TWI503546B - 使用折光法估計膽紅素濃度之裝置及方法 - Google Patents
使用折光法估計膽紅素濃度之裝置及方法 Download PDFInfo
- Publication number
- TWI503546B TWI503546B TW100119085A TW100119085A TWI503546B TW I503546 B TWI503546 B TW I503546B TW 100119085 A TW100119085 A TW 100119085A TW 100119085 A TW100119085 A TW 100119085A TW I503546 B TWI503546 B TW I503546B
- Authority
- TW
- Taiwan
- Prior art keywords
- bilirubin
- sample
- concentration
- photodetectors
- light
- Prior art date
Links
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title claims description 244
- 238000000034 method Methods 0.000 title claims description 23
- 238000005259 measurement Methods 0.000 claims description 21
- 230000003287 optical effect Effects 0.000 claims description 10
- 150000008252 erythrosides Chemical class 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 19
- 239000007788 liquid Substances 0.000 description 15
- 238000012545 processing Methods 0.000 description 6
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 206010023126 Jaundice Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 208000036796 hyperbilirubinemia Diseases 0.000 description 4
- 238000005286 illumination Methods 0.000 description 4
- 230000008033 biological extinction Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 208000027119 bilirubin metabolic disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 206010023138 Jaundice neonatal Diseases 0.000 description 1
- 201000006346 Neonatal Jaundice Diseases 0.000 description 1
- 206010036590 Premature baby Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004508 polar body Anatomy 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/4133—Refractometers, e.g. differential
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/4133—Refractometers, e.g. differential
- G01N2021/414—Correcting temperature effect in refractometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35109210P | 2010-06-03 | 2010-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201209412A TW201209412A (en) | 2012-03-01 |
| TWI503546B true TWI503546B (zh) | 2015-10-11 |
Family
ID=44120325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100119085A TWI503546B (zh) | 2010-06-03 | 2011-05-31 | 使用折光法估計膽紅素濃度之裝置及方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8867027B2 (enExample) |
| EP (1) | EP2575594A1 (enExample) |
| JP (1) | JP5941910B2 (enExample) |
| CN (1) | CN102946792B (enExample) |
| BR (1) | BR112012030429A2 (enExample) |
| TW (1) | TWI503546B (enExample) |
| WO (1) | WO2011151743A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102645394B (zh) * | 2012-05-16 | 2014-05-07 | 河海大学 | 一种光学泥沙溶液含沙量测量装置及其测量方法 |
| US10088468B2 (en) * | 2016-02-04 | 2018-10-02 | Nova Biomedical Corporation | Analyte system and method for determining hemoglobin parameters in whole blood |
| US12478291B2 (en) * | 2019-01-29 | 2025-11-25 | Instrumentation Laboratory Company | Hematocrit level detection using IR laser refraction |
| DE112022001785T5 (de) | 2021-03-26 | 2024-02-15 | Hamamatsu Photonics K.K. | Vorrichtung zur abgeschwächten Totalreflexionsspektroskopie und Verfahren zur abgeschwächten Totalreflexionsspektroskopie |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5355211A (en) * | 1993-04-02 | 1994-10-11 | Leica Inc. | Refractometer subassembly method and apparatus |
| US6426045B1 (en) * | 1998-08-27 | 2002-07-30 | Abbott Laboratories | Reagentless analysis of biological samples |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1192849B (enExample) * | 1961-02-20 | |||
