TWI371447B - Radiotherapy enhancer having a pyridine derivative as an active ingredient - Google Patents

Radiotherapy enhancer having a pyridine derivative as an active ingredient

Info

Publication number
TWI371447B
TWI371447B TW095111531A TW95111531A TWI371447B TW I371447 B TWI371447 B TW I371447B TW 095111531 A TW095111531 A TW 095111531A TW 95111531 A TW95111531 A TW 95111531A TW I371447 B TWI371447 B TW I371447B
Authority
TW
Taiwan
Prior art keywords
active ingredient
pyridine derivative
radiotherapy enhancer
radiotherapy
enhancer
Prior art date
Application number
TW095111531A
Other languages
English (en)
Other versions
TW200714588A (en
Inventor
Masakazu Fukushima
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of TW200714588A publication Critical patent/TW200714588A/zh
Application granted granted Critical
Publication of TWI371447B publication Critical patent/TWI371447B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW095111531A 2005-04-01 2006-03-31 Radiotherapy enhancer having a pyridine derivative as an active ingredient TWI371447B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005105938 2005-04-01
JP2005219119 2005-07-28

Publications (2)

Publication Number Publication Date
TW200714588A TW200714588A (en) 2007-04-16
TWI371447B true TWI371447B (en) 2012-09-01

Family

ID=37073534

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095111531A TWI371447B (en) 2005-04-01 2006-03-31 Radiotherapy enhancer having a pyridine derivative as an active ingredient

Country Status (12)

Country Link
US (2) US20090137640A1 (zh)
EP (1) EP1864974B1 (zh)
JP (1) JP5103170B2 (zh)
KR (1) KR101135789B1 (zh)
AU (1) AU2006231809B2 (zh)
BR (1) BRPI0608327A2 (zh)
CA (1) CA2603810C (zh)
HK (1) HK1118807A1 (zh)
NZ (1) NZ562048A (zh)
RU (1) RU2415670C2 (zh)
TW (1) TWI371447B (zh)
WO (1) WO2006106984A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2603810C (en) * 2005-04-01 2012-06-26 Taiho Pharmaceutical Co., Ltd. Potentiator for radiation therapy comprising pyridine derivative as active ingredient
KR20120015318A (ko) * 2009-05-12 2012-02-21 다이호야쿠힌고교 가부시키가이샤 테가푸르?기메라실?오테라실칼륨 배합제 및 옥살리플라틴을 함유하는 항종양제
CN105164107B (zh) 2012-12-20 2017-12-05 卢庆彬 用于与放射结合使用的放射增敏剂化合物
BR102013022567B1 (pt) * 2013-09-03 2021-09-21 Uniao Brasileira De Educacão E Assistência Uso de 6-hidroxi-2-piridonas e seus derivados na preparação de uma composição farmacêutica que atue pela inibição da enzima uridina fosforilase humana
JPWO2021256427A1 (zh) * 2020-06-15 2021-12-23

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6122016A (ja) * 1984-07-10 1986-01-30 Adeka Argus Chem Co Ltd 放射線増感剤
JPS61109719A (ja) * 1984-10-31 1986-05-28 Otsuka Pharmaceut Co Ltd 抗腫瘍活性増強剤
DK175432B1 (da) 1984-10-30 2004-10-18 Otsuka Pharma Co Ltd Middel til forögelse af anticancervirkningen af anticancerforbindelser
JP2531952B2 (ja) * 1987-04-06 1996-09-04 大塚製薬株式会社 フオスホリラ−ゼ阻害剤
JPWO2003004640A1 (ja) * 2001-07-05 2004-10-28 大鵬薬品工業株式会社 抗癌剤感受性測定用ｄｎａアレイ
CN101357134A (zh) * 2003-03-14 2009-02-04 大鹏药品工业株式会社 抗肿瘤效果增强剂和抗肿瘤剂
AU2006231808B2 (en) 2005-04-01 2010-06-24 Taiho Pharmaceutical Co., Ltd. Radiotherapy enhancer
CA2603810C (en) 2005-04-01 2012-06-26 Taiho Pharmaceutical Co., Ltd. Potentiator for radiation therapy comprising pyridine derivative as active ingredient

Also Published As

Publication number Publication date
EP1864974B1 (en) 2013-10-09
US8569324B2 (en) 2013-10-29
EP1864974A4 (en) 2009-09-02
NZ562048A (en) 2011-12-22
RU2415670C2 (ru) 2011-04-10
KR20080002900A (ko) 2008-01-04
AU2006231809B2 (en) 2011-08-25
JP5103170B2 (ja) 2012-12-19
US20110091016A1 (en) 2011-04-21
WO2006106984A1 (ja) 2006-10-12
KR101135789B1 (ko) 2012-04-16
RU2007140384A (ru) 2009-05-10
JPWO2006106984A1 (ja) 2008-09-25
TW200714588A (en) 2007-04-16
HK1118807A1 (en) 2009-02-20
CA2603810A1 (en) 2006-10-12
EP1864974A1 (en) 2007-12-12
AU2006231809A1 (en) 2006-10-12
US20090137640A1 (en) 2009-05-28
CA2603810C (en) 2012-06-26
BRPI0608327A2 (pt) 2009-12-29

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees