AR073923A1 - Pirido( 4,3-b) indoles que contienen restos rigidos - Google Patents
Pirido( 4,3-b) indoles que contienen restos rigidosInfo
- Publication number
- AR073923A1 AR073923A1 ARP090104220A ARP090104220A AR073923A1 AR 073923 A1 AR073923 A1 AR 073923A1 AR P090104220 A ARP090104220 A AR P090104220A AR P090104220 A ARP090104220 A AR P090104220A AR 073923 A1 AR073923 A1 AR 073923A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- independently
- halo
- alkoxy
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- -1 perhaloalkyl Chemical group 0.000 abstract 10
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000001475 halogen functional group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 125000004442 acylamino group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 4
- 125000005102 carbonylalkoxy group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 150000003573 thiols Chemical class 0.000 abstract 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 125000005121 aminocarbonylalkoxy group Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11051908P | 2008-10-31 | 2008-10-31 | |
| US17396009P | 2009-04-29 | 2009-04-29 | |
| US24515009P | 2009-09-23 | 2009-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073923A1 true AR073923A1 (es) | 2010-12-09 |
Family
ID=42129313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104220A AR073923A1 (es) | 2008-10-31 | 2009-10-30 | Pirido( 4,3-b) indoles que contienen restos rigidos |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8907097B2 (enExample) |
| EP (1) | EP2346332A4 (enExample) |
| JP (2) | JP5588991B2 (enExample) |
| CN (1) | CN102271508B (enExample) |
| AR (1) | AR073923A1 (enExample) |
| AU (1) | AU2009308706C1 (enExample) |
| BR (1) | BRPI0919948A2 (enExample) |
| CA (1) | CA2742320A1 (enExample) |
| TW (1) | TWI477503B (enExample) |
| WO (1) | WO2010051501A1 (enExample) |
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| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| EP2280968A2 (en) | 2008-03-24 | 2011-02-09 | Medivation Technologies, Inc. | Pyrido [3, 4-b]indoles and methods of use |
| CA2742320A1 (en) | 2008-10-31 | 2010-05-06 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles containing rigid moieties |
| AU2009308708B2 (en) | 2008-10-31 | 2015-11-19 | Medivation Technologies, Inc. | Azepino [4, 5-b] indoles and methods of use |
| EP2385829B1 (en) | 2009-01-09 | 2018-08-01 | Board of Regents of the University of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| BRPI1008020A2 (pt) * | 2009-02-11 | 2016-03-15 | Sunovion Pharmaceuticals Inc | antagonistas e agonistas inversos h3 da histamina e métodos de uso dos mesmos |
| AU2010282990B2 (en) * | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
| EP2424364A4 (en) * | 2009-04-29 | 2012-12-19 | Medivation Technologies Inc | PYRIDO [4.3-B] INDOLES AND METHODS OF USE |
| EP2475664A2 (en) * | 2009-09-11 | 2012-07-18 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
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| IN2013MN01699A (enExample) * | 2011-02-18 | 2015-06-12 | Medivation Technologies Inc | |
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| US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
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| EP2925129A4 (en) * | 2012-08-24 | 2016-06-08 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
| EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
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| CN112654354A (zh) | 2018-08-16 | 2021-04-13 | 菲尼克思药业股份有限公司 | 1,3,4,9-四氢-2H-吡啶并[3,4-b]吲哚衍生物化合物及其用途 |
| EA202191320A1 (ru) | 2020-03-19 | 2021-10-22 | Андрей Александрович ИВАЩЕНКО | Норадренергический и специфически серотонинергический анксиолитик и антидепрессант, способ его получения и применения |
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| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
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| AU2010298168B2 (en) | 2009-09-23 | 2015-11-19 | Medivation Technologies, Inc. | Pyrido(3,4-b)indoles and methods of use |
| US20130137705A1 (en) | 2009-09-23 | 2013-05-30 | Sarvajit Chakravarty | Pyrido[3,4-b]indoles and methods of use |
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| US20140303144A1 (en) | 2011-02-18 | 2014-10-09 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
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| WO2012112962A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| US9035056B2 (en) | 2011-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| TWI489247B (zh) * | 2012-01-19 | 2015-06-21 | Wistron Corp | 擴充鍵盤裝置 |
| WO2014031170A1 (en) | 2012-08-22 | 2014-02-27 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
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-
2009
- 2009-10-30 CA CA2742320A patent/CA2742320A1/en not_active Abandoned
- 2009-10-30 TW TW098137048A patent/TWI477503B/zh not_active IP Right Cessation
- 2009-10-30 JP JP2011534826A patent/JP5588991B2/ja not_active Expired - Fee Related
- 2009-10-30 WO PCT/US2009/062869 patent/WO2010051501A1/en not_active Ceased
- 2009-10-30 CN CN200980153434.2A patent/CN102271508B/zh not_active Expired - Fee Related
- 2009-10-30 AU AU2009308706A patent/AU2009308706C1/en not_active Ceased
- 2009-10-30 EP EP09824199A patent/EP2346332A4/en not_active Withdrawn
- 2009-10-30 US US12/610,217 patent/US8907097B2/en not_active Expired - Fee Related
- 2009-10-30 BR BRPI0919948-9A patent/BRPI0919948A2/pt not_active IP Right Cessation
- 2009-10-30 AR ARP090104220A patent/AR073923A1/es unknown
-
2013
- 2013-03-08 US US13/791,544 patent/US8906925B2/en not_active Expired - Fee Related
-
2014
- 2014-04-21 JP JP2014087277A patent/JP2014133759A/ja not_active Withdrawn
- 2014-11-03 US US14/531,915 patent/US9458155B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150051218A1 (en) | 2015-02-19 |
| AU2009308706B2 (en) | 2015-09-03 |
| US8906925B2 (en) | 2014-12-09 |
| CN102271508B (zh) | 2015-04-29 |
| WO2010051501A1 (en) | 2010-05-06 |
| JP2012507566A (ja) | 2012-03-29 |
| US20130190322A1 (en) | 2013-07-25 |
| BRPI0919948A2 (pt) | 2015-08-25 |
| AU2009308706C1 (en) | 2016-01-21 |
| TWI477503B (zh) | 2015-03-21 |
| EP2346332A1 (en) | 2011-07-27 |
| AU2009308706A1 (en) | 2010-05-06 |
| HK1164057A1 (en) | 2012-09-21 |
| EP2346332A4 (en) | 2012-08-08 |
| US20100216814A1 (en) | 2010-08-26 |
| TW201022264A (en) | 2010-06-16 |
| US8907097B2 (en) | 2014-12-09 |
| CN102271508A (zh) | 2011-12-07 |
| JP2014133759A (ja) | 2014-07-24 |
| CA2742320A1 (en) | 2010-05-06 |
| JP5588991B2 (ja) | 2014-09-10 |
| US9458155B2 (en) | 2016-10-04 |
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