TWI478915B - 宿主防禦之合成模擬物及其用途 - Google Patents
宿主防禦之合成模擬物及其用途 Download PDFInfo
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- TWI478915B TWI478915B TW098136112A TW98136112A TWI478915B TW I478915 B TWI478915 B TW I478915B TW 098136112 A TW098136112 A TW 098136112A TW 98136112 A TW98136112 A TW 98136112A TW I478915 B TWI478915 B TW I478915B
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- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10859508P | 2008-10-27 | 2008-10-27 |
Publications (2)
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| TW201020249A TW201020249A (en) | 2010-06-01 |
| TWI478915B true TWI478915B (zh) | 2015-04-01 |
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| TW098136112A TWI478915B (zh) | 2008-10-27 | 2009-10-26 | 宿主防禦之合成模擬物及其用途 |
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| EP (1) | EP2358380A4 (enExample) |
| JP (1) | JP2012506908A (enExample) |
| KR (1) | KR20110074995A (enExample) |
| CN (1) | CN102256614B (enExample) |
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| CA (1) | CA2741764A1 (enExample) |
| IL (1) | IL212275A0 (enExample) |
| MX (1) | MX2011004360A (enExample) |
| RU (1) | RU2540077C2 (enExample) |
| TW (1) | TWI478915B (enExample) |
| UA (1) | UA104875C2 (enExample) |
| WO (1) | WO2010062573A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090092574A1 (en) | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
| US8278309B2 (en) * | 2008-10-27 | 2012-10-02 | Polymedix, Inc. | Synthetic mimetics of host defense and uses thereof |
| RU2606128C2 (ru) | 2011-05-16 | 2017-01-10 | Селлсьютикс Корпорейшн | Соединения для применения в лечении мукозита |
| US9758607B2 (en) | 2013-10-10 | 2017-09-12 | Research Foundation Of The City University Of New York | Polymer with antibacterial activity |
| JP6047203B2 (ja) * | 2015-02-20 | 2016-12-21 | セルセウティックス コーポレイション | 消化管の炎症性疾患の予防および／または治療のための宿主防御タンパク質（ｈｄｐ）模倣薬 |
| CN107574581B (zh) * | 2017-08-03 | 2019-09-10 | 天津大学 | 一种抗菌性聚(ε-己内酯)/模拟抗菌肽电纺纤维膜及其制备方法 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US11771694B2 (en) | 2020-06-05 | 2023-10-03 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
Citations (1)
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| WO2008083256A2 (en) * | 2006-12-29 | 2008-07-10 | Polymedix, Inc. | Ophthalmic and otic compositions of facially amphiphilic polymers and oligomers and uses thereof |
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| US3496179A (en) * | 1967-10-11 | 1970-02-17 | Pfizer & Co C | 2-amino-3,4-dihydroquinazolines |
| CA2128612C (en) * | 1992-01-23 | 1999-06-15 | Mamoru Tomita | Antimicrobial agents and method for treating products therewith |
| WO2000010990A2 (en) * | 1998-08-20 | 2000-03-02 | University Of North Carolina At Chapel Hill | Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof |
| US6482799B1 (en) * | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| JP2001261674A (ja) * | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
| FR2813080B1 (fr) * | 2000-08-17 | 2002-11-29 | Stago Diagnostica | Peptides anti-heparine |
| ES2311035T3 (es) * | 2000-11-08 | 2009-02-01 | Fxs Ventures, Llc | Soluciones oftalmicas y para lentes de contacto mejoradas que contienen formas de vitamina b. |
| EP1372551B1 (en) | 2001-03-08 | 2008-09-17 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers as anti-infective agents |
| AU2002346457A1 (en) | 2001-11-21 | 2003-06-10 | Pharmacia And Upjohn Company | Pharmaceutical formulations comprising indolinone derivatives |
| CA2487454A1 (en) * | 2002-05-28 | 2003-12-04 | The Trustees Of The University Of Pennsylvania | Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers |
| CA2489378A1 (en) * | 2002-06-13 | 2003-12-24 | The Trustees Of The University Of Pennsylvania | Methods, systems, and computer program products for simulating biomembranes using coarse grain models |
| WO2004082634A2 (en) * | 2003-03-17 | 2004-09-30 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers and oligomers and uses thereof |
| AU2003249114A1 (en) | 2003-03-20 | 2004-10-11 | Shiseido International France | Cosmetic composition |
| US20050065091A1 (en) * | 2003-09-18 | 2005-03-24 | Gholam Peyman | Stabilized ocular solutions |
| CA2554163A1 (en) | 2004-01-23 | 2005-08-11 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof |
| JP2007534693A (ja) | 2004-04-23 | 2007-11-29 | サイデックス・インコーポレイテッド | スルホアルキルエーテルシクロデキストリンを含有するｄｐｉ製剤 |
| CN102653515A (zh) | 2004-06-15 | 2012-09-05 | 宝利麦迪克斯股份有限公司 | 聚阳离子化合物及其用途 |
| WO2006132647A2 (en) | 2004-07-23 | 2006-12-14 | The Trustees Of The University Of Pennsylvania | Antimicrobial copolymers and uses thereof |
| EP2486942B1 (en) | 2004-11-24 | 2018-10-10 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| JP2008524318A (ja) * | 2004-12-21 | 2008-07-10 | ファイザー・プロダクツ・インク | 安定なアジスロマイシン非二水和物の経口用懸濁液剤 |
| KR20080004475A (ko) | 2005-02-25 | 2008-01-09 | 유니버시티 오브 매사추세츠 | 표면적으로 양친매성인 중합체 및 올리고머, 그 조성물 및암치료방법으로서의 그 용도 |
| RU2325151C2 (ru) * | 2006-06-29 | 2008-05-27 | ООО "Научно-производственный центр "Амфион" | Способ получения системы доставки водонерастворимых и плохорастворимых биологически активных веществ и лекарственная форма на ее основе |
| JP2008137978A (ja) * | 2006-12-05 | 2008-06-19 | Canon Inc | カルバゾール誘導体及びこれを用いた有機発光素子 |
| US20100297257A1 (en) | 2007-11-09 | 2010-11-25 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) | Anticoagulant antagonist and hemophillia procoagulant |
| JP2011529502A (ja) * | 2008-07-28 | 2011-12-08 | ポリメディックス・インコーポレーテッド | 抗マラリア化合物 |
| US8278309B2 (en) * | 2008-10-27 | 2012-10-02 | Polymedix, Inc. | Synthetic mimetics of host defense and uses thereof |
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| WO2008083256A2 (en) * | 2006-12-29 | 2008-07-10 | Polymedix, Inc. | Ophthalmic and otic compositions of facially amphiphilic polymers and oligomers and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| UA104875C2 (uk) | 2014-03-25 |
| MX2011004360A (es) | 2011-08-12 |
| US20130090345A1 (en) | 2013-04-11 |
| US20100105703A1 (en) | 2010-04-29 |
| RU2540077C2 (ru) | 2015-01-27 |
| US8278309B2 (en) | 2012-10-02 |
| CN102256614A (zh) | 2011-11-23 |
| CN102256614B (zh) | 2014-01-08 |
| IL212275A0 (en) | 2011-06-30 |
| AU2009320139B2 (en) | 2013-07-25 |
| US8975262B2 (en) | 2015-03-10 |
| AU2009320139A1 (en) | 2010-06-03 |
| TW201020249A (en) | 2010-06-01 |
| BRPI0920251A2 (pt) | 2016-01-05 |
| EP2358380A1 (en) | 2011-08-24 |
| CA2741764A1 (en) | 2010-06-03 |
| JP2012506908A (ja) | 2012-03-22 |
| EP2358380A4 (en) | 2012-05-02 |
| KR20110074995A (ko) | 2011-07-05 |
| RU2011121354A (ru) | 2012-12-10 |
| WO2010062573A1 (en) | 2010-06-03 |
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