TWI444198B - 用於治療革蘭氏陽性菌感染的新穎抗菌劑 - Google Patents

用於治療革蘭氏陽性菌感染的新穎抗菌劑 Download PDF

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Publication number
TWI444198B
TWI444198B TW098143962A TW98143962A TWI444198B TW I444198 B TWI444198 B TW I444198B TW 098143962 A TW098143962 A TW 098143962A TW 98143962 A TW98143962 A TW 98143962A TW I444198 B TWI444198 B TW I444198B
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TW
Taiwan
Prior art keywords
group
acid
compound
compounds
clostridium
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TW098143962A
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English (en)
Chinese (zh)
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TW201028161A (en
Inventor
Andre Lee Pearson
Chester A Metcalf Iii
Jing Li
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Cubist Pharm Inc
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Application filed by Cubist Pharm Inc filed Critical Cubist Pharm Inc
Publication of TW201028161A publication Critical patent/TW201028161A/zh
Application granted granted Critical
Publication of TWI444198B publication Critical patent/TWI444198B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • C07K7/645Cyclosporins; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW098143962A 2008-12-22 2009-12-21 用於治療革蘭氏陽性菌感染的新穎抗菌劑 TWI444198B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13987508P 2008-12-22 2008-12-22

Publications (2)

Publication Number Publication Date
TW201028161A TW201028161A (en) 2010-08-01
TWI444198B true TWI444198B (zh) 2014-07-11

Family

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Family Applications (1)

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TW098143962A TWI444198B (zh) 2008-12-22 2009-12-21 用於治療革蘭氏陽性菌感染的新穎抗菌劑

Country Status (26)

Country Link
US (3) US8507647B2 (OSRAM)
EP (2) EP2674437A1 (OSRAM)
JP (1) JP5670914B2 (OSRAM)
KR (1) KR101717795B1 (OSRAM)
CN (1) CN102325787B (OSRAM)
AR (1) AR074833A1 (OSRAM)
AU (1) AU2009330245C1 (OSRAM)
BR (1) BRPI0923567A2 (OSRAM)
CA (1) CA2747965C (OSRAM)
CY (1) CY1114883T1 (OSRAM)
DK (1) DK2379580T3 (OSRAM)
ES (1) ES2442167T3 (OSRAM)
HR (1) HRP20131170T1 (OSRAM)
IL (1) IL213638A0 (OSRAM)
MX (1) MX2011006803A (OSRAM)
NZ (1) NZ594019A (OSRAM)
PL (1) PL2379580T3 (OSRAM)
PT (1) PT2379580E (OSRAM)
RS (1) RS53152B (OSRAM)
RU (1) RU2512396C2 (OSRAM)
SG (1) SG172299A1 (OSRAM)
SI (1) SI2379580T1 (OSRAM)
SM (1) SMT201400037B (OSRAM)
TW (1) TWI444198B (OSRAM)
WO (1) WO2010075215A1 (OSRAM)
ZA (1) ZA201104693B (OSRAM)

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KR20140037877A (ko) * 2011-05-26 2014-03-27 큐비스트 파마슈티컬즈 인코포레이티드 Cb-183,315 조성물 및 관련 방법
US10377699B2 (en) * 2013-11-06 2019-08-13 The University Of Hong Kong Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
WO2015172047A1 (en) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Cyclic peptide compounds and related methods, salts and compositions
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
CN109071566B (zh) * 2016-04-22 2021-08-31 阿斯利康(瑞典)有限公司 用于治疗癌症的大环mcl-1抑制剂
US10098890B2 (en) 2016-10-29 2018-10-16 Cipla Limited Stable carfilzomib formulations
IT201600127655A1 (it) * 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US10526343B2 (en) 2018-03-26 2020-01-07 University Of Sharjah Heterocyclic systems and pharmaceutical applications thereof
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения

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IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production
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DE4411025A1 (de) 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
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Also Published As

Publication number Publication date
US20140073558A1 (en) 2014-03-13
ES2442167T3 (es) 2014-02-10
PL2379580T3 (pl) 2014-05-30
HRP20131170T1 (hr) 2014-01-03
WO2010075215A1 (en) 2010-07-01
HK1161886A1 (en) 2012-08-10
SI2379580T1 (sl) 2014-02-28
AR074833A1 (es) 2011-02-16
CN102325787A (zh) 2012-01-18
AU2009330245C1 (en) 2013-09-26
EP2379580B1 (en) 2013-10-23
AU2009330245A1 (en) 2011-08-04
US20100184649A1 (en) 2010-07-22
US20150337013A1 (en) 2015-11-26
TW201028161A (en) 2010-08-01
RU2011130278A (ru) 2013-01-27
DK2379580T3 (da) 2014-01-20
EP2379580A1 (en) 2011-10-26
EP2674437A1 (en) 2013-12-18
RS53152B (sr) 2014-06-30
CA2747965C (en) 2017-06-27
ZA201104693B (en) 2013-01-30
SMT201400037B (it) 2014-05-07
AU2009330245B2 (en) 2013-05-02
KR101717795B1 (ko) 2017-03-17
BRPI0923567A2 (pt) 2016-09-27
US8507647B2 (en) 2013-08-13
SG172299A1 (en) 2011-07-28
KR20110114592A (ko) 2011-10-19
RU2512396C2 (ru) 2014-04-10
CN102325787B (zh) 2014-05-28
MX2011006803A (es) 2011-09-06
JP2012513467A (ja) 2012-06-14
CA2747965A1 (en) 2010-07-01
PT2379580E (pt) 2014-01-20
IL213638A0 (en) 2011-07-31
JP5670914B2 (ja) 2015-02-18
NZ594019A (en) 2013-08-30
CY1114883T1 (el) 2016-12-14

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