TWI377209B - Novel n-glucoside derivatives having a sglt inhibitory activity - Google Patents
Novel n-glucoside derivatives having a sglt inhibitory activity Download PDFInfo
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- TWI377209B TWI377209B TW093122844A TW93122844A TWI377209B TW I377209 B TWI377209 B TW I377209B TW 093122844 A TW093122844 A TW 093122844A TW 93122844 A TW93122844 A TW 93122844A TW I377209 B TWI377209 B TW I377209B
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- 125000000217 alkyl group Chemical group 0.000 claims description 114
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
Landscapes
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US49152303P | 2003-08-01 | 2003-08-01 |
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| TW200510440A TW200510440A (en) | 2005-03-16 |
| TWI377209B true TWI377209B (en) | 2012-11-21 |
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| TW093122844A TWI377209B (en) | 2003-08-01 | 2004-07-30 | Novel n-glucoside derivatives having a sglt inhibitory activity |
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| EP (1) | EP1654269B1 (https=) |
| JP (1) | JP4717811B2 (https=) |
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| CN (2) | CN102060888A (https=) |
| AU (1) | AU2004260760B2 (https=) |
| BR (1) | BRPI0413233A (https=) |
| CA (1) | CA2534022C (https=) |
| EA (1) | EA011025B1 (https=) |
| ES (1) | ES2527053T3 (https=) |
| IL (1) | IL173051A (https=) |
| MX (1) | MXPA06001273A (https=) |
| NO (1) | NO333679B1 (https=) |
| NZ (1) | NZ545305A (https=) |
| TW (1) | TWI377209B (https=) |
| UA (5) | UA86042C2 (https=) |
| WO (1) | WO2005012321A1 (https=) |
| ZA (2) | ZA200601686B (https=) |
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| LT2896397T (lt) * | 2003-08-01 | 2017-11-27 | Mitsubishi Tanabe Pharma Corporation | Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį |
| US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| TWI365186B (en) | 2005-01-31 | 2012-06-01 | Mitsubishi Tanabe Pharma Corp | Indole derivatives |
| JP5073948B2 (ja) * | 2005-01-31 | 2012-11-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| AR053329A1 (es) * | 2005-01-31 | 2007-05-02 | Tanabe Seiyaku Co | Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt) |
| TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| UY30730A1 (es) * | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| CN101611032B (zh) * | 2006-12-04 | 2012-07-18 | 詹森药业有限公司 | 作为抗糖尿病药的含噻吩基的吡喃葡糖基衍生物 |
| WO2008109591A1 (en) * | 2007-03-08 | 2008-09-12 | Lexicon Pharmaceuticals, Inc. | Phlorizin analogs as inhibitors of sodium glucose co-transporter 2 |
| MX2010002695A (es) | 2007-09-10 | 2010-04-01 | Janssen Pharmaceutica Nv | Proceso para la preparacion de compuestos utiles como inhibidores de transportador de glucosa dependiente de sodio (sglt). |
| CL2008003653A1 (es) | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
| US8791077B2 (en) | 2008-05-22 | 2014-07-29 | Astrazeneca Ab | Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same |
| MY155418A (en) | 2008-08-28 | 2015-10-15 | Pfizer | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| EA201100502A1 (ru) * | 2008-09-19 | 2011-10-31 | Новартис Аг | Гликозидные производные и их применения |
| US9056850B2 (en) * | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
| US20110009347A1 (en) * | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| KR101532412B1 (ko) | 2009-07-10 | 2015-06-29 | 얀센 파마슈티카 엔.브이. | 1-(β-Ｄ-글루코피라노실)-4-메틸-3-(5-(4-플루오로페닐)-2-티에닐메틸) 벤젠의 결정화 방법 |
| SI2488515T1 (sl) * | 2009-10-14 | 2017-04-26 | Janssen Pharmaceutica Nv | Postopek za pripravo spojin, ki so uporabne kot inhibitorji SGLT2 |
| EA021983B1 (ru) | 2009-11-02 | 2015-10-30 | Пфайзер Инк. | Производные диоксабицикло[3.2.1]октан-2,3,4-триола |
| TWI599360B (zh) | 2010-05-11 | 2017-09-21 | 健生藥品公司 | 醫藥調配物 |
| RS55056B1 (sr) | 2011-04-13 | 2016-12-30 | Janssen Pharmaceutica Nv | Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2 |
| TWI542596B (zh) * | 2011-05-09 | 2016-07-21 | 健生藥品公司 | （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體 |
| JP6173427B2 (ja) * | 2013-02-26 | 2017-08-02 | 田辺三菱製薬株式会社 | α−ハロテトラアシルグルコースの製造方法 |
