 (en) 2016-07-12 2022-06-07 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus
US11555177B2 (en) 2016-07-13 2023-01-17 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
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Also Published As

Publication number Publication date
CN103748093A (zh) 2014-04-23
CA2837727A1 (en) 2012-12-27
US8609688B2 (en) 2013-12-17
JP6046710B2 (ja) 2016-12-21
EP2723741A2 (en) 2014-04-30
KR20140040773A (ko) 2014-04-03
IL229719A0 (en) 2014-01-30
ES2579855T3 (es) 2016-08-17
HK1196371A1 (zh) 2014-12-12
EP2723741B1 (en) 2016-04-27
US20120329791A1 (en) 2012-12-27
WO2012177844A2 (en) 2012-12-27
EP2723741A4 (en) 2014-12-03
WO2012177844A3 (en) 2013-04-04
ZA201308929B (en) 2016-03-30
AU2016269408B2 (en) 2018-04-05
BR112013033182A2 (pt) 2016-09-06
DK2723741T3 (en) 2016-06-06
AU2012272937B2 (en) 2016-09-29
CA2837727C (en) 2019-12-03
AU2016269408A1 (en) 2016-12-22
IL286152A (en) 2021-10-31
PH12013502565A1 (en) 2017-05-29
US8962619B2 (en) 2015-02-24
IL265897A (en) 2019-06-30
TW201311687A (zh) 2013-03-16
EP2723741B8 (en) 2016-09-21
KR101974673B1 (ko) 2019-05-02
MX339862B (es) 2016-06-15
PH12013502565B1 (en) 2017-05-29
MX2013015006A (es) 2014-12-08
IL265897B (en) 2021-09-30
CN103748093B (zh) 2016-06-01
KR20190015600A (ko) 2019-02-13
JP2014517072A (ja) 2014-07-17
US20140073635A1 (en) 2014-03-13
AU2012272937A1 (en) 2013-12-19

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