CR20120269A - Derivados de etinilo - Google Patents

Derivados de etinilo

Info

Publication number
CR20120269A
CR20120269A CR20120269A CR20120269A CR20120269A CR 20120269 A CR20120269 A CR 20120269A CR 20120269 A CR20120269 A CR 20120269A CR 20120269 A CR20120269 A CR 20120269A CR 20120269 A CR20120269 A CR 20120269A
Authority
CR
Costa Rica
Prior art keywords
lower alkyl
hydrogen
alkoxy
hydroxy
optionally substituted
Prior art date
Application number
CR20120269A
Other languages
English (en)
Inventor
Luke Green
Wolfgang Guba
Georg Jaeschke
Synese Jolidon
Lothar Lindemann
Heinz Stadler
Eric Veira
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43446449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120269(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20120269A publication Critical patent/CR20120269A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención se refiere a derivados de etinilo de la fórmula I en la que: X es N o C-R1; Y es N o C-R2; Z es CH o N;R4 es un sustituyente aromático de 6 eslabones que contiene 0, 1 ó 2 átomos de nitrógeno, opcionalmente sustituido de 1 a 3 veces por grupos elegidos entre halógeno, al-quilo inferior, alcoxi inferior y NRR'; R1 es hidrógeno, alquilo inferior, alcoxi inferior, hidroxi, hidroxialquilo inferior, cicloalquilo inferior o es heterocicloalquilo opcionalmente sustituido por hidroxi o alcoxi; R2 es hidrógeno, CN, alquilo inferior o heterocicloalquilo;R y R' son con independencia entre sí hidrógeno o alquilo inferior; o a una sal farmacéuticamente aceptable o una sal de adi-ción de ácido, a una mezcla racémica, o a sus correspon-dientes enantiómeros y/o isómeros ópticos y/o estereoisómeros.
CR20120269A 2009-12-17 2012-05-22 Derivados de etinilo CR20120269A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09179719 2009-12-17

Publications (1)

Publication Number Publication Date
CR20120269A true CR20120269A (es) 2012-07-04

Family

ID=43446449

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120269A CR20120269A (es) 2009-12-17 2012-05-22 Derivados de etinilo

Country Status (27)

Country Link
US (2) US8586581B2 (es)
EP (1) EP2513102B1 (es)
JP (1) JP5763094B2 (es)
KR (1) KR101407856B1 (es)
CN (1) CN102686589B (es)
AR (1) AR079467A1 (es)
AU (1) AU2010332987B2 (es)
BR (1) BR112012014770A2 (es)
CA (1) CA2780155A1 (es)
CL (1) CL2012001596A1 (es)
CO (1) CO6531478A2 (es)
CR (1) CR20120269A (es)
EC (1) ECSP12011977A (es)
ES (1) ES2551582T3 (es)
HK (1) HK1171225A1 (es)
IL (1) IL219371A (es)
MA (1) MA33802B1 (es)
MX (1) MX2012006789A (es)
MY (1) MY162998A (es)
NZ (1) NZ599553A (es)
PE (1) PE20121443A1 (es)
RU (1) RU2553461C2 (es)
SG (1) SG181779A1 (es)
TW (1) TWI448465B (es)
UA (1) UA107002C2 (es)
WO (1) WO2011073172A1 (es)
ZA (1) ZA201204429B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE040156T2 (hu) 2010-11-05 2019-02-28 Oat Agrio Co Ltd Etinilfenilamidinvegyület vagy sója, eljárás azok elõállítására, és fungicid mezõgazdasági és kertészeti alkalmazásra
HUE025031T2 (en) 2011-04-26 2016-02-29 Hoffmann La Roche Ethinyl derivatives as positive allosteric modulators of MGLUR5
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
EA025482B1 (ru) * 2012-09-27 2016-12-30 Ф. Хоффманн-Ля Рош Аг Производные арилэтинила
NZ703537A (en) * 2012-10-18 2018-06-29 Hoffmann La Roche Ethynyl derivatives
MX2015005375A (es) * 2012-11-07 2015-07-21 Hoffmann La Roche Compuestos de triazolo.
CN107849006B (zh) 2015-06-03 2020-11-13 豪夫迈·罗氏有限公司 乙炔基衍生物
CN107580598B (zh) 2015-07-15 2020-11-13 豪夫迈·罗氏有限公司 作为代谢型谷氨酸受体调节剂的乙炔基衍生物
PE20190382A1 (es) 2016-07-18 2019-03-08 Hoffmann La Roche Derivados etinilo

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID29095A (id) * 1998-10-02 2001-07-26 Novartis Ag Cs Antagonis mglur5 untuk pengobatan rasa sakit dan kegelisahan
AR029803A1 (es) * 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0027987D0 (en) * 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
US6910976B2 (en) 2001-06-26 2005-06-28 Stx, Llc Multi-component lacrosse stick head
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
US8183241B2 (en) * 2005-06-01 2012-05-22 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives
DE602006021645D1 (de) 2005-11-15 2011-06-09 Array Biopharma Inc Verfahren und Zwischenverbindungen zur Herstellung von N4-Phenyl-Quinazolin-4-Amin Derivaten
EP2044063A1 (en) 2006-06-30 2009-04-08 Astra Zeneca AB Pyrimidine derivatives useful in the treatment of cancer
EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
NZ596724A (en) * 2007-04-30 2013-06-28 Abbott Lab Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and processes for their preparation
WO2008151184A1 (en) 2007-06-03 2008-12-11 Vanderbilt University Benzamide mglur5 positive allosteric modulators and methods of making and using same
TW201116532A (en) * 2009-08-05 2011-05-16 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
US8933094B2 (en) 2015-01-13
CO6531478A2 (es) 2012-09-28
IL219371A (en) 2015-02-26
RU2012128551A (ru) 2014-01-27
IL219371A0 (en) 2012-06-28
EP2513102B1 (en) 2015-08-19
MX2012006789A (es) 2012-07-10
HK1171225A1 (en) 2013-03-22
AU2010332987A1 (en) 2012-06-07
US20110152257A1 (en) 2011-06-23
JP5763094B2 (ja) 2015-08-12
ECSP12011977A (es) 2012-07-31
KR101407856B1 (ko) 2014-06-16
CL2012001596A1 (es) 2013-01-04
SG181779A1 (en) 2012-07-30
BR112012014770A2 (pt) 2016-03-29
PE20121443A1 (es) 2012-10-26
UA107002C2 (uk) 2014-11-10
CN102686589A (zh) 2012-09-19
ES2551582T3 (es) 2015-11-20
ZA201204429B (en) 2013-02-27
TW201144314A (en) 2011-12-16
WO2011073172A1 (en) 2011-06-23
JP2013514305A (ja) 2013-04-25
RU2553461C2 (ru) 2015-06-20
MA33802B1 (fr) 2012-12-03
TWI448465B (zh) 2014-08-11
AR079467A1 (es) 2012-01-25
NZ599553A (en) 2014-05-30
CA2780155A1 (en) 2011-06-23
CN102686589B (zh) 2014-12-10
US8586581B2 (en) 2013-11-19
US20140073638A1 (en) 2014-03-13
KR20120095472A (ko) 2012-08-28
EP2513102A1 (en) 2012-10-24
AU2010332987B2 (en) 2015-08-13
MY162998A (en) 2017-07-31

Similar Documents

Publication Publication Date Title
CR20120269A (es) Derivados de etinilo
ECSP14013296A (es) Derivados de etinilo
UY31367A1 (es) Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica
AR088352A1 (es) Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
AR078756A1 (es) Moduladores alostericos positivos (map)
CL2009000089A1 (es) Procesos de preparacion de un derivado del acido y-amino-o-bifenil-x-metil-pentanoico;compuestos intermediarios y su proceso de preparacion; uso de los compuestos en la sintesis de compuestos inhibidores de nep, utiles en enfermedades cardiovasculares, tales como hipertension, insuficiencia cardiaca congestiva, entre otras.
AR064760A1 (es) Derivados de diazol como inhibidores de la eg-5
MX2012008533A (es) Naftiridinas sustituidas y su uso como inhibidores de syk quinasa.
AR082111A1 (es) Furopiridinas o tienopiridinas condensadas, composiciones farmaceuticas que las contienen utiles para tratar trastornos psicoticos y del sistema nervioso central, y metodo de preparacion de las mismas
TW200800962A (en) Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
AR082004A1 (es) Compuestos de fusion de piridina
TW200740795A (en) Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
PE20141940A1 (es) Compuestos triciclicos, composiciones que los comprenden y usos de los mismos
ECSP13012980A (es) Derivados de fenil- o piridinil-etinilo
CO6241116A2 (es) Pirimidil piperazinas utiles como ligandos del receptor d3/d2
EA201270421A1 (ru) 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт
CO6341621A2 (es) Piperidinas arilamino y heteroarilamino sustituidas como inhibidores de glyt-1
AR074558A1 (es) Espiro azepan oxazolidinonas como bloqueadores del canal de potasio kv1.3
ECSP13012990A (es) Derivados de pirazolidin-3-ona
EA201390374A1 (ru) Гетероциклические соединения для лечения или профилактики расстройств, вызываемых ослабленной нейротрансмиссией серотонина, норэпинефрина или допамина
EA200970002A1 (ru) Двойственные молекулы, содержащие пероксидное производное, их синтез и их терапевтические применения
CR20150158A (es) Derivados de etinilo como moduladores de receptor de actividad mglur5
EA201290344A1 (ru) БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА
UA113223C2 (xx) Арилетинілпіримідини
PE20121683A1 (es) DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75