| CN103896930B (zh) * | 2014-04-02 | 2016-08-17 | 安徽联创生物医药股份有限公司 | 卡格列净半水合物药用晶型的制备方法 |
| EP3148979B1 (en) | 2014-05-27 | 2019-02-06 | Glenmark Pharmaceuticals Limited | Process for preparation of canagliflozin |
| CN104045673B (zh) * | 2014-06-06 | 2017-01-18 | 安徽省食品药品检验研究院 | 双‑三氮唑缀合的假二糖衍生物及其制备方法 |
| CN104478968A (zh) * | 2015-01-14 | 2015-04-01 | 佛山市赛维斯医药科技有限公司 | 含噻唑基的o-半乳糖苷衍生物、其制备方法和用途 |
| CN106188022A (zh) * | 2015-04-30 | 2016-12-07 | 上海医药工业研究院 | 伊格列净的制备方法 |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| KR20260037123A (ko) | 2017-11-30 | 2026-03-17 | 이도르시아 파마슈티컬스 리미티드 | 엔도텔린 관련 질병의 치료를 위한 sglt-2 저해제와의 4-피리미딘설파미드 유도체의 병용 |
| BR112021000139A2 (pt) | 2018-07-19 | 2021-04-06 | Astrazeneca Ab | Métodos de tratamento da hfpef empregando dapagliflozina e composições compreendendo a mesma |
| TW202220672A (zh) | 2020-07-27 | 2022-06-01 | 瑞典商阿斯特捷利康公司 | 用達格列淨治療慢性腎臟病之方法 |
| AU2021202643B2 (en) | 2020-07-27 | 2023-02-02 | Astrazeneca Ab | Methods of treating chronic kidney disease with dapagliflozin |
| EP4315350A1 (en) | 2021-04-01 | 2024-02-07 | AstraZeneca UK Limited | Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition |
| US20250108065A1 (en) | 2022-01-26 | 2025-04-03 | Astrazeneca Ab | Methods of treating prediabetes or reducing the risk of developing type 2 diabetes with dapagliflozin |
| WO2025125513A1 (en) | 2023-12-15 | 2025-06-19 | AstraZeneca Ireland Limited | Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1075626B (de) * | 1960-02-18 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brunmg, Frankfurt/M | Verfahren zur Herstellung von wasserlöslichen chemotherapeutisch wirksamen Glykosiden | |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| ES2254376T3 (es) * | 2000-03-17 | 2006-06-16 | Kissei Pharmaceutical Co., Ltd. | Derivados glucopiranosiloxibencilbenceno, preparaciones medicinales que los contienen e intermediarios para la preparacion de los indicados derivados. |
| US6683056B2 (en) * | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| US6872706B2 (en) * | 2000-09-29 | 2005-03-29 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
| AU2002223127A1 (en) * | 2000-11-30 | 2002-06-11 | Kissei Pharmaceutical Co., Ltd. Intellectual Property | Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| PL209375B1 (pl) | 2000-12-28 | 2011-08-31 | Kissei Pharmaceutical | Pochodne glukopiranozyloksypirazolu, kompozycja farmaceutyczna zawierająca takie pochodne i zastosowanie tych pochodnych do wytwarzania kompozycji farmaceutycznej |
| TWI255817B (en) * | 2001-02-14 | 2006-06-01 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
| US20030087843A1 (en) | 2001-09-05 | 2003-05-08 | Washburn William N. | O-pyrazole glucoside SGLT2 inhibitors and method of use |
| DE102004048388A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
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- 2004-07-30 UA UAA200605346A patent/UA87991C2/ru unknown
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Also Published As
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|---|---|
| TW200510440A (en) | 2005-03-16 |
| NO20060219L (no) | 2006-04-28 |
| EP1654269A1 (en) | 2006-05-10 |
| JP2007518682A (ja) | 2007-07-12 |
| UA86599C2 (en) | 2009-05-12 |
| CN102060888A (zh) | 2011-05-18 |
| US7521430B2 (en) | 2009-04-21 |
| AU2004260760A1 (en) | 2005-02-10 |
| BRPI0413233A (pt) | 2006-10-03 |
| UA86042C2 (en) | 2009-03-25 |
| NZ545305A (en) | 2008-11-28 |
| EP1654269B1 (en) | 2014-10-15 |
| US20070060545A1 (en) | 2007-03-15 |
| KR101101500B1 (ko) | 2012-01-03 |
| NO333679B1 (no) | 2013-08-05 |
| JP4717811B2 (ja) | 2011-07-06 |
| CA2534022A1 (en) | 2005-02-10 |
| ZA200601686B (en) | 2007-05-30 |
| UA87991C2 (en) | 2009-09-10 |
| ES2527053T3 (es) | 2015-01-20 |
| EA200600348A1 (ru) | 2006-08-25 |
| AU2004260760B2 (en) | 2009-08-13 |
| KR20060132539A (ko) | 2006-12-21 |
| IL173051A0 (en) | 2006-06-11 |
| ZA200603880B (en) | 2010-01-27 |
| UA85569C2 (ru) | 2009-02-10 |
| CA2534022C (en) | 2012-10-02 |
| UA83377C2 (uk) | 2008-07-10 |
| CN1829728A (zh) | 2006-09-06 |
| WO2005012321A1 (en) | 2005-02-10 |
| MXPA06001273A (es) | 2006-04-11 |
| IL173051A (en) | 2012-06-28 |
| EA011025B1 (ru) | 2008-12-30 |
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