AU2009308706C1 - Pyrido (4,3-b) indoles containing rigid moieties - Google Patents

Pyrido (4,3-b) indoles containing rigid moieties Download PDF

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Publication number
AU2009308706C1
AU2009308706C1 AU2009308706A AU2009308706A AU2009308706C1 AU 2009308706 C1 AU2009308706 C1 AU 2009308706C1 AU 2009308706 A AU2009308706 A AU 2009308706A AU 2009308706 A AU2009308706 A AU 2009308706A AU 2009308706 C1 AU2009308706 C1 AU 2009308706C1
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Prior art keywords
substituted
unsubstituted
formula
compound
alkyl
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Ceased
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AU2009308706A
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AU2009308706A1 (en
AU2009308706B2 (en
Inventor
Sarvajit Chakravarty
Marco Giorgetti
David T. Hung
Rajendra Parasmal Jain
Andrew Asher Protter
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Medivation Technologies LLC
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Medivation Technologies LLC
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Priority to AU2013203621A priority Critical patent/AU2013203621A1/en
Publication of AU2009308706B2 publication Critical patent/AU2009308706B2/en
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Publication of AU2009308706C1 publication Critical patent/AU2009308706C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009308706A 2008-10-31 2009-10-30 Pyrido (4,3-b) indoles containing rigid moieties Ceased AU2009308706C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013203621A AU2013203621A1 (en) 2008-10-31 2013-04-11 Pyrido(4,3-b)indoles containing rigid moieties

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11051908P 2008-10-31 2008-10-31
US61/110,519 2008-10-31
US17396009P 2009-04-29 2009-04-29
US61/173,960 2009-04-29
US24515009P 2009-09-23 2009-09-23
US61/245,150 2009-09-23
PCT/US2009/062869 WO2010051501A1 (en) 2008-10-31 2009-10-30 Pyrido (4,3-b) indoles containing rigid moieties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013203621A Division AU2013203621A1 (en) 2008-10-31 2013-04-11 Pyrido(4,3-b)indoles containing rigid moieties

Publications (3)

Publication Number Publication Date
AU2009308706A1 AU2009308706A1 (en) 2010-05-06
AU2009308706B2 AU2009308706B2 (en) 2015-09-03
AU2009308706C1 true AU2009308706C1 (en) 2016-01-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009308706A Ceased AU2009308706C1 (en) 2008-10-31 2009-10-30 Pyrido (4,3-b) indoles containing rigid moieties

Country Status (10)

Country Link
US (3) US8907097B2 (enExample)
EP (1) EP2346332A4 (enExample)
JP (2) JP5588991B2 (enExample)
CN (1) CN102271508B (enExample)
AR (1) AR073923A1 (enExample)
AU (1) AU2009308706C1 (enExample)
BR (1) BRPI0919948A2 (enExample)
CA (1) CA2742320A1 (enExample)
TW (1) TWI477503B (enExample)
WO (1) WO2010051501A1 (enExample)

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US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
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JP5869484B2 (ja) 2009-09-23 2016-02-24 メディベイション テクノロジーズ， インコーポレイテッド 架橋複素環化合物およびその使用
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US9040519B2 (en) 2010-02-18 2015-05-26 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
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US9187471B2 (en) 2010-02-19 2015-11-17 Medivation Technologies, Inc. Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
AU2011274787B2 (en) 2010-07-07 2016-06-16 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US20140155384A1 (en) 2011-02-18 2014-06-05 Medivation Technologies, Inc. Compounds and methods of treating diabetes
WO2012112961A1 (en) * 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods of treating hypertension
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
BR112013021126A2 (pt) 2011-02-18 2019-09-24 Medivation Technologies Inc método para reduzir a pressão sanguínea, método para aumentar o fluxo sanguíneo renal ou diminuir a reabsorção de sódio, método para tratar uma doença, kit, composto e composição farmacêutica
US20150315188A1 (en) * 2012-08-22 2015-11-05 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
WO2014031170A1 (en) * 2012-08-22 2014-02-27 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
JP6231566B2 (ja) * 2012-08-24 2017-11-15 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 神経新生促進化合物
EP3068388A4 (en) 2013-11-11 2017-04-12 Board of Regents of the University of Texas System Neuroprotective compounds and use thereof
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US12371429B2 (en) 2018-08-16 2025-07-29 Recreo Pharmaceuticals Llc Antibiotic resistance-modifying tricyclic heteroaryl compounds and uses thereof
EA202191320A1 (ru) 2020-03-19 2021-10-22 Андрей Александрович ИВАЩЕНКО Норадренергический и специфически серотонинергический анксиолитик и антидепрессант, способ его получения и применения
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