RU2540077C2 - Синтетические миметики иммунной защиты и их применение - Google Patents

Синтетические миметики иммунной защиты и их применение Download PDF

Info

Publication number
RU2540077C2
RU2540077C2 RU2011121354/04A RU2011121354A RU2540077C2 RU 2540077 C2 RU2540077 C2 RU 2540077C2 RU 2011121354/04 A RU2011121354/04 A RU 2011121354/04A RU 2011121354 A RU2011121354 A RU 2011121354A RU 2540077 C2 RU2540077 C2 RU 2540077C2
Authority
RU
Russia
Prior art keywords
compound
gram
formula
tert
butoxycarbonyl
Prior art date
Application number
RU2011121354/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2011121354A (ru
Inventor
Уилльям Ф. ДЕГРАДО
Дахой ЛЮ
Ричард У. СКОТТ
Юнцзян СЮЙ
Хайчжун ТАН
Божена КОРЧАК
Original Assignee
Селлсьютикс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селлсьютикс Корпорейшн filed Critical Селлсьютикс Корпорейшн
Publication of RU2011121354A publication Critical patent/RU2011121354A/ru
Application granted granted Critical
Publication of RU2540077C2 publication Critical patent/RU2540077C2/ru

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2011121354/04A 2008-10-27 2009-10-27 Синтетические миметики иммунной защиты и их применение RU2540077C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10859508P 2008-10-27 2008-10-27
US61/108,595 2008-10-27
US12/605,584 2009-10-26
US12/605,584 US8278309B2 (en) 2008-10-27 2009-10-26 Synthetic mimetics of host defense and uses thereof
PCT/US2009/062147 WO2010062573A1 (en) 2008-10-27 2009-10-27 Synthetic mimetics of host defense and uses thereof

Publications (2)

Publication Number Publication Date
RU2011121354A RU2011121354A (ru) 2012-12-10
RU2540077C2 true RU2540077C2 (ru) 2015-01-27

Family

ID=42118100

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011121354/04A RU2540077C2 (ru) 2008-10-27 2009-10-27 Синтетические миметики иммунной защиты и их применение

Country Status (14)

Country Link
US (2) US8278309B2 (enExample)
EP (1) EP2358380A4 (enExample)
JP (1) JP2012506908A (enExample)
KR (1) KR20110074995A (enExample)
CN (1) CN102256614B (enExample)
AU (1) AU2009320139B2 (enExample)
BR (1) BRPI0920251A2 (enExample)
CA (1) CA2741764A1 (enExample)
IL (1) IL212275A0 (enExample)
MX (1) MX2011004360A (enExample)
RU (1) RU2540077C2 (enExample)
TW (1) TWI478915B (enExample)
UA (1) UA104875C2 (enExample)
WO (1) WO2010062573A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2606128C2 (ru) * 2011-05-16 2017-01-10 Селлсьютикс Корпорейшн Соединения для применения в лечении мукозита

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US8278309B2 (en) * 2008-10-27 2012-10-02 Polymedix, Inc. Synthetic mimetics of host defense and uses thereof
US9758607B2 (en) 2013-10-10 2017-09-12 Research Foundation Of The City University Of New York Polymer with antibacterial activity
JP6047203B2 (ja) * 2015-02-20 2016-12-21 セルセウティックス コーポレイション 消化管の炎症性疾患の予防および/または治療のための宿主防御タンパク質(hdp)模倣薬
CN107574581B (zh) * 2017-08-03 2019-09-10 天津大学 一种抗菌性聚(ε-己内酯)/模拟抗菌肽电纺纤维膜及其制备方法
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US11771694B2 (en) 2020-06-05 2023-10-03 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2325151C2 (ru) * 2006-06-29 2008-05-27 ООО "Научно-производственный центр "Амфион" Способ получения системы доставки водонерастворимых и плохорастворимых биологически активных веществ и лекарственная форма на ее основе

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496179A (en) 1967-10-11 1970-02-17 Pfizer & Co C 2-amino-3,4-dihydroquinazolines
CA2128612C (en) 1992-01-23 1999-06-15 Mamoru Tomita Antimicrobial agents and method for treating products therewith
JP2003523927A (ja) 1998-08-20 2003-08-12 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル ジカチオンジベンゾフランおよびジベンゾチオフェン化合物並びにその使用法
US6482799B1 (en) 1999-05-25 2002-11-19 The Regents Of The University Of California Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial
JP2001261674A (ja) 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
FR2813080B1 (fr) 2000-08-17 2002-11-29 Stago Diagnostica Peptides anti-heparine
CN1263463C (zh) 2000-11-08 2006-07-12 生物概念实验室 含有过氧化物源和阳离子型聚合物防腐剂的改进的眼科和隐型眼镜用溶液
CN1522148A (zh) 2001-03-08 2004-08-18 ��Ϧ�������ݴ�ѧ���»� 作为抗感染药的表面两亲聚合物
BR0214357A (pt) 2001-11-21 2004-09-14 Sugen Inc Formulações farmacêuticas compreendendo derivados de indolinona
WO2003100701A1 (en) 2002-05-28 2003-12-04 The Trustees Of The University Of Pennsylvania Methods, systems, and computer program products for computational analysis and design of amphiphilic polymers
EP1513622A4 (en) 2002-06-13 2005-09-14 Univ Pennsylvania METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR STIMULATING BIOMEMBRANES USING ROUGH GRAIN MODELS
EP2471524A3 (en) 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Facially amphiphllic polymers and oligomers and uses thereof
WO2004082643A2 (fr) 2003-03-20 2004-09-30 Shiseido International France Composition cosmetique
US20050065091A1 (en) 2003-09-18 2005-03-24 Gholam Peyman Stabilized ocular solutions
EP2468711A3 (en) 2004-01-23 2012-09-19 The Trustees Of The University Of Pennsylvania Facially amphiphilic polyaryl and polarylalkynyl polymers and oligomers and uses thereof
HUE058227T2 (hu) * 2004-04-23 2022-07-28 Cydex Pharmaceuticals Inc DPI készítmény, amely szulfoalkil-éter-ciklodextrint tartalmaz
WO2005123660A2 (en) 2004-06-15 2005-12-29 Polymedix, Inc. Polycationic compounds and uses thereof
JP5027659B2 (ja) 2004-07-23 2012-09-19 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗菌コポリマーおよびその使用
EP1827499A4 (en) 2004-11-24 2010-03-17 Medpointe Healthcare Inc COMPOSITIONS COMPRISING AZELASTIN AND METHODS OF USE
EP1830860A2 (en) * 2004-12-21 2007-09-12 Pfizer Products Incorporated Stable non-dihydrate azithromycin oral suspensions
CA2599205A1 (en) 2005-02-25 2006-09-08 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer
JP2008137978A (ja) 2006-12-05 2008-06-19 Canon Inc カルバゾール誘導体及びこれを用いた有機発光素子
US20090092574A1 (en) * 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US20100297257A1 (en) 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
CA2732572A1 (en) 2008-07-28 2010-02-04 Polymedix, Inc. Anti-malarial compounds
US8278309B2 (en) * 2008-10-27 2012-10-02 Polymedix, Inc. Synthetic mimetics of host defense and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2325151C2 (ru) * 2006-06-29 2008-05-27 ООО "Научно-производственный центр "Амфион" Способ получения системы доставки водонерастворимых и плохорастворимых биологически активных веществ и лекарственная форма на ее основе

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2606128C2 (ru) * 2011-05-16 2017-01-10 Селлсьютикс Корпорейшн Соединения для применения в лечении мукозита
US9795575B2 (en) 2011-05-16 2017-10-24 Innovation Pharmaceuticals Inc. Compounds for use in treatment of mucositis
US10206894B2 (en) 2011-05-16 2019-02-19 Innovation Pharmaceuticals Inc. Compounds for use in treatment of mucositis
US10603294B2 (en) 2011-05-16 2020-03-31 Innovation Pharmaceuticals Inc. Compounds for use in treatment of mucositis

Also Published As

Publication number Publication date
BRPI0920251A2 (pt) 2016-01-05
AU2009320139B2 (en) 2013-07-25
JP2012506908A (ja) 2012-03-22
EP2358380A4 (en) 2012-05-02
WO2010062573A1 (en) 2010-06-03
UA104875C2 (uk) 2014-03-25
US20130090345A1 (en) 2013-04-11
CN102256614A (zh) 2011-11-23
CN102256614B (zh) 2014-01-08
US8278309B2 (en) 2012-10-02
MX2011004360A (es) 2011-08-12
AU2009320139A1 (en) 2010-06-03
KR20110074995A (ko) 2011-07-05
RU2011121354A (ru) 2012-12-10
IL212275A0 (en) 2011-06-30
US20100105703A1 (en) 2010-04-29
TWI478915B (zh) 2015-04-01
TW201020249A (en) 2010-06-01
US8975262B2 (en) 2015-03-10
EP2358380A1 (en) 2011-08-24
CA2741764A1 (en) 2010-06-03

Similar Documents

Publication Publication Date Title
RU2540077C2 (ru) Синтетические миметики иммунной защиты и их применение
US20110071108A1 (en) Beta-Cyclodextrin Derivatives as Antibacterial Agents
US8895561B2 (en) Compounds and methods for treating candidiasis and aspergillus infections
KR102361131B1 (ko) 항생제 내성 균주에 대해 항균활성을 갖는 항균용 조성물
US6841661B2 (en) Glycopeptide antibacterial compounds, compositions containing same and methods of using same
US20210403430A1 (en) Polycationic Amphiphiles as Antimicrobial Agents and Methods Using Same
WO2010136804A1 (en) Pyrimidine derivatives for use as antibiotics
US11014891B2 (en) Reduction-triggered antibacterial sideromycins
US20020045574A1 (en) Glycopeptide antibacterial compounds and methods of using same
AU2015339039B2 (en) Synergistic compositions for treating microbial infections
US20220378044A1 (en) Antimicrobial agents and compositions and uses thereof
CN119431249B (zh) 菲并[9,10−d]咪唑季铵盐类衍生物及其制备方法和抗菌应用
EP3724184B1 (en) 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1h-tetrazole for the topical treatment of bacterial infections
AU2021261230A1 (en) Guanidine-modified C-terminus vancomycin compounds, compositions and methods
Cushman et al. Cushman et al.(43) Pub. Date: May 1, 2014
HK1183616B (en) Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine
HK1183616A (en) Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant
MM4A The patent is invalid due to non-payment of fees

Effective date: 20161028