| US3625620A (en) * | 1970-08-24 | 1971-12-07 | American Optical Corp | Refractometer |
| JPS54148586A (en) | 1978-05-15 | 1979-11-20 | Minolta Camera Co Ltd | Jaundice meter |
| JPS61159137A (ja) * | 1984-12-30 | 1986-07-18 | Susumu Nakagawa | 濃度計 |
| US4952055A (en) * | 1988-10-03 | 1990-08-28 | Wyatt Technology Corporation | Differential refractometer |
| US5772606A (en) * | 1994-03-04 | 1998-06-30 | Kyoto Dai-Ichi Kagaku Co., Ltd. | Method of and apparatus for measuring uric components |
| US6045502A (en) * | 1996-01-17 | 2000-04-04 | Spectrx, Inc. | Analyzing system with disposable calibration device |
| US6605471B1 (en) * | 1996-05-30 | 2003-08-12 | Radiometer Medical A/S | Method and system for determining at least one parameter of at least one sample of a physiological liquid, a holder and a test device |
| US5969808A (en) * | 1997-07-31 | 1999-10-19 | Leicamicrosystems, Inc. | Brake check handheld refractometer |
| JPH11295220A (ja) * | 1998-04-13 | 1999-10-29 | Kdk Corp | 液体試料検査方法、および液体試料検査装置 |
| JP2000105195A (ja) * | 1998-09-29 | 2000-04-11 | Tokico Ltd | 濃度検出装置 |
| US6195160B1 (en) * | 1998-10-14 | 2001-02-27 | The Mercury Iron & Steel Co. | Illuminating means for refractometer |
| JP3754581B2 (ja) * | 1999-08-31 | 2006-03-15 | 株式会社堀場製作所 | 多成分有機溶液の分析方法 |
| US6396576B1 (en) | 2001-02-27 | 2002-05-28 | Leica Microsystems Inc. | Method for determining shadowline location on a photosensitive array and critical angle refractometer employing the method |
| US6816248B2 (en) * | 2001-04-26 | 2004-11-09 | Reichert, Inc. | Hand-held automatic refractometer |
| EP1634078B1 (en) | 2003-06-03 | 2008-04-16 | Bayer HealthCare LLC | Native analyte as reference in lateral flow assays |
| JP3934652B2 (ja) * | 2005-01-27 | 2007-06-20 | 株式会社アタゴ | 手持ち屈折計 |
| JP2007218632A (ja) * | 2006-02-14 | 2007-08-30 | Olympus Corp | 分析装置、屈折率測定装置および分析方法 |
| JP2008008622A (ja) * | 2006-06-27 | 2008-01-17 | Showa Shell Sekiyu Kk | 油分測定方法 |
| CN101216422B (zh) * | 2008-01-16 | 2011-07-20 | 中国科学技术大学 | 液体浓度检测装置及检测方法 |
-
2011
- 2011-04-27 EP EP11722916.1A patent/EP2575594A1/en not_active Withdrawn
- 2011-04-27 JP JP2013513010A patent/JP5941910B2/ja not_active Expired - Fee Related
- 2011-04-27 WO PCT/IB2011/051859 patent/WO2011151743A1/en not_active Ceased
- 2011-04-27 CN CN201180027411.4A patent/CN102946792B/zh not_active Expired - Fee Related
- 2011-04-27 BR BR112012030429A patent/BR112012030429A2/pt not_active Application Discontinuation
- 2011-04-27 US US13/701,058 patent/US8867027B2/en not_active Expired - Fee Related
- 2011-05-31 TW TW100119085A patent/TWI503546B/zh not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5355211A (en) * | 1993-04-02 | 1994-10-11 | Leica Inc. | Refractometer subassembly method and apparatus |
| US6426045B1 (en) * | 1998-08-27 | 2002-07-30 | Abbott Laboratories | Reagentless analysis of biological samples |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102946792B (zh) | 2016-05-18 |
| EP2575594A1 (en) | 2013-04-10 |
| CN102946792A (zh) | 2013-02-27 |
| JP5941910B2 (ja) | 2016-06-29 |
| US8867027B2 (en) | 2014-10-21 |
| US20130070230A1 (en) | 2013-03-21 |
| TW201209412A (en) | 2012-03-01 |
| WO2011151743A1 (en) | 2011-12-08 |
| JP2013527468A (ja) | 2013-06-27 |
| BR112012030429A2 (pt) | 2016-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |