TWI448465B - 乙炔基衍生物 - Google Patents
乙炔基衍生物 Download PDFInfo
- Publication number
- TWI448465B TWI448465B TW099143811A TW99143811A TWI448465B TW I448465 B TWI448465 B TW I448465B TW 099143811 A TW099143811 A TW 099143811A TW 99143811 A TW99143811 A TW 99143811A TW I448465 B TWI448465 B TW I448465B
- Authority
- TW
- Taiwan
- Prior art keywords
- pyrimidine
- pyrazolo
- triazolo
- phenylethynyl
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09179719 | 2009-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201144314A TW201144314A (en) | 2011-12-16 |
TWI448465B true TWI448465B (zh) | 2014-08-11 |
Family
ID=43446449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW099143811A TWI448465B (zh) | 2009-12-17 | 2010-12-14 | 乙炔基衍生物 |
Country Status (27)
Country | Link |
---|---|
US (2) | US8586581B2 (ru) |
EP (1) | EP2513102B1 (ru) |
JP (1) | JP5763094B2 (ru) |
KR (1) | KR101407856B1 (ru) |
CN (1) | CN102686589B (ru) |
AR (1) | AR079467A1 (ru) |
AU (1) | AU2010332987B2 (ru) |
BR (1) | BR112012014770A2 (ru) |
CA (1) | CA2780155A1 (ru) |
CL (1) | CL2012001596A1 (ru) |
CO (1) | CO6531478A2 (ru) |
CR (1) | CR20120269A (ru) |
EC (1) | ECSP12011977A (ru) |
ES (1) | ES2551582T3 (ru) |
HK (1) | HK1171225A1 (ru) |
IL (1) | IL219371A (ru) |
MA (1) | MA33802B1 (ru) |
MX (1) | MX2012006789A (ru) |
MY (1) | MY162998A (ru) |
NZ (1) | NZ599553A (ru) |
PE (1) | PE20121443A1 (ru) |
RU (1) | RU2553461C2 (ru) |
SG (1) | SG181779A1 (ru) |
TW (1) | TWI448465B (ru) |
UA (1) | UA107002C2 (ru) |
WO (1) | WO2011073172A1 (ru) |
ZA (1) | ZA201204429B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3006745C (en) | 2010-11-05 | 2021-03-30 | Oat Agrio Co., Ltd. | Ethynylphenylamidine compound or salt thereof, method for producing same, and fungicide for agricultural and horticultural use |
KR101554803B1 (ko) | 2011-04-26 | 2015-09-21 | 에프. 호프만-라 로슈 아게 | Mglur5의 양성 알로스테릭 조절체로서 에틴일 유도체 |
US20130123254A1 (en) | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
DK2900659T3 (en) * | 2012-09-27 | 2016-10-03 | Hoffmann La Roche | ARYLETHYNYL DERIVATIVES |
CA2879489A1 (en) * | 2012-10-18 | 2014-04-24 | F.Hoffmann-La Roche Ag | Ethynyl derivatives as modulators of mglur5 receptor activity |
WO2014072261A1 (en) * | 2012-11-07 | 2014-05-15 | F. Hoffmann-La Roche Ag | Triazolo compounds |
AU2016273751B2 (en) | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
JP6761821B2 (ja) | 2015-07-15 | 2020-09-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 代謝性グルタミン酸受容体モジュレーターとしてのエチニル誘導体 |
SG11201811829QA (en) | 2016-07-18 | 2019-02-27 | Hoffmann La Roche | Ethynyl derivatives |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001062756A1 (en) * | 2000-02-21 | 2001-08-30 | Smithkline Beecham P.L.C. | Pyridinylimidazoles |
WO2003042211A1 (en) * | 2001-11-15 | 2003-05-22 | Smithkline Beecham Corporation | Phenyl substituted triazoles and their use as selective inhibors of akl5 kinase |
US20090124625A1 (en) * | 2004-06-17 | 2009-05-14 | Addex Pharmaceuticals Sa | Novel alkynyl derivatives as modulators of metatropic glutamate receptors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL142047A0 (en) * | 1998-10-02 | 2002-03-10 | Sibia Neurosciences Inc | Mglur5 antagonists for the treatment of pain and anxiety |
GB0027987D0 (en) * | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
US6910976B2 (en) | 2001-06-26 | 2005-06-28 | Stx, Llc | Multi-component lacrosse stick head |
GB0127433D0 (en) * | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
TWI292318B (en) * | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
WO2006048771A1 (en) | 2004-11-04 | 2006-05-11 | Addex Pharmaceuticals Sa | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
US8178533B2 (en) * | 2005-06-01 | 2012-05-15 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses |
CA2632194C (en) | 2005-11-15 | 2012-01-03 | Array Biopharma Inc. | N4-phenyl-quinazoline-4-amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
AU2007263655A1 (en) | 2006-06-30 | 2008-01-03 | Astrazeneca Ab | Pyrimidine derivatives useful in the treatment of cancer |
EP1972628A1 (en) | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
CA2685524A1 (en) * | 2007-04-30 | 2008-11-06 | Abbott Laboratories | Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme |
NZ581817A (en) | 2007-06-03 | 2012-05-25 | Univ Vanderbilt | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
TW201116532A (en) * | 2009-08-05 | 2011-05-16 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
-
2010
- 2010-12-10 US US12/964,785 patent/US8586581B2/en not_active Expired - Fee Related
- 2010-12-14 KR KR1020127018589A patent/KR101407856B1/ko not_active IP Right Cessation
- 2010-12-14 MX MX2012006789A patent/MX2012006789A/es active IP Right Grant
- 2010-12-14 PE PE2012000817A patent/PE20121443A1/es not_active Application Discontinuation
- 2010-12-14 MY MYPI2012002710A patent/MY162998A/en unknown
- 2010-12-14 CA CA2780155A patent/CA2780155A1/en not_active Abandoned
- 2010-12-14 EP EP10790960.8A patent/EP2513102B1/en not_active Not-in-force
- 2010-12-14 WO PCT/EP2010/069593 patent/WO2011073172A1/en active Application Filing
- 2010-12-14 ES ES10790960.8T patent/ES2551582T3/es active Active
- 2010-12-14 UA UAA201207427A patent/UA107002C2/ru unknown
- 2010-12-14 AU AU2010332987A patent/AU2010332987B2/en not_active Ceased
- 2010-12-14 TW TW099143811A patent/TWI448465B/zh not_active IP Right Cessation
- 2010-12-14 BR BR112012014770A patent/BR112012014770A2/pt not_active Application Discontinuation
- 2010-12-14 RU RU2012128551/04A patent/RU2553461C2/ru not_active IP Right Cessation
- 2010-12-14 SG SG2012044814A patent/SG181779A1/en unknown
- 2010-12-14 NZ NZ599553A patent/NZ599553A/en not_active IP Right Cessation
- 2010-12-14 JP JP2012543676A patent/JP5763094B2/ja not_active Expired - Fee Related
- 2010-12-14 CN CN201080057081.9A patent/CN102686589B/zh not_active Expired - Fee Related
- 2010-12-15 AR ARP100104641A patent/AR079467A1/es unknown
-
2012
- 2012-04-23 IL IL219371A patent/IL219371A/en not_active IP Right Cessation
- 2012-04-25 CO CO12068169A patent/CO6531478A2/es active IP Right Grant
- 2012-05-22 CR CR20120269A patent/CR20120269A/es unknown
- 2012-05-24 MA MA34890A patent/MA33802B1/fr unknown
- 2012-06-14 CL CL2012001596A patent/CL2012001596A1/es unknown
- 2012-06-15 ZA ZA2012/04429A patent/ZA201204429B/en unknown
- 2012-06-15 EC ECSP12011977 patent/ECSP12011977A/es unknown
- 2012-11-23 HK HK12112004.5A patent/HK1171225A1/xx not_active IP Right Cessation
-
2013
- 2013-10-16 US US14/055,047 patent/US8933094B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001062756A1 (en) * | 2000-02-21 | 2001-08-30 | Smithkline Beecham P.L.C. | Pyridinylimidazoles |
WO2003042211A1 (en) * | 2001-11-15 | 2003-05-22 | Smithkline Beecham Corporation | Phenyl substituted triazoles and their use as selective inhibors of akl5 kinase |
US20090124625A1 (en) * | 2004-06-17 | 2009-05-14 | Addex Pharmaceuticals Sa | Novel alkynyl derivatives as modulators of metatropic glutamate receptors |
Non-Patent Citations (1)
Title |
---|
Alagille D. et al., Bioorg. Med. Chem., 2005, 13: 197-209 * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |