TWI319707B - Method of purifying pravastatin - Google Patents

Method of purifying pravastatin

Info

Publication number
TWI319707B
TWI319707B TW093135997A TW93135997A TWI319707B TW I319707 B TWI319707 B TW I319707B TW 093135997 A TW093135997 A TW 093135997A TW 93135997 A TW93135997 A TW 93135997A TW I319707 B TWI319707 B TW I319707B
Authority
TW
Taiwan
Prior art keywords
purifying pravastatin
pravastatin
purifying
provides
present
Prior art date
Application number
TW093135997A
Other languages
English (en)
Chinese (zh)
Other versions
TW200518745A (en
Inventor
Vilmos Keri
Istvan Melczer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of TW200518745A publication Critical patent/TW200518745A/zh
Application granted granted Critical
Publication of TWI319707B publication Critical patent/TWI319707B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
TW093135997A 2003-11-24 2004-11-23 Method of purifying pravastatin TWI319707B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52549403P 2003-11-24 2003-11-24
US53231403P 2003-12-22 2003-12-22
US55416504P 2004-03-18 2004-03-18

Publications (2)

Publication Number Publication Date
TW200518745A TW200518745A (en) 2005-06-16
TWI319707B true TWI319707B (en) 2010-01-21

Family

ID=34637188

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093135997A TWI319707B (en) 2003-11-24 2004-11-23 Method of purifying pravastatin

Country Status (12)

Country Link
US (2) US7425644B2 (ja)
EP (2) EP1641447B1 (ja)
JP (2) JP2007512366A (ja)
AT (1) ATE412409T1 (ja)
CA (1) CA2546377A1 (ja)
DE (3) DE202004020671U1 (ja)
ES (1) ES2251894T3 (ja)
HR (1) HRP20080686T3 (ja)
PL (1) PL1641447T3 (ja)
PT (1) PT1641447E (ja)
TW (1) TWI319707B (ja)
WO (1) WO2005051372A2 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005121062A2 (en) * 2004-06-09 2005-12-22 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
JP4775727B1 (ja) * 2010-08-17 2011-09-21 貞宏 平山 印刷物の微小マークによる一般人が容易にできる真贋判定方法
WO2014119568A1 (ja) * 2013-01-29 2014-08-07 学校法人産業医科大学 シスプラチン耐性がんの治療のためのHMG-CoA還元酵素阻害薬の使用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4346277A (en) * 1979-10-29 1982-08-24 Eaton Corporation Packaged electrical heating element
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
EP0215665B1 (en) 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
KR100286242B1 (ko) 1992-05-20 2001-04-16 스타르크, 카르크 돌라스타틴 유도체
NZ250609A (en) 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
IL112639A0 (en) 1994-03-11 1995-05-26 Bristol Myers Squibb Co A pharmaceutical composition containing pravastin
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
WO1997006128A1 (en) 1995-08-03 1997-02-20 Gist-Brocades B.V. Selective process for the deacylation of acylated compounds
US5883109A (en) 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
WO1998037220A1 (en) 1997-02-20 1998-08-27 Dsm N.V. Nitrogen feed in statin fermentation
KR100210482B1 (ko) 1997-04-10 1999-07-15 김종인 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
WO1999010499A1 (en) 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
JP2931971B1 (ja) 1998-02-23 1999-08-09 利夫 佐藤 プラバスタチンの製造法
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SI20305A (sl) 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
CN1260344C (zh) 1999-02-03 2006-06-21 药物研究所有限公司 培养物
US6682913B1 (en) 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
EP1265604B1 (en) * 1999-11-30 2006-10-18 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for recovering statin compounds from a fermentation broth
WO2001081611A1 (en) * 2000-04-27 2001-11-01 Biocon India Limited A novel process for the manufacture and purification of compactin
JP3737801B2 (ja) 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP3463881B2 (ja) * 2002-08-06 2003-11-05 三共株式会社 プラバスタチン又はその薬理上許容される塩の単離・精製方法
TW589178B (en) * 2003-02-21 2004-06-01 China Chemical & Pharmaceutica A novel industrial process to obtain pravastatin sodium of high purity

Also Published As

Publication number Publication date
PL1641447T3 (pl) 2009-04-30
PT1641447E (pt) 2008-12-10
US7425644B2 (en) 2008-09-16
US20050113446A1 (en) 2005-05-26
EP1641447B1 (en) 2008-10-29
DE602004017461D1 (de) 2008-12-11
DE202004020671U1 (de) 2005-12-08
JP2009161542A (ja) 2009-07-23
CA2546377A1 (en) 2005-06-09
ES2251894T3 (es) 2009-04-01
DE04811862T1 (de) 2006-03-02
WO2005051372A2 (en) 2005-06-09
JP2007512366A (ja) 2007-05-17
WO2005051372A3 (en) 2005-08-11
TW200518745A (en) 2005-06-16
EP2033636A1 (en) 2009-03-11
HRP20080686T3 (en) 2009-03-31
ES2251894T1 (es) 2006-05-16
ATE412409T1 (de) 2008-11-15
EP1641447A2 (en) 2006-04-05
US20080300305A1 (en) 2008-12-04

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees