TWI477503B - 含有剛性部分之吡啶并〔４，３－ｂ〕吲哚 - Google Patents

Info

Publication number

TWI477503B

TWI477503B TW098137048A TW98137048A TWI477503B TW I477503 B TWI477503 B TW I477503B TW 098137048 A TW098137048 A TW 098137048A TW 98137048 A TW98137048 A TW 98137048A TW I477503 B TWI477503 B TW I477503B

Authority

TW

Taiwan

Prior art keywords

substituted

group

unsubstituted

compound

alkyl

Prior art date

2008-10-31

Links

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• RDMFHRSPDKWERA-UHFFFAOYSA-N 5H-Pyrido[4,3-b]indole Chemical class C1=NC=C2C3=CC=CC=C3NC2=C1 RDMFHRSPDKWERA-UHFFFAOYSA-N 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 659
• -1 perhaloalkyl Chemical group 0.000 claims description 382
• 125000000217 alkyl group Chemical group 0.000 claims description 340
• 125000005843 halogen group Chemical group 0.000 claims description 265
• 125000001072 heteroaryl group Chemical group 0.000 claims description 211
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• 125000003545 alkoxy group Chemical group 0.000 claims description 181
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 178
• 150000003839 salts Chemical class 0.000 claims description 174
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 169
• 125000000623 heterocyclic group Chemical group 0.000 claims description 145
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 94
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 94
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 86
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 82
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 75
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 74
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 74
• 229910052739 hydrogen Inorganic materials 0.000 claims description 73
• 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 70
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• WNJHDSAISXIKTF-DTQAZKPQSA-N 5-[(e)-2-(4-fluorophenyl)prop-1-enyl]-2,8-dimethyl-3,4-dihydro-1h-pyrido[4,3-b]indole Chemical compound C1N(C)CCC2=C1C1=CC(C)=CC=C1N2\C=C(/C)C1=CC=C(F)C=C1 WNJHDSAISXIKTF-DTQAZKPQSA-N 0.000 claims 1
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
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