TW557277B - Medicine packing apparatus - Google Patents

Abstract

The present invention provides a medicine packing apparatus which can easily surely clean medicine passage to remove remaining medicine, whereby reducing labor of pharmacist and supplying patient with safe medicine. The apparatus is provided with a cleaning material feed apparatus for feeding cleaning material contained in a cleaning material container to any of sequential medicine passages between a receiving hopper and an outlet of a packing hopper. When cleaning is necessary, the cleaning material is fed to the medicine passage and then the cleaning material is recovered together with the remaining medicine on the medicine passage, whereby the medicine passage is cleaned up.

Description

说明 Description of the invention [Technical field to which the invention belongs] The present invention relates to a technology for cleaning a pharmaceutical packaging device for integrating tablets or powders into a single dose for a patient. More specifically, the present invention relates to the use of cleaning materials to remove powders or powdered ingots attached to pharmaceutical contacting components such as dividing discs, withdrawal devices, funnels, and chute in powder packaging devices. Agents to prevent contamination of subsequent treatment agents and improve cleanliness. C Prior art 3 In the past, as shown in FIG. 39, the dividing disk 201 is annular and has a concave groove (hereinafter referred to as an R groove) 202 having an arc-shaped cross section. The dividing disk 201 is composed of It is made of stainless steel and is polished to a mirror-like level by abrasive materials. In addition, the powder deposited on the divided disk 001 in a uniform sentence is brought into contact with the stone eve rubber 204 of the pull-out device 203, and is then pulled out and supplied to the packaging device. However, if the powder composed of calcium lactate is divided by such a dividing disk 201, the calcium lactate particles will fall between the silicone rubber 204 of the extraction device 203 and the surface of the R groove 202 of the dividing disk 201, and will be dialed out. The silicone rubber 204 of the device 203 is compressed. As a result, as shown in FIG. 40, the lactic acid component contained in the lactic acid mom 205 was generated in the form of a liquid floating particle surface, and the liquid lactic acid component 206 was drawn in and attached to the surface of the R groove 202 of the dividing disc 201. And stick to the problem on it. The powder adhered in this state is cleaned by a pharmacist using a cleaner nozzle (see Japanese Patent Laid-Open Publication No. Hei 09-132201), or it is automatically removed by an automatic rotating suction cleaning device. In addition, the tablet packaging device has a structure that can open the medicine channel. 0 Continued pages (when the description page of the invention is insufficient, please note and use the continued page) 5 557277 玖 Continued pages of the invention description and use cloth or A non-woven cloth is wiped open to this patent publication and a pharmacist regularly opens and inspects the medicine passage to remove medicines attached to the medicine passage (see Hippei 09-201399).

The amount of bilin-based agents can still cause allergic reactions. 10 For this reason, after packaging the medicament with the aforementioned powerful effect, the pharmacist needs to carefully clean it with the aforementioned cleaning equipment, or put in an appropriate amount of excipients such as lactose or conditioning starch from the input funnel, by leaving a few residues in the medicament channel The medicine and the excipient are packaged together to remove the remaining medicine. μ If it is a capsule tablet, although it will not be powdered and remain in the drug channel, 15 bare tablets, sugar-coated tablets, compressed solid tablets, etc. will generate powder dust due to falling impact or contact, and the powder dust will remain in the drug channel. And it is attached to the capsule tablets or sugar-coated tablets to be packaged later, which may cause the patient to take a very small amount of pharmaceutical ingredients. In the case of Biling-based medicines, in order to prevent such dangers, it is necessary to pack them without passing through a common channel, or only pack Biling-based medicines separately. 2 [Summary of the Invention] Problems to be Solved by the Invention As described above, the remaining pharmaceutical treatment of the pharmaceutical packaging device is manually cleaned by a pharmacist, which is a complicated and inevitably time-consuming operation. If you neglect to clean up ’, it will increase the mixing for the follow-up patients. 0 Continuation page (if the description page of the invention is insufficient, please note and use the continuation page) 6 557277

发明 The invention illustrates the danger of effective medicines, so it is a consuming spirit. The present invention was created to solve the above problems. The problem is to provide: Thanks to the labor of a pharmacist and the means for solving the problem, the pharmaceutical packaging device that supplies patient-safe medicament. Before explaining the method to solve the aforementioned problem, the principle of medicament adhesion will be explained first. If the medicine used in the medicine packaging device is powder, the reason why the powder # body is attached to the wall of the object is mainly due to the adsorption energy of the object, static electricity 10, and liquid bridge force. Most of the medicines use the adsorption energy and static electricity of the object as the main adhesion factors. For some medicines such as calcium lactate, when pressure or vibration is applied as described above, the water in the particles floats on the surface, and the water adheres to the object through the water ', so the liquid bridge force is also the main reason for adhesion. The first reason is that the adsorption energy is the attraction between objects. The adsorption energy of an object is expressed by Hamaker constant. The larger the Hamaker constant, the higher the adsorption energy of the object and the easier it is to attach. In a composite class composed of different substances, the combination rule of Hamaker constants as shown in the following formula holds. [Number 1] ‘8 12 = / ~ (All A22) 20: Hamaker constant between matter 1 and matter 2

Au: Hamaker constant between matter 1 and matter A22: Hamaker constant between matter 2 and matter 2 Moreover, the adsorption energies of an object are different between a ball-to-ball and a ball-to-plane time. When ball-to-ball, the contact area is smaller than the ball-to-plane, so the adsorption energy is small. 0 Continued pages (If the description page of the invention is inadequate, please note and use the continuation page) 7 发明. Description of the invention __ Continued page In the powder packaging device, the powder and drug contact members form a ball-to-plane state, so the adsorption energy It is large and forms an environment where the powder easily adheres to the medicine contact member. Generally, the object system contacts at 0.4 nanometers, but if the object has surface roughness, the adsorption energy of the object becomes smaller. For example, when a sphere of 10 micrometers is in contact, if the two have a roughness of 0.1 micrometers, the adsorption energy of the object is reduced to 1 / 60,000 compared to when there is no roughness. Therefore, in order to reduce the adsorption energy of the object, it is necessary to use a material with a small Hamaker constant on the surface and give a moderate thickness to reduce the contact area. The second reason is the adsorption caused by static electricity, whether the particles or contact surfaces are electrified or not, the adhesion caused by the contact electrification, and the particles or the contact surface caused by the static electricity. Adhesion caused by contact charging is caused by the effect of the difference in contact potential between the contact objects that causes the charge to move to a stable state. There is no contact potential difference in the same material, so it is difficult to cause adhesion due to contact charging. However, the same material also has some contact potential differences due to different production sites or processing methods. The adhesion stress (Maxwell's stress) Pee caused by contact charging is shown in the following formula. [Number 2]

Pce =-(1/2) ε E2 £: Dielectric constant of the object E: Electric field strength of the object In the above formula, if the electric field E is Vc / z, the following formula is obtained. [Number 3]

Pce = — ε Vc2 / 2z2 13 Continued pages (If the description page of the invention is insufficient, please note and use the continued page) 8 557277 发明 Description of the invention Continued page of the invention

Vc: static capacitance z: contact distance between objects (usually 0.4nm or less) If the ball in a powder packaging device is in contact with a plane, if the foregoing formula is used to integrate the area element ds, the adhesion caused by contact charging Can be expressed in the following formula. [Number 4]

Fce = i Pceds = Pee · SS: Contact area (= π & 2) _ Among them, when a substance as soft as a powder particle comes into contact, if the contact surface is considered to be as large as a rubber ball, it is determined by Hertz theory. In other words, the radius of the contact circle can be expressed by the following formula. [Eq. 5] a = (3Fkd / 8) I'3 k: elastic constant (= (1-V! 2) / E1 + (1-v22) / E2) The adhesion force caused by contact charging increases with particle size. Big and increased. However, in reality, the gravity, centrifugal force, and separation force due to vibration are proportional to the third power of the particle size. Therefore, particles with a smaller particle size are more likely to adhere and are difficult to separate. ~ Adhesion caused by static electricity is caused by the charging of objects. The adhesion increases with the increase of the charged amount, and disappears when the charged electrons are lost. The electrostatic adhesion between similarly charged particles can be expressed by the following formula. [Number 6]

Fe = — πσισ2ά2 / ε 〇0 Continued pages (when the description page of the invention is insufficient, please note and use the continued page) 9 坎, invention description continued page 〇i: surface charge density bu qi / 7lDpi2) Φ: Charge Dpi: Particle size D · Calculated particle pinch ε 〇: Dielectric constant of vacuum Adsorption caused by static electricity is caused by + charge to one charge, and repulsion occurs when the charge potential is the same polarity. In order to minimize this electrostatic-induced adsorption, it is necessary to minimize the potential difference and choose a conductive material with a charged potential that is easy to move. The third reason is that the adsorption caused by the liquid bridge force is a phenomenon in which a film of water is formed on the outside of the powder particles, and the film and the film are adsorbed due to the surface tension of the water. Because the powder used in the powder packaging device has a small amount of water, it usually does not develop to the point of adsorption due to liquid bridge force. However, due to mechanical factors such as compression, sliding, and vibration during the division or transfer of the drug, it is caused by the liquid bridge force. That is, if pressure is applied to the powder, or the powder is vibrated for a long time, the water in the particles of the drug floods out to form a film, and adsorption is caused by the liquid bridge force. In order to suppress the adsorption caused by the liquid bridge force, it is also possible to consider waterproofing the contact surface of the drug contact member. Collecting the above measures for powder adhesion, the following measures can be considered for the adsorption caused by the adsorption energy of the object. (1) The powder contact surface is coated with a substance having a small Hamaker constant. (2) The powder contact surface is selected according to the combination rule of Hamaker constant. (3) Set a moderate roughness on the powder contact surface. For the adsorption caused by static electricity, the following measures can be considered. 0 Continued pages (Please note and use continuation pages when the description page of the invention is insufficient.) 557277 发明, description of the invention continued page (1) Surface treatment of powder contact surface or selection of materials to reduce potential difference. (2) Make the surface hard or roughen the particle diameter of the powder to reduce the contact area. 5 (3) Suppression of charge ' and promotion of charge movement. For the adsorption caused by the liquid bridge force, the following measures can be considered. (1) Improve the waterproof effect by surface treatment of the powder contact surface.

It can be known from the above measures that in order to remove the residual medicine, a large Hamaker constant relationship is formed between the adhered particles and the cleaning material, and the residual medicine is reduced by increasing the weight of the attached medicine. The first invention relates to a pharmaceutical packaging device especially for powders. That is, the present invention is a medicament packaging device, which is used to supply the powder inputted through the input funnel to the dividing device, and the dividing device is used to divide the powder according to the serving size, and the divided medicine is supplied through the packaging funnel Place it in the bag, and then pack the packaging device to pack _ in the bag;

It is characterized in that the medicine packaging device has a cleaning material supply device 'for supplying any one of a series of medicine channels between the aforementioned input funnel and the exit of the aforementioned packaging funnel to the cleaning 收容 contained in the cleaning ㈣㈣; During cleaning, after the cleaning material is supplied to the medicine channel, the medicine channel is cleaned by recovering the powder and cleaning materials remaining in the medicine channel from the medicine channel. Where the full material should be supplied to the aforementioned investment ... Eight, the aforementioned cleaning material supply device m m material is supplied to the aforementioned medicine minus 0 continuation page (when the invention description page is insufficient, please note and use the continuation page) η &, Description of the invention Description of the invention continued page = most parts. Furthermore, the aforementioned packaging device may pack the cleaning materials supplied to the aforementioned medicine channel in at least one packaging bag and recycle them. At this time, it is desirable to have a printing device, such that a part or all of the description packaging bag used for packaging and recycling the aforementioned cleaning materials is printed with the cleaning materials. In the present invention, it is preferable to use a suction-type cleaning device to recover the cleaning materials supplied to the aforementioned medicine passage. For the suction device, a commercially available vacuum cleaner suction port should be arranged in the medicine channel. The exit side of the packaging funnel should have a packaging channel to guide the powder to another packaging bag, and a recovery channel to recover the cleaning materials. When the cleaning materials are recovered, the packaging The channel is switched to the narrated recovery channel. In this case, it is preferable that the recovery channel has a recovery container for recovering the cleaning materials. The cleaning material supply device preferably has a spreading device for spreading the cleaning material toward the wall surface of the medicine channel. The second invention relates to a medicinal packaging device especially used for tablets. That is, the present invention is a medicament packaging device for supplying tablets per serving from a plurality of cassette containers containing tablets according to each type, and collecting the tablets by a collection funnel through a common channel, and The collected tablets are supplied to a packaging device through a packaging funnel, and the tablets are packaged in a packaging bag by the packaging device; characterized in that the drug packaging device has a cleaning material supply device 'for storing in The cleaning materials in the cleaning material container are supplied to any of the series of drug passages from the outlet of the box-type trough to the outlet of the packaging funnel. Continued on the next page (if there is not enough scale, please note and continue the page) 12 557277 The invention is described on the next page of the channel; L ~-When cleaning is needed, after the cleaning material is supplied to the aforementioned medicine channel, the medicine remaining in the medicine channel and the cleaning agent are recovered from the medicine channel. Use material to clean the medicine channel. Among them, granular cleaning materials should be used. In the second invention, the exit side of the packaging funnel preferably has a packaging passage for bowing the tablets to the packaging bag, and a recovery passage for recovering the π cleaning materials, and the cleaning materials At the time of recycling, it is switched from the packaging channel to the aforementioned recycling channel. At this time, the recovery channel is provided with a suction device, and the cleaning material and the residual medicament are simultaneously sucked from the outlet of the packaging funnel and recovered in a recovery container. In addition, it has a separating device for separating the cleaning materials attracted by the suction device from the residual medicine, and the cleaning materials separated by the separation device can be supplied to the medicine channel for circulation again. After the aforementioned 15 cleaning materials are recycled, the cleaning materials separated by the aforementioned separating device are recovered. Embodiment C; j A · Surface treatment of the medicine contact member 1 · Injection funnel ί0 The inject funnel 1 shown in Fig. 1 is formed into an inverted pyramid shape, and is arranged above the vibrating feeder 2 and has a fixed amount of medicine. Storage function. A medicament is stored in the input funnel 1, and if the medicament is sent out by the vibrating feeder 2, a fine powder adheres to the inner wall of the input funnel 1. As shown in Figure 2, if the medicine is aspirin and the funnel i is the original stainless steel 0 continuation page (when it is said that the surface is not enough, the surface is female and female) 13 玖 Description of the invention Description of the invention continued For sheet steel, static electricity will be generated with the vibration of the vibration feeder 2, but because the input funnel 1 or the vibration feeding tank 3 is placed on the ground, the charging caused by static electricity (storage force) is almost almost absent. However, aspirin is a crystal formed by a rectangular parallelepiped of 02mm to 0.8mm. Therefore, the flat part of the crystal is attached to the inner wall of the input funnel 1 in a state of being arranged in a stone-cut and brick-like manner, and it is not caused by slight hitting. Falling strong adhesion. The main reason for this adhesion is the strong adsorption energy generated by face-to-face contact between aspirin and stainless steel input funnel. Since the input funnel 1 is metal, the value of the Hamaker constant is large, and the adsorption energy is also large. In addition, since aspirin is a crystalline body, the increase in the effect of the flat portion and the flat portion of the stainless steel input funnel 1 is also the reason for the increased adhesion. For example, if Polycarbonate is used to make the input funnel 1 and then the same test is performed, the Hamaker constant value of the resin-based material is small, so that the force of aspirin to adhere to the wall is weak and falls by its own weight. In addition, since the resin-based material is an insulating material, the charged potential of vibration cannot be transmitted to ground. However, even though the charging potential was higher than that of the stainless steel charging funnel 1, no adhesion due to aspirin charging was observed. In this way, it is determined that the main reason why aspirin adheres to the stainless steel input funnel 1 is the adsorption energy of the object. When the funnel 1 is put into resin, the biggest problem is the countermeasure against static electricity (Coulomb force). The medicine packaging device needs to be able to support most kinds of medicines. By using a material in which a conductive material has been incorporated into a resin as the material put into the funnel 1, it is possible to improve the electrostatic adhesion of the medicine to a certain extent. However, if the contact potential between the funnel 1 and the medicine is high, the effect of the resin-based material on the fine powder medicine will be very thin. Continued page (when the description sheet of the invention is not enough, please note the fiber page) 14 发明. Description of the invention The description of the invention is weak. The fine powder medicine cannot be made to fall because of its light weight. The energy that can cause the fine powder of such agents to fall requires a force of 10,000 times its particle size weight when the particle size is 10 μηι, and the force used to separate it is proportional to the third power of the particle size, so The smaller the particle size, the more difficult it is to drop it with a slight stroke. In addition, the noise becomes more intense. That is, even if you want to knock down fine powder drugs by knocking, you also need to choose materials with small Hamaker constant values and set the conditions for reducing the contact potential difference with various drugs, and you can tap them to drop them and other general countermeasures. After reviewing the inventor 4, it was learned that the use of the composite materials described below on the surface of the funnel 丨 can suppress the adsorption energy of objects and is a highly effective treatment for electrostatic countermeasures (Coulomb force). < Composite material 1 > The composite material used for the surface of the funnel 1 丨 is formed by forming the funnel j from aluminum, forming an oxide film on the surface, and then impregnating the resin with cracks or porous interiors generated on the oxide film. And those who cover the surface. As shown in FIG. 4, the surface treatment is to form an alumite layer 5 on the aluminum substrate 4 with a film thickness of about 5 μm to 100 μm, and to impregnate the polytetrafluoroethylene resin 7 into the film formation process. The pores 6 of the porous portion generated in the Zn or SiO 2 are heated to 300 as shown in FIG. 5. 〇 ~ 400 ° C It is then quenched, etc., so that cracks 8 are formed on the surface of the aluminum oxide layer 5, and the cracks and the pores 6 in the porous portion are impregnated with resin. The aluminum substrate 4 is limited to an aluminum material or an aluminum alloy material, and the die-casting material tends to have a poor film formation state. The surface after this treatment is alumina and fluorinated tree. (Continued if the description page is not enough, please note and use the continued page) 15 Description page of the invention, such as Hamaker 发明, Disperse composite film of the description of fat, and Has its own excellent characteristics. The values of the constants are 15.5 for alumina and 3.2 to 12.3 for resin, which are lower than the stainless steel (Fe / Ni alloy) 49.2. The forming of the aluminum base material 4 can also consider the forming of sheet metal welding, but the material of the welded part will change, and if the surface treatment is performed, color spots will be generated, so the product quality is not ideal. Therefore, forming by scraper extrusion processing, pressure deep drawing processing, dewaxing, die casting, casting, etc. is ideal for maintaining quality, but dewaxing, die casting, and casting are as described above, and the aluminum oxide skins they produce are The quality is not ideal. A preferred method for forming the aluminum substrate 4 is, for example, a blade pressing process performed by a blade pressing roller 9 as shown in FIG. 6 (a) into a cone shape, as shown in FIG. 6 (b). A pyramid was formed by press working, and the excess portion was cut out as shown in Fig. 6 (c) while leaving a shank portion 10, and then the shank portion 10 was f-curved as shown in Fig. 6 (d). This forming method does not require the use of abrasives and has good forming efficiency, thereby reducing costs. As mentioned above, in order to inhibit the adhesion of the drug to a certain degree of surface roughness, if the surface roughness is greater than 12 μm, the grooves will obviously retain the drug, so the surface rough seam: the degree should be less than 12 μm. The formed funnel has an electrode for applying an electric field to the film-forming liquid. The electrode is fixed at a position that does not prevent the powder from being poured, or is supported on the position by a clamp. Those with fixed electrodes can also be cut off after surface treatment, so the quality is improved. When supported by a clamp, the clamp part cannot be completely surface-treated, so the part is significantly whiter than the dark-colored surface treatment part, and the powder is easy to adhere. 0 Continued pages (when the invention page is not enough, remember the female page) 16 玖, description of the invention, description of the invention, continuation page ... Difficult ........ The funnel is formed into a wide angled cone and a narrow angled cone below. A support part ii for mounting the funnel on the device is welded on the outer periphery of the funnel. Now, the supporting part 11 can also be fixed by adhesive instead of welding. If the adhesive is used without peeling during the treatment, the surface treatment process is successfully completed, and if necessary, it is appropriate to carry out the procedure of the aforementioned Figure 6 before attaching parts. Here we explain the basic process of the aluminum oxide treatment according to the flow chart in Figure 7. When receiving the aluminum oxide treatment, first of all, check whether the material of the treatment material is no problem. For example, whether there is adhesion of tape or coating, the selection of copper alloy materials with different film forming processing methods, the presence or absence of scars, etc., must be confirmed. The best processing state is installed on the electrode frame used to energize the product. After the attachment frame is completed, the processing material is immersed in the degreasing treatment tank and degreased. The types of degreasing can be roughly divided into non-etching degreasing, degreasing and electrolytic degreasing. Different types of degreasing treatment liquids are different, but mainly use alkaline liquids, such as sodium hydroxide or neutral or organic cleaning agents. And use fluoric acid or nitric acid, hydrochloric acid as acidic degreasing liquid. The degreasing time varies with the treatment solution or method, but degreasing and degreasing is about 丨 ~ 3 minutes. After the degreasing is completed, the treated material is immersed in a water washing tank and the degreasing solution is washed. The next step is to remove the oxide film (thin natural oxygen film) that is naturally formed on the surface of the oxide skin aluminum. The remaining treatment can be roughly divided into electrolytic polishing and chemical polishing. Electrolytic grinding method is to immerse the treated material. 0 Continued pages (invention page is not enough to make scales, remember the female page) 17 玖 Description of the invention Description of the invention continued page Collapsed in sulfuric acid or phosphoric acid liquid for electrolytic grinding. For chemical grinding, phosphoric acid or nitric acid, acetic acid, etc. are used. When phosphoric acid is used, the treatment material is immersed in the treatment liquid at a temperature of 80 to 100 t: 2 for 6 to 120 seconds, and then washed in a water washing tank. After that, depending on the type of etching treatment, a neutralization process and a water washing process are required. After waiting for the salamander treatment procedure, the oxygen skin aluminum treatment procedure is performed. Depending on the type of processing solution, the oxygen skin film has a different growth rate or porous thickness, and the color of the film changes accordingly. For the formation of hard oxide skin aluminum, use an oxalic acid or sulfuric acid based bath. When an oxalic acid-based bath is used, a film is formed by passing a current of 100A / m2 to 2000A / m2 for 60 minutes or more. At this time, in order to reduce the density of the porous body, it is necessary to keep the bath temperature at 5 to 10 t. If the temperature of the bath is too high, the porosity becomes coarse and the surface hardness decreases, and a hard oxygen skin name cannot be formed. As the film grows, the surface portion is insulated and the current value decreases, so the condition of the film can be confirmed from the current value. After the oxygen skin aluminum film is completed, take it out of the bath and wash it in the water washing tank. If it is not sufficiently cleaned at this time, a kind of stain called liquid spot will be generated. The person-permeation treatment is permissible, and anyone who can permeate the porous part generated on the oxygen skin aluminum film may do so, but the color permeation which is not effective for the non-adhesion of the agent of the present invention is not described. For example, when saturated with PTFE, as shown in Fig. 10, the container is filled with a solvent that has been diluted with a liquid fluorine lubricating solution through a fluorinated solvent, etc., and immersed in the solvent containing H 12 Further, the container U is sunk in the water of the ultrasonic bath 13 and placed on the mesh table 15 on the vibration element 14. At this time, in order to promote the button, the ultrasonic generating device M

0 Continued pages (turning pages are not enough to make scales, please note the fiber page) U Mei, description of the invention Description of the invention continued page Vibration. Process the material afterwards! Wash with water, and blow steam as sealing treatment if necessary. After washing with hot water, dry it and remove the frame for inspection. The same steps are taken when metal ions / permeability are used, but when silver ions are impregnated, the treatment material is set on the cathode side and a silver electrode is set on the anode side. The above is a description of the impregnation procedure for fluorine-based and metal-based resins, but impregnation with acrylic resins, epoxy resins, or the like is also acceptable. In this way, the surface of the treated material made of PTFE and oxygen-permeable leather is as shown in Fig. 8. Oxygen aluminum Al203 and PTFE resin are aligned. When the force of the drug particle adhesion 10 is high in the contact potential difference, the relationship between oxygen skin aluminum > PTFE is established, and when the effect of electrostatic (Coulomb force) is high, the relationship between oxygen skin aluminum < PTFE is established . Among them, when the cohesive force of the drug is large, the value of the particle diameter dx generated due to the cohesion becomes large ', so that it is easily peeled from the surface by a slight knock or vibration. In contrast to this, when the cohesive force of the drug is small, the diameter d of the drug particle has a large effect on the peeling effect of knocking or vibration. Of course, if the diameter d of the drug particle is small, the knocking or vibration force required for peeling is similar to that of the drug particle. The third power of the diameter d is proportional, so it is difficult to peel off. If the influence of the contact potential difference is considered to be high, the adhesion of the pharmaceutical particles will form oxygen skin aluminum> gt? Because of the relationship between £, only the agents attached to the PTFE field with low contact resistance have a peeling effect on a certain knocking force, while the agents attached to the oxygen-coated aluminum field with high contact resistance remain. That is, a drug that is highly likely to form a residual drug is a drug that adheres to the field of oxygen aluminum. Also, "When the cohesive force of the drug is large, the value of the particle diameter dx caused by the cohesion is 0. Continued pages (if the reprint page is not used, please note and make the dirty page) 19 玖, description of the invention, description of the continuation page becomes larger ' Therefore, the peeling effect on a certain vibration is of course increased. On the other hand, the medicaments around the PTFE field (medicines attached to the aluminum skin field) are also condensed. If the peeling effect is exceeded here, the medicine attached to the skin of aluminum skin will also be peeled off due to cohesive force, so the residual drug dose is more reduced than the aforementioned conditions. This result has a slight effect on the adhesion in the field of oxygen peel aluminum with weak peeling effect. Then, when the influence of static electricity (Coulomb force) is considered to be high, the aforementioned peeling effect is reversed. Oxygen aluminum is difficult to be affected by static electricity. Therefore, the medicine attached to the PTFE field which is easily affected by static electricity will remain. On the other hand, the medicine attached to the oxygen aluminum field will peel off with certain vibration. Therefore, residual chemicals are easily generated in the field of PTFE. At this time, it is also the same as above. If the cohesive force of the agent is large, the agent attached to the skin of aluminum oxide is likely to have a peeling effect with a certain vibration. Therefore, the agent attached to the pTFE field is also involved in the peeling. As a result, the overall residual drug dose was reduced. Oxygen aluminum has been treated with metal ions. When the effect of contact potential difference is high and the effect of static electricity (Coulomb force) is high, the two surface materials interact and reduce residues for various agents as a whole. Dosage: In this way, the funnel that has been impregnated with fluororesin or metal ions on the skin aluminum can easily peel off the temporarily attached medicine by applying external stress. The aforementioned external stress means that the funnel is struck or vibrated, or sucked by a cleaner. In addition, the material impregnated with oxygen-coated aluminum can be described in detail in the composite material 2 described later, but metal materials such as copper, gold, silver, nickel, tin, and titanium may also be used. In particular, silver or titanium oxide is particularly effective as a countermeasure against the adhesion of the agent. C When the invention description page is insufficient, please note and make the title page) 202, the description of the invention description continued page These penetrating materials are compared with the effect of static electricity (Coulomb force) when the effect of the contact potential difference is high as mentioned above. When it is high, the two surface materials interact, and the residual drug dose can be reduced overall for a variety of agents. When performing the aforementioned surface treatment, care must be taken to place the electrode at a location unrelated to the adhesion of the agent. In addition, the impregnation treatment is applicable to ordinary oxygen-coated aluminum and rigid oxygen-coated aluminum. 〇In addition to PTFE and PFA, polyethylene can be used as the impregnating resin, but PTFE is generally used. There are various methods of impregnation depending on the resin material. When the resin is saturated, the sealing process is performed to prevent the resin from falling off from the holes formed on the substrate, which can stabilize the quality for a long time and achieve the desired effect. The non-adhesion of pharmaceutical powder is improved by reducing the potential difference between the powder and the surface through the compound surface of the alumina A1203 base surface and the resin impregnated in the holes of the base surface, such as the fluorine-based resin. . Basically, the non-adhesion characteristic of powders lies in whether the contact potential difference between the composite surface formed by the alumina Al2O3 base surface and the resin surface with respect to the powder is large or small. Non-fluorine resin directly affects the non-adhesion properties of the powder. If the ratio of the fluororesin surface to the alumina Al203 base surface is high, it will be greatly affected by the contact potential difference caused by the contact with fluorine, so the non-adhesion characteristics of the powder will deteriorate. Generally, when there is a single material, the metal has a tendency to increase the contact potential difference. However, the contact potential difference is also small, and the contact potential difference can be further reduced by oxidation. 0 Continued pages (Please note and use continuation pages when the invention description page is not enough.) 21 玖 Description of invention invention continued page [Table 1] Contact potential difference oxide-based materials 6 to 15 Metal 15 to 50 Resin 3.2 to 12.3 Generally speaking, the contact potential difference of the resin is low, but most of them have high insulation properties. On the other hand, the powder is charged during repeated contact and detachment, and the powder adheres due to this effect. The base surface of the oxide chain ai2o3 is an insulator, but the middle layer below the surface is made of Ming or Shao alloy, which makes it highly conductive. Therefore, the oxygen film treatment with a film thickness of about 50 μηι will not cause the powder to adhere due to charging. The static electricity generated between the resin and the resin that has been soaked will not play the role of large electrostatic capacitance because the resin particles are very small. Therefore, even if it is temporarily charged, because the film has electrons moving, the surface treated with the resin-impregnated aluminum skin will not carry high static electricity. < Composite material 2 > Next, the composite material 2 used on the surface of the funnel 1 is one which uses titanium oxide or silver ions as a metal-impregnating material for demonstrating the non-adhesion effect of the powder, and impregnates the surface of oxygen-coated aluminum. In order to impregnate silver ions during the impregnation process, silver was used as the anode plate and placed in a processing tank, and the current was used to dissolve the silver in the impregnation treatment solution to form silver ions, and the solution was placed in an oxygen-coated aluminum alloy. By applying the cathode voltage to the treated material, the ionized silver can be impregnated into the holes generated on the aluminum oxide layer. The surface impregnated with the silver ion is greatly affected by the quality of the non-adhesive properties of the powder due to the influence of the material. Oxygen aluminum is used in hard oxygen skins. 0 Continued pages (If the description pages are not enough, please note and use the continuation pages) 22 发明 Description of the invention Description of the invention Continued pages The name of the processor and the holes formed on the surface are denser. 1 — ~ The powder with better non-adhesion is the one that has been impregnated with A1100—〇 material (annealed material) and A2017—〇 material (annealed material), and has the same effect as the aforementioned impregnation with PTFE resin. The same A2017 material is heat-treated T5, T6 (slow quenching artificial aging hardening at South temperature, artificial aging hardening after solution treatment) or F (the original manufacturing method will worsen the non-adhesion characteristics. In addition, A5052—〇 The non-adhesion characteristics of the material or 6061-10 material are also not good. This is largely affected by the alloy secondary material. For example, when using A2017 material, during the aluminum oxide treatment, the Cu metal edge is ionized to form an oxygen scale. Shao's surface state is also easy to rough, and the number of holes, density, and size change. If it is soaked with silver, the distribution ratio of silver on the widely distributed surface will increase or decrease accordingly. If the proportion of silver increases, the surface contacts The potential difference is increased, and the powder adheres to it. Those who have been soaked in titanium oxide have a low contact potential difference because of the original titanium oxide, so it is difficult to be affected by the properties of the material. In this way, it is known that composite materials with materials that have a low contact potential difference are already used. It is very effective in improving the non-adhesion properties of the two powders. In addition, those who are soaked in silver ions, because the electrical conductivity of the aluminum skin surface is improved, resulting in a lower electrostatic charge potential, The adhesion caused by static electricity is also improved, so the non-adhesion properties of the powder are improved. After the titanium oxide or silver ions are soaked, the sealing process is performed after the soaking to prevent it from falling off from the holes formed on the base surface. In this way, the quality can also be stable for a long time and achieve the desired effect. The surface of the composite material 1 or composite material 2 described above is continued on the next page (if the description page of the invention is insufficient, please note and use the continued page) 23发明 Description of the invention In the description of the invention, the continuation sheet can also be used for the packaging funnel 18 of the packaging part 17 shown in Fig. 9. The packaging funnel 18 and the heating roller 19 of the packaging part 17 dry the air θ caused by heating, and the valley is easy to generate static electricity. And it is structured to temporarily store the powder in the packaging funnel 18 and supply it to the packaging portion 17 at the same time. Therefore, the medicine with fine particles is easily attached to the inside of the packaging funnel + 18. However, by applying the packaging funnel 18 With the aforementioned surface treatment, the amount of the fine particles of the medicine attached to the inside of the packaging funnel 18 will be reduced. The fine medicine temporarily remains in the packaging funnel 18, and is knocked by a percussion device in the prescription room. Almost all the medicines can be knocked off easily. To improve the non-adhesion of the medicine in the packaging funnel 18, the ultrasonic vibration element can be fixed on the packaging funnel 18 and vibrated. Although this method is very effective, However, if the material is aluminum, there is a problem that the vibration resonance efficiency of the ultrasonic vibration element is halved. Therefore, as shown in FIG. 9 (a), a stainless steel plate 20 is adhered to the outer side of the packaging funnel 18, and the vibration effect is diffused to the packaging. If the entire funnel 18 is used, the vibration resonance efficiency of the ultrasonic vibration element 21 will return to a certain value. However, the vibration resonance efficiency of the ultrasonic vibration το 21 will be lower than that when it is directly attached to the stainless steel funnel. Therefore, if you use After the alumina ceramics are formed and fired, a fluorine-impregnated person is used as the packaging funnel 18, and an ultrasonic vibration element 21 is directly installed on the outer side surface thereof. It is expected that a packaging funnel with high cost but good characteristics can be formed. Since the aforementioned packaging funnel 18 is made of metal or ceramic, it does not melt or deform due to the heat near the heating drum 19, and does not burn like a resin molded product. However, if the temperature of the packaging funnel 18 rises to about 60 ° C due to the heat of the heating roller 13, the powder in the packaging funnel 18 will be accumulated or slipped off. And make the title page) 24. Description of the invention Description of the invention The continuation of the page temperature rises and it is easy to adhere to the inner surface of the packaging funnel 18. In particular, Digosin, Bicillin, Fibano (transliteration: 7 workers and 8 years, one barbiturate), Mejikang (transliteration: Xixi: ^^), etc. Easy to attach. Therefore, as shown in FIG. 9 (b), a heat pipe 22 may be arranged on the outside of the packaging funnel 18, and the heat absorbing side may be formed on the lower part of the packaging funnel 18 and the heat radiating side may be formed on the packaging funnel 18 A heat sink 23 is installed on the upper side to cool the packaging funnel 18. Or, as shown in FIG. 9 (c), a fan 24 is installed near the packaging funnel is and then the air is sent along the heat sink 25 provided on the packaging funnel 18 to cool the packaging funnel 18. Basically, the oxide-based material is exposed to a difference in contact potential. The value becomes smaller, so it is suitable to use aluminum, magnesium, and titanium, which easily form metal oxides. If processing or material properties are taken into consideration, aluminum can be expected to prevent the attachment of chemicals, and the production cost can be controlled by deep drawing of the funnel. In addition, blade extrusion processing can also be expected to suppress production costs. 2_Vibration feeding tank 3—Generally, the surface of stainless steel is electrolytically polished to make the surface frosted glass. In these tanks 3, it was confirmed that calcium lactate remained on the surface of the tank 3 in a net shape as shown in the nth figure. If such a medicament residue situation occurs, the amount of medicament taken by the patient will be reduced compared to the actual dosage. These phenomena are referred to as the recovery rate of the packaging device. In general, the recovery rate of powder medicine is the worst, but occasionally particles equal to the case of jumping up during distribution, which reduces the recovery rate. 0 Continued pages (Insufficient to turn pages, please apply for the title page) 25 557277 玖, description of the invention Description of the invention continued pages to solve the phenomenon of the aforementioned drugs remaining in the groove 3 in the form of a net, as long as the non- Adhesive treatment is sufficient, but there are cases where non-adhesiveness deteriorates relative to the surface condition. For example. In other words, during coating, pTFE resin 5 is mixed with the coating agent, and powders such as pottery are mixed to strengthen the surface hardness. After being treated with such a coating agent, as shown in FIG. 13, the surface irregularities generated by spraying are mixed with fine powder particles and are thinly adhered to the whole, thereby deteriorating non-adhesion characteristics. In addition, if a large amount of PTFE resin is mixed, it will be charged by the influence of static electricity and the vibration of the vibration feeder, and the powder will adhere to the whole body thinly. The mixing rate of PTFE resin should be in the range of 15% ~ 3 ()%. If the coating film thickness exceeds 30 μm, it will be easily affected by static electricity. This is because even if the substrate is a metal, it is difficult for the charged electrons on the coated surface to move through the substrate. In order to successfully complete the state of the coated surface, screen printing should be used for coating, but as long as the viscosity of the coating material can be reduced, spraying 15 for coating is also very effective, but it should be noted that the film thickness should not be too large. thick. For example, a non-ferrous steel sheet in which a fluorine resin is added to a print coater. These materials are usually used as surface crystallization plates for gas stoves and the like. However, if this material is used to make a tank, the conventional phenomenon of calcium lactate remaining on the surface of the tank as a reticulum can be eliminated, and the cleanliness is good. 20 The structure of the steel plate is shown in FIG. 12. An aluminum-zinc alloy plating layer 32 is applied to the surface of the steel plate 31, and a chemical conversion coating film 33 is applied thereon. Primer 34 is used for screen printing to form a fluororesin coating layer 35, which is baked at a temperature of about 200 ° C, while the inside is screen printed with an inexpensive polyester resin to form a polyester resin. 0Continued page (When the description page of the invention is insufficient, please note and use the continuation page) 26

发明, description of the invention rnmrnmmM coating 36. In addition, since such a non-ferrous steel sheet having a fluororesin cannot be processed by welding or the like, when it is used on a groove, structural connection with the vibrating element or rust on the cut surface are problems. Therefore, if a groove is formed by deep drawing, and as shown in FIG. 14, the crimping portion 37 is formed by repeatedly bending the general cutting portion so that the cut surface does not protrude from the surface, and the bending processing will be used to The structurally connected ear portions 38 of the vibration element can be formed to solve these problems. The surface treatment of the tank 3 is also considered to be a treatment in which the fluororesin is impregnated with oxygen skin aluminum. Such a penetrating treatment can also solve the phenomenon of a net-shaped residual drug on the surface of the tank 3, but sometimes the phenomenon of a net-shaped residual drug may still occur due to vibration or the dose of the drug. But it can be easily removed with a cleaner, etc. Why does the phenomenon of reticular residues of the drug occur due to vibration or dose of the drug during the treatment with the fluoride tree permeation time? The present inventors believe that the reason is the relationship of surface smoothness, but the current cause is unknown. . When the fluororesin is impregnated with oxygen skin aluminum, countless fine grooves with a width of about 2 μm to 5 μm and a depth of about 1 μm to 3 μm exist. In addition, with the resonance of the tank 3, a strong and weak region of the vibration will be generated on the surface of the tank 3. The micro lactic acid contained in the milk S5 # 5 on the tank 3 is liquefied due to vibration and floats on the surface of the lactic acid powder particles. Form a film. From this situation, it is envisaged that the numerous grooves on the aforementioned surface have an increased effect on the calcium lactate compared to the flat surface, and that calcium lactate adheres or does not adhere to the treated surface due to vibration or a dose of the drug. In this way, the countless grooves existing on the surface of the groove 3 will worsen the non-adhesion, but after cleaning with a cleaner, the medicine remaining in a net shape can be easily continued on the next page. Please note the female page) 27 557277 玖, description of the invention Description of the invention Continuation page remover by suction. Therefore, as shown in Fig. 15, by freely moving the surface of the tank cleaner of the cleaning device and the surface of the tank 39, the multiplication effect of the surface treatment can prevent pollution. In addition, if the slot cleaner nozzle 39 is moved to the lens portion of the drop 5 sensor 39a, it is possible to solve the problem that conventionally, fine powder adhered to the drop sensor 39a and fell into an undetectable state. The problem will move. In order to operate the tank cleaner nozzle 39, the operation steps shown in Fig. 16 are required. 10 First, after the feeding operation is completely completed, the input funnel 1 is temporarily withdrawn from the tank 3; the cleaner of the π 溱 device starts to attract, and the tank cleaner nozzle 39 is lowered and contacts the surface of the tank 3, and the tank cleaner nozzle 39 The contact part can be a soft object such as a CR sponge or a brush. Second, the slot cleaner nozzle moves on the surface of the slot, and if the sensor not shown in the figure has reached the end, 15 moves directly in the opposite direction and returns, followed by ^ 敎 as the front end of the slot, the slot The cleaner nozzle 39 is directly cleaned until the lens of the sensor is dropped, and returns to the fixed position. The reason for the cleaning operation from the front end of the tank to the lens of the sensor is to prevent the medicine adhered to the sponge or brush from remaining on the tank 3 because it cannot be attracted. If it is detected that the slot cleaner suction nozzle 39 is in a fixed position, and the shape of the tank cleaner is close to its fixed position, the pouring funnel 丨 is returned to the fixed position. After detecting that the slot cleaner nozzle 39 and the pouring funnel i are in a fixed position, a signal for accepting the next prescription is issued. Based on this signal, it can be indicated that prescription-processing can be performed 'or' if the medicine is placed in the standby loading device and waited, it can be automatically filled. 280 Continued pages (When the description page of the invention is not enough, please note and use it. Continued 557277 玖, the description of the invention description continued page The non-ferrous steel sheet containing fluororesin has very good surface characteristics, and it is printed with a mask (mask printing) Coating and controlling the film thickness is about 20μηι, so it has high smoothness, and the distribution of PTFE exposed on the surface is constant. Therefore, the strong vibration area in the strong vibration area of the surface of the groove 3 generated by the resonance of the groove 3 is non-adherent. The property is also guaranteed, and there is no case where lactic acid # 5 is left in a net shape. When a non-ferrous steel sheet containing fluororesin is used on the surface of the tank 3, the forming method is limited to deep drawing and pressing. For small batch supply, the mold The cost of such materials is increasing, which does not meet the needs of the actual surface. Therefore, corresponding to these small batches of treatment, the fluororesin can be mixed into the coating material with low viscosity at about 15% of the amount dispersed on the surface and sprayed. Attach about 20μηι, and burn at 220 ° C. By doing so, a surface with non-adhesive properties of fluororesin is completed, and the same non-ferrous residue as the aforementioned non-ferrous steel sheet with fluororesin is left in the form of a mesh. In addition, the characteristics of the fluororesin coating material are greatly affected by the conditions of the coating material or auxiliary materials to protect the surface hardness, etc., but it is basically appropriate to make the surface smoothness and the surface distribution ratio of non-adhesive characteristic materials, The static electricity is balanced. 3. The pull-out device is shown in Figure 18. The pull-out device 40 is a rubber disk 41 for blocking the powder accumulated on the dividing disc and turning it into one place. The powdered powder is transferred to the dial rubber 42 of the packaging section 17 (refer to FIG. 9), and a partition rubber 43 for guiding the dialed medicine to the next field without spilling it. . 0 Continued pages (Notes on the use of the invention description page, please note and use the continuation page) 29 玖, description of the invention description continued page These parts are used in the conventional stainless steel burned with silicone rubber, then there is powder The problem of adhesion to non-recorded steel parts. Therefore, in order to remove the chemicals attached to stainless steel or silicone rubber parts, it is removed with a rubber spatula or brush, but the effect is not very good, and a pharmacist must manually clean it with a cleaner. hair As shown in FIG. 17, the rubber disc 41 is composed of two perforated circular plates 44 and 45 formed of aluminum and a ring-shaped silicone rubber 46. The structure of the rubber disc 41 is formed on one circular plate 44 The ring-shaped protrusion 47 on the periphery of the hole 44a is pressed into the hole 45a of the other circular plate 45, and is held between the burnt attachment surfaces 44b and 45b of the outer periphery of the two circular plates 44 and 45 in a conical shape. 46. In the past, there was an excess amount of scorch for setting the scorch strength of Hoshiishi rubber. However, if the exposed area of the silicone rubber is large, the adhesion of the medicament also increases. Therefore, the present invention only exposes the width and diameter of the suji rubber 46. Consumption in the direction. Further, the surfaces of the two circular plates 44 and 45 made of aluminum material were treated with oxygen-coated aluminum, and the oxygen-coated layer was impregnated with polytetrafluoroethylene. After the surface treatment is performed, the adhesion strength of the medicine is reduced, so as shown in FIG. 18, the adhered medicine can be easily removed by simply bringing the nozzle 48 of the β device closer. That is, a cleaner nozzle 48 is provided at the origin position of the pull-out device, and the medicine on the surface of the dial rubber 42 and the partition rubber 43 can be automatically cleaned after the pull-out process is completed. The reason for clearing the 4 Is suction nozzle 48 again is that it is very effective for larger particles by knocking it down, but it is completely ineffective for the smoke-like powder particles generated during the operation of the pull-out device 40, and there is a drug drop. Deal with the problem later. After the pull-out device 40 approaches the cleaner suction nozzle 48, the cleaner suction nozzle 48pa attracts' while the pull-out device 40 rotates. Whenever the dial rubber 42 approaches the _ ^ stomach C invention _ page is not enough to use 'please note and continue the next page) 30 557277 Description of the invention continued page 玖, invention description The suction mouth of the cleaner suction nozzle 48 leaves, After repeated approach, the wheel portion of the dial-out device 40 can be skipped for cleaning, and the ideal cleaning effect can be achieved. In addition, in order to improve the cleaning effect, if a brush 49 is provided near the cleaner nozzle 48, the cleaning effect can be improved. The brush 49 may be a planting pair of acrylic fiber or the like, or a CR sponge may be used. In terms of preventing foreign matter from entering, it is preferable that the cleaning device such as the brush 49 is located at a position separated from the upper surface of the dividing disc. In the present invention, a surface treatment in which aluminum is impregnated with a fluororesin is used. However, if a person is mixed with a fluororesin and a paint on the surface of a steel plate to perform mask printing according to the 10th condition, and the surface breakage is improved, the contact potential difference between the agent and the agent changes Anyone is small. 4 · ν trough discs The V trough discs are made of stainless steel. However, because the medicines adhere to the inside of the trough, many medicines cannot be recovered in the packaging process. In order to improve the yield of this round, a small scraping agent is used to scrape the attached small medicine onto the dividing disc. In addition, the outer ring will hurt the inner disk during the opening and closing operation. Therefore, the problem of increasing the amount of adherence of the drug after long-term use will also arise. Therefore, as shown in Fig. 19, the inner ring 51 of the V-groove disc 50 is made of an ingot alloy A5052 with a thickness of 3mm. After being treated with hard oxygen skin, the non-adhesiveness of the agent is improved by 20-field penetration treatment. In addition, the outer ring 52 of the V-groove disc 50 is made of an alloy A5052 with a thickness of 1 mm, and is treated with fluorene or ordinary oxygen, and then subjected to fluorine impregnation. Other forming processes include doctor blade extrusion or pressure processing. * This is to process the v-groove disc, then open and close the outer ring 52 (continued on the next page) , Remove the scraper. Explanation of the invention / continued pages, the recovery rate is improved, and the non-adhesive treatment of the inner ring 51 of the 5G disc 5G is not required. It is best to perform the fluorine impregnation treatment after the better oxygen treatment. Compared with the gas recording eutectoid power ore, longitudinally, it is also more favorable in terms of adhesion or surface hardness. The surface of the Rutton eutectoid power ore is compared with those treated by hard oxygen skin and fluorine impregnation. , It shows that the contact potential difference is high, and the impact caused by the opening and closing action of the V-groove disc 50 cannot be easily knocked off. In addition, the non-adhesive treatment of coatings cannot determine the hardness of the silk surface, so it is not suitable for the non-adhesive treatment of the V-groove disc 50. In addition, the reason why the aluminum alloy material of the V-groove disc 50 uses the A5052 material is that the hardness of the hard oxide skin aluminum can reach a very hard level. The outer ring 52 of the V-groove disc 50 can also be treated with fluorine impregnation after being treated with hard oxygen-coated aluminum. However, after repeated impact contact between hard materials, both sides will be worn away. 52 should be treated with ordinary oxygen Pi Shao for fluorine impregnation treatment, so that the contact of the outer ring 52 wears round. In addition, the inner ring 51 and the outer ring 52 of the V-groove disc 50 are usually different in color because of the different treatments of aluminum oxide. However, if A5G52 is used, the color tone will be silver-colored, regardless of whether or not the oxygen treatment is different. For example, using A6063 material, the inner ring 51 of the V-groove disc 50 is formed in a pale yellow color, while the outer ring 52 is silver. In order to suppress the chromatic aberration, the thickness of the aluminum oxide film of the v groove disc 50 inner ring 5 J can be formed to 20 μm to 30 μm to control the sense of inconsistency, but the difference in hue can still be easily identified. The one shown in FIG. 20 is the cleaner 53 of the V-groove disc 50. As the 190th continuation page (notice and use the continuation page when the description page of the invention is insufficient) 32 玖, the continuation page of the description of the invention, the V-groove disc 50 and the dividing circle arranged at the lower part The rotation axis of the disc 54 is dislocated from each other and the medicine is dispensed in the V-groove disc 5 (). After the dispensing is completed, the rotation axis of the V-groove disc 50 and the rotation axis of the split disc 54 are moved to the same core. At the position, the bottom of the V-groove disc 5 () is opened, so that the medicament dispensed falls on the dividing disc 54. After the medicine is transferred, the V-groove disc 50 returns to the dispensing position for the next prescription. Here, the V-groove duct 56 is rotated by the motor 55, and the CR sponge 56a is brought into contact with the V-groove disc 50. At the same time, the skirt nozzle 59 is rotated by the motor 55 via the drive transmission belt 57 and the skirt nozzle rotation gear 58, so that the CR sponge 59a contacts the edge of the inner ring 51 of the V-groove disc 50. In this state, an unillustrated vacuum device is operated, and the V-groove disc 50 is rotated to clean the V-groove disc 50. After completion, the V-channel duct 56 and the skirt nozzle 59 return to their original positions. In this way, after the V-groove disc 50 is treated with aluminized aluminum and then subjected to a fluorine impregnation treatment, the cleaning performance can also be improved, so that the drug residue does not exceed that in the past, and contamination can be prevented. 5. As shown in FIG. 21, the V tank is to spread the medicine on the tank 60 and spread it evenly on the surface, and open the bottom of the V tank 60 so that the medicine falls on the divided container 70 below. The packaging funnel 18 applies the non-adhesive treatment to the device in which the medicine in the divided container 70 falls into the packaging unit, and the device is packaged one by one. In a state where the 'V-tank is treated with hard oxygen but with no significant difference in the non-adhesion properties of the drug, the fine powder drug is still attached to the surface. In this way, the thin remaining medicine on the surface is cleaned by the cleaner. 0 Continued pages (When the description page of the invention is insufficient, please note and use the continued page) The rate is bound to deteriorate. Therefore, the present invention performs a fluorine impregnation treatment after the V-groove 60 is treated with hard aluminum oxide. However, when the bottom of the V-groove 60 is opened, the medicine does not completely fall, and some fine powder remains on the surface. However, its cleanliness is greatly improved ', and only a small amount of medicine can be removed by only bringing the nozzle close. The reason why the aforementioned surface treatment was applied to the V tank 60 but the medicine could not be completely dropped is that the opening and closing operation of the ¥ tank 60 is performed quietly, and no vibration occurs during this opening and closing operation. Therefore, as shown in FIG. 21, the V-groove 60 is supported by the resonance spring material 62 by the support member 61, and is hit with a solenoid (solo_id) or the like during the opening and closing operation. As a result, the thinly adhered medicament on the surface is more likely to fall due to the impact force. That is, such a surface treatment is to improve the non-adhesion of the surface, and then increase the effect by imparting vibration. It is not possible to improve the non-adhesion of the medicament only by the surface treatment. The mechanism for vibrating the V-groove 60 can form a plurality of grooves 65 on the support plate 64 of the front plate 63 before the v-groove 60, and an elastic piece 66 can be installed in the groove 60 to properly fix the portion to provide the groove 65. The protrusion 66a of the front end portion contacts the aforementioned groove 65, so that the V groove 60 is vibrated in sequence when the protrusion 6 crosses the groove in sequence when the V groove 60 is opened or closed, or it may be struck by a solenoid tapping device. The V-groove 60 is vibrated by an ultrasonic vibration element. At this time, in order to make the vibration work effectively for a long time, the equivalent effect can be achieved by supporting the V-groove 60 with a leaf spring or the like. Furthermore, the attached medicine can be attracted by the dust collecting duct 67. Since the surface treatment of the V-groove 60 does not require surface hardness, vertical surface treatment is not a problem. However, when vibration is not imparted, the effect is 0. Continued on the page. (Use continuation page) 24 24, description of the invention Description of the invention Continuation pages should not be expected too much. In addition to the V-groove 60, the leveling scraper used to smooth the surface is also treated with a surface. After use, the blade shaft can be knocked off easily after use, so it is very effective in terms of non-adhesion. 6. Divided container With regard to the divided container 70, non-adhesive processing is also effective. In order not to cost, when the oxygen-coated aluminum layer is subjected to fluorine impregnation treatment, it can be constituted as shown in FIG. 23. That is, it is composed of two end square plates 71, two side square plates 72, a plurality of partition plates 73, and shutters 74, and these materials are made of aluminum, and then press-processed into the shape shown in the figure. The partition plate support grooves 75 provided on the side plate 72 are formed by embossing 300 tons. A slit 76 provided on the outer periphery of the side square plate 72 is used to prevent warping. The partition wall 73 is thinner and thicker than the side of the door 74, and has a tapered shape. Therefore, as shown in FIG. 24 in the assembled state, the interval between the sides of the adjacent partition plate 73 of the dividing container 70 is as shown in FIG. 22 (b), which is wider on the side of the stop 74 and narrows upward. . The shutter 74 is pivotally supported in the shaft hole 77a of the shutter support plate 77 provided on the side square plate 72 and is rotatable, and the division container 70 is closed by adsorption by the magnet 78 provided on the side square plate 72. The bottom. In order to remove the residual medicine in the partition container 70, the applicant filed an application for this patent application No. 09-67831 related to the cleaning device. By adopting the aforementioned non-adhesive treatment and the invention of the cleaning device, the pollution can be completely removed. However, when the shutter 74 of the split container 70 is opened, the split container 70 _ page (the face and neck are not scaled, and the face has been turned into a page) is 557277. It also causes vibration. That is to say, if the non-adhesive treatment is applied to the dividing container 70, the inner surface of the dividing container 70 will still have a phenomenon of thin powder and thin powder adherence, and the residual medicine will be removed by the cleaning device. 5 In order to solve this problem, it is preferable to apply vibration to the dividing container 70. For example, forming a plurality of grooves in the direction of the dividing container 70 and sliding the elastic piece provided with a protrusion at the front end portion so that the protrusions contact the grooves can impart vibration to the dividing container. This is an ideal method. It is also possible to consider a method such as installing a striking device on the door 74 or its opening and closing mechanism, or installing an ultrasonic vibration element. By providing such a mechanism, the non-adhesive treatment can be effectively performed. B. Cleaning of the cleaning material of the powder packaging device The main part of the present invention will be described from now on. The same reference numerals are used for the same constituent parts. 15 1 · Structure of powder packaging device The powder packaging device shown in Figure 25 is an example. In the powder packaging device, if the powder is put into the input funnel, the powder is placed under the input funnel. The vibrating feeder 2 of P vibrates the groove 3, and the powder is evenly deposited on the R groove 111 provided near the outer periphery of the dividing disc 11 for rotating the lower portion of the groove 3 at a certain speed. Although the aforementioned input funnel 1 is not explicitly shown in this figure, it can freely adjust the size of the exit opening and the clearance between the exit and the surface of the groove 3. If one side of the aforementioned divided disc 110 is rotated by an angle corresponding to the amount of dose and the dial-out device 40 is operated, it will be evenly stacked on the R groove i 丨 丨 continued on the next page. Please note that although the continuation sheet is used) 36 玖, the medicine described in the invention is divided and supplied to the packaging funnel 18 through the packaging funnel 18, and the powder is packed in the packaging bag ι3 by the packaging unit 17. Information on the contents of the package can be printed on the printer M 113 by the printer 112. After the packaging bag 113 is formed into a packing 胄 114, it is conveyed to the discharge port by a conveyor 115. After a series of packaging operations such as Hai are completed, the tapping device is called to apply a tapping vibration to the input funnel 1 to attach it to the input funnel i. The medicine falls into the groove 3 and the groove 3 is driven with the maximum vibration so that the remaining medicine on the groove 3 is also supplied to the R groove 111. Then, the attached brush suction cleaning device 117 is operated in a state in which it contacts R groove ill, and the dividing disc 11 is rotated to remove the remaining medicine. 2. Cleaning of the input funnel Fig. 26 is an enlarged view of the input funnel 1 having a cleaning material supply device. This cleaning material supply device is composed of a cleaning material container 118 and a supply nozzle 119. When the cleaning material container 118 is rotated, the supply nozzle 119 can be positioned directly above the input funnel 1. As shown in FIG. 27 and FIG. 28, a lower part of the cleaning material container 118 is provided with a spiral feeder 120, which is rotated by a motor 121 and conveys the cleaning material in the cleaning material container 118 to the supply nozzle 119 By. The cleaning material container 118 contains cleaning materials to be described later, and an upper end opening portion thereof is closed by a moisture-proof cover 129. The supply nozzle 119 includes: a shutter 122 that can open and close its supply port, a rotating shaft 123 for rotating the shutter 122, and an inserting and engaging hole 123a formed in the upper end of the rotating shaft 123. Slotted shaft 124, 0 Continued pages (If the description page is not enough, please note and use the continuation page) 37 557277 玖, Illustrated invention description Continued page 5 10 and one of the rotations of the slotted shaft 124 Door rotation motor 125. An electromagnet 126 is disposed around the rotating shaft 123 so as to face the magnetic body 123b fixed to the upper end of the rotating shaft 123. A spring 127 is disposed between the magnetic body 123b and the electromagnetic iron 126 to give the shutter 122 a potential energy in the closing direction. A vane 128 is provided on the aforementioned door. If the electromagnet 126 is excited in a state where the supply nozzle 119 is positioned on the input funnel 1 as shown in FIG. 26, the state shown in FIG. 27 is changed to that shown in FIG. 28, and the magnetic body 123b receives the electromagnet. 126 attracts and causes the spring 127 to compress, so that the rotation shaft 123 slides relative to the bolt groove shaft 124 and moves downward. As a result, the shutter 122 is lowered, and the supply port of the supply nozzle 119 is opened. Next, if the door rotation motor 125 is driven, the door 122 is rotated at high speed by the bolt groove shaft 124 and the rotation shaft 123, and the cleaning materials on the door 122 are scattered and supplied in the circumferential direction, as shown in FIG. 26. Shown along the input drain

15 The inner wall of bucket 1 falls. When the screw feeder 120 is rotated by the motor 121, the cleaning materials in the cleaning material container 118 can be continuously supplied through the supply nozzle 119. After a certain amount of cleaning material is supplied, first stop the motor 121 of the screw feeder 120, then stop the door rotation motor 125, and then demagnetize the electromagnet 126. Thereby, the magnetic body 123b can be pushed up by the potential energy given by the spring 127, and the rotation shaft 123 moves upward, and the shutter 122 rises, thereby closing the supply port of the supply nozzle 119. In this way, the cleaning materials are actively scattered on the inner wall surface of the input funnel 1, so that the medicine remaining on the inner wall surface is adsorbed on the cleaning materials, and the next page is cleared to 0 (when the invention description page is insufficient, please Note and use continued pages) 38

、 Explanation of the invention Continued description of the shaft Continuing cleaning materials fall on the groove 3 together. ~-While the π cleaning material is being supplied to the inner wall surface of the input funnel 1, if the knocking device 116 is used to apply knock vibration to the input funnel 1, the residual medicine can be removed. In addition, as previously explained, if the input funnel is formed of aluminum and is treated with T-type oxygen skin, then surface treatments such as impregnation of fluorine particles, the adhesion of the drug to the funnel 1 wall surface will weaken. Therefore, by carrying out both the surface treatment of the funnel 1 and the cleaning of the cleaning materials, the remaining medicine can be completely removed. Μ 3. Cleaning of the tank Cleaning of the tank 3 can be done with the aforementioned input funnel! Clean it together. During the supply of the medicine, the tank 3 will be vibrated, so the medicine on the tank 3 reaches a position higher than the outlet of the lower end of the input funnel 1, and the medicine will adhere to the lower end of the input funnel 丨 or the inner side wall of the tank 3. However, the cleaning material supplied to the tank 3 from the input funnel i is difficult to reach the height at which the medicine adheres, so there is a problem that the medicine attached to the higher position of the tank 3 cannot contact the cleaning material and remains. To solve such problems, three methods can be considered. The first method is to supply more cleaning materials than the amount of the previous packaged medicament and clear the medicament input into the funnel 丨 to a certain extent, then expand the gap between the input funnel 丨 the outlet and the tank 3 and use the vibration feeder 2 Vibration is applied to the tank 3, and after the cleaning material reaches the position where the medicine remains, the vibration level of the vibration feed H 2 is adjusted to the maximum to clean it. However, this method requires a large amount of cleaning materials, which is not economical. The second method is to arrange the cleaning 0 continuation page shown in Fig. 27 along the side wall of the groove 3. (When the description page of the invention is insufficient, please note and use the continuation page) 39 ' Supply the device, and make the cleaning materials slide down and clean on the side of the tank 3. This method is to adjust the vibration level of the vibration feeder 2 to the maximum at the beginning, and directly contact the cleaning materials that fall down by the vibration of the tank 3 with the powder, so that the residual medicine attached to the side wall of the tank can be effectively removed. On the other hand, it is necessary to provide a space or a supply device for the cleaning material to slide directly on the side wall of the tank 3, which becomes a reason for increasing costs. The third method is to use a suction-type cleaning device for the surface of the tank shown in Fig. 15 described above, in addition to the cleaning materials supplied to the tank 3 from the input funnel 1. A small amount of cleaning material can be supplied to the tank 3, and the tank cleaner nozzle 39 is moved without being sucked to make the cleaning material contact the surface of the tank 3, and the cleaning material remains on the surface of the tank 3 when the cleaning material contacts. After the medicine, the vibration level of the vibration feeder 2 of the tank 3 is raised to the maximum to shake off the remaining medicine, and the suction is removed by the suction nozzle 39 of the tank cleaner. This third method is different from the first and second methods in that it can remove the residual medicament as shown in the figure, and can completely remove the residual medicament, and also uses less cleaning materials, so it is ideal from an economic perspective. In addition to these cleaning methods, the cleaning effect can be enhanced by applying the aforementioned surface treatment to the groove 3. 4. Cleaning of the V-groove discs The cleaning of the V-groove discs 50 as shown in FIGS. 19 and 20 is also There are three methods. The first method is to supply cleaning materials equivalent to the amount of medicine deposited on the v-groove disc 50, but it is the same as the aforementioned tank 3, which is not economical due to the large amount of cleaning materials used. After the cleaning materials are supplied to the v-groove disc, the v-groove disc 50 is opposed to the lower divided disc 54 and the v-groove circle 0_ # is opened. 〇 玖, the invention explains the disc 50 so that the cleaning material falls to the lower divided disc 547 ^ 7 ^ tube 56 to clean the inside of the v-groove disc 50. The V-groove disc 50 rotates during the cleaning material supply. 5 10 15 The second method is to disperse and supply the cleaning materials dropped from the front end of the tank 3 in a state of falling on the wall surface of the 5G disc 5G. The cleaning materials directly contact the 5G wall surface of the v-groove disc, so it can be cleaned in a smaller amount than the first method. After supplying the cleaning materials to the V-groove disc 50, the V-groove disc 50 faces the lower part. After the disc 54 is divided, the V-groove disc 50 is opened for cleaning «54 in the lower part, and the inside of the V-groove disc 5G is cleaned by the v-groove duct%. The device for dispersing the cleaning materials can be described after the weighing The packaging funnel material can also be rotated by the board _ drop down ^ in the cleaning material supply, the V-groove disc 50 is rotated. The third method is set-the v-groove disc 5G is dedicated to the cleaning materials shown in Figure 27 The supply device '俾 directly supplies cleaning materials to the v-groove disc center. This method also allows the cleaning materials to directly contact the wall surface of the v-groove disc 50, so it can be cleaned in a smaller amount than the first method. After the material is placed in the V-slot disc 50, the V-slot disc 50 is opposed to the lower divided disc. Moxibustion opens the V-slot disc 50 so that the cleaning material falls on the lower divided disc 54 and is cleaned by the V-slot duct 56 Inside the V-groove disc 50. 20 The above method is to supply cleaning materials to the lower part of the disc 54 and then use the V-groove duct 56 The method of cleaning the inside of the V-groove disc 50, but the part with the cleaning material supply device at the lower dividing disc 54 can also be cleaned by the v-groove duct 56 to attract the cleaning materials in the V-groove disc 50. 5. Dividing Cleaning of discs 0 Continued pages (If the description page of the invention is insufficient, please note and use the continuation page) 41 557277 玖, the description of the invention Continuation page Continuation of the cleaning of the divided disk m, 54 can be used ^^ ~ For example, there is a method of supplying cleaning materials from the v-slot disc% and supplying cleaning materials from the tank 3 by vibration of the vibration feed 11 2, or by a dedicated cleaning shown in FIG. 27. A method for supplying 5 cleaning materials by the material supply device. The dividing disc 110 usually has a suction suction cleaning device 117 shown in FIG. 25 or a pull-out device 40 shown in FIG. 18, so these two types of devices can be used for cleaning. Three methods of monthly cleaning materials supply method: After supplying a certain amount of cleaning materials, use the pull-out device 40 to transfer the cleaning materials to the packaging funnel 18 provided on the dividing disks ι0 and 1054. Dispose of residual potions. In order to effectively carry out the residual chemical treatment, the number of dials is about 3 to 4 times. If the dividing disc 110 54 is rotated for one turn, as shown in FIG. 18, the rubber disc 41 can be placed on the knife cutting disc. When contacting the cleaning materials, the __ side can dispose of the residual medicine attached to the dividing disc 110'54. In addition, when a large amount of cleaning materials is used in the preceding procedure, it is appropriate to increase the number of allocations, which is an inevitable procedure. In addition, the cleaning device 117 can also be used for cleaning with the attached brush, but at this time, it is suitable to have a dedicated cleaning material supply device on the packaging funnel 18 for the subsequent process. When using the attached brush to attract the cleaning device 117, there is also a method of directly attracting the supplied / monthly cleaning materials, but it is preferable to perform the cleaning operation after using the aforementioned withdrawal device 20 40. When there are many cleaning materials, it is not suitable to use only a brush to attract the cleaning device 117 for cleaning. Furthermore, if the cleaning device 40 is used on the right side, the cleaning materials are still attached to the rubber disc 41 and the like of the extraction device 40, but the remaining medicine adhered to these parts can be removed by the cleaner nozzle 48. 0 Continued pages (If the description page of the invention is not enough, please note and use the continuation page) 42 557277 玖, the description of the invention description Continued page Please refer to Figure 25 to explain, if there is strong adhesion such as calcium lactate to the disc 11G ， 54 上 ', the cleaning materials can not be removed, so the fluorine recording eutectoid power ore and so on can be performed on the partition discs 110 and 54 in advance. 6. · Cleaning of the packaging funnel. As shown in FIG. 29, the packaging funnel 18 has a dispersing device 130 for dispersing the cleaning materials supplied by the withdrawal device 40 on the inner wall surface of the packaging funnel μ. It consists of a motor 132 supported by a support member (not shown), a rotating shaft 133 connected to the motor 132, and a dispersing head 134 installed at the front end of the rotating shaft 133. Not shown before

The non-supporting member has —moving «, which is used to move the tiller 134 between the retreat position that does not hinder the packaging of the medicament and the dispersing head 134 in the action position inside the packaging funnel M. The dispersing head m may be only a conical flat plate, but may also have a blade 128 as described by the supply nozzle 119. 15 The cleaning action of the packaging funnel 18 is as follows. The dispersing device 13 is divided into a dispersing head 134 inside the packaging funnel 18, and the cleaning material dispensed by the dispensing device 40 is supplied to the dispersing unit 134. The supplied clear__ is dispersed in the direction of the wall surface of the packaging funnel 18 by the rotation of the dispersing master U4. At this time, it is more effective to vibrate with the heart of the packaging material 18, and if the surface treatment described above is applied to the packaging funnel 18, the residual medicine can be completely removed. In addition, it can also be knocked. Instead, the device is vibrated by a vibration motor or an ultrasonic element.

'AT J 又 is also a cleaning material supply device dedicated to the packaging hopper 18 composed of the Xintian material container 118 and the supply nozzle 119, which directly supplies the cleaning material to the packaging hopper 18. 0 Continued pages (with bright female pages, I »note female continued pages) 43 20 557277

发明, Description of the invention 7. Other cleaning The present invention can also be used in the Japanese Patent Laid-Open No. Hei 2 ~ Kai Kai 8-U Jia powder packaging device. In particular, when supplying cleaning materials to the v-groove in JP-A-8-133202, a duct-like cleaning material supply device 135β dried as shown in Figure π is used. The cleaning material supply device is cleaned by its minus end. The feed container 118 and a screw feeder (not shown) supply cleaning materials to the two duct portions 137. The aforesaid ⑽conduit section 视 is seen as a mountain shape from one end, and the upper walls thereof are connected in a state of Μ ο 15 by a shaft Wa. The bottom wall of each duct portion 137 is open, and it can be closed by a mountain-shaped guide plate 136.

Normally, when a medicine is injected into the V tank 60, the cleaning material supply device 135 is located at a position separated from the ν tank 60 as shown in Fig. 30 (a). When cleaning is required, the cleaning material supply device 135 is moved to a position above the V tank 60 as shown in FIG. 30 (b). Moreover, as shown in FIG. 30 (c), the shaft 137a is used as the center to rotate the duct portion 137 upward and the bottom of the duct portion 137 is opened. The internal cleaning materials are slid down along the guide plate 136 and directly supplied. Clean the inner wall of the V-groove 60. Secondly, the bottom of the V tank 60 is opened for supplying a cleaning container 70 in the lower part of the V tank 60. At this time, if vibration is applied to the V tank 60 by a vibration motor or a 20 tapping device, the residual medicine inside the ▽ tank 60 is supplied to the dividing container 70 together with the cleaning material, and no residual medicine is generated. In addition, if the aforementioned surface treatment is applied to the V-groove 60 first, no residual medicine is generated at all. Regarding the cleaning of the divided container 70, if the technology of Japanese Patent Laid-Open No. Hei 10-258111 is adopted, the remaining medicine can be combined with the cleaning materials_continued on the next page (please note and use the continued page when the invention description page is insufficient) 44 557277 发明, description of the invention is removed by a cleaner. 8 · Recycling of cleaning materials方 One person consumes, 'There are 3 collections of Yuejie materials ..., cleaning materials and residual medicaments—the bucket 18 flows out and leaks in the packaging department for recycling. 乂 乂 At least one package is packed and mouthed. Close. At this time, in order to distinguish the packaging and cleaning of the powder, there are cleaning materials and residues in the packaging = ⑴ '《First and last packaging bags 113, or all packaging == on the printing machine 112 to print the packaging There are words for cleaning materials. 10 The second method is to recover the cleaning materials supplied to the medicine passage by a suction cleaning device. The suction-type cleaning device can use a commercially available vacuum cleaner and directly suck the cleaning materials and the residual medicament through the medicine channel through the vacuum cleaner. If the first method and the second method are used at the same time, it is possible to reduce the collection of packaging bags' and to save packaging paper to the minimum. 15 Description of the invention The side of the mouth of the continuation sheet is provided with a method for returning cleaning materials to the packaging during cleaning. The third method is to guide the powder to the packaging channel of the packaging bag 113 at the exit of the packaging funnel 18 and one to be closed The recycling channel in the recycling container shown in the figure is switched to the recycling channel. C. Cleaning of tablet packaging devices In the past, tablet packaging devices were cleaned by opening each part of the medicine channel and wiping the part contaminated with tablet dust with a cloth or the like, but the operation was very complicated. Here, the automatic cleaning of the tablet packaging device of the present invention will be described. Before cleaning the materials, please refer to the powder used when the powder packaging device is not used. 0 Continued pages (When the description page of the invention is insufficient, please note and use the continued page.) 45 发明 Description of the invention. Granular cleaning materials. 1. Structure of Lozenge Packaging Device Figure 31 is a perspective view of a lozenge packaging device. Lozenges are stored in lozenge boxes 139 for each type, and each lozenge box 139 is mounted on a motor base 14 provided on each outer peripheral surface of a two-layer cylindrical drum. A drop guide 141 is formed on the inner surface of each drum to allow the tablets to be discharged from each tablet case 139. An intermediate stop 141a is provided in the drop guide 141. A collection funnel 142 is provided below the drop guide 141. A packaging funnel 18 is arranged below the exit of the collecting funnel 142 near the central axis of the drum. The tablets discharged from the tablet box 39 by the action of the motor base 140 fall into the collection funnel through the drop guide 141 and are supplied to the packaging section 17 by the packaging funnel 18 and are supplied to the packaging section 17 by the roller. The wrapping paper 143 can be printed with prescribed information on the printer 112. In the packaging unit 17, the packaging paper 143 is folded in two to form a packaging bag 113, and the tablets are packed therein. The packing belt 114 is conveyed to the take-out port by a conveyor 115. 2. Cleaning device The tablet packing device has an automatic cleaning device, which is used to automatically clean the medicine channel between the drop guide 141 at the exit of the tablet box 139 and the exit of the packaging funnel 18 to remove the remaining medicine. The automatic cleaning device has a separating device 144 disposed on the upper portion of the tablet packaging device. The separation device 144 is provided with an A pipeline on the input side and B and c pipelines on the output side. The A pipe on the input side is connected to the suction port 146 located near the exit of the packaging funnel 18 as shown in Figs. 32 and 33. The B line on the output side is connected to a cleaner insertion port 145 provided on the outside of the lower portion of the tablet packaging device. C tube on the output side 0 Continued pages (Notes and use of continuation pages when the invention description page is inadequate) 46,557277 发明, invention description — The description of the invention is connected to the upper end of the drop guide 141. The granular cleaning material supplied to the drop guide 141 by the c line passes through the drug passages such as the drop guide 141, the collection funnel 142, and the packaging funnel 18, and then passes through the suction line 146 together with the dust of the tablet through the A line. Suction into the 5 device 144. The suction port 146 has a driving support portion 147 for moving the suction port 146 between the packaging position close to the packaging funnel 18 and the cleaning position isolated from the packaging funnel 18 as shown in Figs. 32 and 33. You can switch between the cleaning position and the packaging position by setting a changeover switch (not shown). If the changeover switch is switched to the packing position, the power supply to the socket 148 adjacent to the cleaner insertion port 145 is stopped. If it is switched to the cleaning position, the socket 148 is powered, and the connection to the cleaner insertion port 145 can be stopped. The cleaner supplies power. Figures 34 and 35 are a perspective view and a sectional view 15 of the separating device 144, respectively. The separation chamber 149 of the recovery container of the present invention is provided with a squeegee 150 having 4 blades, and the scraper 150 can be driven to rotate by the scraper motor 151. On both sides of the separation chamber 149 located on both sides of the A pipe connection port, about 60 are formed in the vertical direction. Fan-shaped opening 154 (see FIG. 37) of the development range. A tube header 155 is formed on the outer side of the openings 154 to connect with the B pipe. A net 152 is disposed in the gap between the two ends of the blade of the scraper 150 and the two walls of the separation chamber 149. The net 152 is arranged so that it can be rotated about 120 by an electric motor (not shown) around the axis of the scraper blade 150. And can be changed to a position for closing the aforementioned opening portion 154 and a position for opening. The above-mentioned scraper blade 0 continuation page (please note and use the continuation page when the invention description page is not enough) 47 Invention description Continuation page 60 degree angle fan, both ends of each blade of the invention description can be unfolded toward the rear side of the rotation direction The blocking plate 153 is shaped to block a part of the opening portion 154. The tablet dust and particulate cleaning materials and air sucked through the A pipe are introduced into the separation chamber 149. In the state of Fig. 36 (a), the blade of the scraper I50 facing up and down will prevent the air from flowing into the c pipe due to the negative pressure of the B pipe, so the air passes from the A pipe through the net 152 and the opening 154. Move from pipe header to pipe B. The cleaning materials can be collected by the net 152 and accumulated. As shown in Figure 36 (b), if the scraper is rotated 60 ° by 60 °, the closing plate ι53 behind the scraper 150 located below the A pipeline will close the lower part of the mesh M), and the scraper located below the A pipeline The space is concentrated without decompression. Therefore, when the 'scraper 150 is rotated from Fig. 36 (a) to Fig. 36 (b), air does not flow into the net 152 through the C pipe, and the attraction force of the suction port 146 does not decrease. In such a series of processes, the cleaning materials accumulated in the net 152 are conveyed by the rotation of the scraper 150, and are supplied to the c line, and then supplied to the drop guide 141. In this way, after the cleaning material is circulated for a certain period of time, the tablet dust attached to the tablet channel is sucked up with the cleaning material and separated in the separating device 144 from the cleaning material, and is attracted by the cleaner, and Allows the keyway to be completely cleaned. It is also possible to pass air without using cleaning materials, but it has no effect because the dust accumulated in the key agent channel is flying. If granular cleaning materials are used, the accumulated dust will fly up due to the impact of falling cleaning materials, etc., and will be discharged with the air flow, so the cleaning effect is very high. After cleaning, as shown in Fig. 37, 'make the net 152 rotate about 120 degrees, and open the opening part 0 to continue the page (turn 1 ¾ to make up, pay attention to the female page) 48 Rose, description of the invention Description of the invention Continued on I54. Thereby, the A pipe is connected to the B pipe through the opening 154, and the cleaning materials are also recovered by the cleaner, and the cleaning of the inside of the tablet packaging device is finished. The cleaning materials can also be fed in using a portion of the tablet cassette 139. In addition, a cleaning material supply port may be provided in a part of the tablet passage, and the cleaning material is supplied manually therefrom. D. Cleaning materials The cleaning materials used in the powder packaging device and the tablet packaging device have previously been described differently. Here, the cleaning materials are explained in detail. h The cleaning materials of the powder packaging device are used for the cleaning materials of the powder packaging device. When the pharmacist performs manual cleaning, most of them use lactose or modified starch. These are used to make strong ingredients such as potent drugs in the medicine. It is called an excipient when it is prescribed for prescription. Because lactose contains sugar, it has water absorption properties. This moderate water absorption will increase the adsorption force of the substance, but on the other hand, there will be a problem that the amount of adhesion to the contact members of each drug will increase. In addition, lactose is weak in heat resistance, and it also liquefies due to the effects of heat and heat. Therefore, it is not suitable to supply pure lactose as a cleaning material to a powder packaging device. In addition, the "adjusting starch is made from baron taro as raw material, so the main component is carbohydrates" and the hygroscopicity is weak due to the nature of the powder, and the particle shape is also large and has a dry feeling. However, the adsorption of substances, especially active adsorption Residual potency is weak. However, once adsorbed, the shape of the particles becomes larger, and there is an effect that they can be easily dropped by a slight impact. The ideal cleaning material needs to be left in the powder channel without affecting the patient. The candidate is preferably a food powder. For example, wheat flour, buckwheat flour, and __ pages are not enough, please note and continue the page) 49 玖, description of the invention Description of the invention continued page Corn flour, salt, sugar, etc. Among them, those containing a large amount of vegetable and animal fats and oils are not used to the extent that they cannot be used as cleaning materials, but if the particle shape is too detailed, it tends to adhere with the residual chemicals. Examples of such powder include sesame powder and milk powder. On the other hand, it is known that oat flour is preferred as a powder that is easy to exert the cleaning material properties such as residual chemical adsorption. Regarding milk powder, it is more effective if it is composed of degreasing ingredients and larger particles, but it is more expensive to use as a cleaning material, and dairy products must be considered. Zongzi, millet and other miscellaneous grain powders also have less oil, so they have a cleaning effect and are less likely to cause patient allergies, so they can be used as cleaning materials. The cleaning materials mixed with multiple powders can make up for the shortcomings of various powders and show excellent results. The cleaning effect is mixed with the weight ratio of oat flour 2, killing powder G.5, and lactose G5, or the cleaning material mixed with the weight ratio of corn flour 丨, starch 0.5, and lactose 0.5. high. Various other combinations can be considered for cleaning materials with high cleaning effect. It is also conceivable to use a crystalline powder such as a chemical seasoning as a cleaning material ', but it is also known that it is easily affected by static electricity. 2. Cleaning materials for pastille packaging equipment. Know the candidate of cleaning materials for packaging equipment, such as small grain soybeans, red denier, rice, etc. as examples. When the cleaning material is soybean, if the attractive force of the cleaner is insufficient, it cannot be sucked from the packaging funnel to the upper part of the tablet packing device, and there is a problem of clogging. The person who cut the rice into a circle has a certain degree of effect, but there is a problem that the missing rice blocks the net 152. The red beans are ideal in terms of size, use, and so on. 0 Continued pages (if the invention description page is not _, please note the sickle surface page) 50 玖, invention description issued the next page Continue to use Shi Xiqiu as a cleaning material. At this time, if the inside of the cleaning material is sealed, «Electric ID visits the location of the residual material, it can prevent Shi Xiball from mixing into the package and reaching the patient's hands, and it can be used permanently by washing. The dream ball industry has been confirmed to be more effective with a diameter of about 3mm to 8mm. E · Control of cleaning action To make the cleaning action more automatic, you can control the appointment. In particular, those drugs that will cause problems if mixed into the medications of subsequent patients, such as potent drugs, poisons, narcotics, psychotherapeutics, and bilin-based drugs, will cause severe allergic reactions, first as a management drug, as shown in Figure 38 As shown in the registration of the pharmacy registration main building, and the management of the medicament and the cleaning action control are connected, the machine can determine when the powder packaging device or tablet packaging device is processed by data communication when it is used. For simple operations, an activation button can also be provided to initiate cleaning when the pharmacist thinks it is necessary. According to the present invention, the powder packaging device has a cleaning material supply device for supplying cleaning materials contained in the cleaning material container to any one of a series of medicament channels from the input funnel to the outlet of the packaging funnel. When cleaning is needed, after cleaning materials are supplied to the medicine channel, the medicine channel is cleaned by recovering the powder and cleaning materials remaining in the medicine channel from the medicine channel, so it can completely prevent poisons, potent drugs, and psychotherapy drugs. , Narcotic drugs, anticancer agents, bilin-based drugs and other high-risk drugs are mixed into the subsequent prescription packaging of drugs. In addition, there is no need for the pharmacist to use hands, through the setting and start buttons and other mechanisms, from the input funnel of the medicament and through the dividing device to the packaging leakage 0 Continued page (if the invention description page is insufficient, please note and use the continued page) 557277 The description of the invention, no matter how much the residue of the medicine is, use the material, and use the cleaning material and residual medicine = cleaning material in the funnel, then the material supply device can be used at the lowest position, and it can be minimized. The amount of the cleaning material cleans all the medicine channels. Ding inch, the monthly loan agent, and the monthly cleaning material supply device can supply cleaning materials to most parts of the medicine channel, which can shorten the cleaning time. 10 The packaging device will supply the medicines to the medicine. The cleaning materials of the aisle are packed in at least one packing bag, and the cleaning operation is efficiently performed. In addition, because there is-a part or all of the packaging ^ used to clean the packaging at the time of printing is printed with the word "packed" Printing device, you can easily use different cleaning materials. '15 Description of the invention Continuing pages can be automatically supplied with cleaning agent and collected as needed. Recovered by suction cleaning device The cleaning materials for the medicine channel can reduce the reliance of the packaging bag and save the packaging paper to the minimum. By using a commercially available vacuum cleaner as the suction device and arranging its suction population in the medicine channel, there is no need to Set up a new device and reduce costs. The spoon has a packaging channel on the exit side of the packaging funnel to guide the powder to the packaging bag, and a recovery channel to recover cleaning materials. The packaging channel can be used when cleaning materials are recycled. It is switched to the recovery channel, so there is no need to use wrapping paper when recovering cleaning materials. The monthly cleaning material supply device has a spreading device for spreading the monthly cleaning materials towards the wall of the medicine channel, so that the adhesion can be reliably removed. The medicine on the wall of the medicine channel. — Also, according to the present invention, the tablet packaging device has a cleaning material for _ & the stomach description page is inadequate for use, the “hidden female page”) 52 20 发明, invention description invention Describe the continuation sheet feeding device, which is used to supply any of the materials contained in the cleaning material container 7 to the outlet of the E-type container to the outlet of the packaging funnel. When cleaning is needed, after the cleaning material is supplied to the medicine channel, the medicine channel is cleaned by recovering the medicine and cleaning materials remaining in the medicine channel from a certain channel, so the same as the aforementioned powder packaging device can be achieved. The effect is that by using granular cleaning materials to impinge on the dust-like residual medicine attached to the medicine passage, the medicine can be reliably removed. At the exit side of the packaging funnel, there is a mechanism for guiding tablets to the packaging bag. The packaging channel and a recovery channel for recovering cleaning materials can be switched from the packaging channel to the recovery channel when the cleaning materials are recovered, so the cleaning material can be quickly and easily recovered. At this time, the recovery channel has a purpose The suction device that simultaneously sucks cleaning materials and residual medicaments from the outlet of the packaging funnel and then recovers them in the recovery capacity state can save cleaning materials and use economically. In addition, there is a cleaning material for attracting the cleaning devices. The separating device separated from the residual medicine is supplied to the aforementioned medicine passage again by cleaning materials separated by the separating device. To be recycled, then clean with the use of the material can be cost-effective. Furthermore, after the cleaning materials are recycled, the cleaning materials separated by the separating device can be recovered, thereby replenishing new cleaning materials and improving the cleaning effect. [Brief description of the formula] Figure 1 is a front view showing the powder feeding funnel and its vibration mechanism. 0 Figure 2 is a cross-sectional view of the funnel showing the powder attachment status. Fig. 3 is a cross-sectional view of a funnel showing the state of powder attachment. 0 Continued pages (please note and use continuation pages when the invention description page is insufficient) 53 玖. Invention description invention description _ stomach ·· " · 执 '狐 · * ::: iber: job; gang fiber_ί Xi Xianlian .........., .. x ::: Secretary always condescending! The one shown in FIG. 4 is one of the non-adhesive scale aluminum layers. The one shown in FIG. 5 is another example of the non-adhesive scale. The processes shown in Figures 6 (a) to (d) are the forming process of the funnel. Fig. 7 is a process chart of oxygen skin treatment. The one shown in Fig. 8 is a film-forming surface. In Figure 9, (a) is a side view showing a funnel vibration device, (b) is a side view of a funnel equipped with a cooling mechanism and a heat pipe, and ((0 is equipped with a fan and a heat sink as a cooling mechanism) Side view of the funnel. Figure 10 is a schematic view showing a soaking treatment tank. Figure 11 is a plan view of a tank showing a state of powder attachment. Figure 12 is a cross-sectional view of a non-adhesive layer of the tank. Figure 13 is a view showing a state of powder attachment Slot plan. Figures 14 (a) to (c) are plan, side, and partially enlarged views of the slot. Figure 15 is a front view of the slot and cleaning device. Figure 16 is a flowchart showing the operation of the slot manufacturing device. Figures 17 (a) and (b) are manufacturing process drawings and exploded sectional views of the withdrawal device. Figures 18 (a) and (b) are perspective views of the withdrawal device. Figure 19 is a V-groove disc A perspective view of a split disc. Figure 20 is a cross-sectional view of a V-slot disc. Figure 21 is a cross-sectional view of a V-slot. Figures 22 (a) to (c) are enlarged views of a split container. Figure 23 This is an exploded perspective view of the entire divided container. 0 Continued pages (When the description page of the invention is insufficient, please note and use the continued ) 54 557277 发明 Description of the invention Description of the invention Continued Figure 24 is an overall perspective view of a divided container. Figure 25 is a schematic perspective view of a powder packaging device. Figure 26 is a diagram showing an input funnel and cleaning material supply of the powder packaging device. An enlarged perspective view of the device. Fig. 27 is a sectional view showing a closed state of a door of the cleaning material supply device.

Fig. 28 is a sectional view showing an open state of a door of the cleaning material supply device. Figure 29 is a side view showing the powder packaging funnel and the dispersing device. Fig. 30 is a perspective view showing the supply of cleaning materials to the v tank. (0 is a cleaning standby state at a fixed position, (b) is a state that has been moved to a cleaning position, and (c) is an open door for cleaning. Fig. 31 is a perspective view showing the outline of a tablet packaging device. Fig. 32 is a front view showing a packaging funnel and a nozzle in cleaning. Fig. 33 is a view showing a packaging funnel and a nozzle in cleaning standby. face

Figure 34 is a perspective view of the separation device. Fig. 35 is a sectional view of the separating device. In the% chart, ⑴ is a cross-sectional view showing the blade action ^^ 20, and 〇 is a cross-sectional view of the separating device showing the squeegee action 3 > ^ action B state. Fig. 37 is a sectional view showing the operation of the net in the separating device. The picture shown in Figure 38 is the main screen of drug registration. II: It is the distinction and contact between the 4s and the contact members. When the description page is not enough, please note and bribe the continuation page) 55 557277, description of the invention Description of the invention continued page No. 40 is an enlarged view of the powder particles. t H9 type main components represent the symbol table h ·· input funnel 22 ... heat pipe 1 ... treatment material 23 ... radiator 2 ... vibration feeder 24 ... fan 3 ... vibration feed tank 25 ... heat sink 4 ... · Aluminum base material 31 ... Steel plate 5 ... Oxidation layer 32 ··· Shao-zinc alloy ore layer 6 ·· Hole 33 ··· Chemical conversion coating film 7… Polytetrafluoroethylene resin 34 ·· Primer 8 ... crack 35 ... fluororesin coating 9 ... squeegee squeeze roller 36 ... polyester resin coating 10 ... handle 37 ... crimp 11 ... supporting part 38 ... ear 12 ... container 39 ... Slot cleaner nozzle 13 ... Ultrasonic bath 39a ... Drop sensor 14 ... Vibration element 40 ... Pull-out device 15 ... Stage 41 ... Rubber disc 16 ... Ultrasonic Generating device 42 ... paddle rubber 17 ... packing section 43 ... separation rubber 18 ... packing funnel 44,45 ... perforated circular plate 19 ... heating roller 44a, 45a ... 孑 L 20 .. .Stainless steel plate 44b, 45b ... Burning surface 21 ... Ultrasonic vibration element 46 ..... Silicon rubber 0 Continued page (when the description page of the invention is insufficient, please note and use continued page) 56 557277 玖Description of the invention 48… Nozzle 49 ··· Brush 50 .. .V groove disc 51 .. Inner ring 52... Outer ring 53... Cleaner 54... Split disc 55... Motor 56.. V Slotted duct 56a ... CR sponge 57 ... Drive transmission belt 58 ... Skirt nozzle rotation gear 59 ... Skirt nozzle 59a ... CR sponge 60..V Slot 61 .. Support member 62..Resonance Spring material 63 ... Front plate 64 ... Support plate 65 ... Recess 66 ... Elastic sheet 66a ... Protrusion 67 ... Dust collection duct invention description Continued 70 ... Divided container 71 ... End face block Plate 7 2 ... Side square plate 73 .. Dividing plate 74 ... Block door 75 .. Supporting groove 7 for partition plate 7 6 ... Slot 77..Block supporting plate 77a ... Axle hole 78 … Magnet 110 .. Divided disc 111… R groove 112 .. Printing machine 113 ··· Packing bag 114 .. · Packing belt 115 ··· Conveyor 116 ... Percussion device 117 ... With brush suction cleaning device 118 … Cleaning material container 119… Supply nozzle 120 ... Screw feeder 121 ... Electric motor 122 ... Door 123 ... Rotary shaft 0 Continued page (If the description page of the invention is insufficient, please note and use Continued) 57 557277 玖, description of the invention 123a ... hole 123b ... magnetic body 124 ... Slot shaft 125 .. Door rotation motor 126 ... Electromagnet 127 .. Spring 128 .. Blade 129 .. Moisture-proof cover 130. Dispersion device 132 .. Motor 133 ... Rotary shaft 134. Dispersion head 135 ... Cleaning material supply device 136 ... Guide plate 137 ..... duct section 137a ... Shaft 139 ... Lozenge box 140 ... Motor base 141 ... Down guide 141a ... Intermediate door 142 ... Collection funnel 143 .. Description of the invention of the wrapping paper Last page 144 ... Separation device 145 ... Cleaner insertion port 146 ... Suction port 147 ... Drive support 148 ... Socket 149 ... Separation chamber 150 ... Squeegee 151 ... to Knife motor 152 ... Net 153 ... Blocking plate 154 ... Opening 155 ... Tube header 201 ... Split disk 202 ... R groove 203 ... Pull-out device 204 " Silicone 205 ... · Lactic acid mom 206 ... Liquid lactic acid ingredient

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Claims (1)

557277 The patent application and packaging scope of the “medicine and medicine packaging device” is used to supply the powder input through the input funnel to the county, and use this branch to place the amount of powder 1 to divide the amount of powder 1 into the industry & The medicament is supplied to the packaging device through the packaging funnel, and the powder is packed in the packaging bag by the packaging device; 〃 It is characterized in that the medicament packaging device has a cleaning material supply device for collecting grain in the cleaning material container The cleaning materials are supplied to any one of a series of medicine channels from the input funnel to the outlet of the packaging funnel; 10 15 20… * When cleaning, 俟 supply the aforementioned cleaning materials to the aforementioned medicine channel ’to clean the medicine channel by recovering the powder and cleaning materials remaining in the medicine channel from the medicine channel. 2. The pharmaceutical packaging device according to item i of the patent application scope, which supplies the aforementioned cleaning materials to the aforementioned input funnel. 3. If the pharmaceutical packaging of item i in the scope of the patent application is aggregated, it is used to supply the former cleaning agent to most parts of the foregoing medicine channel by the aforementioned cleaning material supply device. 4. For a pharmaceutical packaging device according to item i of the patent application scope, the aforementioned packaging device is used to package the cleaning materials supplied to the aforementioned pharmaceutical channel in at least one packing bag for recycling. 5. If the pharmaceutical packaging device according to item 4 of the patent application has a printing device, it is used to print part or all of the aforementioned packaging bags with the words "cleaning materials" on them. & as the scope of patent application! The pharmaceutical packaging device of the item is a cleaning material that is supplied to the aforementioned passage by a suction cleaning device. Month 0 Continuation Page (Patent application scope page is insufficient, please note and use continuation page) ^ 557277, patent application scope, patent application scope continued 7. If the pharmaceutical packaging device of the first patent application scope, the exit side has a bagging channel for guiding the aforementioned powder to the aforementioned packaging bag, and a recycling The recovery channel of the cleaning material; and when the cleaning material is recovered, the packaging channel is switched to the recovery channel. 8. The pharmaceutical packaging device according to item 7 of the scope of patent application, wherein the recovery channel has a recovery container for recovering the aforementioned cleaning materials. 9. The pharmaceutical packaging device according to the scope of application for patent item (i), wherein the cleaning material supply device has a spreading device for distributing cleaning materials toward the wall of the aforementioned medicine channel. 10 · Pharmaceutical packaging devices for supplying tablets per serving from a large number of cassette containers containing tablets according to each type, and collecting the tablets in a collection funnel through a common channel, and collecting the tablets The tablets are supplied to the packaging device through the packaging funnel, and the tablets are packaged in the packaging bag with the packaging device; ~ It is characterized in that the drug packaging device has a cleaning material supply device, which is used to store the tablets in cleaning The cleaning materials in the material container are supplied to any one of a series of medicine channels from the outlet of the cassette container to the outlet of the packaging funnel. When cleaning is needed, the cleaning materials are supplied to the medicine channel, and then Recover the medicament and / or cleaning materials remaining in the medicament channel from the medicament channel to clean the medicament channel. 11. If the pharmaceutical packaging device of item 1G of the patent application scope, wherein the exit side of the packaging funnel is provided with a 0-continuing page for guiding the aforementioned tablets to the aforementioned packaging bag (when the application range of the application range is insufficient, please (Notes and continued pages) 60 557277 Pick up, apply for patents, apply for patents, end of packaging channels, and a recycling channel for recycling the aforementioned cleaning; and, when the aforementioned cleaning materials are recycled, switch from the aforementioned packaging channels to The aforementioned recovery channel. 12. The pharmaceutical packaging device according to item u of the patent application scope, wherein the recovery channel has a suction device for sucking the bow from the outlet of the packaging funnel at the same time. By. 13. If the pharmaceutical packaging device according to item 12 of the patent application scope, it further has a separation device for separating the cleaning materials attracted by the aforementioned suction device from the residual drugs, and the cleaning materials separated by the separation device It is again supplied to the aforementioned medicine channel and circulated. 14. If the pharmaceutical packaging device of item 13 in the scope of the patent application is for recycling the aforementioned cleaning materials, the cleaning materials separated by the separating device described in the previous industry are recovered. 61