TWI281398B - Administration of non-oral androgenic steroids to women - Google Patents

Administration of non-oral androgenic steroids to women Download PDF

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Publication number
TWI281398B
TWI281398B TW089111386A TW89111386A TWI281398B TW I281398 B TWI281398 B TW I281398B TW 089111386 A TW089111386 A TW 089111386A TW 89111386 A TW89111386 A TW 89111386A TW I281398 B TWI281398 B TW I281398B
Authority
TW
Taiwan
Prior art keywords
ketone
estrogen
testosterone
therapeutic effect
equivalent
Prior art date
Application number
TW089111386A
Other languages
English (en)
Chinese (zh)
Inventor
Theresa Rosario-Jansen
Norman A Mazer
Original Assignee
Watson Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Watson Pharmaceuticals Inc filed Critical Watson Pharmaceuticals Inc
Application granted granted Critical
Publication of TWI281398B publication Critical patent/TWI281398B/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW089111386A 1999-06-11 2000-06-09 Administration of non-oral androgenic steroids to women TWI281398B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13885499P 1999-06-11 1999-06-11
US13885199P 1999-06-11 1999-06-11
US13932399P 1999-06-11 1999-06-11

Publications (1)

Publication Number Publication Date
TWI281398B true TWI281398B (en) 2007-05-21

Family

ID=27385240

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089111386A TWI281398B (en) 1999-06-11 2000-06-09 Administration of non-oral androgenic steroids to women

Country Status (25)

Country Link
US (3) US6583129B1 (enExample)
EP (1) EP1189619A4 (enExample)
JP (2) JP5184727B2 (enExample)
KR (2) KR20020011437A (enExample)
CN (1) CN1220491C (enExample)
AR (1) AR024566A1 (enExample)
AU (1) AU775145B2 (enExample)
BR (1) BR0011740A (enExample)
CA (1) CA2376797C (enExample)
CO (1) CO5180583A1 (enExample)
CZ (1) CZ299198B6 (enExample)
HK (1) HK1048269B (enExample)
HU (1) HUP0301813A2 (enExample)
IL (1) IL147010A0 (enExample)
MX (1) MXPA01012769A (enExample)
MY (1) MY126960A (enExample)
NO (1) NO20016046L (enExample)
NZ (1) NZ516502A (enExample)
PE (1) PE20010404A1 (enExample)
PL (1) PL352250A1 (enExample)
SA (1) SA00210404B1 (enExample)
SK (1) SK18212001A3 (enExample)
TR (1) TR200200406T2 (enExample)
TW (1) TWI281398B (enExample)
WO (1) WO2000076522A1 (enExample)

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Publication number Publication date
EP1189619A1 (en) 2002-03-27
US6583129B1 (en) 2003-06-24
CA2376797C (en) 2011-03-22
MXPA01012769A (es) 2003-06-24
HK1048269A1 (en) 2003-03-28
KR20070063609A (ko) 2007-06-19
NO20016046L (no) 2002-02-06
CO5180583A1 (es) 2002-07-30
PE20010404A1 (es) 2001-04-09
MY126960A (en) 2006-11-30
JP5184727B2 (ja) 2013-04-17
AU5475800A (en) 2001-01-02
CZ20014499A3 (cs) 2002-05-15
TR200200406T2 (tr) 2002-06-21
IL147010A0 (en) 2002-08-14
US20030153540A1 (en) 2003-08-14
HK1048269B (zh) 2006-01-13
JP2013049682A (ja) 2013-03-14
US7186706B2 (en) 2007-03-06
PL352250A1 (en) 2003-08-11
CZ299198B6 (cs) 2008-05-14
CN1367698A (zh) 2002-09-04
AR024566A1 (es) 2002-10-16
HUP0301813A2 (hu) 2003-09-29
SK18212001A3 (sk) 2002-04-04
SA00210404B1 (ar) 2006-08-21
BR0011740A (pt) 2002-05-14
EP1189619A4 (en) 2004-06-09
US20070190120A1 (en) 2007-08-16
CN1220491C (zh) 2005-09-28
JP2003505345A (ja) 2003-02-12
NZ516502A (en) 2004-03-26
CA2376797A1 (en) 2000-12-21
KR20020011437A (ko) 2002-02-08
AU775145B2 (en) 2004-07-22
WO2000076522A1 (en) 2000-12-21
NO20016046D0 (no) 2001-12-11
US8551516B2 (en) 2013-10-08

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