TW581677B

TW581677B - Use of alkylated iminosugars to treat multidrug resistance

Use of alkylated iminosugars to treat multidrug resistance Download PDF

Info

Publication number: TW581677B
Authority: TW; Taiwan
Prior art keywords: galactitol; dideoxy; imino; pharmaceutical composition; glucositol
Prior art date: 1997-11-10

Application number

TW087118629A

Other languages

English (en)

Chinese (zh)

Inventor

Gary S Jacob

Original Assignee

Searle & Co

Priority date

1997-11-10

Filing date

1998-12-11

Publication date

2004-04-01

1998-12-11 Application filed by Searle & Co filed Critical Searle & Co

2004-04-01 Application granted granted Critical

2004-04-01 Publication of TW581677B publication Critical patent/TW581677B/zh

Links

230000036457 multidrug resistance Effects 0.000 title claims abstract description 20
FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical class OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims abstract description 121
150000001875 compounds Chemical class 0.000 claims abstract description 71
239000002246 antineoplastic agent Substances 0.000 claims abstract description 56
229940127089 cytotoxic agent Drugs 0.000 claims abstract description 33
-1 galactitol compound Chemical class 0.000 claims description 125
239000008194 pharmaceutical composition Substances 0.000 claims description 47
150000002148 esters Chemical class 0.000 claims description 42
239000003814 drug Substances 0.000 claims description 41
229940079593 drug Drugs 0.000 claims description 32
125000000217 alkyl group Chemical group 0.000 claims description 28
239000000126 substance Substances 0.000 claims description 17
230000000973 chemotherapeutic effect Effects 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 15
238000012360 testing method Methods 0.000 claims description 14
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 11
230000000259 anti-tumor effect Effects 0.000 claims description 11
229910052739 hydrogen Inorganic materials 0.000 claims description 11
239000001257 hydrogen Substances 0.000 claims description 11
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 10
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