JP5588991B2 - 剛性の部分を有するピリド[4,3−b]インドール - Google Patents

剛性の部分を有するピリド[4,3−b]インドール Download PDF

Info

Publication number
JP5588991B2
JP5588991B2 JP2011534826A JP2011534826A JP5588991B2 JP 5588991 B2 JP5588991 B2 JP 5588991B2 JP 2011534826 A JP2011534826 A JP 2011534826A JP 2011534826 A JP2011534826 A JP 2011534826A JP 5588991 B2 JP5588991 B2 JP 5588991B2
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
compound
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011534826A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012507566A5 (enExample
JP2012507566A (ja
Inventor
デイビッド ティー. ハン,
アンドリュー アッシャー プロッター,
ラジェンドラ パラスマル ジェイン,
サルバジット チャクラバルティ,
マルコ ジョルゲッティ,
Original Assignee
メディベイション テクノロジーズ, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディベイション テクノロジーズ, インコーポレイテッド filed Critical メディベイション テクノロジーズ, インコーポレイテッド
Publication of JP2012507566A publication Critical patent/JP2012507566A/ja
Publication of JP2012507566A5 publication Critical patent/JP2012507566A5/ja
Application granted granted Critical
Publication of JP5588991B2 publication Critical patent/JP5588991B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011534826A 2008-10-31 2009-10-30 剛性の部分を有するピリド[4,3−b]インドール Expired - Fee Related JP5588991B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11051908P 2008-10-31 2008-10-31
US61/110,519 2008-10-31
US17396009P 2009-04-29 2009-04-29
US61/173,960 2009-04-29
US24515009P 2009-09-23 2009-09-23
US61/245,150 2009-09-23
PCT/US2009/062869 WO2010051501A1 (en) 2008-10-31 2009-10-30 Pyrido (4,3-b) indoles containing rigid moieties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014087277A Division JP2014133759A (ja) 2008-10-31 2014-04-21 剛性の部分を有するピリド[4,3−b]インドール

Publications (3)

Publication Number Publication Date
JP2012507566A JP2012507566A (ja) 2012-03-29
JP2012507566A5 JP2012507566A5 (enExample) 2012-12-20
JP5588991B2 true JP5588991B2 (ja) 2014-09-10

Family

ID=42129313

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011534826A Expired - Fee Related JP5588991B2 (ja) 2008-10-31 2009-10-30 剛性の部分を有するピリド[4,3−b]インドール
JP2014087277A Withdrawn JP2014133759A (ja) 2008-10-31 2014-04-21 剛性の部分を有するピリド[4,3−b]インドール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014087277A Withdrawn JP2014133759A (ja) 2008-10-31 2014-04-21 剛性の部分を有するピリド[4,3−b]インドール

Country Status (10)

Country Link
US (3) US8907097B2 (enExample)
EP (1) EP2346332A4 (enExample)
JP (2) JP5588991B2 (enExample)
CN (1) CN102271508B (enExample)
AR (1) AR073923A1 (enExample)
AU (1) AU2009308706C1 (enExample)
BR (1) BRPI0919948A2 (enExample)
CA (1) CA2742320A1 (enExample)
TW (1) TWI477503B (enExample)
WO (1) WO2010051501A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP5586577B2 (ja) * 2008-03-24 2014-09-10 メディベイション テクノロジーズ, インコーポレイテッド 架橋複素環化合物およびその使用
EP2280968A2 (en) * 2008-03-24 2011-02-09 Medivation Technologies, Inc. Pyrido [3, 4-b]indoles and methods of use
CN102271508B (zh) 2008-10-31 2015-04-29 梅迪维新技术公司 含有刚性部分的吡啶并[4,3-b]吲哚类化合物
CA2742322A1 (en) * 2008-10-31 2010-05-06 Medivation Technologies, Inc. Azepino[4,5-b]indoles and methods of use
CN102405043B (zh) 2009-01-09 2017-08-22 得克萨斯州大学系统董事会 前神经原性化合物
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
WO2010093425A1 (en) * 2009-02-11 2010-08-19 Sepracor Inc. Histamine h3 inverse agonists and antagonists and methods of use thereof
JP5827943B2 (ja) * 2009-04-29 2015-12-02 メディベイション テクノロジーズ, インコーポレイテッド ピリド[4,3−b]インドールおよびその使用方法
US9255094B2 (en) 2009-04-29 2016-02-09 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
CA2772522A1 (en) * 2009-09-11 2011-03-17 Sunovion Pharmaceuticals Inc. Histamine h3 inverse agonists and antagonists and methods of use thereof
EP2480078A4 (en) * 2009-09-23 2013-03-06 Medivation Technologies Inc PYRIDO- [4,3-B] INDOLE AND USE METHOD THEREFOR
WO2011038164A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
CN102724875B (zh) 2009-09-23 2015-05-27 梅迪维新技术公司 吡啶并[3,4-b]吲哚化合物及其使用方法
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
WO2011103485A1 (en) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
WO2011103448A1 (en) * 2010-02-19 2011-08-25 Medivation Technologies, Inc. Methods and compositions for treating psychotic disorders using antipsychotic combination therapy
WO2011103430A1 (en) 2010-02-19 2011-08-25 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
CA2804161A1 (en) 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US20140303144A1 (en) 2011-02-18 2014-10-09 Medivation Technologies, Inc. Compounds and methods of treating hypertension
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9199985B2 (en) 2011-02-18 2015-12-01 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
AU2012219251B2 (en) 2011-02-18 2016-05-12 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
EP2887805A4 (en) * 2012-08-22 2016-08-17 Medivation Technologies Inc COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE
WO2014031170A1 (en) * 2012-08-22 2014-02-27 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
JP6231566B2 (ja) * 2012-08-24 2017-11-15 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 神経新生促進化合物
EP3068388A4 (en) 2013-11-11 2017-04-12 Board of Regents of the University of Texas System Neuroprotective compounds and use thereof
WO2016037106A1 (en) 2014-09-05 2016-03-10 Allosteros Therapeutics, Inc CaMKII INHIBITORS AND USES THEREOF
US12371429B2 (en) 2018-08-16 2025-07-29 Recreo Pharmaceuticals Llc Antibiotic resistance-modifying tricyclic heteroaryl compounds and uses thereof
EP4137208A4 (en) 2020-03-19 2024-08-28 Savchuk, Nikolay Filippovich NORADRENERGIC AND SPECIFIC SEROTONERGIC ANXIOLYTIC AND ANTIDEPRESSANTS AND PROCESSES FOR THE PRODUCTION THEREOF AND USE THEREOF
US12016847B2 (en) 2021-03-12 2024-06-25 Bristol-Myers Squibb Company Methods of treating prostate cancer

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH445509A (de) 1964-12-03 1967-10-31 Geigy Ag J R Verfahren zur Herstellung von neuen Indolderivaten
FR1524830A (fr) 1966-05-31 1968-05-10 Geigy Ag J R Nouveaux dérivés de l'indole et leur préparation
US3525750A (en) 1966-05-31 1970-08-25 Geigy Chem Corp 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives
JPS63163347A (ja) * 1986-12-25 1988-07-06 Konica Corp 有機着色物質の光褪色防止方法
US4754038A (en) * 1987-02-26 1988-06-28 American Home Products Corporation Carboline histamine H1 antagonists
FR2663935A1 (fr) 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
RU2106864C1 (ru) 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
TW470745B (en) * 1996-05-23 2002-01-01 Janssen Pharmaceutica Nv Hexahydro-pyrido[4,3-b]indole derivatives
US6140337A (en) 1997-12-23 2000-10-31 Schering Corporation Methods for the treatment of mental disorders
AR035493A1 (es) 2000-09-20 2004-06-02 Upjohn Co Derivados de azepino (4,5b) indolina sustituidos, composicion farmaceutica y el uso de dichos derivados para preparar un medicamento
US7736889B2 (en) 2003-06-10 2010-06-15 The United States Of America As Represented By The Secretary Of The Navy Fluidic force discrimination
AU2004259009A1 (en) 2003-07-23 2005-02-03 Exelixis, Inc. Azepine derivatives as pharmaceutical agents
RU2283108C2 (ru) 2003-12-08 2006-09-10 Сергей Олегович Бачурин ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
US20070179174A1 (en) 2003-12-08 2007-08-02 Bachurin Sergei O Methods and compositions for slowing aging
JP2008534496A (ja) 2005-03-22 2008-08-28 アストラゼネカ・アクチエボラーグ CB1’受容体リガンドとしての新規なテトラヒドロ−1H−ピリド[4,3−b]インドール誘導体
US20070027178A1 (en) 2005-07-28 2007-02-01 Bristol-Myers Squibb Company Substituted tetrahydro-1H-pyrido[4,3-b]indoles as serotonin receptors agonists and antagonists
EP1937263A2 (en) 2005-10-04 2008-07-02 Medivation, Inc. Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
RU2338537C2 (ru) 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
AU2007297618A1 (en) 2006-09-20 2008-03-27 Medivation Neurology, Inc. Hydrogenated pyrido [4,3-b] indoles such as dimebon for treating canine Cognitive Dysfunction Syndrome
AU2007297539A1 (en) 2006-09-20 2008-03-27 Medivation Neurology, Inc. Methods and compositions for treating amyotrophic lateral sclerosis (ALS)
RU2009120048A (ru) 2006-10-27 2010-12-10 Медивэйшн Ньюролоджи, Инк. (Us) Способы и комбинированные средства для лечения болезни альцгеймера
RU2334514C1 (ru) 2006-12-01 2008-09-27 Институт физиологически активных веществ Российской Академии наук СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
RU2340342C2 (ru) 2006-12-07 2008-12-10 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ОСТРЫХ И ХРОНИЧЕСКИХ НАРУШЕНИЙ МОЗГОВОГО КРОВООБРАЩЕНИЯ, В ТОМ ЧИСЛЕ ИНСУЛЬТА, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО[4,3-b]ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
EP2145887B1 (en) 2007-04-05 2016-04-27 Alla Chem, LLC. Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and use thereof
RU2339637C1 (ru) * 2007-04-05 2008-11-27 Андрей Александрович Иващенко Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием
KR20100024951A (ko) 2007-05-25 2010-03-08 메디베이션 뉴롤로지 인코퍼레이티드 세포를 자극하기 위한 방법 및 조성물
RU2338533C1 (ru) 2007-06-28 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО, ОБЛАДАЮЩЕЕ АНКСИОЛИТИЧЕСКИМ ДЕЙСТВИЕМ, НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
WO2009017836A1 (en) 2007-08-01 2009-02-05 Medivation Neurology, Inc. Methods and compositions for treating schizophrenia using antipsychotic combination therapy
EP2189048A1 (en) 2007-09-14 2010-05-26 Services Pétroliers Schlumberger Particle acceleration devices and methods thereof
WO2009039420A1 (en) 2007-09-21 2009-03-26 Medivation Neurology, Inc. Methods and compositions for treating neuronal death mediated ocular diseases
RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
WO2009111540A1 (en) 2008-03-04 2009-09-11 Medivation Neurology, Inc. Methods for preparing pyridylethyl-substituted carbolines
EP2280968A2 (en) 2008-03-24 2011-02-09 Medivation Technologies, Inc. Pyrido [3, 4-b]indoles and methods of use
JP5586577B2 (ja) 2008-03-24 2014-09-10 メディベイション テクノロジーズ, インコーポレイテッド 架橋複素環化合物およびその使用
WO2009135091A1 (en) 2008-04-30 2009-11-05 Medivation Technologies, Inc. Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions
CA2742322A1 (en) 2008-10-31 2010-05-06 Medivation Technologies, Inc. Azepino[4,5-b]indoles and methods of use
CN102271508B (zh) 2008-10-31 2015-04-29 梅迪维新技术公司 含有刚性部分的吡啶并[4,3-b]吲哚类化合物
JP5827943B2 (ja) 2009-04-29 2015-12-02 メディベイション テクノロジーズ, インコーポレイテッド ピリド[4,3−b]インドールおよびその使用方法
US9255094B2 (en) 2009-04-29 2016-02-09 Medivation Technologies, Inc. Pyrido[4,3-B]indoles and methods of use
WO2011014695A1 (en) 2009-07-29 2011-02-03 Medivation Technologies, Inc. New 2,3,4,5-tetrahydro-1h-pyrido[4,3-b] indoles and methods of use
EP2480078A4 (en) 2009-09-23 2013-03-06 Medivation Technologies Inc PYRIDO- [4,3-B] INDOLE AND USE METHOD THEREFOR
CN102724875B (zh) 2009-09-23 2015-05-27 梅迪维新技术公司 吡啶并[3,4-b]吲哚化合物及其使用方法
JP5791611B2 (ja) 2009-09-23 2015-10-07 メディベイション テクノロジーズ, インコーポレイテッド ピリド[3,4−b]インドールおよび使用方法
WO2011038164A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
WO2011103485A1 (en) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US20130172320A1 (en) 2010-02-18 2013-07-04 Sarvajit Chakravarty Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
WO2011103448A1 (en) 2010-02-19 2011-08-25 Medivation Technologies, Inc. Methods and compositions for treating psychotic disorders using antipsychotic combination therapy
WO2011103430A1 (en) 2010-02-19 2011-08-25 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9035056B2 (en) 2011-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
AU2012219251B2 (en) 2011-02-18 2016-05-12 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US20140303144A1 (en) 2011-02-18 2014-10-09 Medivation Technologies, Inc. Compounds and methods of treating hypertension
US9199985B2 (en) 2011-02-18 2015-12-01 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
TWI489247B (zh) * 2012-01-19 2015-06-21 Wistron Corp 擴充鍵盤裝置
EP2887805A4 (en) 2012-08-22 2016-08-17 Medivation Technologies Inc COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE
WO2014031170A1 (en) 2012-08-22 2014-02-27 Medivation Technologies, Inc. Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use

Also Published As

Publication number Publication date
US20150051218A1 (en) 2015-02-19
US9458155B2 (en) 2016-10-04
AU2009308706C1 (en) 2016-01-21
EP2346332A1 (en) 2011-07-27
CA2742320A1 (en) 2010-05-06
US20130190322A1 (en) 2013-07-25
CN102271508A (zh) 2011-12-07
CN102271508B (zh) 2015-04-29
BRPI0919948A2 (pt) 2015-08-25
TWI477503B (zh) 2015-03-21
JP2012507566A (ja) 2012-03-29
EP2346332A4 (en) 2012-08-08
HK1164057A1 (en) 2012-09-21
WO2010051501A1 (en) 2010-05-06
US20100216814A1 (en) 2010-08-26
AU2009308706B2 (en) 2015-09-03
AU2009308706A1 (en) 2010-05-06
US8907097B2 (en) 2014-12-09
TW201022264A (en) 2010-06-16
JP2014133759A (ja) 2014-07-24
US8906925B2 (en) 2014-12-09
AR073923A1 (es) 2010-12-09

Similar Documents

Publication Publication Date Title
JP5588991B2 (ja) 剛性の部分を有するピリド[4,3−b]インドール
JP5551708B2 (ja) アゼピノ[4,5−b]インドール化合物およびその使用方法
AU2010282990B2 (en) Pyrido [4, 3-b] indoles and methods of use
JP5791611B2 (ja) ピリド[3,4−b]インドールおよび使用方法
AU2010242910B2 (en) Pyrido [4,3-b] indoles and methods of use
US9040519B2 (en) Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9187471B2 (en) Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use
US9433626B2 (en) Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use
WO2011103487A1 (en) Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
AU2013203621A1 (en) Pyrido(4,3-b)indoles containing rigid moieties
AU2013203575A1 (en) Pyrido [4,3-b] indoles and methods of use
AU2013203574A1 (en) Pyrido [4,3-b] indoles and methods of use
HK1176814A (en) Pyrido[3,4-b]indoles and methods of use

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121030

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121030

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140121

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140123

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140421

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140710

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140728

R150 Certificate of patent or registration of utility model

Ref document number: 5588991

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees